LOCUS       NM_018896               8602 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens calcium voltage-gated channel subunit alpha1 G
            (CACNA1G), transcript variant 1, mRNA.
ACCESSION   NM_018896
VERSION     NM_018896.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8602)
  AUTHORS   Mirbahari,S.N., Fatemi,N., Savabkar,S., Chaleshi,V., Zali,N.,
            Taleghani,M.Y., Mirzaei,E., Rejali,L., Moghadam,P.K. and
            Mojarad,E.N.
  TITLE     Unmasking early colorectal cancer clues: in silico and in vitro
            investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G in
            SSA polyps
  JOURNAL   Mol Biol Rep 51 (1), 764 (2024)
   PUBMED   38874740
  REMARK    GeneRIF: Unmasking early colorectal cancer clues: in silico and in
            vitro investigation of downregulated IGF2, SOCS1, MLH1, and CACNA1G
            in SSA polyps.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8602)
  AUTHORS   Kehribar,L., Betul Celik,Z., Yalcin Kehribar,D., Eseoglu,I.,
            Gunaydin,C. and Aydin,M.
  TITLE     The relationship of promoter methylation of calcium voltage-gated
            channel alpha 1 and interleukin-16 to primary osteoarthritis
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (10), 4436-4441 (2023)
   PUBMED   37259724
  REMARK    GeneRIF: The relationship of promoter methylation of calcium
            voltage-gated channel alpha 1 and interleukin-16 to primary
            osteoarthritis.
REFERENCE   3  (bases 1 to 8602)
  AUTHORS   Dinh,H.A., Stolting,G. and Scholl,U.I.
  TITLE     CaV3.2 (CACNA1H) in Primary Aldosteronism
  JOURNAL   Handb Exp Pharmacol 279, 249-262 (2023)
   PUBMED   37311830
  REMARK    GeneRIF: CaV3.2 (CACNA1H) in Primary Aldosteronism.
            Review article
REFERENCE   4  (bases 1 to 8602)
  AUTHORS   Banderali,U., Jain,M., Thakur,S., Jayanthan,A., Belke,D.D.,
            Giles,W.R. and Narendran,A.
  TITLE     The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is
            Regulated by the Epidermal Growth Factor Receptor via the MAPK
            Signaling Pathway
  JOURNAL   Curr Eye Res 47 (3), 426-435 (2022)
   PUBMED   34674590
  REMARK    GeneRIF: The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma
            Cells is Regulated by the Epidermal Growth Factor Receptor via the
            MAPK Signaling Pathway.
REFERENCE   5  (bases 1 to 8602)
  AUTHORS   Pan,C.C., Du,Z.H., Zhao,Y., Chu,H.Q. and Sun,J.W.
  TITLE     Downregulation of Cav3.1 T-type Calcium Channel Expression in
            Age-related Hearing Loss Model
  JOURNAL   Curr Med Sci 41 (4), 680-686 (2021)
   PUBMED   34403092
  REMARK    GeneRIF: Downregulation of Cav3.1 T-type Calcium Channel Expression
            in Age-related Hearing Loss Model.
REFERENCE   6  (bases 1 to 8602)
  AUTHORS   Monteil,A., Chemin,J., Bourinet,E., Mennessier,G., Lory,P. and
            Nargeot,J.
  TITLE     Molecular and functional properties of the human alpha(1G) subunit
            that forms T-type calcium channels
  JOURNAL   J Biol Chem 275 (9), 6090-6100 (2000)
   PUBMED   10692398
REFERENCE   7  (bases 1 to 8602)
  AUTHORS   Cribbs,L.L., Gomora,J.C., Daud,A.N., Lee,J.H. and Perez-Reyes,E.
  TITLE     Molecular cloning and functional expression of Ca(v)3.1c, a T-type
            calcium channel from human brain
  JOURNAL   FEBS Lett 466 (1), 54-58 (2000)
   PUBMED   10648811
  REMARK    Erratum:[FEBS Lett 2000 Mar 31;470(3):378]
REFERENCE   8  (bases 1 to 8602)
  AUTHORS   Mittman,S., Guo,J. and Agnew,W.S.
  TITLE     Structure and alternative splicing of the gene encoding alpha1G, a
            human brain T calcium channel alpha1 subunit
  JOURNAL   Neurosci Lett 274 (3), 143-146 (1999)
   PUBMED   10548410
REFERENCE   9  (bases 1 to 8602)
  AUTHORS   Toyota,M., Ho,C., Ohe-Toyota,M., Baylin,S.B. and Issa,J.P.
  TITLE     Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant
            methylation of its 5' CpG island in human tumors
  JOURNAL   Cancer Res 59 (18), 4535-4541 (1999)
   PUBMED   10493502
REFERENCE   10 (bases 1 to 8602)
  AUTHORS   Perez-Reyes,E., Cribbs,L.L., Daud,A., Lacerda,A.E., Barclay,J.,
            Williamson,M.P., Fox,M., Rees,M. and Lee,J.H.
  TITLE     Molecular characterization of a neuronal low-voltage-activated
            T-type calcium channel
  JOURNAL   Nature 391 (6670), 896-900 (1998)
   PUBMED   9495342
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021491.16, BC110995.1,
            AF227750.1, AF134986.1, AC004590.1 and R43876.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018896.4.
            
            Summary: Voltage-sensitive calcium channels mediate the entry of
            calcium ions into excitable cells, and are also involved in a
            variety of calcium-dependent processes, including muscle
            contraction, hormone or neurotransmitter release, gene expression,
            cell motility, cell division, and cell death. This gene encodes a
            T-type, low-voltage activated calcium channel. The T-type channels
            generate currents that are both transient, owing to fast
            inactivation, and tiny, owing to small conductance. T-type channels
            are thought to be involved in pacemaker activity, low-threshold
            calcium spikes, neuronal oscillations and resonance, and rebound
            burst firing. Many alternatively spliced transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF134986.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359106.10/ ENSP00000352011.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               AC021491.16        48448-48800         c
            354-745             BC110995.1         1-392
            746-2336            AF227750.1         1-1591
            2337-8393           AF134986.1         1592-7648
            8394-8567           AC004590.1         93941-94114
            8568-8602           R43876.1           16-50               c
FEATURES             Location/Qualifiers
     source          1..8602
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..8602
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /note="calcium voltage-gated channel subunit alpha1 G"
                     /db_xref="GeneID:8913"
                     /db_xref="HGNC:HGNC:1394"
                     /db_xref="MIM:604065"
     exon            1..987
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1099
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1233
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1331
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1491
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1792
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1885
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2669
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..3046
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3198
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3384
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3499
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3655
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3724
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3809
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            3810..4003
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4435
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4536
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            4537..4660
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            4661..4729
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            4730..4914
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            4915..5041
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5042..5167
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5168..5257
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5450
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5451..5504
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5505..5656
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5657..5766
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5767..5900
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5901..5971
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            5972..6050
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            6051..6172
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            6173..6526
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            6527..6670
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            6671..6805
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            6806..6974
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            6975..7144
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     exon            7145..8602
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8179..8184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /note="hexamer: ATTAAA"
     polyA_site      8200
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /note="major polyA site"
     polyA_site      8249
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
     regulatory      8577..8582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
                     /note="hexamer: AATAAA"
     polyA_site      8602
                     /gene="CACNA1G"
                     /gene_synonym="Ca(V)T.1; Cav3.1; NBR13; SCA42; SCA42ND"
ORIGIN      
        1 gtgcgcgggg ctcctcgccg ccgctttcgc tcgctcgctc cgcgtctcgg ccggaggagg
       61 aggctgtggc gccggcgaca gctacggcag cggcagccac cgcggcggct gcggcggcgg
      121 catctccgcc tccactcccg cccgggactg ccccccactg tctccccgcc cctcccggac
      181 agtgagcccg cggcggggcg ggggaaggag ccgcccccac cccctccaag cccaccccta
      241 aagagatccc tcctcccctc ccccgccgcc tggcgcggag ccgggacgat gctgacccct
      301 tagatccggc tccagctgcg ccgcgggaag agggggcgcc cctccccgga cccccgccct
      361 ccgccgctgc cccccttttc gttcgccctc tcggggcggc ttcgccgaag gtagcgccga
      421 atccggcaac cggagcctgg gcgcgaagcg aagaagccgg aacaaagtga gggggagccg
      481 gccggctggc ccgggaagcc ccaggggcgc aggggaagcg ggactcgcgc cgggcggggt
      541 ttccctgcgc cccggcgccc cgcgggcagc atgcccctgc gggcaggggg agctgggctg
      601 aactggccct cccgggggct cagcttgcgc cctagagccc accagatgtg cccccgccgg
      661 ggcccccggg ttgcgtgagg acacctcctc tgaggggcgc cgcttgcccc tctccggatc
      721 gcccggggcc ccggctggcc agaggatgga cgaggaggag gatggagcgg gcgccgagga
      781 gtcgggacag ccccggagct tcatgcggct caacgacctg tcgggggccg ggggccggcc
      841 ggggccgggg tcagcagaaa aggacccggg cagcgcggac tccgaggcgg aggggctgcc
      901 gtacccggcg ctggccccgg tggttttctt ctacttgagc caggacagcc gcccgcggag
      961 ctggtgtctc cgcacggtct gtaacccctg gtttgagcgc atcagcatgt tggtcatcct
     1021 tctcaactgc gtgaccctgg gcatgttccg gccatgcgag gacatcgcct gtgactccca
     1081 gcgctgccgg atcctgcagg cctttgatga cttcatcttt gccttctttg ccgtggagat
     1141 ggtggtgaag atggtggcct tgggcatctt tgggaaaaag tgttacctgg gagacacttg
     1201 gaaccggctt gactttttca tcgtcatcgc agggatgctg gagtactcgc tggacctgca
     1261 gaacgtcagc ttctcagctg tcaggacagt ccgtgtgctg cgaccgctca gggccattaa
     1321 ccgggtgccc agcatgcgca tccttgtcac gttgctgctg gatacgctgc ccatgctggg
     1381 caacgtcctg ctgctctgct tcttcgtctt cttcatcttc ggcatcgtcg gcgtccagct
     1441 gtgggcaggg ctgcttcgga accgatgctt cctacctgag aatttcagcc tccccctgag
     1501 cgtggacctg gagcgctatt accagacaga gaacgaggat gagagcccct tcatctgctc
     1561 ccagccacgc gagaacggca tgcggtcctg cagaagcgtg cccacgctgc gcggggacgg
     1621 gggcggtggc ccaccttgcg gtctggacta tgaggcctac aacagctcca gcaacaccac
     1681 ctgtgtcaac tggaaccagt actacaccaa ctgctcagcg ggggagcaca accccttcaa
     1741 gggcgccatc aactttgaca acattggcta tgcctggatc gccatcttcc aggtcatcac
     1801 gctggagggc tgggtcgaca tcatgtactt tgtgatggat gctcattcct tctacaattt
     1861 catctacttc atcctcctca tcatcgtggg ctccttcttc atgatcaacc tgtgcctggt
     1921 ggtgattgcc acgcagttct cagagaccaa gcagcgggaa agccagctga tgcgggagca
     1981 gcgtgtgcgg ttcctgtcca acgccagcac cctggctagc ttctctgagc ccggcagctg
     2041 ctatgaggag ctgctcaagt acctggtgta catccttcgt aaggcagccc gcaggctggc
     2101 tcaggtctct cgggcagcag gtgtgcgggt tgggctgctc agcagcccag cacccctcgg
     2161 gggccaggag acccagccca gcagcagctg ctctcgctcc caccgccgcc tatccgtcca
     2221 ccacctggtg caccaccacc accaccatca ccaccactac cacctgggca atgggacgct
     2281 cagggccccc cgggccagcc cggagatcca ggacagggat gccaatgggt cccgccggct
     2341 catgctgcca ccaccctcga cgcctgccct ctccggggcc ccccctggtg gcgcagagtc
     2401 tgtgcacagc ttctaccatg ccgactgcca cttagagcca gtccgctgcc aggcgccccc
     2461 tcccaggtcc ccatctgagg catccggcag gactgtgggc agcgggaagg tgtatcccac
     2521 cgtgcacacc agccctccac cggagacgct gaaggagaag gcactagtag aggtggctgc
     2581 cagctctggg cccccaaccc tcaccagcct caacatccca cccgggccct acagctccat
     2641 gcacaagctg ctggagacac agagtacagg tgcctgccaa agctcttgca agatctccag
     2701 cccttgcttg aaagcagaca gtggagcctg tggtccagac agctgcccct actgtgcccg
     2761 ggccggggca ggggaggtgg agctcgccga ccgtgaaatg cctgactcag acagcgaggc
     2821 agtttatgag ttcacacagg atgcccagca cagcgacctc cgggaccccc acagccggcg
     2881 gcaacggagc ctgggcccag atgcagagcc cagctctgtg ctggccttct ggaggctaat
     2941 ctgtgacacc ttccgaaaga ttgtggacag caagtacttt ggccggggaa tcatgatcgc
     3001 catcctggtc aacacactca gcatgggcat cgaataccac gagcagcccg aggagcttac
     3061 caacgcccta gaaatcagca acatcgtctt caccagcctc tttgccctgg agatgctgct
     3121 gaagctgctt gtgtatggtc cctttggcta catcaagaat ccctacaaca tcttcgatgg
     3181 tgtcattgtg gtcatcagcg tgtgggagat cgtgggccag caggggggcg gcctgtcggt
     3241 gctgcggacc ttccgcctga tgcgtgtgct gaagctggtg cgcttcctgc cggcgctgca
     3301 gcggcagctg gtggtgctca tgaagaccat ggacaacgtg gccaccttct gcatgctgct
     3361 tatgctcttc atcttcatct tcagcatcct gggcatgcat ctcttcggct gcaagtttgc
     3421 ctctgagcgg gatggggaca ccctgccaga ccggaagaat tttgactcct tgctctgggc
     3481 catcgtcact gtctttcaga tcctgaccca ggaggactgg aacaaagtcc tctacaatgg
     3541 tatggcctcc acgtcgtcct gggcggccct ttatttcatt gccctcatga ccttcggcaa
     3601 ctacgtgctc ttcaatttgc tggtcgccat tctggtggag ggcttccagg cggaggaaat
     3661 cagcaaacgg gaagatgcga gtggacagtt aagctgtatt cagctgcctg tcgactccca
     3721 ggggggagat gccaacaagt ccgaatcaga gcccgatttc ttctcaccca gcctggatgg
     3781 tgatggggac aggaagaagt gcttggcctt ggtgtccctg ggagagcacc cggagctgcg
     3841 gaagagcctg ctgccgcctc tcatcatcca cacggccgcc acacccatgt cgctgcccaa
     3901 gagcaccagc acgggcctgg gcgaggcgct gggccctgcg tcgcgccgca ccagcagcag
     3961 cgggtcggca gagcctgggg cggcccacga gatgaagtca ccgcccagcg cccgcagctc
     4021 tccgcacagc ccctggagcg ctgcaagcag ctggaccagc aggcgctcca gccggaacag
     4081 cctcggccgt gcacccagcc tgaagcggag aagcccaagt ggagagcggc ggtccctgtt
     4141 gtcgggagaa ggccaggaga gccaggatga agaggagagc tcagaagagg agcgggccag
     4201 ccctgcgggc agtgaccatc gccacagggg gtccctggag cgggaggcca agagttcctt
     4261 tgacctgcca gacacactgc aggtgccagg gctgcatcgc actgccagtg gccgagggtc
     4321 tgcttctgag caccaggact gcaatggcaa gtcggcttca gggcgcctgg cccgggccct
     4381 gcggcctgat gaccccccac tggatgggga tgacgccgat gacgagggca acctgagcaa
     4441 aggggaacgg gtccgcgcgt ggatccgagc ccgactccct gcctgctgcc tcgagcgaga
     4501 ctcctggtca gcctacatct tccctcctca gtccaggttc cgcctcctgt gtcaccggat
     4561 catcacccac aagatgttcg accacgtggt ccttgtcatc atcttcctta actgcatcac
     4621 catcgccatg gagcgcccca aaattgaccc ccacagcgct gaacgcatct tcctgaccct
     4681 ctccaattac atcttcaccg cagtctttct ggctgaaatg acagtgaagg tggtggcact
     4741 gggctggtgc ttcggggagc aggcgtacct gcggagcagt tggaacgtgc tggacgggct
     4801 gttggtgctc atctccgtca tcgacattct ggtgtccatg gtctctgaca gcggcaccaa
     4861 gatcctgggc atgctgaggg tgctgcggct gctgcggacc ctgcgcccgc tcagggtgat
     4921 cagccgggcg caggggctga agctggtggt ggagacgctg atgtcctcac tgaaacccat
     4981 cggcaacatt gtagtcatct gctgtgcctt cttcatcatt ttcggcatct tgggggtgca
     5041 gctcttcaaa gggaagtttt tcgtgtgcca gggcgaggat accaggaaca tcaccaataa
     5101 atcggactgt gccgaggcca gttaccggtg ggtccggcac aagtacaact ttgacaacct
     5161 tggccaggcc ctgatgtccc tgttcgtttt ggcctccaag gatggttggg tggacatcat
     5221 gtacgatggg ctggatgctg tgggcgtgga ccagcagccc atcatgaacc acaacccctg
     5281 gatgctgctg tacttcatct cgttcctgct cattgtggcc ttctttgtcc tgaacatgtt
     5341 tgtgggtgtg gtggtggaga acttccacaa gtgtcggcag caccaggagg aagaggaggc
     5401 ccggcggcgg gaggagaagc gcctacgaag actggagaaa aagagaagga atctaatgct
     5461 ggacgatgta attgcttccg gcagctcagc cagcgctgcg tcagaagccc agtgcaaacc
     5521 ttactactcc gactactccc gcttccggct cctcgtccac cacttgtgca ccagccacta
     5581 cctggacctc ttcatcacag gtgtcatcgg gctgaacgtg gtcaccatgg ccatggagca
     5641 ctaccagcag ccccagattc tggatgaggc tctgaagatc tgcaactaca tcttcactgt
     5701 catctttgtc ttggagtcag ttttcaaact tgtggccttt ggtttccgtc ggttcttcca
     5761 ggacaggtgg aaccagctgg acctggccat tgtgctgctg tccatcatgg gcatcacgct
     5821 ggaggaaatc gaggtcaacg cctcgctgcc catcaacccc accatcatcc gcatcatgag
     5881 ggtgctgcgc attgcccgag tgctgaagct gctgaagatg gctgtgggca tgcgggcgct
     5941 gctggacacg gtgatgcagg ccctgcccca ggtggggaac ctgggacttc tcttcatgtt
     6001 gttgtttttc atctttgcag ctctgggcgt ggagctcttt ggagacctgg agtgtgacga
     6061 gacacacccc tgtgagggcc tgggccgtca tgccaccttt cggaactttg gcatggcctt
     6121 cctaaccctc ttccgagtct ccacaggtga caattggaat ggcattatga aggacaccct
     6181 ccgggactgt gaccaggagt ccacctgcta caacacggtc atctcgccta tctactttgt
     6241 gtccttcgtg ctgacggccc agttcgtgct agtcaacgtg gtgatcgccg tgctgatgaa
     6301 gcacctggag gagagcaaca aggaggccaa ggaggaggcc gagctagagg ctgagctgga
     6361 gctggagatg aagaccctca gcccccagcc ccactcgcca ctgggcagcc ccttcctctg
     6421 gcctggggtc gagggccccg acagccccga cagccccaag cctggggctc tgcacccagc
     6481 ggcccacgcg agatcagcct cccacttttc cctggagcac cccacggaca ggcagctgtt
     6541 tgacaccata tccctgctga tccagggctc cctggagtgg gagctgaagc tgatggacga
     6601 gctggcaggc ccagggggcc agccctctgc cttcccttct gcccccagcc tgggaggctc
     6661 cgacccacag atccctctag ctgagatgga ggctctgtct ctgacgtcag agattgtgtc
     6721 tgaaccgtcc tgctctctag ctctgacgga tgactctttg cctgatgaca tgcacacact
     6781 cttacttagt gccctggaga gcaatatgca gccccacccc acggagctgc caggaccaga
     6841 cttactgact gtgcggaagt ctggggtcag ccgaacgcac tctctgccca atgacagcta
     6901 catgtgtcgg catgggagca ctgccgaggg gcccctggga cacaggggct gggggctccc
     6961 caaagctcag tcaggctccg tcttgtccgt tcactcccag ccagcagata ccagctacat
     7021 cctgcagctt cccaaagatg cacctcatct gctccagccc cacagcgccc caacctgggg
     7081 caccatcccc aaactgcccc caccaggacg ctcccctttg gctcagaggc cactcaggcg
     7141 ccaggcagca ataaggactg actccttgga cgttcagggt ctgggcagcc gggaagacct
     7201 gctggcagag gtgagtgggc cctccccgcc cctggcccgg gcctactctt tctggggcca
     7261 gtcaagtacc caggcacagc agcactcccg cagccacagc aagatctcca agcacatgac
     7321 cccgccagcc ccttgcccag gcccagaacc caactggggc aagggccctc cagagaccag
     7381 aagcagctta gagttggaca cggagctgag ctggatttca ggagacctcc tgccccctgg
     7441 cggccaggag gagcccccat ccccacggga cctgaagaag tgctacagcg tggaggccca
     7501 gagctgccag cgccggccta cgtcctggct ggatgagcag aggagacact ctatcgccgt
     7561 cagctgcctg gacagcggct cccaacccca cctgggcaca gacccctcta accttggggg
     7621 ccagcctctt ggggggcctg ggagccggcc caagaaaaaa ctcagcccgc ctagtatcac
     7681 catagacccc cccgagagcc aaggtcctcg gaccccgccc agccctggta tctgcctccg
     7741 gaggagggct ccgtccagcg actccaagga tcccttggcc tctggccccc ctgacagcat
     7801 ggctgcctcg ccctccccaa agaaagatgt gctgagtctc tccggtttat cctctgaccc
     7861 agcagacctg gacccctgag tcctgcccca ctttcccact cacctttctc cactgggtgc
     7921 caagtcctag ctcctcctcc tgggctatat tcctgacaaa agttccatat agacaccaag
     7981 gaggcggagg cgctcctccc tgcctcagtg gctctgggta cctgcaagca gaacttccaa
     8041 agagagttaa aagcagcagc cccggcaact ctggctccag gcagaaggag aggcccggtg
     8101 cagctgaggt tcccgacacc agaagctgtt gggagaaagc aatacgtttg tgcagaatct
     8161 ctatgtatat tctattttat taaattaatt gaatctagta tatgcgggat gtacgacatt
     8221 ttgtgactga agagacttgt ttccttctac ttttatgtgt ctcagaatat ttttgaggcg
     8281 aaggcgtctg tctcttggct attttaacct aaaataacag tctagttata ttccctcttc
     8341 ttgcaaagca caagctggga ccgcgagcac attgcagccc caacggtggc ccatcttcag
     8401 cggagagcga gaaccatttt ggaaactgta atgtaactta ttttttcctt taacctcgtc
     8461 atcattttct gtagggaaaa aaaaaagaaa aagaaaaaat gagattttac aagtgaaatg
     8521 gaaccttttt atatatacat acatacatat ctatctatct atctatatat atataaaata
     8581 aagtaatttt cctaaataaa aa
//
