LOCUS       NM_031896               2754 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens calcium voltage-gated channel auxiliary subunit gamma
            7 (CACNG7), transcript variant 1, mRNA.
ACCESSION   NM_031896 XM_017027093
VERSION     NM_031896.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Yang,L., Katchman,A., Morrow,J.P., Doshi,D. and Marx,S.O.
  TITLE     Cardiac L-type calcium channel (Cav1.2) associates with gamma
            subunits
  JOURNAL   FASEB J 25 (3), 928-936 (2011)
   PUBMED   21127204
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Kato,A.S., Gill,M.B., Ho,M.T., Yu,H., Tu,Y., Siuda,E.R., Wang,H.,
            Qian,Y.W., Nisenbaum,E.S., Tomita,S. and Bredt,D.S.
  TITLE     Hippocampal AMPA receptor gating controlled by both TARP and
            cornichon proteins
  JOURNAL   Neuron 68 (6), 1082-1096 (2010)
   PUBMED   21172611
REFERENCE   4  (bases 1 to 2754)
  AUTHORS   Chen,R.S., Deng,T.C., Garcia,T., Sellers,Z.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits: a functionally diverse protein
            family
  JOURNAL   Cell Biochem Biophys 47 (2), 178-186 (2007)
   PUBMED   17652770
  REMARK    Review article
REFERENCE   5  (bases 1 to 2754)
  AUTHORS   Moss,F.J., Viard,P., Davies,A., Bertaso,F., Page,K.M., Graham,A.,
            Canti,C., Plumpton,M., Plumpton,C., Clare,J.J. and Dolphin,A.C.
  TITLE     The novel product of a five-exon stargazin-related gene abolishes
            Ca(V)2.2 calcium channel expression
  JOURNAL   EMBO J 21 (7), 1514-1523 (2002)
   PUBMED   11927536
REFERENCE   6  (bases 1 to 2754)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   7  (bases 1 to 2754)
  AUTHORS   Burgess,D.L., Gefrides,L.A., Foreman,P.J. and Noebels,J.L.
  TITLE     A cluster of three novel Ca2+ channel gamma subunit genes on
            chromosome 19q13.4: evolution and expression profile of the gamma
            subunit gene family
  JOURNAL   Genomics 71 (3), 339-350 (2001)
   PUBMED   11170751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008440.9.
            
            On or before Jun 26, 2020 this sequence version replaced
            XM_017027093.1, NM_031896.4.
            
            Summary: The protein encoded by this gene is a type II
            transmembrane AMPA receptor regulatory protein (TARP). TARPs
            regulate both trafficking and channel gating of the AMPA receptors.
            This gene is part of a functionally diverse eight-member protein
            subfamily of the PMP-22/EMP/MP20 family and is located in a cluster
            with two family members, a type I TARP and a calcium channel gamma
            subunit. [provided by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1322408.1,
                                           SRR14038194.2716291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391767.6/ ENSP00000375647.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC008440.9         53642-53881
            241-465             AC008440.9         57167-57391
            466-552             AC008440.9         58864-58950
            553-693             AC008440.9         59729-59869
            694-839             AC008440.9         85834-85979
            840-2754            AC008440.9         86400-88314
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2754
                     /gene="CACNG7"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 7"
                     /db_xref="GeneID:59284"
                     /db_xref="HGNC:HGNC:13626"
                     /db_xref="MIM:606899"
     exon            1..240
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     exon            241..465
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1097
                     /gene="CACNG7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal voltage-gated calcium channel gamma-7 subunit;
                     voltage-dependent calcium channel gamma-7 subunit; TARP
                     gamma-7; transmembrane AMPAR regulatory protein gamma-7;
                     calcium channel, voltage-dependent, gamma subunit 7"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-7
                     subunit isoform 1"
                     /protein_id="NP_114102.2"
                     /db_xref="CCDS:CCDS12868.1"
                     /db_xref="GeneID:59284"
                     /db_xref="HGNC:HGNC:13626"
                     /db_xref="MIM:606899"
                     /translation="MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQ
                     NQTTEVKMALHAGLWRVCFFAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATP
                     FPMVSLFLVFTAFVISNIGHIRPQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEV
                     MNRPSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYR
                     PRLSDCSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC"
     exon            466..552
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     exon            553..693
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     exon            694..839
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     exon            840..2754
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2500..2505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNG7"
                     /note="hexamer: AATAAA"
     polyA_site      2521
                     /gene="CACNG7"
                     /note="major polyA site"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNG7"
                     /note="hexamer: AATAAA"
     polyA_site      2754
                     /gene="CACNG7"
ORIGIN      
        1 agtagccaat gagcggccgc cggttcctgc tcccggctcc gtccgccgag tgaggccgcg
       61 gccgcggggg gtggggggtg ggaggccggg agggggccgg gacgccgggc tccggggcgg
      121 gggcgggggg cgcgggcacc ggcgaccccg gtggcggcgg cggcggccgg gggaagcctc
      181 ggggccggtc atgcggctgc ggggcccgcg gcccggagcg tccgcccagc cctgagcgag
      241 gccccgcagg gcgccccctg cctctgagga tgagtcactg cagcagccgc gccctgaccc
      301 tgctgagcag cgtgtttggt gcgtgtggcc tgctcctggt aggcatcgcg gtcagcactg
      361 actactggct gtacatggaa gaaggcacag tgctaccgca gaaccagacc accgaggtca
      421 agatggccct gcacgccggc ctctggcgag tctgcttctt tgcaggtcgg gagaaaggtc
      481 gctgtgtggc ctcagaatat tttcttgaac cggagatcaa tttggtgacg gaaaacacgg
      541 agaatattct gaagacagtg cgcacggcca cccccttccc catggtcagc ctcttcctcg
      601 tgttcacggc cttcgtcatc agcaacatcg gccacatccg cccgcagagg accattctgg
      661 cttttgtctc tggcatcttc ttcatactat cgggcctctc cttggtggtg ggcttggttc
      721 tttacatctc cagcatcaac gacgaggtca tgaacaggcc cagcagctct gagcagtatt
      781 ttcattatcg ctacgggtgg tcttttgcct tcgccgcttc ctccttccta ctcaaagagg
      841 gggccggcgt gatgtccgtg tacctgttca ccaagcgcta cgcggaggag gagatgtacc
      901 gtccacaccc ggccttctac cgcccgcgtc tcagcgactg ctccgactac tcgggccagt
      961 tcctgcagcc cgaggcgtgg cgccgcggcc ggagcccctc cgacatctcc agcgacgtgt
     1021 ccatccaaat gacgcagaac taccctcccg ccatcaagta cccggaccac ctgcacatct
     1081 ccacctcgcc ctgctgaggc ccgcccctcg gagctccccc tgcctcctcc tcctcctcgt
     1141 cttagggggg tctccctgca atgcagcgcc cccttccgtc ctcgggactc ctcgctccca
     1201 cccggaggag gctgcgccag ctttaggccc cgccctcctc ccaatggctc cgcccacaga
     1261 ctcccttatt tcaatggccg cgccctcttt tcccgacctc tccttttcat tggtccctct
     1321 cactcccaaa tgactcctcc ccttcgttgg cccgcccctt tcctctggcc cctcctctcc
     1381 aagaaaatta gctcctccct cgttctccac ctgctctgag ctgggagcag ccagaggcgg
     1441 tgcaagcgcc cagctcccca gagctcccca acctcggacc tcaccgcagg ggcgctgggc
     1501 tggagagcag gttcgggcag ccgtcgggaa taccgaccat cctcttctcc cttctaacct
     1561 gggcttcctt tttccctgcc taatctcacc tcctgacctg ctgggtcctc cggtgcagtg
     1621 ggagggccgg cttgctccac ccgcagcccc ggggtggcgt agggaagggg gctggaagcc
     1681 acgggtacgg ttaacctggc ccttccctcc ccatctcccc tacttccctg gaaggtccca
     1741 ttctttctca ccggctgggc tcttttctgc ttcctgaagg ttacctgcct tttagggggc
     1801 tcttgtctaa aggatcttct tgctttctca gctatccttg gcttcttttt cgtcttcctc
     1861 ctcctttaac tctttctctc ctttcctccc ttcacccgtt cgtcccaagc ccttgggtgc
     1921 atcccgccct aggcgcacac cagacggcca gaatggggac cctagggtgg agggaattcc
     1981 cccacgccat ctccgcacct gtgcccgcct ctcccccctc gaggccccgt cgagggaggg
     2041 aggggcagta gcgggggtcg acaccccccc caaacctcta agtcttccat tttctggctc
     2101 tcctcctcat tgacgtccct cttcccccct cagaacccca actctggcct ctttcaaggg
     2161 cccgtccgcc ccgttggaca gattttgggg ggagaggagg tcaccaggaa ctcgcccacc
     2221 cccccttatt agggaaagag gggcgaggta gcacagtgct gtacacggaa ccagaatggc
     2281 ccccggggtg gggggagggg ggcaggggag ggacgggggc ttttagtttg catcttaggt
     2341 gggagggggg aggggggacc cgccgcagtt aacctgactt tacgcagcga tttttaacga
     2401 ggctgggggg aggggggcac tggggtgggg acagggtggg gtggggggcc tggctctgtt
     2461 atttaccgtg tatcatatgt aaatatcgac agaaacttca ataaacttta tttcaaacac
     2521 gtctccgcct gcccggaggg aagggattgg atagaggggg cttagtctgg gtctctgctt
     2581 ctagggttgc aggcctaaag tactgcagaa tgacgttaga tgggtcgttg ttaaatgact
     2641 taatcatcat cattatcaac ggcagcgctt tatacttcag tccgtgtaaa gcatgcagga
     2701 ccgtaaatga tactggtcag gatcaataaa cgctttctcc tggtattatt atga
//
