LOCUS       NM_031895               8850 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens calcium voltage-gated channel auxiliary subunit gamma
            8 (CACNG8), mRNA.
ACCESSION   NM_031895
VERSION     NM_031895.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8850)
  AUTHORS   Donato,L., Alibrandi,S., Scimone,C., Rinaldi,C., Dascola,A.,
            Calamuneri,A., D'Angelo,R. and Sidoti,A.
  TITLE     The impact of modifier genes on cone-rod dystrophy heterogeneity:
            An explorative familial pilot study and a hypothesis on
            neurotransmission impairment
  JOURNAL   PLoS One 17 (12), e0278857 (2022)
   PUBMED   36490268
  REMARK    GeneRIF: The impact of modifier genes on cone-rod dystrophy
            heterogeneity: An explorative familial pilot study and a hypothesis
            on neurotransmission impairment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8850)
  AUTHORS   Bai,W.J., Luo,X.G., Jin,B.H., Zhu,K.S., Guo,W.Y., Zhu,X.Q., Qin,X.,
            Yang,Z.X., Zhao,J.J., Chen,S.R., Wang,R., Hao,J., Wang,F.,
            Shi,Y.S., Kong,D.Z. and Zhang,W.
  TITLE     Deficiency of transmembrane AMPA receptor regulatory protein
            gamma-8 leads to attention-deficit hyperactivity disorder-like
            behavior in mice
  JOURNAL   Zool Res 43 (5), 851-870 (2022)
   PUBMED   36031768
  REMARK    GeneRIF: Deficiency of transmembrane AMPA receptor regulatory
            protein gamma-8 leads to attention-deficit hyperactivity
            disorder-like behavior in mice.
REFERENCE   3  (bases 1 to 8850)
  AUTHORS   Peng,S.X., Wang,Y.Y., Zhang,M., Zang,Y.Y., Wu,D., Pei,J., Li,Y.,
            Dai,J., Guo,X., Luo,X., Zhang,N., Yang,J.J., Zhang,C., Gao,X.,
            Liu,N. and Shi,Y.S.
  TITLE     SNP rs10420324 in the AMPA receptor auxiliary subunit TARP gamma-8
            regulates the susceptibility to antisocial personality disorder
  JOURNAL   Sci Rep 11 (1), 11997 (2021)
   PUBMED   34099816
  REMARK    GeneRIF: SNP rs10420324 in the AMPA receptor auxiliary subunit TARP
            gamma-8 regulates the susceptibility to antisocial personality
            disorder.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8850)
  AUTHORS   Guan,F., Zhang,T., Liu,X., Han,W., Lin,H., Li,L., Chen,G. and Li,T.
  TITLE     Evaluation of voltage-dependent calcium channel gamma gene families
            identified several novel potential susceptible genes to
            schizophrenia
  JOURNAL   Sci Rep 6, 24914 (2016)
   PUBMED   27102562
  REMARK    GeneRIF: These results indicate that CACNG4, CACNG5, CACNG6 and
            CACNG8 may contribute to the risk of SCZ. The statistical epistasis
            identified between CACNG5 and CACNG6 suggests that there may be an
            underlying biological interaction between the two genes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8850)
  AUTHORS   Ortega,A., Tarazon,E., Rosello-Lleti,E., Gil-Cayuela,C., Lago,F.,
            Gonzalez-Juanatey,J.R., Cinca,J., Jorge,E., Martinez-Dolz,L.,
            Portoles,M. and Rivera,M.
  TITLE     Patients with Dilated Cardiomyopathy and Sustained Monomorphic
            Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes
            and CACNG8-Linked Left Ventricular Dysfunction
  JOURNAL   PLoS One 10 (12), e0145518 (2015)
   PUBMED   26710323
  REMARK    GeneRIF: Patients with Dilated Cardiomyopathy and Sustained
            Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and
            KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8850)
  AUTHORS   Sager,C., Tapken,D., Kott,S. and Hollmann,M.
  TITLE     Functional modulation of AMPA receptors by transmembrane AMPA
            receptor regulatory proteins
  JOURNAL   Neuroscience 158 (1), 45-54 (2009)
   PUBMED   18304745
  REMARK    Review article
REFERENCE   7  (bases 1 to 8850)
  AUTHORS   Correia,S.S., Bassani,S., Brown,T.C., Lise,M.F., Backos,D.S.,
            El-Husseini,A., Passafaro,M. and Esteban,J.A.
  TITLE     Motor protein-dependent transport of AMPA receptors into spines
            during long-term potentiation
  JOURNAL   Nat Neurosci 11 (4), 457-466 (2008)
   PUBMED   18311135
REFERENCE   8  (bases 1 to 8850)
  AUTHORS   Chen,R.S., Deng,T.C., Garcia,T., Sellers,Z.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits: a functionally diverse protein
            family
  JOURNAL   Cell Biochem Biophys 47 (2), 178-186 (2007)
   PUBMED   17652770
  REMARK    Review article
REFERENCE   9  (bases 1 to 8850)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   10 (bases 1 to 8850)
  AUTHORS   Burgess,D.L., Gefrides,L.A., Foreman,P.J. and Noebels,J.L.
  TITLE     A cluster of three novel Ca2+ channel gamma subunit genes on
            chromosome 19q13.4: evolution and expression profile of the gamma
            subunit gene family
  JOURNAL   Genomics 71 (3), 339-350 (2001)
   PUBMED   11170751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008440.9 and AF288388.1.
            
            On Jun 2, 2019 this sequence version replaced NM_031895.5.
            
            Summary: The protein encoded by this gene is a type I transmembrane
            AMPA receptor regulatory protein (TARP). TARPs regulate both
            trafficking and channel gating of the AMPA receptors. This gene is
            part of a functionally diverse eight-member protein subfamily of
            the PMP-22/EMP/MP20 family and is located in a cluster with two
            family members, a type II TARP and a calcium channel gamma subunit.
            The mRNA for this gene is believed to initiate translation from a
            non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288388.1, AF361354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000270458.4/ ENSP00000270458.3
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC008440.9         107301-107539
            240-1520            AF288388.1         1-1281
            1521-8850           AC008440.9         127250-134579
FEATURES             Location/Qualifiers
     source          1..8850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..8850
                     /gene="CACNG8"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 8"
                     /db_xref="GeneID:59283"
                     /db_xref="HGNC:HGNC:13628"
                     /db_xref="MIM:606900"
     exon            1..489
                     /gene="CACNG8"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1484
                     /gene="CACNG8"
                     /note="non-AUG (CUG) translation initiation codon;
                     neuronal voltage-gated calcium channel gamma-8 subunit;
                     calcium channel, voltage-dependent, gamma subunit 8; TARP
                     gamma-8; transmembrane AMPAR regulatory protein gamma-8"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-8
                     subunit"
                     /protein_id="NP_114101.4"
                     /db_xref="CCDS:CCDS33104.1"
                     /db_xref="GeneID:59283"
                     /db_xref="HGNC:HGNC:13628"
                     /db_xref="MIM:606900"
                     /translation="MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYW
                     LYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCV
                     KINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIIL
                     GAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEV
                     IGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRS
                     SSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVG
                     AFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPA
                     PAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV"
     exon            490..573
                     /gene="CACNG8"
                     /inference="alignment:Splign:2.1.0"
     exon            574..714
                     /gene="CACNG8"
                     /inference="alignment:Splign:2.1.0"
     exon            715..8850
                     /gene="CACNG8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8831..8836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNG8"
                     /note="hexamer: AATAAA"
     polyA_site      8850
                     /gene="CACNG8"
                     /note="major polyA site"
ORIGIN      
        1 ccttgccctc caccagccgc cgaccatggc cgcgctctga ccccctcccc ggccgcagcc
       61 tcctcctcgc cgcccccctc cccagccccg ccggccccgg gccccccgct tctgcctgcg
      121 ctgtgaaccc ccccccagcc gccggcacgg ccccgccccc gctgccccgg tggtggccca
      181 cggccccccg gctgcccgtg gtcaaactgg agtcgctgaa gcgctggaac gaagagcggg
      241 gcctctggtg cgagaagggg gtgcaggtgc tgctgacgac ggtgggcgcc ttcgccgcct
      301 tcggcctcat gaccatcgcc atcagcactg actactggct ctacacgcgc gccctcatct
      361 gcaacaccac caacctcacg gccggcggcg acgacgggac cccccaccgc gggggcggcg
      421 gcgcctcgga gaagaaggac cccggcggcc tcacgcactc gggcctctgg aggatctgct
      481 gcctggaagg gttgaaaaga ggcgtctgcg tgaagatcaa tcatttcccg gaggacacgg
      541 actacgacca cgacagcgcg gagtatctac tccgagttgt ccgggcctcc agcatcttcc
      601 ccatccttag cgccatcctg ctgctgctcg ggggtgtgtg cgtggcggcc tcccgcgtct
      661 acaagtccaa gaggaacatc attctgggcg cagggatcct gttcgtggca gcaggcctga
      721 gcaacatcat cggcgtgatc gtgtacatct ccgccaacgc gggcgagccg ggcccgaagc
      781 gggacgagga gaagaaaaac cactactcgt acggctggtc cttctacttc ggcgggctgt
      841 cgttcatcct ggccgaggtg ataggcgtgc tggccgtcaa catctacatc gagcgcagcc
      901 gcgaggcgca ctgccagtct cgctcggacc tgctcaaggc cggcgggggc gcgggcggca
      961 gtggcgggag cggcccctcg gccatcctcc gtctgcccag ttaccgcttc cgctaccgcc
     1021 gccgctcccg ctctagctcc cgctccagcg agccgtcgcc gtcgcgggac gcgtctcccg
     1081 gcggccccgg gggcccgggc tttgcctcca cggacatctc catgtacacg ctcagccgcg
     1141 acccctccaa gggcagcgtg gccgcggggc tggcgggggc cggcggcggc ggcggcggcg
     1201 ccgtgggggc gttcggcggc gcggccgggg gcgccggggg cggcggcgga ggcggcggcg
     1261 gggcgggtgc cgagcgggac cgcggggggg cgtccggctt cctcacgctg cacaacgcct
     1321 tccccaagga ggcgggcggc ggcgtcacgg tcacggtcac cgggccgccc gccccgcccg
     1381 cgcccgcgcc acccgcgccc tctgcgcccg cccccgggac cctggccaag gaggccgccg
     1441 cctccaacac caacacgctc aacaggaaaa ccacgcctgt gtaggggcgc ggcgggggag
     1501 ccgaggggcg tgtccggggc gcgtgcgcgg gcgcgcgtgc atcgaggctg ccggggtcgg
     1561 gggcgccccc gctttccccc gtgagcgcgc tggagactgc tgggcccgcc ccacgcccac
     1621 cctccccgcc cccctccccc tccgaagcag ggaccccgag ggagggggca ggggagggag
     1681 ggggccgctg tgagggagcg tcgtgtttta tttttttggg ggatctatgg ggagggggga
     1741 gggccatggt gttttttgca gtttcgagat gttttctttt tcatgttttg ctgtgtgcat
     1801 ggggggcggg gcggggggag gggagggagg gactcccagc ccagcccaac tcctggagag
     1861 gggcccataa tacacgaata catagttaca cccacaaact atatatatgc cctatataaa
     1921 gagacacagc gaagggatgc agaaaggcag aaagaagggt tggacgcggg cattcattca
     1981 tttttttcat tcattattcc acaagggctt attaagcacc tactgtgtac caggcactgg
     2041 tacataagaa ggcattggag caggggacac gaacgaggca cagaaagggc cttctcattc
     2101 attcattcat taccggcaat ttatttgtgc gccttaaaaa gctaggcatt gtgctccgtg
     2161 ctcagcgtgc aggaggcagg aaaacagcca ggggccccga cgtctcatag agtaaacatc
     2221 ttgtgcatga gacaggcatt aatcgatcat gtacatacac aataaattac agttaggcta
     2281 taggagaaac gagatgctat gaaatgctcc atcaggggag cctaacccag ttgtgaggaa
     2341 gagatttcag tggacagtga aaggatgaga agaagccagc agggcggagc tggggcagga
     2401 gtgtggcagg cagagcagca cgtgcaaagg ccccggggca ggaaggagct tgcagcgagg
     2461 gctgaagggt agtgaggcag gtgagcgggg atcaaggtga ggccggagac acagacaggg
     2521 ccagattgtg caggggctcg taggtcagga gttcagattt tattctagga gtggtgaggg
     2581 ccgtggaacg ggtttaagca ggacgctaac gtgaatggtg tacaaaggga agacaggaac
     2641 tcggaggcaa gagtaggagg cagagatgtg ctgaaataca gcatcaaaca tgggcacggg
     2701 cccttggagc tcacactctt gtgggaggaa gcacgtaatt acacagatgc tgaagcatag
     2761 tcatggtgtc tggtgtgcag gagaaagccg tggggcttag agactcatgt gtctgtcact
     2821 cgttcattca gccactcacc cattgccatt tttggccatc tgctaaggta ccaggaagtg
     2881 tgttaggatc cagatcccca ggggtgaaac agactctagc cctgctctca agcagtttat
     2941 tgtcatcaaa caccgccatc caggcagggc aatcggtgct ggaacccgga ccaccgtggg
     3001 taccgtggca cacggtggac agagtgacca actgccagga gtgagcagca cttggggtag
     3061 gcttcctgga gaatatgatg cccattctgg gtcttgaaga aatgagtggg catcttctgg
     3121 ttgatgaaag gcatgagaaa ggcttgtggg gccaaagaac aacttgggtg aaaacgggag
     3181 gaagtgaacg agcatgatgt attggggtca gtgctaacag ttctgggatg ctgatgtaca
     3241 aggtggggct gggagatgag gccgggaaag tagccacaag ctagagtgta aaggtaccag
     3301 ggtggccggg cgcggtggct catgcctgta atcccagcgc tttgggaggc tgaggctgga
     3361 gtatcacttg agcccaggag tttgagacca gcctggataa catggcgaaa ccctgtctct
     3421 acaaaacatt aaaaaaaatt agccgggcgt ggtggagcac acctgtggac acagctactc
     3481 aggaggctga gggaggagga ccatttgact ccaagagttc gaggctgcag tgagctagga
     3541 tcgcggcact acactccagc ctgagcaaca gactgagatc ctgtctcaga aaaaaagaga
     3601 aaaaggtgcc tgagttccag gcagagggac tgaggctctt ctaaggatgg tgagagagga
     3661 tgacagctgc gcgggggcaa gggctgtgcg gtgattggag gggatgggtt tgaagttcac
     3721 tgagaaggca gaggggacag cgcccagtag gcttcccttc catatttgct cagcaagtgt
     3781 ttcctgaggc ctcccccgaa gccttgtgct gggcggtgct gggagtggag aggtgatttt
     3841 gatcttgccc tgctctcaag gggctcccag tctggcggga aaacaggcac agacgcagct
     3901 tgaggaggac gtggcagcgg tggtgccatg ctgccagggg ctctgcgtgc ccttctcttg
     3961 acggaagggt acagatcaga gctgggtgtt cagaatttct ctccgaggcc tgtgtggaag
     4021 gaccaggaag agagagactg aaggtcccta ggaagaattc tgccaaggcg gtttcaggaa
     4081 gagatgctgg gaaatgtagg aaaaggaata caaatcagtg agacggagaa gcgctgagtg
     4141 agagagacgg atacgtggag agaagaggga tgccggagcg ggtgttaaaa gagacaaatc
     4201 tggccgggtg ctgtggctcc taatcccagc actttgggag actgaggcag gcagattgag
     4261 ctcaggagtt ccagaccagc caacatattg aaatcttgtc tctaccaaaa atacaaaaat
     4321 tagccgggtg tggtggtgca cgcctgtagt cccggctact caggaggctg aggtgaaagg
     4381 atctcgcttg ggcctgggag ggtgaggctg cagtgacccg tgatggcacc actgcgctcc
     4441 agcctgggcg aaagagcgag actctgtctc aaaaaaaaaa aaaaaattga gagacagcaa
     4501 atatttgctg gaagagggag agggaactgg ttaggggaga atggattcta gagtctgaag
     4561 gccaaacaga acgagagaga gagagagaga gagagaaaga atgaggttga gggtaggcag
     4621 gaggaagagc aagatgggga gggaggggga gagcaggaga gaccaaacta gtagagtcac
     4681 agacagagaa aaagtcaaag acaggaaggt gatacagagg agagagaaga ggaagaggag
     4741 agactgacag gtgcacaaat cagagaagtc ccagagatag cagaaacaca cacagagaca
     4801 gagatagaga gggagaggta agccggagac agactcagag attcgcacaa aaagcaacgt
     4861 ggagactcag aagcaagcgc agcgtcaagg aatgctccat ttctggtgtg ttgttttccc
     4921 agtattcaag aaatatttat tgagtgccaa cctgttctag acccaatctc ggccagggga
     4981 tgtggtggca aatagacgga caagggcctg ctctcctgaa acacactgga gagataaaca
     5041 ataaataata tcatttcagt aaccaaaaag tgctttaaaa attaagctga aggccgggcg
     5101 cagtggctca tgcctgtaat cccagcactt tgggaggccg aggctggtgg atcacttgag
     5161 gtcaggagtt cgagaccagc ctggtcaaca tggtgaaact tcatctctac caataaataa
     5221 ataaagtagc tgggtgtgct ggtgtgcctg tagtcccagc tacttgggag gctgagaaag
     5281 aaggatcact tgaacccagg aggcagaggt tgcagtgagc tgagatcgcg ccactgcact
     5341 ccagcctggg cgacagtgag tggtaacaga atgacagagc aaggatgact ttagatgagg
     5401 tccttggagt agaccttgtg gcagaggtca cagagatgtg gattgtgagt aggaaagaga
     5461 ggtgagaaag tctgggggcc aggcattcca cccaccagag gcagccccaa agcccagaaa
     5521 agtagcaggt cttcgaggag gcctgtgcgg tgagcagatc caccatagga cagaggcaca
     5581 gggtaggggc tgatcagtta gggccttgga tccttgggaa gaaatctgaa ttttattcta
     5641 gatctgatgg gaagtgcttg gagggttttg agcacaggca tgccatgatc atatttttat
     5701 tttcttattt atatttattt tgaaaaagag tcttgctctg tctcaggctg gagtccagtg
     5761 ggctgatctc ggctcactgc caacctccgc ctcccaagtt caagtgattc tcctgcctca
     5821 gcctcctgag tagctgggat tacaggcatg tgccaccacg cctggctaat ttttttgtat
     5881 ttttagtaaa gacgggattt caccgtgttg gccaggccaa tctgaaattc ctggcttcaa
     5941 atgatccacc tgcctcggcc tcccaaaatg ctgggattac aggagtgagc cactgcgccc
     6001 ggcctcatat ttttatttaa acaagaacag cagaattaca ttgctgtgct gagcatacgt
     6061 agacttcagg agtcaaaggg gaaggaagga ggtagcgggc tgttgccttc ctctggttgc
     6121 tggaggcctg gaccaaggtg gagttagtgg gatggaggaa gtggaagaag gcatgggatt
     6181 ttggaggcta gagcctgcat tggtggtgaa ctggatgtca tagaggaggg aaggaaaagg
     6241 aaccaggaag agaagaactc tctgaattgg gcacgcacat ctctgatggg caccgatgag
     6301 gattgttacc aggaacgagg agactgggat caggaaagtg gctttgggag ggaggaacca
     6361 aggcttctct tttggatgtg tcaagataga tctgccttcg agaaatccga gttgtggtat
     6421 caaatagcca gttggatatg tgagactgga gtttggggga aagagaggcc gtggctcaaa
     6481 aacgtaagtt ttggaaacgt caacataaag ccacaggatt gggtgacgtg gcctagcagg
     6541 ggggtgggga cagagaagcg accctggcca gagccttggg gacatctaca tctgggggag
     6601 aaggggatgt agcaaaacga gcttaggagt gatctcgagg taggctgaaa ccaggagggt
     6661 tacagagggc aaatgcacct ttgtgtttca agaaggagag gagacagcca gctgtgccaa
     6721 gggctgctga gacttggaca aggatgcaga gagcagagtg accattaggt ctgatgacat
     6781 ggacagggtt ggtgatcttg ataagataag atgtcagttc agtgcagtgg tggggacaga
     6841 agccctgctg gagtggaggg gagagagaat ttggggggaa gacagaagga aagggaattc
     6901 aggcaagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt aactgacaca aaggccaggt
     6961 gcgatggctc acgtgtgtaa tcccagcact ttgggaggcc gaagtgggtg gatcacttga
     7021 ggtcaggagt tcgagaccag cctggccaat atggtgaaac cccgtctcta ctaaaaatac
     7081 agaaattaga caggtgcggt ggtgcacacc tgtaatccca gctacttgag aggctgaagc
     7141 aggagaatct cttgggccca ggaggcagag gttgcagtga gccaagatca caccactgca
     7201 ctctagcctg ggtgacagag caagactctg tctcaaaaaa gaaaaaaggt aaaaaaaaaa
     7261 aaaaatgacc ctgaaaggaa gtagggagac atgcagatag ggagatggga ggcagaaaat
     7321 tgcatcctgc aattagctgt cacagcaggc aggagcaaga gagatgggga agcccagggc
     7381 caggagggga agatgaattc agggggcagg gaagagagga tgctgtcagc taggctctgg
     7441 cagatcccct agccagggat gctctgccca gctcctgtct cttgctgctg tcagcgccgg
     7501 gcacactctg ggattccccc tgtagaccct gtcaagacct attgaggtga aggggaagaa
     7561 cacgttttca tcattcattt tcagaaataa acattcactc agttcttgga aatactttct
     7621 ggccaggctt gggggctcat gcctgtaatc ccagcactct gggaggccaa gacaggagga
     7681 ttgcttgagg cttggcgttt gagaccagcc tgggcaatat agtaagaccc cgtctctaca
     7741 aaaatgaaaa atgagctgtg gcgtggtggc tcacgcctgt agtcctagat actcgggagg
     7801 ctgaggcggg aggattgctt gagtccagga gtttaaggtt gcagtgagct atgattgcac
     7861 cattgcactt caggctgggc cacagagcaa gaccctgtct cagaaaacag aaagaaagaa
     7921 agtcaaagaa ataaagtcaa agacaagaag gtgatacaga gaagacagaa aaggaggagg
     7981 agagagactg acaggtacac aaatcagaga agtcccagag ataacaaaaa cacaaccaca
     8041 gagataggga gacgtaagcc ggagaaagac ccagagattc gcatagaaag caacgtggag
     8101 actcagaagc aagcacagca tcaaggaatg atcaataaaa agaaaaaaaa atatttcctg
     8161 aggacttcca agtacaaggc cctgcaatct caggccactt ctgtcccatc tctgccttca
     8221 gaggggggga caggtagtcc agacaattag aatacagagg gggctgtgtt ctgacggggc
     8281 cacgcgggca ttgaggaaac gcagcaggcc cctcccctag ctggggcggg gatgtctgtg
     8341 tgccatcatc tcactccatc tggtcattcc tttgcccatt catccatcca ttcattcaag
     8401 tcaccccatg cacattttcc aagactgcct gtgacctggc cctgtgccgg gtagagctga
     8461 ggatgccaag gtgaattcct cctgtgcctg gccccggccc cagtctgctg gaagaaccag
     8521 acacagacaa tcacactgcg gggaaacacg tgctccatcg gaaaagtcca gagcaggggg
     8581 tgggcagaga ggcccagcgt gcaccagagc ctcgctcagg tcagcgccag gcctgcctgg
     8641 agcagccaac tgtgggagaa gaaggagttg gtgaaaggtg ggtcccacct gggccgtcca
     8701 cagaagggct gaggggtagg gggtgagggg ttgaagatca ggccctgccg ccatgccaca
     8761 cggctgtcct ctgtccctgc tcctggggga gctgaaactg catggaaggt cccccagggg
     8821 tgccccgtct aataaactcg atgaagagga
//
