LOCUS       NM_014405               3583 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens calcium voltage-gated channel auxiliary subunit gamma
            4 (CACNG4), mRNA.
ACCESSION   NM_014405 NM_032659
VERSION     NM_014405.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3583)
  AUTHORS   Guan,F., Zhang,T., Liu,X., Han,W., Lin,H., Li,L., Chen,G. and Li,T.
  TITLE     Evaluation of voltage-dependent calcium channel gamma gene families
            identified several novel potential susceptible genes to
            schizophrenia
  JOURNAL   Sci Rep 6, 24914 (2016)
   PUBMED   27102562
  REMARK    GeneRIF: These results indicate that CACNG4, CACNG5, CACNG6 and
            CACNG8 may contribute to the risk of SCZ. The statistical epistasis
            identified between CACNG5 and CACNG6 suggests that there may be an
            underlying biological interaction between the two genes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3583)
  AUTHORS   Yang,L., Katchman,A., Morrow,J.P., Doshi,D. and Marx,S.O.
  TITLE     Cardiac L-type calcium channel (Cav1.2) associates with gamma
            subunits
  JOURNAL   FASEB J 25 (3), 928-936 (2011)
   PUBMED   21127204
REFERENCE   3  (bases 1 to 3583)
  AUTHORS   Kato,A.S., Gill,M.B., Ho,M.T., Yu,H., Tu,Y., Siuda,E.R., Wang,H.,
            Qian,Y.W., Nisenbaum,E.S., Tomita,S. and Bredt,D.S.
  TITLE     Hippocampal AMPA receptor gating controlled by both TARP and
            cornichon proteins
  JOURNAL   Neuron 68 (6), 1082-1096 (2010)
   PUBMED   21172611
REFERENCE   4  (bases 1 to 3583)
  AUTHORS   Sager,C., Tapken,D., Kott,S. and Hollmann,M.
  TITLE     Functional modulation of AMPA receptors by transmembrane AMPA
            receptor regulatory proteins
  JOURNAL   Neuroscience 158 (1), 45-54 (2009)
   PUBMED   18304745
  REMARK    Review article
REFERENCE   5  (bases 1 to 3583)
  AUTHORS   Chen,R.S., Deng,T.C., Garcia,T., Sellers,Z.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits: a functionally diverse protein
            family
  JOURNAL   Cell Biochem Biophys 47 (2), 178-186 (2007)
   PUBMED   17652770
  REMARK    Review article
REFERENCE   6  (bases 1 to 3583)
  AUTHORS   Moss,F.J., Dolphin,A.C. and Clare,J.J.
  TITLE     Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4;
            an investigation of their specific localization in human brain and
            their influence on CaV2.1 voltage-dependent calcium channels
            expressed in Xenopus oocytes
  JOURNAL   BMC Neurosci 4, 23 (2003)
   PUBMED   14505496
  REMARK    GeneRIF: examined distribution of the stargazin-like proteins
            gamma2, gamma3, and gamma4 in human CNS: gamma2 is expressed in
            cerebellum, cerebral cortex, hippocampus and thalamus, whereas
            gamma3 abounds in cerebral cortex & amygdala and gamma4 in basal
            ganglia
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3583)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   8  (bases 1 to 3583)
  AUTHORS   Burgess,D.L., Gefrides,L.A., Foreman,P.J. and Noebels,J.L.
  TITLE     A cluster of three novel Ca2+ channel gamma subunit genes on
            chromosome 19q13.4: evolution and expression profile of the gamma
            subunit gene family
  JOURNAL   Genomics 71 (3), 339-350 (2001)
   PUBMED   11170751
REFERENCE   9  (bases 1 to 3583)
  AUTHORS   Burgess,D.L., Davis,C.F., Gefrides,L.A. and Noebels,J.L.
  TITLE     Identification of three novel Ca(2+) channel gamma subunit genes
            reveals molecular diversification by tandem and chromosome
            duplication
  JOURNAL   Genome Res 9 (12), 1204-1213 (1999)
   PUBMED   10613843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005988.1, BC034532.1 and
            AC005544.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014405.3.
            
            Summary: The protein encoded by this gene is a type I transmembrane
            AMPA receptor regulatory protein (TARP). TARPs regulate both
            trafficking and channel gating of the AMPA receptors. This gene is
            part of a functionally diverse eight-member protein subfamily of
            the PMP-22/EMP/MP20 family and is located in a cluster with two
            family members, a type II TARP and a calcium channel gamma subunit.
            [provided by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034532.1, AF162692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262138.4/ ENSP00000262138.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC005988.1         163230-163432
            204-954             BC034532.1         1-751
            955-955             AC005544.1         110879-110879       c
            956-3583            BC034532.1         753-3380
FEATURES             Location/Qualifiers
     source          1..3583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..3583
                     /gene="CACNG4"
                     /note="calcium voltage-gated channel auxiliary subunit
                     gamma 4"
                     /db_xref="GeneID:27092"
                     /db_xref="HGNC:HGNC:1408"
                     /db_xref="MIM:606404"
     exon            1..425
                     /gene="CACNG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1189
                     /gene="CACNG4"
                     /note="neuronal voltage-gated calcium channel gamma-4
                     subunit; TARP gamma-4; transmembrane AMPAR regulatory
                     protein gamma-4; calcium channel, voltage-dependent, gamma
                     subunit 4"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-4
                     subunit"
                     /protein_id="NP_055220.1"
                     /db_xref="CCDS:CCDS11667.1"
                     /db_xref="GeneID:27092"
                     /db_xref="HGNC:HGNC:1408"
                     /db_xref="MIM:606404"
                     /translation="MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGT
                     NLTMDDGPPPRRARGDLTHSGLWRVCCIEGIYKGHCFRINHFPEDNDYDHDSSEYLLR
                     IVRASSVFPILSTILLLLGGLCIGAGRIYSRKNNIVLSAGILFVAAGLSNIIGIIVYI
                     SSNTGDPSDKRDEDKKNHYNYGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKTK
                     REFLKASSSSPYARMPSYRYRRRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSM
                     YTLSREPLKVTTAASYSPDQEASFLQVHDFFQQDLKEGFHVSMLNRRTTPV"
     exon            426..509
                     /gene="CACNG4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..650
                     /gene="CACNG4"
                     /inference="alignment:Splign:2.1.0"
     exon            651..3583
                     /gene="CACNG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3565..3570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNG4"
                     /note="hexamer: AATAAA"
     polyA_site      3583
                     /gene="CACNG4"
                     /note="major polyA site"
ORIGIN      
        1 actcgtcgcc gcgcctcgga gtttgagccc cagcgctgcc ggagcgcagg cacgcccggg
       61 gcgcggggtc ggagcgcgca gcgcggcgcc gccccccggc cctcggcccc ccaaccccgg
      121 cgcccccgga gcggcgcgcg gagggaggag ggcgggcggg cgcggcgggc cgggccggcg
      181 ggcggcggac tatgaggcgc ccaccatggt gcgatgcgac cgcgggctgc agatgctgct
      241 gaccacggcc ggagccttcg ccgccttctc gctcatggcc atcgccatcg gcaccgacta
      301 ctggctgtac tccagcgcgc acatctgcaa cggcaccaac ctgaccatgg acgacgggcc
      361 cccgccccgc cgcgcccgcg gcgacctcac ccactctggt ctgtggcggg tgtgctgcat
      421 cgaagggatc tataaagggc actgcttccg gatcaatcac ttcccagagg acaatgacta
      481 cgaccacgac agctcggagt acctcctccg catcgtgcga gcctccagcg tcttccccat
      541 cctcagcacc atcctgctcc tgctgggtgg cctgtgcatc ggtgctggca ggatctacag
      601 ccgcaagaac aacatcgtcc tcagtgccgg catcctcttc gtggctgcag gcctcagtaa
      661 catcatcggt atcatcgtct acatttccag caacacaggt gacccgagtg acaagcggga
      721 cgaagacaaa aagaaccatt acaactacgg ctggtctttt tactttggag ctctgtcttt
      781 cattgtggct gagaccgtgg gcgtcctggc tgtaaacatt tacattgaga aaaataaaga
      841 gttgaggttt aagaccaaac gggaattcct taaggcgtct tcctcttctc cttatgccag
      901 gatgccgagc tacaggtacc ggcgacggcg ctcgaggtcc agctcaaggt ccaccgaggc
      961 ctcgccctcc agggacgtgt cgcccatggg cctgaagatc acaggggcca tccccatggg
     1021 ggagctgtcc atgtacacgc tgtccaggga gcccctcaag gtgaccaccg cagccagcta
     1081 cagccccgac caggaggcca gcttcctgca ggtgcatgac tttttccagc aggacctgaa
     1141 ggaaggtttc cacgtcagca tgctgaaccg acggacgacc cctgtgtgag ccgcctgccc
     1201 tttctctccg ctccagcctc tccccagaac ggctcttttt gtcacacagg atggcatgtg
     1261 atcctcaaga cgacgaacaa tgaactaaag ccaaatgcag ccctccctgg cctccagagg
     1321 tggcgtgggc tggctttgca cgaaggttgt gctgggagac cggacccggg gctgcagaag
     1381 aagctgaagg ctgactttgt cccctccccg aaaaagggtg ttttgatgcc tcagggtctc
     1441 tgaaatctcc cgggaagccc cagagctttc ctgaggctgc ctggccttga tcaacttggg
     1501 aagacaaaat tgagccatta tctcctcttg gaaacgaatc ttgccagaaa aacgggattt
     1561 cagggccttc cctccctgcc tgggtgtcgg gccaccagaa ggctctgccg gacgccaaga
     1621 agacggtctc tgggctcttg tcagctgctt ttgaacctga ggttcctgcg tcgttgagcc
     1681 agaaatcaga ccaccgaagc tcactccctt cctctccatc tctccctctc tccaagactc
     1741 tggcagtggc ctatgatcct gaagacagct ctgcagccaa ctggtgcttt ggcctttgcg
     1801 ctgtcccggg gccagcttcc ctcgacctgg ggaggccgtg gcctgtggag gaggcccagg
     1861 taaaggctgg gggctgttgc tggctatcct ctttgcttct ggaagtttct gcctcactca
     1921 gaatgggcag gacagaccca ctgactggac ttcagagtct ggagggttcc atcggtcagg
     1981 ggaatggcgg ccacgtgacc tcttgccgtg ccccttgtca tagacccaag gagcaactct
     2041 gtcccctgag cgttgggggt cccgggggag aggtggacag acacctccct ccaactggca
     2101 tttggcaaca ggagcctgga cttctgtgca agaaagggag acctaagggt gaacagtggc
     2161 caataaaaac cctagagaac aaacatccat ttcctaggtg gttacaaatc ataacttcct
     2221 gcaaatcaac gccaggagag caacttacct tcatttcttt gtcttaaaaa gtagcagcaa
     2281 ctggccccac aactcctgtc attgtaagtt attctgccac cacctaacag gacggagtgg
     2341 agtgagtttg gataaacgga ccgagctggg cttctcttcc tccctacaga ggggagatct
     2401 cagcactttg tccggagctg aggaagtggt ttctgtgttt tacagttttt ccagccattc
     2461 ttttcttccc cctcctgaag caagcaaaga gcgtggaggc gtgtgcaggc ttggaagaag
     2521 aactctccag aacatggaac ttaaccctct tttgtataaa acatgtgctt tctaaagaaa
     2581 aattgtttct tattttttga gactccttga tccaccctgg aacagtcgcc tgtagtcctg
     2641 gtagctgttg tgcttggaaa taacgagcgc atccttgcct cagctacctg ctcacagccc
     2701 atgggtggac tcggccccct ggggttcaga cccaggtccg ttcggcctag tgatgatgtc
     2761 atcgtccatc ccatcttcct ttgcccccag gaaaggacgc atccaccggt agcggcccca
     2821 gctgactgtc gccgtgtgct ggggatctga aatgaggcct gccagggccc ctgtgtgctg
     2881 tgctccagag ccttcgctcc catcagggtt ggcatcatct gatggcatgt ccaagtgtgc
     2941 ccagcagcgg atgctgaagc accagagctc aaggccttca cctgctctag gccagccctg
     3001 tcaccacctc cactgccatg accaggccga aggcagggaa cgccctcccc agtcccgctg
     3061 tccagcaagg ccccgagact tttcttctgt gatttccaaa agcaaggcag ccgtgctgtt
     3121 ctagttcctc tccatccgcc acctcccctc ccgctgcccc agaagtttct atcattccat
     3181 ggagaaagct gtgttccaat gaatcctacc tcttgcccag tcccaggcag agtaagcagg
     3241 gcccacctag ggaccaagaa agagtaggaa gaaggggacg agccgggagc aaaaccacct
     3301 cagacacccg ggccttctca gccttctccc cgcggccagc tgggtctccg gggaccctgg
     3361 gccctgggcc gcccattcct ggccctcccg ctgcatctca gacctgacac ccaacggggg
     3421 gatgtggtgg cctgtgccca ccttctctcc ctcctcccga cccgccccct cgcccccacc
     3481 cctgtgtgtt tcgccagtta agcacctgtg actccagtac ctactactgg ttttgggttg
     3541 gttgttctgt ctttttttta attaaataaa aacattttta aaa
//
