LOCUS       NM_001205293           16420 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens calcium voltage-gated channel subunit alpha1 E
            (CACNA1E), transcript variant 1, mRNA.
ACCESSION   NM_001205293
VERSION     NM_001205293.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16420)
  AUTHORS   Di Micco,V., Affronte,L., Khinchi,M.S., Ronde,G., Miranda,M.J.,
            Hammer,T.B., Specchio,N., Beniczky,S., Olofsson,K., Moller,R.S. and
            Gardella,E.
  TITLE     Seizure and movement disorder in CACNA1E developmental and
            epileptic encephalopathy: Two sides of the same coin or same side
            of two different coins?
  JOURNAL   Epileptic Disord 26 (4), 520-526 (2024)
   PUBMED   38780451
  REMARK    GeneRIF: Seizure and movement disorder in CACNA1E developmental and
            epileptic encephalopathy: Two sides of the same coin or same side
            of two different coins?
REFERENCE   2  (bases 1 to 16420)
  AUTHORS   Sampedro-Castaneda,M., Baltussen,L.L., Lopes,A.T., Qiu,Y.,
            Sirvio,L., Mihaylov,S.R., Claxton,S., Richardson,J.C., Lignani,G.
            and Ultanir,S.K.
  TITLE     Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium
            channel Cav2.3, altering inactivation kinetics and neuronal
            excitability
  JOURNAL   Nat Commun 14 (1), 7830 (2023)
   PUBMED   38081835
  REMARK    GeneRIF: Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated
            calcium channel Cav2.3, altering inactivation kinetics and neuronal
            excitability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 16420)
  AUTHORS   Gao,S.H., Wang,G.Z., Wang,L.P., Feng,L., Zhou,Y.C., Yu,X.J.,
            Liang,F., Yang,F.Y., Wang,Z., Sun,B.B., Wang,D., Liang,L.J.,
            Xie,D.W., Zhao,S., Feng,H.P., Li,X., Li,K.K., Tang,T.S.,
            Huang,Y.C., Wang,S.Q. and Zhou,G.B.
  TITLE     Mutations and clinical significance of calcium voltage-gated
            channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer
  JOURNAL   Cell Calcium 102, 102527 (2022)
   PUBMED   35026540
  REMARK    GeneRIF: Mutations and clinical significance of calcium
            voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell
            lung cancer.
            Erratum:[Cell Calcium. 2024 May;119:102866. doi:
            10.1016/j.ceca.2024.102866.. PMID: 38428281]
REFERENCE   4  (bases 1 to 16420)
  AUTHORS   Contreras,G.F., Saavedra,J., Navarro-Quezada,N., Mellado,G.,
            Gonzalez,C. and Neely,A.
  TITLE     Direct inhibition of CaV2.3 by Gem is dynamin dependent and does
            not require a direct alfa/beta interaction
  JOURNAL   Biochem Biophys Res Commun 586, 107-113 (2022)
   PUBMED   34837834
  REMARK    GeneRIF: Direct inhibition of CaV2.3 by Gem is dynamin dependent
            and does not require a direct alfa/beta interaction.
REFERENCE   5  (bases 1 to 16420)
  AUTHORS   Royer-Bertrand,B., Jequier Gygax,M., Cisarova,K., Rosenfeld,J.A.,
            Bassetti,J.A., Moldovan,O., O'Heir,E., Burrage,L.C., Allen,J.,
            Emrick,L.T., Eastman,E., Kumps,C., Abbas,S., Van Winckel,G.,
            Chabane,N., Zackai,E.H., Lebon,S., Keena,B., Bhoj,E.J., Umair,M.,
            Li,D., Donald,K.A. and Superti-Furga,A.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     De novo variants in CACNA1E found in patients with intellectual
            disability, developmental regression and social cognition deficit
            but no seizures
  JOURNAL   Mol Autism 12 (1), 69 (2021)
   PUBMED   34702355
  REMARK    GeneRIF: De novo variants in CACNA1E found in patients with
            intellectual disability, developmental regression and social
            cognition deficit but no seizures.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16420)
  AUTHORS   Diriong,S., Lory,P., Williams,M.E., Ellis,S.B., Harpold,M.M. and
            Taviaux,S.
  TITLE     Chromosomal localization of the human genes for alpha 1A, alpha 1B,
            and alpha 1E voltage-dependent Ca2+ channel subunits
  JOURNAL   Genomics 30 (3), 605-609 (1995)
   PUBMED   8825650
REFERENCE   7  (bases 1 to 16420)
  AUTHORS   Williams,M.E., Marubio,L.M., Deal,C.R., Hans,M., Brust,P.F.,
            Philipson,L.H., Miller,R.J., Johnson,E.C., Harpold,M.M. and
            Ellis,S.B.
  TITLE     Structure and functional characterization of neuronal alpha 1E
            calcium channel subtypes
  JOURNAL   J Biol Chem 269 (35), 22347-22357 (1994)
   PUBMED   8071363
REFERENCE   8  (bases 1 to 16420)
  AUTHORS   Schneider,T., Wei,X., Olcese,R., Costantin,J.L., Neely,A.,
            Palade,P., Perez-Reyes,E., Qin,N., Zhou,J., Crawford,G.D. et al.
  TITLE     Molecular analysis and functional expression of the human type E
            neuronal Ca2+ channel alpha 1 subunit
  JOURNAL   Recept Channels 2 (4), 255-270 (1994)
   PUBMED   7536609
REFERENCE   9  (bases 1 to 16420)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     3,400 new expressed sequence tags identify diversity of transcripts
            in human brain
  JOURNAL   Nat Genet 4 (3), 256-267 (1993)
   PUBMED   8358434
REFERENCE   10 (bases 1 to 16420)
  AUTHORS   Soong,T.W., Stea,A., Hodson,C.D., Dubel,S.J., Vincent,S.R. and
            Snutch,T.P.
  TITLE     Structure and functional expression of a member of the low
            voltage-activated calcium channel family
  JOURNAL   Science 260 (5111), 1133-1136 (1993)
   PUBMED   8388125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL160059.7, BP230397.1,
            L27745.2, BP230632.1, AL161734.12 and KF510705.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001205293.2.
            
            Summary: Voltage-dependent calcium channels are multisubunit
            complexes consisting of alpha-1, alpha-2, beta, and delta subunits
            in a 1:1:1:1 ratio. These channels mediate the entry of calcium
            ions into excitable cells, and are also involved in a variety of
            calcium-dependent processes, including muscle contraction, hormone
            or neurotransmitter release, gene expression, cell motility, cell
            division and cell death. This gene encodes the alpha-1E subunit of
            the R-type calcium channels, which belong to the 'high-voltage
            activated' group that maybe involved in the modulation of firing
            patterns of neurons important for information processing.
            Alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Apr 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the longest isoform (1, also known as
            alpha-1E).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L27745.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367573.7/ ENSP00000356545.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL160059.7         102955-102987
            34-611              BP230397.1         4-581
            612-2171            L27745.2           384-1943
            2172-2497           BP230632.1         129-454
            2498-6090           L27745.2           2270-5862
            6091-6091           AL161734.12        29071-29071
            6092-7170           L27745.2           5864-6942
            7171-15079          AL161734.12        37385-45293
            15080-15467         KF510705.1         1-388
            15468-16420         AL161734.12        45681-46633
FEATURES             Location/Qualifiers
     source          1..16420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..16420
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /note="calcium voltage-gated channel subunit alpha1 E"
                     /db_xref="GeneID:777"
                     /db_xref="HGNC:HGNC:1392"
                     /db_xref="MIM:601013"
     exon            1..494
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..7170
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium channel, R type, alpha-1 polypeptide;
                     voltage-gated calcium channel alpha subunit Cav2.3; brain
                     calcium channel II; voltage-dependent R-type calcium
                     channel subunit alpha-1E; voltage-dependent calcium
                     channel alpha 1E subunit; calcium channel, L type, alpha-1
                     polypeptide"
                     /codon_start=1
                     /product="voltage-dependent R-type calcium channel subunit
                     alpha-1E isoform 1"
                     /protein_id="NP_001192222.1"
                     /db_xref="CCDS:CCDS55664.1"
                     /db_xref="GeneID:777"
                     /db_xref="HGNC:HGNC:1392"
                     /db_xref="MIM:601013"
                     /translation="MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKA
                     QRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIAN
                     CIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGW
                     NVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAM
                     VPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAG
                     YECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPL
                     IIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEE
                     VMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSA
                     KVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLL
                     YYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSF
                     GISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQL
                     FGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIY
                     FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSA
                     PNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALN
                     REEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGSL
                     KGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFEDRARH
                     RQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDHELRGNHGAKEPT
                     IQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEGSS
                     EQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHI
                     SNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRAC
                     HYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIK
                     MIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRV
                     LRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTD
                     SSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVL
                     QHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEE
                     CSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVV
                     LMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIG
                     SITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV
                     CLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEI
                     MLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNF
                     EYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSK
                     VAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAI
                     WPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQ
                     RMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDG
                     QFQERQSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRASSMPRLTVDPQVVTDPSS
                     MRRSFSTIRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSD
                     THRSGGRERGRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNR
                     QGTGSLSESSIPSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLIRHAGSISPPADGSE
                     EGSPLTSQALESNNACLTESSNSPHPQQSQHASPQRYISEPYLALHEDSHASDCGEEE
                     TLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSD
                     TEEDDKC"
     exon            495..600
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            601..740
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            741..844
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            845..997
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1179
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1283
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1399
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1453
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1543
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1753
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1866
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1979
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2111
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2184
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2302
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2370
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2468
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2525
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..3176
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3490
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3650
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3780
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3840
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..3947
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..3959
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4056
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4217
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            4218..4355
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            4356..4557
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4722
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4833
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..4917
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            4918..5043
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5044..5109
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5110..5201
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5202..5367
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5368..5495
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5496..5592
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5593..5698
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5699..5806
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5807..5907
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            5908..6014
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            6015..6126
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            6127..6255
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            6256..6436
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            6437..6627
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     exon            6628..16420
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9893..9898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /note="hexamer: AATAAT"
     polyA_site      9916
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /note="major polyA site"
     regulatory      15099..15104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /note="hexamer: AATAAA"
     polyA_site      15120
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /note="major polyA site"
     regulatory      16400..16405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
                     /note="hexamer: TATAAA"
     polyA_site      16420
                     /gene="CACNA1E"
                     /gene_synonym="BII; CACH6; CACNL1A6; Cav2.3; DEE69;
                     EIEE69; gm139"
ORIGIN      
        1 cttcttgagg aatggagctt cgcagaggtt gcatttagat tcaacagttc acagcggcgg
       61 gctgctgctg ctgcctctcc gaagagctcg cggagctccc cagaggcggt ggtccccgtg
      121 cttgtctgga tgcggctctg agtctccgtg tgtctttctg cttgttgctg tgtgcgggtg
      181 ttcggccgcg atcacctttg tgtgtcttct gtctgtttaa acctcaggat ggctcgcttc
      241 ggggaggcgg tggtcgccag gccagggtcc ggcgatggag actcggacca gagcaggaac
      301 cggcaaggaa cccccgtgcc ggcctcgggg caggcggccg cctacaagca gacgaaagca
      361 cagagggcgc ggactatggc tttgtacaac cccattcccg tccggcagaa ctgtttcacc
      421 gtcaacagat ccctgttcat cttcggagaa gataacattg tcaggaaata tgccaagaag
      481 ctcatcgatt ggccgccatt tgagtacatg atcctggcca ccatcattgc caactgcatc
      541 gtcctggccc tggagcagca tcttcctgag gatgacaaga cccccatgtc ccgaagactg
      601 gagaagacag aaccttattt cattgggatc ttttgctttg aagctgggat caaaattgtg
      661 gccctggggt tcatcttcca taagggctct tacctccgca atggctggaa tgtcatggac
      721 ttcatcgtgg tcctcagtgg catcctggcc actgcaggaa cccacttcaa tactcacgtg
      781 gacctgagga ccctccgggc tgtgcgtgtc ctgcggcctt tgaagctcgt gtcagggata
      841 cctagcctgc agattgtgtt gaagtccatc atgaaggcca tggtacctct tctgcagatt
      901 ggccttctgc tcttctttgc catcctgatg tttgctatca ttggtttgga gttctacagt
      961 ggcaagttac atcgagcatg cttcatgaac aattcaggta ttctagaagg atttgacccc
     1021 cctcacccat gtggtgtgca gggctgccca gctggttatg aatgcaagga ctggatcggc
     1081 cccaatgatg ggatcaccca gtttgataac atcctttttg ctgtgctgac tgtcttccag
     1141 tgcatcacca tggaagggtg gaccactgtg ctgtacaata ccaatgatgc cttaggagcc
     1201 acctggaatt ggctgtactt catccccctc atcatcattg gatccttctt tgttctcaac
     1261 ctagtcctgg gagtgctttc cggggaattt gccaaagaga gagagagagt ggagaaccga
     1321 agggctttca tgaagctgcg gcgccagcag cagattgagc gtgagctgaa tggctaccgt
     1381 gcctggatag acaaagcaga ggaagtcatg ctcgctgaag aaaataaaaa tgctggaaca
     1441 tccgccttag aagtgcttcg aagggcaacc atcaagagga gccggacaga ggccatgact
     1501 cgagactcca gtgatgagca ctgtgttgat atctcctctg tgggcacacc tctggcccga
     1561 gccagtatca aaagtgcaaa ggtagacggg gtctcttatt tccggcacaa ggaaaggctt
     1621 ctgcgcatct ccattcgcca catggttaaa tcccaggtgt tttactggat tgtgctgagc
     1681 cttgtggcac tcaacactgc ctgtgtggcc attgtccatc acaaccagcc ccagtggctc
     1741 acccacctcc tctactatgc agaatttctg tttctgggac tcttcctctt ggagatgtcc
     1801 ctgaagatgt atggcatggg gcctcgcctt tattttcact cttcattcaa ctgctttgat
     1861 tttggggtca cagtgggcag tatctttgaa gtggtctggg caatcttcag acctggtacg
     1921 tcttttggaa tcagtgtctt gcgagccctc cggcttctaa gaatatttaa aataaccaag
     1981 tattgggctt ccctacggaa tttggtggtc tccttgatga gctcaatgaa gtctatcatc
     2041 agtttgcttt tcctcctctt cctcttcatc gttgtctttg ctctcctagg aatgcagtta
     2101 tttggaggca ggtttaactt taatgatggg actccttcgg caaattttga taccttccct
     2161 gcagccatca tgactgtgtt ccagatcctg acgggtgagg actggaatga ggtgatgtac
     2221 aatgggatcc gctcccaggg tggggtcagc tcaggcatgt ggtctgccat ctacttcatt
     2281 gtgctcacct tgtttggcaa ctacacgcta ctgaatgtgt tcttggctat cgctgtggat
     2341 aatctcgcca acgcccagga actgaccaag gatgaacagg aggaagaaga ggccttcaac
     2401 cagaaacatg cactgcagaa ggccaaggag gtcagcccga tgtctgcacc caacatgcct
     2461 tcgatcgaaa gagacagaag gagaagacac cacatgtcga tgtgggagcc acgcagcagc
     2521 cacctgaggg agcggaggcg ccggcaccac atgtccgtgt gggagcagcg taccagccag
     2581 ctgaggaagc acatgcagat gtccagccag gaggccctca acagagagga ggcgccgacc
     2641 atgaacccgc tcaaccccct caacccgctc agctccctca acccgctcaa tgcccacccc
     2701 agcctttatc ggcgacccag ggccattgag ggcctggccc tgggcctggc cctggagaag
     2761 ttcgaggagg agcgcatcag ccgtgggggg tccctcaagg gggatggagg ggaccgatcc
     2821 agtgccctgg acaaccagag gacccctttg tccctgggcc agcgggagcc accatggctg
     2881 gccaggccct gtcatggaaa ctgtgacccg actcagcagg aggcaggggg aggagaggct
     2941 gtggtgacct ttgaggaccg ggccaggcac aggcagagcc aacggcgcag ccggcatcgc
     3001 cgcgtcagga cagaaggcaa ggagtcctct tcagcctccc ggagcaggtc tgccagccag
     3061 gaacgcagtc tggatgaagc catgcccact gaaggggaga aggaccatga gctcaggggc
     3121 aaccatggtg ccaaggagcc aacgatccaa gaagagagag cccaggattt aaggaggacc
     3181 aacagtctga tggtgtccag aggctccggg ctggcaggag gccttgatga ggctgacacc
     3241 cccctagtcc tgccccatcc tgagctggaa gtggggaagc acgtggtgct gacggagcag
     3301 gagccagaag gcagcagtga gcaggccctg ctggggaatg tgcagctaga catgggccgg
     3361 gtcatcagcc agagcgagcc tgacctctcc tgcatcacgg ccaacacgga caaggccacc
     3421 accgagagca ccagcgtcac cgtcgccatc cccgacgtgg accccttggt ggactcaacc
     3481 gtggtgcaca ttagcaacaa gacggatggg gaagccagtc ccttgaagga ggcagagatc
     3541 agagaggatg aggaggaggt ggagaagaag aagcagaaga aggagaagcg tgagacaggc
     3601 aaagccatgg tgccccacag ctcaatgttc atcttcagca ccaccaaccc gatccggagg
     3661 gcctgccact acatcgtgaa cctgcgctac tttgagatgt gcatcctcct ggtgattgca
     3721 gccagcagca tcgccctggc ggcagaggac cccgtcctga ccaactcgga gcgcaacaaa
     3781 gtcctgaggt attttgacta tgtgttcacg ggcgtgttca cctttgagat ggttataaag
     3841 atgatagacc aaggcttgat cctgcaggat gggtcctact tccgagactt gtggaacatc
     3901 ctggactttg tggtggtcgt tggcgcattg gtggcctttg ctctggcgaa cgctttggga
     3961 accaacaaag gacgggacat caagaccatc aagtctctgc gggtgctccg agttctaagg
     4021 ccactgaaaa ccatcaagcg cttgcccaag ctcaaggccg tcttcgactg cgtagtgacc
     4081 tccttgaaga atgtcttcaa catactcatt gtgtacaagc tcttcatgtt catctttgct
     4141 gtcatcgcag ttcagctctt caagggaaag ttcttttatt gcacggacag ttccaaggac
     4201 acagagaagg agtgcatagg caactatgta gatcatgaga aaaacaagat ggaggtgaag
     4261 ggccgggaat ggaagcgcca tgaattccac tacgacaaca ttatctgggc cctgctgacc
     4321 ctcttcaccg tctccacagg ggaaggatgg cctcaagttc tgcagcactc tgtagatgtg
     4381 acagaggaag accgaggccc aagccgcagc aaccgcatgg agatgtctat cttttatgta
     4441 gtctactttg tggtcttccc cttcttcttt gtcaatatct ttgtggctct catcatcatc
     4501 accttccagg agcaagggga taagatgatg gaggagtgca gcctggagaa gaatgagagg
     4561 gcgtgcatcg acttcgccat cagcgccaaa cctctcaccc gctacatgcc gcagaacaga
     4621 cacaccttcc agtaccgcgt gtggcacttt gtggtgtctc cgtcctttga gtacaccatt
     4681 atggccatga tcgccttgaa tactgttgtg ctgatgatga agtattattc tgctccctgt
     4741 acctatgagc tggccctgaa gtacctgaat atcgccttca ccatggtgtt ttccctggaa
     4801 tgtgtcctga aggtcatcgc ttttggcttt ttgaactatt tccgagacac ctggaatatc
     4861 tttgacttca tcaccgtgat tggcagtatc acagaaatta tcctgacaga cagcaagctg
     4921 gtgaacacca gtggcttcaa tatgagcttt ctgaagctct tccgagctgc ccgcctcata
     4981 aagctcctgc gtcagggcta taccatacgc attttgctgt ggacctttgt gcagtccttt
     5041 aaggccctcc cttatgtctg ccttttaatt gccatgcttt tcttcattta tgccatcatt
     5101 gggatgcagg tatttggaaa cataaaatta gacgaggaga gtcacatcaa ccggcacaac
     5161 aacttccgga gtttctttgg gtccctaatg ctactcttca ggagtgccac aggtgaggcc
     5221 tggcaggaga ttatgctgtc atgccttggg gagaagggct gtgagcctga caccaccgca
     5281 ccatcagggc agaacgagaa cgaacgctgc ggcaccgatc tggcctacgt gtactttgtc
     5341 tccttcatct tcttctgctc cttcttgatg ctcaacctgt ttgtggccgt catcatggac
     5401 aactttgagt acctgactcg ggactcctcc atcctggggc ctcaccactt ggacgagttt
     5461 gtccgcgtct gggcagaata tgaccgagca gcatgtggcc gcatccatta cactgagatg
     5521 tatgaaatgc tgactctcat gtcacctccg ctaggcctcg gcaagagatg tccctccaaa
     5581 gtggcatata agaggttggt cctgatgaac atgccagtag ctgaggacat gacggtccac
     5641 ttcacctcca cacttatggc tctgatccgg acagctctgg acattaaaat tgccaaaggt
     5701 ggtgcagaca ggcagcagct agactcagag ctacaaaagg agaccctagc catctggcct
     5761 cacctatccc agaagatgct ggatctgctt gtgcccatgc ccaaagcctc tgacctgact
     5821 gtgggcaaaa tctatgcagc aatgatgatc atggactact ataagcagag taaggtgaag
     5881 aagcagaggc agcagctgga ggaacagaaa aatgccccca tgttccagcg catggagcct
     5941 tcatctctgc ctcaggagat cattgctaat gccaaagccc tgccttacct ccagcaggac
     6001 cccgtttcag gcctgagtgg ccggagtgga tacccttcga tgagtccact ctctccccag
     6061 gatatattcc agttggcttg tatggacccc gccgatgacg gacagttcca agaacggcag
     6121 tctctggagc cagaggttag tgaattaaaa agcgtgcagc cctctaacca tggcatctac
     6181 cttccttcgg acacccagga gcatgcggga tctgggaggg catcttctat gccacgtctg
     6241 actgtggatc cccaggtggt gacagaccct agctccatga gacgttcatt ttccactatt
     6301 cgggataagc gttcaaattc ctcgtggttg gaggaattct ccatggagcg aagcagtgaa
     6361 aatacctaca agtcccgtcg ccggagttac cactcctcct tgcggctgtc agcccaccgc
     6421 ctgaactctg attcaggcca caagtctgac actcaccgct cagggggcag ggagcgggga
     6481 cgatcaaaag agcgaaagca tcttctctct cctgatgtct cccgctgcaa ttcagaagag
     6541 cgagggaccc aggctgactg ggagtcccca gagcgccgtc aatccaggtc acccagtgag
     6601 ggcaggtcac agacgcccaa cagacagggc acaggttccc taagtgagag ctccatcccc
     6661 tctgtctctg acaccagcac cccaagaaga agtcgtcggc agctcccacc cgtcccgcca
     6721 aagccccggc ccctcctttc ctacagctcc ctgattcgac acgcgggcag catctctcca
     6781 cctgctgatg gaagcgagga gggctccccg ctgacctccc aagctctgga gagcaacaat
     6841 gcttgcctga ccgagtcttc caactctccg cacccccagc agagccaaca tgcctcccca
     6901 cagcgctaca tctccgagcc ctacttggcc ctgcacgaag actcccacgc ctcagactgt
     6961 ggtgaggagg agacgctcac tttcgaagca gccgtggcta ctagcctggg ccgttccaac
     7021 accatcggct cagccccacc cctgcggcat agctggcaga tgcccaacgg gcactatcgg
     7081 cggcggaggc gcggggggcc tgggccaggc atgatgtgtg gggctgtcaa caacctgcta
     7141 agtgacacgg aagaagatga caaatgctag aggctgctcc cccctccgat gcatgctctt
     7201 ctctcacatg gagaaaacca agacagaatt gggaagccag tgcggcccgg gggggaggaa
     7261 gagggaaaag gaagatggaa ggacaccatg cattatcaga gaagaggaag taaaggacaa
     7321 tcagaacacc agtcaaaccc accaaattgc tttattcccc tttgcaagat gggcactgcc
     7381 atagttctgc ctctttgctg gggaaagaaa ccaggaacgt ggagggttat tactgcggga
     7441 gaagggacac gaggatggct ttgcttcccc ttgccccttc ccacttttct aaaagctgtg
     7501 gagggatcta gctggcctat gtctacactc agtgccctga gaagcctgga agactttctg
     7561 gctcttaact ggggagtagt ggagaccata ggagaggact ctcctccctc accagctctt
     7621 acgcctcagc cagcaccact gccaccaggg caactgcagc agcatctcat gcataaccct
     7681 gtggcttgct tcccccaggg cagcacaggc taagtcagga acatcggatg ccagggaggg
     7741 aggagaaagc cgaagcgaaa ggggtcaggg tgctgaggca acagcagcaa gggctggtct
     7801 ggacaagaaa agccatagcc cggcagcccc taccatgagg gagacagaga aacagaactg
     7861 gtggtgctgg ggggtatagc cccccatcct tgaggcctgt cacccacaca gtaggtgctg
     7921 agagttagga caggtcagga agtcccccag ggtccacaaa ggtgcctgag gctctggtaa
     7981 gggtgaagat aaaagtattt aacaaccgct atggcatcaa tgtaagtgga gtttggtcct
     8041 agtgccggag cccatgctat tccaggcatt ggctctttag atgccagtca tgggggaacc
     8101 ctgagggtgt gggtagagta gcaggggcca cctaagagat taaaaacagt ctgttttcca
     8161 accagtgtgg aagcaattaa atatgcgtaa cagtgctacg gccacaccag cacctcctgg
     8221 ctgaaggtca gcccacactc tggtccatga ggcagcaagg ccagtgctgt gccaagcccg
     8281 gtaaggccaa gtgccgaggc ccagccttcc ctgccactcc tctgagaggg cagaacacac
     8341 atatccaagt aggctaccca ccactgggta gggatttctg taaagatggg aaaggctgat
     8401 agattgaaat aagcttctgt gaaagtctgg atttactgag gacctcccct gaggagggac
     8461 cgttgggacc gcagattctg cagctggtgt ggggttcagg tcagtttgtc aggatgcttt
     8521 aaggtgatta gtaaatatac ctcagcttag acttgggctg ctccttctag caaagcaggc
     8581 tccagtgggg cctcatcata caggatgaca agactggggc cctgttcacc ttgaacatgc
     8641 ccctgggcca agatggggct tcacccctcc ccagagtaag agctggggct gacagtccca
     8701 ccctgtcatt cctaatagcc caaacgcaga agcactgagc aagagagccc tttcttgcca
     8761 agccagtgct cttttggtat atggcataca gctccattgg aggggacaca tcactggctt
     8821 tatctggtgg aaatgtacct ttcccttaag ttcctcctta gtgccatcac agcaggtgaa
     8881 tgggtgccct acggggccct ccttccccca ccaggaacag atggaacctg ccacccagga
     8941 tcctgatctg ccctgcactg agcactcagt ggataaacac tcctccagcc cagacacact
     9001 cctcctcttg ggcaggagca atccagagtt gttatttttc ttagaaggag cctcttttcc
     9061 ctctattttt taaattgaaa tataatagct gcatcagccc tgaaaagcca aattcaacca
     9121 catggctgga gaatcatttg tcatggcccc gccttctctt ctgatactaa tggagcttca
     9181 tgacccacgg tcagccccca aaccaaagtt gtcccaacag aggaggccag tgaggcagag
     9241 acagagctct cccactctca gaccctcttt tgtcttcatt ttcctctccc acttagcaca
     9301 tgtgtgcttg agggtggctg ggaatgtgat atacagcacc ctgatcctaa caggtgtgat
     9361 tgttacgtaa gacgctgata ctgggccttg tattgctttt aaagtttcct ctgctcagca
     9421 tcatttcatg ccaaagtgct gctatgggct gctttgtgtg cacaaaattg ctttttccac
     9481 ctcggaaatg cagctttccc tagggggagg cctacaacag gacgaccatt ctgagccagt
     9541 gagtctattg catggtgttt tgagaaaggg aattttagtg acaccttatg ccatttcaag
     9601 aggagaaatg caggctggca gagcaatttc cagaaatgga atttgcctgc aaatagtata
     9661 aacaacacta aatttactgt gccaggaaat cttcctgaac tccttgaact catacacaca
     9721 ggtatttgag tcctgaataa agtgttggaa agcactgcag atgcggtcac ctgactgacc
     9781 acctgggttt tctattacca gtgaatttct tttattcacc ttcccttgac caagaaattg
     9841 ggtttctttt ccctcagcct gcacttactc ttctattaag accagaaaat aaaataattt
     9901 tccgttgagt cacaaactca tcatcttgtt tggtgttctg ctgcctctga acaaaagtga
     9961 atgccagcct tcccttgctg ggtgtcagag tctgcctccc ttgaaaagag gcccctgtag
    10021 accccaacac ctattctttt ctctggttaa ttacagcagc atctgagaaa ttccatgcaa
    10081 aagaagacta caaccagtgt ttcagatata ccacaagatc aaatttgggc actggtggtc
    10141 cacctcagaa gactcttgag tcatatattc agtttctctt gctaatatat gactcgtctt
    10201 caccatctcc tcaaaacaag agcaaagcca agatagagga aggtaaaagg aggaggaaag
    10261 gaaaccaagg cagggagatg ttctaagtag gtttgcattt agttacccct catttcactt
    10321 aaggctccag acagactcca ggtagggaat gcatgctgtc tctttctctg tgtctgtctc
    10381 cccatctcct agaggacaga gtgccagcga cctctggaca ggggcagggc tccagccaag
    10441 gtgcccctga gccagggtca acatagaatt tcctgccccg tgaagggctg gcaccagcta
    10501 gcatcccctt ggctccacat gagtcatgaa cacaattgtc agtgggggtc tctgctgctc
    10561 ttctggctga agaatctgtt tttcttctgg gcttcacttg tagttcctat tcaatgtctc
    10621 catagggcac tgagatcacc aagaacatta cccagaagct gaagtccaaa tgttctagat
    10681 tttgacctct cttgactctg gggccacaaa gagaaggccc cataatccac ctctcagcca
    10741 gtatctccct tctttgcaca gattcctccc aaccccatag agcctatgtg gtgagcatga
    10801 gggtcgtctt ccctctgttc tcccatccca gcctctgttt tgctgcatgt tagcgctgat
    10861 ccagctcctg agatggttaa ttccacccaa tccaagctta tttgcttgcc tgactgactc
    10921 caccactctc tcagctatgg gggaatattg cattctaatg aaatagggtt tggaactcac
    10981 ctggtgctcc tcgcaagaca actgacacaa ggtgtagggt gtgggggtgg acaaaatgcc
    11041 cacctactgg ataaaagctc actgcaggaa aatgaggtct cctggcataa tgcaacaaaa
    11101 atctcatata attttgattt ttaaaaagtt gttctcaatt tttcattaca tcctacttct
    11161 cagccctctg gatgtttcat ttttttggac aaagtgtttc tttagtggtt ggggccaggg
    11221 acaggttgag ggatatttct cggctcattt ataagatata aatattatga ggttgtatgt
    11281 aaagaaaggg caaacgtaca gcagaagggg agcaaatagc tacctttcaa ggattttgag
    11341 atttgaaggt taaggaattt ttactgctat ttttgttcat cagtttcatg tctgttatgt
    11401 tttgagatcc tcagaggcct agggttagcg tataccaaga atcctggtga gaggcgttgc
    11461 catgccttgg ggtgaattct tccccactag ctctctcacc cagcctacaa gtccttctct
    11521 catagatccc agagcaatgg gcaccgtcca ggaggtacag gagaggactt tatgatgcag
    11581 gaaagaagga agaagtgggt cccttgcaag tggccagaca gggaatgatg gtttgactcc
    11641 agaaatcagg aatcaggttc aggtttggat aacttctctt taaaatatct ccacattgag
    11701 actcttattt taacaaaatc caaacaaaat taactcaggg cttgtgacct aacctttgta
    11761 agaaggtgat caaagagatc ctacattaat aagcactgcc tgtagcacca gctttgtctt
    11821 tttgtctttt gttgtttctt tcctgaacca ccctgtacat catagccagg tctaccccaa
    11881 atagagcagc agctgatggc ttctctgctg tctgtggagg gagggctcgg ctgcagacct
    11941 atggtgtttt gtcagctgtt aggtgctaca gcccacccag tcagagtaca tagacatagc
    12001 gctttaaggg acaaaggaca aacagaacta tctttgcttt ccggaggcca tctttttctt
    12061 tccttgaatc ctttctgctt taaacttctg aggtttatgc atcccagaga ggtcacacca
    12121 agccaaagag aaaaaattca tagattgtcc cagcctaccc aaagggcctg aaaagcctct
    12181 ctaaacaaaa ctcaagatag ctgagaagta tgaatggggt tcacagcaaa gtccaattga
    12241 tggcttttga ggctgggaca cccccaaact gcccttctgt ttttgtagtt ttgctttctt
    12301 ccacccaccc tctctccgca tgctgtaagt taggggagtt agtatcttga acttctaaat
    12361 gcaaaaggag attttataat aagccatgct acctgtaaat acattattga ggtttgcatt
    12421 tttatttttg gaggtatgaa agagttgagt agaccaagtc aaaagaggtg tggggattta
    12481 tgtttatttt tatttgtttg gggttgtttg gttggtggct gggtttcttg taacagacct
    12541 attctggaat agcaaagaag gataccttgg tgatctgcaa tgtttctgaa tctgtttctc
    12601 tttaggaagt gattgccatc aaatttagtg atatgatatt tgagtcaaaa atctgaggtt
    12661 atagtaccag ctgtcttttc tctctggtct cctttttgtc gtctttctct ttctgtctaa
    12721 attggcctct gtcttttcct aaggacttaa aatataaccc aaattaatga agaactgccc
    12781 caaaacttca gtgaaagcca aggaggtaca gaattttttc aggacatctt taaccaatac
    12841 aaaatttatg tcttaagaag ataattttta caatagtgta gtaatctgat aaatgaaaac
    12901 tattggaagt caatagtttt ttatattcca gctttctgta ttcaaacttg tgccttcagc
    12961 aagcatctct tcactttctt tcccttgtca attgaaacat gaatgtttgg ctaactcatg
    13021 atgtaaagtg tctgttaagt taataataca taatttaaag cacttagtct ccacaaagca
    13081 atttagaaaa atcttcactt gttagatccc atgaagtacc tatgaaattc tcagcattgc
    13141 tataagcatt tgattttttt taaggaaact tcctgtttaa tggaatctga atccaagatt
    13201 tgctttaatt tcactctatt cttcccattt tcccttattc ttcttgttgt ctctctaatt
    13261 aaaaaaaaaa aaaacctagg cttttttttt tctatccaga aagttgggtt ttcatgatct
    13321 gagcttcctt atgtctcctt ctctttgtgc aaacttaaac cagtcataga ttgtcaccca
    13381 gacatattct ccaacccagc attggaaatc tgaacgaatc ttttctcttt ttgtcctaca
    13441 agtttgtcag agatgagaat ggattgctgt ctacattcta caaccagacc ctagacttta
    13501 taccaggctg tgccacttcc tcttcacttc actcagagga tggccccaaa actgaaaagg
    13561 aaatgaaata atcaaatata ccaaatccga atttgacttt atttgatgac tcaatatttt
    13621 ccttccagta ctctaatttt tttttatggc aatggcctat atggcacaag aaccaccact
    13681 taaagcaaat ctgttgaaca tttttataag ggatgagcaa gaaaaacaca ctccaaaatt
    13741 ttaaagtgcc attaatcaat ttttaagaat aaaggtaata tgaaatgagg gctaaacaat
    13801 gtaatataac tgccagttaa ggtagacagt agttgtggtc ttagttacat ttgatatgga
    13861 gttgtgtaat attaagcaga tcccagtgga gttagtaaaa acataggtat tgagttttaa
    13921 tggctaccaa ttgggatata tacttagcct gcaggctgaa ctttagtcag tgtttttcta
    13981 tcatgttgtt ttgtgaacaa gtcaaaattt atacaaagct accctaagtg ctgcaattgc
    14041 agaggaactt gcctcttcgt gatattagag ggcagtccaa ctccgctcaa actgagtcca
    14101 agatttgaat tcatccagaa aaacaaatgg aggagaaaag cctaatgcac cacatgtgtt
    14161 tggcatttca tggctgggac aatggagtag agggtaggaa gacaagctgt agaacaaaag
    14221 caaagtgagg tagaaagtaa caggtcccag acgaggacag acttagagat gtgtaacctt
    14281 ggatcctctt tttcacttag aatatgggta aacttcttag cacaagactg gattaagaga
    14341 agttctttct gttaaactca cctagggtag tggctttgaa ggcctcagag gattaataga
    14401 ttcccaaaat tttcttccag acctgggaga tggagagaaa gaggttcttg ctttaaagcg
    14461 gctcgaagac aatctttatg acttcagcaa ctcttcaaca tagtagcacc aataaaggag
    14521 agattatgtt aacttcctag tggtgagaat accatgggat gggagaaggg ccagtgagtg
    14581 ggatgggaat gagcttcatc aggaacagat ttcagactct gcagggtgca ccggttctag
    14641 cctcaaataa caacattgca aggaggtgga ctacagggtc cacaccctct gtccttcggg
    14701 gcccatggtc aggccattcc ctctttgttt tgctcctaga ggatgagcat gtaagatgag
    14761 atcaggaggg aaattgggtg ctctgcctca ggctgttaaa atgctgctac ctgcattcta
    14821 aaacgtgcaa gtcatgcccc acaagacacc tccttagggc agcatccact gtggtgtgcc
    14881 agcctgacac ccctgcagtc acggtgtttg aatggcagct gatgctggcc cacccagagt
    14941 atcggtgcat ctctcctaaa gccacagttc agcactgcat gttgaccagg cggatatcct
    15001 ataatataga tgctcgtttg gatccaaaag gaaaaccatt aaaaataaaa gaaagatgaa
    15061 aaactttaat gttttggggg ggataaaaga aaagaataaa taaaaccttg ttgtaaagaa
    15121 tgcatcggcc tgatttccct cacttgatgt gtttctttgc tgctaccaga aagggaaatc
    15181 atgggagtga agcctgccag gaccctcagg gtaagctggc agcaggctct gcagctgcac
    15241 ttagttgggg tctgctcaga ccagtcagga ggaattcagg aggctttcaa agtcccaagg
    15301 acatcctggc tctgaaaggt tttcttttgt taaaaaatgc actttgtgct gtgtgtggta
    15361 gctcgtatgt gttaccccag ctattcagga agctagggca gaaggattgc ttgaggctag
    15421 gaattcaaga ctggcctgga tgacagagtg aaaccctcat ctcttaaaaa aaaaaaaaag
    15481 gaataaaaat gttctctgcc ttggataaca ttttttttta aagattccat acaaactcat
    15541 tccctgaaag agaaaaacag attttctaat caggacattg tcctgatctg caagcgagga
    15601 gtttaacaag gtaggcagag aacttcctta tggaacaaca gggctctgtg accagaaaaa
    15661 ctatgaccag cctcctctga aaaaaggtgg ggggattata gggcaccagc tcagccgcca
    15721 agttcaggaa gcagctgatt cccaagactc ttaggagata ctgtccattc ttcctcctgt
    15781 ccacatcact ccccatttaa ctgcaattgc tcccttgcca cagggaaagc agcaagcccc
    15841 aggcccaggc ctccatttga tttgccactc cgagaactgt ctgcttcatt ctgcttgagg
    15901 agatatcttc acctaatcct agtgttaatt attttaatct gagcaacgct tttatcaatt
    15961 agatagaaac cagcattcca aaataagtcc cctaagtttg tagtttgagc caagatattt
    16021 tcttgagccc taagatatat gactttatta gctaggattt ttcttatgat taaaaacatc
    16081 caaaaatgtg atatgtggtc atctctcagg gaggtctagg tccttgcagg ctggatttta
    16141 gaaatttcta agattctcta caacttttaa attttatgtt atttttcaat cataatttct
    16201 ttcctgtggc ttctatcacc attggagtta gaatctgaca acctttaact tcacactttt
    16261 atgagataat aagttggttt cttgggcaaa ggttggtttg taagccattt acatggattg
    16321 atgatttctg ttcttgtttt cttctaacct agaactcagg tccacagttt tccacaggct
    16381 aatggcacta tgaaacagat ataaagaaaa atagacactg
//
