LOCUS       NM_201596               6129 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens calcium voltage-gated channel auxiliary subunit beta 2
            (CACNB2), transcript variant 2, mRNA.
ACCESSION   NM_201596
VERSION     NM_201596.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6129)
  AUTHORS   Zhong,R., Zhang,F., Yang,Z., Li,Y., Xu,Q., Lan,H., Cyganek,L.,
            El-Battrawy,I., Zhou,X., Akin,I. and Borggrefe,M.
  TITLE     Epigenetic mechanism of L-type calcium channel beta-subunit
            downregulation in short QT human induced pluripotent stem
            cell-derived cardiomyocytes with CACNB2 mutation
  JOURNAL   Europace 24 (12), 2028-2036 (2022)
   PUBMED   35894107
  REMARK    GeneRIF: Epigenetic mechanism of L-type calcium channel
            beta-subunit downregulation in short QT human induced pluripotent
            stem cell-derived cardiomyocytes with CACNB2 mutation.
REFERENCE   2  (bases 1 to 6129)
  AUTHORS   Xin,Q., Xin,G., Li,L., Sun,W., Jiang,W., Wang,J., Luan,Y.,
            Zhang,Y., Cheng,L., Duan,S., Hong,F., Ji,Q. and Ma,W.
  TITLE     Association study of hypertension susceptibility genes ITGA9,
            MOV10, and CACNB2 with preeclampsia in Chinese Han population
  JOURNAL   J Matern Fetal Neonatal Med 35 (25), 5227-5235 (2022)
   PUBMED   33491517
  REMARK    GeneRIF: Association study of hypertension susceptibility genes
            ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han
            population.
REFERENCE   3  (bases 1 to 6129)
  AUTHORS   Martins,H.C., Gilardi,C., Sungur,A.O., Winterer,J., Pelzl,M.A.,
            Bicker,S., Gross,F., Kisko,T.M., Malikowska-Racia,N., Braun,M.D.,
            Brosch,K., Nenadic,I., Stein,F., Meinert,S., Schwarting,R.K.W.,
            Dannlowski,U., Kircher,T., Wohr,M. and Schratt,G.
  TITLE     Bipolar-associated miR-499-5p controls neuroplasticity by
            downregulating the Cav1.2 subunit CACNB2
  JOURNAL   EMBO Rep 23 (10), e54420 (2022)
   PUBMED   35969184
  REMARK    GeneRIF: Bipolar-associated miR-499-5p controls neuroplasticity by
            downregulating the Cav1.2 subunit CACNB2.
REFERENCE   4  (bases 1 to 6129)
  AUTHORS   Zhong,R., Schimanski,T., Zhang,F., Lan,H., Hohn,A., Xu,Q.,
            Huang,M., Liao,Z., Qiao,L., Yang,Z., Li,Y., Zhao,Z., Li,X.,
            Rose,L., Albers,S., Maywald,L., Muller,J., Dinkel,H., Saguner,A.,
            Janssen,J.W.G., Swamy,N., Xi,Y., Lang,S., Kleinsorge,M., Duru,F.,
            Zhou,X., Diecke,S., Cyganek,L., Akin,I. and El-Battrawy,I.
  TITLE     A Preclinical Study on Brugada Syndrome with a CACNB2 Variant Using
            Human Cardiomyocytes from Induced Pluripotent Stem Cells
  JOURNAL   Int J Mol Sci 23 (15), 8313 (2022)
   PUBMED   35955449
  REMARK    GeneRIF: A Preclinical Study on Brugada Syndrome with a CACNB2
            Variant Using Human Cardiomyocytes from Induced Pluripotent Stem
            Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6129)
  AUTHORS   Westhoff,M. and Dixon,R.E.
  TITLE     Mechanisms and Regulation of Cardiac CaV1.2 Trafficking
  JOURNAL   Int J Mol Sci 22 (11), 5927 (2021)
   PUBMED   34072954
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6129)
  AUTHORS   Brust,P.F., Simerson,S., McCue,A.F., Deal,C.R., Schoonmaker,S.,
            Williams,M.E., Velicelebi,G., Johnson,E.C., Harpold,M.M. and
            Ellis,S.B.
  TITLE     Human neuronal voltage-dependent calcium channels: studies on
            subunit structure and role in channel assembly
  JOURNAL   Neuropharmacology 32 (11), 1089-1102 (1993)
   PUBMED   8107964
REFERENCE   7  (bases 1 to 6129)
  AUTHORS   Rosenfeld,M.R., Wong,E., Dalmau,J., Manley,G., Egan,D.,
            Posner,J.B., Sher,E. and Furneaux,H.M.
  TITLE     Sera from patients with Lambert-Eaton myasthenic syndrome recognize
            the beta-subunit of Ca2+ channel complexes
  JOURNAL   Ann N Y Acad Sci 681, 408-411 (1993)
   PUBMED   8395157
REFERENCE   8  (bases 1 to 6129)
  AUTHORS   Rosenfeld,M.R., Wong,E., Dalmau,J., Manley,G., Posner,J.B., Sher,E.
            and Furneaux,H.M.
  TITLE     Cloning and characterization of a Lambert-Eaton myasthenic syndrome
            antigen
  JOURNAL   Ann Neurol 33 (1), 113-120 (1993)
   PUBMED   8494331
REFERENCE   9  (bases 1 to 6129)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
REFERENCE   10 (bases 1 to 6129)
  AUTHORS   Williams,M.E., Feldman,D.H., McCue,A.F., Brenner,R., Velicelebi,G.,
            Ellis,S.B. and Harpold,M.M.
  TITLE     Structure and functional expression of alpha 1, alpha 2, and beta
            subunits of a novel human neuronal calcium channel subtype
  JOURNAL   Neuron 8 (1), 71-84 (1992)
   PUBMED   1309651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL360231.16, S60415.1 and
            AL450384.34.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_201596.2.
            
            Summary: This gene encodes a subunit of a voltage-dependent calcium
            channel protein that is a member of the voltage-gated calcium
            channel superfamily. The gene product was originally identified as
            an antigen target in Lambert-Eaton myasthenic syndrome, an
            autoimmune disorder. Mutations in this gene are associated with
            Brugada syndrome. Alternatively spliced variants encoding different
            isoforms have been described. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.218003.1, S60415.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324631.13/ ENSP00000320025.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AL360231.16        139352-139604
            254-1855            S60415.1           1-1602
            1856-4331           AL450384.34        25912-28387
            4332-6129           AL450384.34        28388-30185
FEATURES             Location/Qualifiers
     source          1..6129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.33-p12.31"
     gene            1..6129
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /note="calcium voltage-gated channel auxiliary subunit
                     beta 2"
                     /db_xref="GeneID:783"
                     /db_xref="HGNC:HGNC:1402"
                     /db_xref="MIM:600003"
     exon            1..433
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..2296
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /note="isoform 2 is encoded by transcript variant 2;
                     voltage-dependent L-type calcium channel subunit beta-2;
                     myasthenic (Lambert-Eaton) syndrome antigen B;
                     lambert-Eaton myasthenic syndrome antigen B; calcium
                     channel voltage-dependent subunit beta 2; calcium channel,
                     voltage-dependent, beta 2 subunit"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-2 isoform 2"
                     /protein_id="NP_963890.2"
                     /db_xref="CCDS:CCDS7125.1"
                     /db_xref="GeneID:783"
                     /db_xref="HGNC:HGNC:1402"
                     /db_xref="MIM:600003"
                     /translation="MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGK
                     GARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQ
                     AQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWI
                     GRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKS
                     TPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYD
                     VVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLN
                     NPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPI
                     IVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDAC
                     EHLADYLEAYWKATHPPSSSLPNPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSA
                     PIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTSRGLSRQETFDSETQESRDSA
                     YVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRDVDREQDHNECNKQ
                     RSRHKSKDRYCEKDGEVISKKRNEAGEWNRDVYIRQ"
     exon            434..526
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            527..646
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            647..769
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            770..906
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            907..983
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1117
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1198
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1257
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1367
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1519
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1615
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1801
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..6129
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /note="hexamer: TATAAA"
     polyA_site      3196
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
     regulatory      3659..3664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /note="hexamer: AATAAA"
     polyA_site      3695
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /note="major polyA site"
     regulatory      5692..5697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /note="hexamer: AATAAA"
     polyA_site      5717
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
     regulatory      6094..6099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /note="hexamer: ATTAAA"
     regulatory      6106..6111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
                     /note="hexamer: AATATA"
     polyA_site      6117
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
     polyA_site      6129
                     /gene="CACNB2"
                     /gene_synonym="CAB2; CACNLB2; CAVB2; MYSB"
ORIGIN      
        1 gccgcgctgc gcccgctctc ccggccccgg ctgccccgct gagggctccc ctctcccagg
       61 caccgcagcc gcgcccccgc gtcccgcctc ccgagcggct cgcttcgccc gatgccccgg
      121 ccccgtcccg cgcactgagc gcctggcagc agggcgccga gtcccggggc gctgcggggc
      181 gctgcgccga gaacggccgg gcctgagccc tgggcggccc ccagagccga tcagagcgcg
      241 gggaggcggg ggcgaggagg aggggacccg ccgccggggg ctggctgctt cgctccgagc
      301 cgacttttcg ccaatggtcc aaagggacat gtccaagtcg cctcccacag cggcggcggc
      361 ggtggcgcag gagatccaga tggaactgct agagaacgtg gctcccgcgg gggcgctcgg
      421 agccgccgca cagtcatatg gaaaaggagc cagaaggaaa aacagattta aaggatctga
      481 tggaagcacg tcatctgata ctacctcaaa tagttttgtt cgccagggtt cggcagactc
      541 ctacactagc cgtccatccg attccgatgt atctctggag gaggaccggg aggcagtgcg
      601 cagagaagcg gagcggcagg cccaggcaca gttggaaaaa gcaaagacaa agcccgttgc
      661 atttgcggtt cggacaaatg tcagctacag tgcggcccat gaagatgatg ttccagtgcc
      721 tggcatggcc atctcattcg aagcaaaaga ttttctgcat gttaaggaaa aatttaacaa
      781 tgactggtgg atagggcgat tggtaaaaga aggctgtgaa atcggattca ttccaagccc
      841 agtcaaacta gaaaacatga ggctgcagca tgaacagaga gccaagcaag ggaaattcta
      901 ctccagtaaa tcaggaggaa attcatcatc cagtttgggt gacatagtac ctagttccag
      961 aaaatcaaca cctccatcat ctgctataga catagatgct actggcttag atgcagaaga
     1021 aaatgatatt ccagcaaacc accgctcccc taaacccagt gcaaacagtg taacgtcacc
     1081 ccactccaaa gagaaaagaa tgcccttctt taagaagaca gagcacactc ctccgtatga
     1141 tgtggtacct tccatgcgac cagtggtcct agtgggccct tctctgaagg gctacgaggt
     1201 cacagatatg atgcaaaaag cgctgtttga ttttttaaaa cacagatttg aagggcggat
     1261 atccatcaca agggtcaccg ctgacatctc gcttgccaaa cgctcggtat taaacaatcc
     1321 cagtaagcac gcaataatag aaagatccaa cacaaggtca agcttagcgg aagttcagag
     1381 tgaaatcgaa aggatttttg aacttgcaag aacattgcag ttggtggtcc ttgacgcgga
     1441 tacaattaat catccagctc aactcagtaa aacctccttg gcccctatta tagtatatgt
     1501 aaagatttct tctcctaagg ttttacaaag gttaataaaa tctcgaggga aatctcaagc
     1561 taaacacctc aacgtccaga tggtagcagc tgataaactg gctcagtgtc ctccagagct
     1621 gttcgatgtg atcttggatg agaaccagct tgaggatgcc tgtgagcacc ttgccgacta
     1681 tctggaggcc tactggaagg ccacccatcc tcccagcagt agcctcccca accctctcct
     1741 tagccgtaca ttagccactt caagtctgcc tcttagcccc accctagcct ctaattcaca
     1801 gggttctcaa ggtgatcaga ggactgatcg ctccgctcct atccgttctg cttcccaagc
     1861 tgaagaagaa cctagtgtgg aaccagtcaa gaaatcccag caccgctctt cctcctcagc
     1921 cccacaccac aaccatcgca gtgggacaag tcgcggcctc tccaggcaag agacatttga
     1981 ctcggaaacc caggagagtc gagactctgc ctacgtagag ccaaaggaag attattccca
     2041 tgaccacgtg gaccactatg cctcacaccg tgaccacaac cacagagacg agacccacgg
     2101 gagcagtgac cacagacaca gggagtcccg gcaccgttcc cgggacgtgg atcgagagca
     2161 ggaccacaac gagtgcaaca agcagcgcag ccgtcataaa tccaaggatc gctactgtga
     2221 aaaggatgga gaagtgatat caaaaaaacg gaatgaggct ggggagtgga acagggatgt
     2281 ttacatccgc caatgagttt tgcccgtttg tgtttttttt tttttttttt tgaagtcttg
     2341 tataactaac agcatcccca aaacaaagtc tttggggtct acactgcaat catatgtgat
     2401 ctgtcttgta atattttgta ttattgctgt tgcttgaata gcaatagcat ggatagagta
     2461 ttgagatact ttttcttttg taagtgctac ataaattggc ctggtatggc tgcagtcctc
     2521 cggttgcata ctggactctt caaaaactgt tttgggtagc tgccacttga acaaaatctg
     2581 ttgccaccca ggtgatgtta gtgttttaag aaatgtagtt gatgtatcca acaagccaga
     2641 atcagcacag ataaaaagtg gaatttcttg tttctccaga tttttaatac gttaatacgc
     2701 aggcatctga tttgcatatt cattcatgga ccactgtttc ttgcttgtac ctctggctga
     2761 ctaaatttgg ggacagattc agtcttgcct tacacaaagg ggatcataaa gttagaatct
     2821 attttctatg tactagtact gtgtactgta tagacagttt gtaaatgtta tttctgcaaa
     2881 caaacacctt cttattatat atataatata tatatatatc agtttgatca cactatttta
     2941 gagtcttaat gccaagtcag cagatttgct ttatgaatta cagggactag aaatgcccac
     3001 attcaggaaa tttgtaataa cattgtctag acacctatcc tcattctagt agaaagtgtg
     3061 tacatactgt aaatatgtgt gattgcttga cttgaaaagg tttgaattct gaatgttata
     3121 ccatccttgt aagtaagttt gtaatttcca ccataaatta tggtaaatat aaaactccag
     3181 aggttgttct actccataca gttcacactg attgtgacac attcttagta gctagtgtct
     3241 gttctagtca ctgcactgga gtctacgagc cggaactcgc tatatgcacg tgtgtgtgtc
     3301 cgtatgtaag aaagtgtgca ccgagtgact gaatggttga gatgaattgg aatgctgaag
     3361 actaacgaag aaactagaga ctgatatcga gcattctgcc cacctcgctc tgtatttaat
     3421 taattgtgct atatgttgct ttaacaaccc attgagcagt cagggaatgt gagtaagctt
     3481 gctgccaaag gtaactagga aagcattcat ctgctgcctc cttgtttttg ctcctagaga
     3541 gtgaaaatac aggcaatttt actgtgagtg tttcactgga aatgtacaat ctttgtgtgt
     3601 tagagtattt gttttagtaa gaaatgttta cacagcttgt ggaattattt cgtgggaaaa
     3661 taaattttta taacttctcc cacttcaatt tctaaccttg cctattgttc ctgttgtttg
     3721 tttacctccc agttacctac cattcctccc caccaccgac tccagcaggt tcactgtctg
     3781 tcagaaccca gaagtgcttc ttataaccaa agtttctgtt cttcagaaga aatcagggca
     3841 aaatggggtg acttgaagtg aataaaatgt taagaatatt atcctacata agacatgtac
     3901 acagaagggg aaccttgaag acattatctc catgcctcaa ttacactgct gtaagaagct
     3961 tacaatgtca tcatgtttaa ggctaagacc ttttccgtgt ctcaagtgta tattttgtcc
     4021 agttataact ggatggtaag acagtattaa gagtgcaagt acctggcact tgaagtttgt
     4081 cccaggaaaa tgcctgtgta taattaccta acttcagatc tgcacattaa cttatttaac
     4141 aaaataaatc agccgggcgc agtggctcat gcctgtaatc ccagcaattt gggaggctga
     4201 ggagggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacgt ggcgaaaccc
     4261 cgtctctact aaaaagataa aaaattagcc aggtgtggtg gtgcacacct gtaatcccag
     4321 ctacttggga ggctgaggca ggagaattgc ttgaacccag gaggtggagc ctgcagtaag
     4381 ccaagatcac accactgtac tccagcctgg gtgacagagt gagactccat ctccaaaaaa
     4441 gaaaaaaaaa caaaaaacaa aaaaaactat ccagcaaaat tataaaatct actttgtttt
     4501 gcttccttga ttattccaag ttcttaccaa atattcttag ccttttataa gtaaaactgt
     4561 tttacattta actccttatt tcccttaccc ccaagaaaac gcaatattaa aaatgattaa
     4621 gctggggtgg tagagtatac ctgtagaccc agctacttgg gaggctgaga taggaggatc
     4681 ccttgagccc aggaggtgga ggctgcagtg aaccgtgact gtaccaatgc actccagcct
     4741 ggtgacaacc tggtgtttaa aaaaagaaaa taaaaattag ttacatatat aatgttttat
     4801 cagcttatat atgaaaaaat ttccctcagt tcgttaatta gccctacact gtttacataa
     4861 atttatttac tgagtataaa atcagtagtc ataataaact tgacaattct tacattggta
     4921 ggaaaccata ttctaattaa aattgaattt ataaaatatt tctgataaaa cttttgtcat
     4981 ggtaagagat tcacaattat tagttcaatc ctttattatt tcatcccaat taatgatttt
     5041 agaatattta aattcttgaa acatagctag tatttatctt acttgctgct atcattaatc
     5101 cctttcaaaa agtagtggtg agagtttcca tcttttttat tttgtatcta gattcttagc
     5161 ttgcacttta ctgtagaaca tattagtgca aatcagaata ttcctcaaag aactagcttg
     5221 aaggatttga cataagagcc gctatatgtg aaaaactgta tagtggacat atgtgtaaac
     5281 tgtgtagtaa atctgtaaat gaggaaataa tctcaagggc aatgggatat ttactgacct
     5341 gcggaatgta aagttacagt cttttcacac aacaaaggct taaccttaac ctactcagtt
     5401 gtagagccat ttttgtagtc aacctagaaa atgctggaaa tgtatttaat agtttttttt
     5461 tttttttttt ttggtcatat ccatttcagt ctttcctatg ctctttctct actgctcatt
     5521 taagttactg ttacaaaaag gtgctgctaa atgtaggatg tcttagtcat gttgtacttt
     5581 gggacaatgc cacattttta acatggtctg ctatgcattc ctgttaaaca ttcactgtca
     5641 gctacactga actgtctaac aaacctggtt taaagtaatt catataaaac aaataaagag
     5701 ctggcttctg cactgtttat tagtagtagt attaattgcc atgttagaaa tgattcatgt
     5761 agttgagact atattaaata ttcaacactt cccagctgca gggcatcttt cttggggcaa
     5821 tgctaaatac tttatgttcc tttagtaatc ttcctattat gtctgattaa aaaaaaagat
     5881 acctccacgt agataaaata ttttattcaa cgtgagctct agcagaataa tctgggtcag
     5941 ttatgagttc tggatcaaga gtttaatttc tgctgcgctg tacttttaac tatttgtact
     6001 ttgcttcatt atttaaaaca tgacacaggg ttttaaagta aatgtactca ctgttgaact
     6061 taagtacttc ttctgtttca tagaaatgtt aatattaaat gttaaaatat atattaattt
     6121 tccctcaca
//
