LOCUS       NM_001384801            2608 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens calcium voltage-gated channel auxiliary subunit gamma
            7 (CACNG7), transcript variant 2, mRNA.
ACCESSION   NM_001384801 XM_005259124
VERSION     NM_001384801.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2608)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2608)
  AUTHORS   Yang,L., Katchman,A., Morrow,J.P., Doshi,D. and Marx,S.O.
  TITLE     Cardiac L-type calcium channel (Cav1.2) associates with gamma
            subunits
  JOURNAL   FASEB J 25 (3), 928-936 (2011)
   PUBMED   21127204
REFERENCE   3  (bases 1 to 2608)
  AUTHORS   Kato,A.S., Gill,M.B., Ho,M.T., Yu,H., Tu,Y., Siuda,E.R., Wang,H.,
            Qian,Y.W., Nisenbaum,E.S., Tomita,S. and Bredt,D.S.
  TITLE     Hippocampal AMPA receptor gating controlled by both TARP and
            cornichon proteins
  JOURNAL   Neuron 68 (6), 1082-1096 (2010)
   PUBMED   21172611
REFERENCE   4  (bases 1 to 2608)
  AUTHORS   Chen,R.S., Deng,T.C., Garcia,T., Sellers,Z.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits: a functionally diverse protein
            family
  JOURNAL   Cell Biochem Biophys 47 (2), 178-186 (2007)
   PUBMED   17652770
  REMARK    Review article
REFERENCE   5  (bases 1 to 2608)
  AUTHORS   Moss,F.J., Viard,P., Davies,A., Bertaso,F., Page,K.M., Graham,A.,
            Canti,C., Plumpton,M., Plumpton,C., Clare,J.J. and Dolphin,A.C.
  TITLE     The novel product of a five-exon stargazin-related gene abolishes
            Ca(V)2.2 calcium channel expression
  JOURNAL   EMBO J 21 (7), 1514-1523 (2002)
   PUBMED   11927536
REFERENCE   6  (bases 1 to 2608)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   7  (bases 1 to 2608)
  AUTHORS   Burgess,D.L., Gefrides,L.A., Foreman,P.J. and Noebels,J.L.
  TITLE     A cluster of three novel Ca2+ channel gamma subunit genes on
            chromosome 19q13.4: evolution and expression profile of the gamma
            subunit gene family
  JOURNAL   Genomics 71 (3), 339-350 (2001)
   PUBMED   11170751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008440.9.
            
            On Jun 26, 2020 this sequence version replaced XM_005259124.4.
            
            Summary: The protein encoded by this gene is a type II
            transmembrane AMPA receptor regulatory protein (TARP). TARPs
            regulate both trafficking and channel gating of the AMPA receptors.
            This gene is part of a functionally diverse eight-member protein
            subfamily of the PMP-22/EMP/MP20 family and is located in a cluster
            with two family members, a type I TARP and a calcium channel gamma
            subunit. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (2) represents the allele encoded
            by the GRCh38 reference genome and encodes isoform (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.731164.1,
                                           ERR4352442.554364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC008440.9         53642-53881
            241-465             AC008440.9         57167-57391
            466-552             AC008440.9         58864-58950
            553-693             AC008440.9         59729-59869
            694-2608            AC008440.9         86400-88314
FEATURES             Location/Qualifiers
     source          1..2608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2608
                     /gene="CACNG7"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 7"
                     /db_xref="GeneID:59284"
                     /db_xref="HGNC:HGNC:13626"
                     /db_xref="MIM:606899"
     exon            1..240
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     exon            241..465
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1187
                     /gene="CACNG7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     neuronal voltage-gated calcium channel gamma-7 subunit;
                     voltage-dependent calcium channel gamma-7 subunit; TARP
                     gamma-7; transmembrane AMPAR regulatory protein gamma-7;
                     calcium channel, voltage-dependent, gamma subunit 7"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-7
                     subunit isoform 2"
                     /protein_id="NP_001371730.1"
                     /db_xref="GeneID:59284"
                     /db_xref="HGNC:HGNC:13626"
                     /db_xref="MIM:606899"
                     /translation="MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQ
                     NQTTEVKMALHAGLWRVCFFAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATP
                     FPMVSLFLVFTAFVISNIGHIRPQRTILAFVSGIFFILSGGRRDVRVPVHQALRGGGD
                     VPSTPGLLPPASQRLLRLLGPVPAARGVAPRPEPLRHLQRRVHPNDAELPSRHQVPGP
                     PAHLHLALLRPAPRSSPCLLLLLVLGGSPCNAAPPSVLGTPRSHPEEAAPALGPALLP
                     MAPPTDSLISMAAPSFPDLSFSLVPLTPK"
     exon            466..552
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     exon            553..693
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     exon            694..2608
                     /gene="CACNG7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2354..2359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNG7"
                     /note="hexamer: AATAAA"
     polyA_site      2375
                     /gene="CACNG7"
                     /note="major polyA site"
     regulatory      2579..2584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNG7"
                     /note="hexamer: AATAAA"
     polyA_site      2608
                     /gene="CACNG7"
ORIGIN      
        1 agtagccaat gagcggccgc cggttcctgc tcccggctcc gtccgccgag tgaggccgcg
       61 gccgcggggg gtggggggtg ggaggccggg agggggccgg gacgccgggc tccggggcgg
      121 gggcgggggg cgcgggcacc ggcgaccccg gtggcggcgg cggcggccgg gggaagcctc
      181 ggggccggtc atgcggctgc ggggcccgcg gcccggagcg tccgcccagc cctgagcgag
      241 gccccgcagg gcgccccctg cctctgagga tgagtcactg cagcagccgc gccctgaccc
      301 tgctgagcag cgtgtttggt gcgtgtggcc tgctcctggt aggcatcgcg gtcagcactg
      361 actactggct gtacatggaa gaaggcacag tgctaccgca gaaccagacc accgaggtca
      421 agatggccct gcacgccggc ctctggcgag tctgcttctt tgcaggtcgg gagaaaggtc
      481 gctgtgtggc ctcagaatat tttcttgaac cggagatcaa tttggtgacg gaaaacacgg
      541 agaatattct gaagacagtg cgcacggcca cccccttccc catggtcagc ctcttcctcg
      601 tgttcacggc cttcgtcatc agcaacatcg gccacatccg cccgcagagg accattctgg
      661 cttttgtctc tggcatcttc ttcatactat cggggggccg gcgtgatgtc cgtgtacctg
      721 ttcaccaagc gctacgcgga ggaggagatg taccgtccac acccggcctt ctaccgcccg
      781 cgtctcagcg actgctccga ctactcgggc cagttcctgc agcccgaggc gtggcgccgc
      841 ggccggagcc cctccgacat ctccagcgac gtgtccatcc aaatgacgca gaactaccct
      901 cccgccatca agtacccgga ccacctgcac atctccacct cgccctgctg aggcccgccc
      961 ctcggagctc cccctgcctc ctcctcctcc tcgtcttagg ggggtctccc tgcaatgcag
     1021 cgcccccttc cgtcctcggg actcctcgct cccacccgga ggaggctgcg ccagctttag
     1081 gccccgccct cctcccaatg gctccgccca cagactccct tatttcaatg gccgcgccct
     1141 cttttcccga cctctccttt tcattggtcc ctctcactcc caaatgactc ctccccttcg
     1201 ttggcccgcc cctttcctct ggcccctcct ctccaagaaa attagctcct ccctcgttct
     1261 ccacctgctc tgagctggga gcagccagag gcggtgcaag cgcccagctc cccagagctc
     1321 cccaacctcg gacctcaccg caggggcgct gggctggaga gcaggttcgg gcagccgtcg
     1381 ggaataccga ccatcctctt ctcccttcta acctgggctt cctttttccc tgcctaatct
     1441 cacctcctga cctgctgggt cctccggtgc agtgggaggg ccggcttgct ccacccgcag
     1501 ccccggggtg gcgtagggaa gggggctgga agccacgggt acggttaacc tggcccttcc
     1561 ctccccatct cccctacttc cctggaaggt cccattcttt ctcaccggct gggctctttt
     1621 ctgcttcctg aaggttacct gccttttagg gggctcttgt ctaaaggatc ttcttgcttt
     1681 ctcagctatc cttggcttct ttttcgtctt cctcctcctt taactctttc tctcctttcc
     1741 tcccttcacc cgttcgtccc aagcccttgg gtgcatcccg ccctaggcgc acaccagacg
     1801 gccagaatgg ggaccctagg gtggagggaa ttcccccacg ccatctccgc acctgtgccc
     1861 gcctctcccc cctcgaggcc ccgtcgaggg agggaggggc agtagcgggg gtcgacaccc
     1921 cccccaaacc tctaagtctt ccattttctg gctctcctcc tcattgacgt ccctcttccc
     1981 ccctcagaac cccaactctg gcctctttca agggcccgtc cgccccgttg gacagatttt
     2041 ggggggagag gaggtcacca ggaactcgcc caccccccct tattagggaa agaggggcga
     2101 ggtagcacag tgctgtacac ggaaccagaa tggcccccgg ggtgggggga ggggggcagg
     2161 ggagggacgg gggcttttag tttgcatctt aggtgggagg ggggaggggg gacccgccgc
     2221 agttaacctg actttacgca gcgattttta acgaggctgg ggggaggggg gcactggggt
     2281 ggggacaggg tggggtgggg ggcctggctc tgttatttac cgtgtatcat atgtaaatat
     2341 cgacagaaac ttcaataaac tttatttcaa acacgtctcc gcctgcccgg agggaaggga
     2401 ttggatagag ggggcttagt ctgggtctct gcttctaggg ttgcaggcct aaagtactgc
     2461 agaatgacgt tagatgggtc gttgttaaat gacttaatca tcatcattat caacggcagc
     2521 gctttatact tcagtccgtg taaagcatgc aggaccgtaa atgatactgg tcaggatcaa
     2581 taaacgcttt ctcctggtat tattatga
//
