LOCUS       NM_001128840            9369 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens calcium voltage-gated channel subunit alpha1 D
            (CACNA1D), transcript variant 2, mRNA.
ACCESSION   NM_001128840
VERSION     NM_001128840.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9369)
  AUTHORS   Tang,X., Ortner,N.J., Nikonishyna,Y.V., Fernandez-Quintero,M.L.,
            Kokot,J., Striessnig,J. and Liedl,K.R.
  TITLE     Pathogenicity of de novo CACNA1D Ca2+ channel variants predicted
            from sequence co-variation
  JOURNAL   Eur J Hum Genet 32 (9), 1065-1073 (2024)
   PUBMED   38553610
  REMARK    GeneRIF: Pathogenicity of de novo CACNA1D Ca[2+] channel variants
            predicted from sequence co-variation.
REFERENCE   2  (bases 1 to 9369)
  AUTHORS   He,Y., Li,B., Zhao,X., Pan,L., Liu,Y., Lan,C., Deng,F., Fu,W.,
            Zhang,Y. and Zuo,X.
  TITLE     Association between CACNA1D polymorphisms and hypospadias in a
            southern Chinese population
  JOURNAL   J Pediatr Urol 20 (3), 438 (2024)
   PUBMED   38378373
  REMARK    GeneRIF: Association between CACNA1D polymorphisms and hypospadias
            in a southern Chinese population.
REFERENCE   3  (bases 1 to 9369)
  AUTHORS   Schwenzer,N., Teiwes,N.K., Kohl,T., Pohl,C., Giller,M.J.,
            Lehnart,S.E. and Steinem,C.
  TITLE     CaV1.3 channel clusters characterized by live-cell and isolated
            plasma membrane nanoscopy
  JOURNAL   Commun Biol 7 (1), 620 (2024)
   PUBMED   38783117
  REMARK    GeneRIF: CaV1.3 channel clusters characterized by live-cell and
            isolated plasma membrane nanoscopy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9369)
  AUTHORS   Stanton,A.M., Heydarpour,M., Williams,J.S., Williams,G.H. and
            Adler,G.K.
  TITLE     CACNA1D Gene Polymorphisms Associate With Increased Blood Pressure
            and Salt Sensitivity of Blood Pressure in White Individuals
  JOURNAL   Hypertension 80 (12), 2665-2673 (2023)
   PUBMED   37846579
  REMARK    GeneRIF: CACNA1D Gene Polymorphisms Associate With Increased Blood
            Pressure and Salt Sensitivity of Blood Pressure in White
            Individuals.
REFERENCE   5  (bases 1 to 9369)
  AUTHORS   Ortner,N.J., Sah,A., Paradiso,E., Shin,J., Stojanovic,S.,
            Hammer,N., Haritonova,M., Hofer,N.T., Marcantoni,A., Guarina,L.,
            Tuluc,P., Theiner,T., Pitterl,F., Ebner,K., Oberacher,H.,
            Carbone,E., Stefanova,N., Ferraguti,F., Singewald,N., Roeper,J. and
            Striessnig,J.
  TITLE     The human channel gating-modifying A749G CACNA1D (Cav1.3) variant
            induces a neurodevelopmental syndrome-like phenotype in mice
  JOURNAL   JCI Insight 8 (20), e162100 (2023)
   PUBMED   37698939
  REMARK    GeneRIF: The human channel gating-modifying A749G CACNA1D (Cav1.3)
            variant induces a neurodevelopmental syndrome-like phenotype in
            mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9369)
  AUTHORS   Seino,S., Yamada,Y., Espinosa,R. 3rd, Le Beau,M.M. and Bell,G.I.
  TITLE     Assignment of the gene encoding the alpha 1 subunit of the
            neuroendocrine/brain-type calcium channel (CACNL1A2) to human
            chromosome 3, band p14.3
  JOURNAL   Genomics 13 (4), 1375-1377 (1992)
   PUBMED   1324226
REFERENCE   7  (bases 1 to 9369)
  AUTHORS   Seino,S., Chen,L., Seino,M., Blondel,O., Takeda,J., Johnson,J.H.
            and Bell,G.I.
  TITLE     Cloning of the alpha 1 subunit of a voltage-dependent calcium
            channel expressed in pancreatic beta cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 584-588 (1992)
   PUBMED   1309948
REFERENCE   8  (bases 1 to 9369)
  AUTHORS   Williams,M.E., Feldman,D.H., McCue,A.F., Brenner,R., Velicelebi,G.,
            Ellis,S.B. and Harpold,M.M.
  TITLE     Structure and functional expression of alpha 1, alpha 2, and beta
            subunits of a novel human neuronal calcium channel subtype
  JOURNAL   Neuron 8 (1), 71-84 (1992)
   PUBMED   1309651
REFERENCE   9  (bases 1 to 9369)
  AUTHORS   Chin,H.M., Kozak,C.A., Kim,H.L., Mock,B. and McBride,O.W.
  TITLE     A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps
            to mouse chromosome 14 and human chromosome 3
  JOURNAL   Genomics 11 (4), 914-919 (1991)
   PUBMED   1664412
REFERENCE   10 (bases 1 to 9369)
  AUTHORS   Mori,Y., Friedrich,T., Kim,M.S., Mikami,A., Nakai,J., Ruth,P.,
            Bosse,E., Hofmann,F., Flockerzi,V., Furuichi,T. et al.
  TITLE     Primary structure and functional expression from complementary DNA
            of a brain calcium channel
  JOURNAL   Nature 350 (6317), 398-402 (1991)
   PUBMED   1849233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005905.1, M76558.1, M83566.1,
            AC132810.2, AB209171.1, AW008794.1 and AC012467.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001128840.2.
            
            Summary: Voltage-dependent calcium channels mediate the entry of
            calcium ions into excitable cells, and are also involved in a
            variety of calcium-dependent processes, including muscle
            contraction, hormone or neurotransmitter release, and gene
            expression. Calcium channels are multisubunit complexes composed of
            alpha-1, beta, alpha-2/delta, and gamma subunits. The channel
            activity is directed by the pore-forming alpha-1 subunit, whereas
            the others act as auxiliary subunits regulating this activity. The
            distinctive properties of the calcium channel types are related
            primarily to the expression of a variety of alpha-1 isoforms,
            namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D
            subunit. Several transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (2) includes alternate in-frame
            exons, compared to variant 1, resulting in a shorter protein
            (isoform b), compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M76558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000350061.11/ ENSP00000288133.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AC005905.1         87769-88206         c
            439-502             M76558.1           393-456
            503-1314            M83566.1           65-876
            1315-1659           M76558.1           1269-1613
            1660-1661           AC132810.2         56098-56099
            1662-2464           M76558.1           1616-2418
            2465-4342           AB209171.1         988-2865
            4343-4592           M76558.1           4297-4546
            4593-7144           AB209171.1         3116-5667
            7145-7681           M76558.1           7099-7635
            7682-8101           AW008794.1         4-423               c
            8102-9369           AC012467.9         102363-103630       c
FEATURES             Location/Qualifiers
     source          1..9369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..9369
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /note="calcium voltage-gated channel subunit alpha1 D"
                     /db_xref="GeneID:776"
                     /db_xref="HGNC:HGNC:1391"
                     /db_xref="MIM:114206"
     exon            1..623
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             557..7042
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /note="isoform b is encoded by transcript variant 2;
                     calcium channel, neuroendocrine/brain-type, alpha 1
                     subunit; calcium channel, L type, alpha-1 polypeptide;
                     voltage-gated calcium channel alpha subunit Cav1.3;
                     calcium channel, voltage-dependent, L type, alpha 1D
                     subunit; voltage-gated calcium channel alpha 1 subunit"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     alpha-1D isoform b"
                     /protein_id="NP_001122312.1"
                     /db_xref="CCDS:CCDS46848.1"
                     /db_xref="GeneID:776"
                     /db_xref="HGNC:HGNC:1391"
                     /db_xref="MIM:114206"
                     /translation="MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPN
                     SSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRP
                     ARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHN
                     LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLT
                     KETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIAL
                     LVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR
                     SGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIF
                     GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP
                     ENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRW
                     NRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALF
                     TCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLL
                     RIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQ
                     TKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGN
                     YILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIAN
                     SDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEK
                     IAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSF
                     RNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGI
                     QSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFA
                     CIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVL
                     SAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNI
                     FVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNS
                     SPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPK
                     GYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRL
                     FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMR
                     DNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCG
                     SNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDP
                     EAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFA
                     LVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATF
                     LIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPE
                     ETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEK
                     PLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENG
                     HHSSHKHDREPQRRSSVKRTRYYETYIRSDSGDEQLPTICREDPEIHGYFRDPHCLGE
                     QEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCY
                     DSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQI
                     MAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVEQSEALDQVNGSL
                     PSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRY
                     ARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGDVGPLSHRQDYELQD
                     FGPGYSDEEPDPGRDEEDLADEMICITTL"
     exon            624..933
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1039
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1179
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1322
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1475
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1672
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1776
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1946
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2034
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2061
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2222
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2448
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2656
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2777
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2892
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..2962
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3029
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3177
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3307
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3367
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3474
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3562
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3670
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3723
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..3870
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4072
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4231
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4342
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4426
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4427..4471
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4600
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4666
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4667..4758
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4759..4918
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            4919..5046
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            5047..5143
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            5144..5246
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..5348
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            5349..5479
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            5480..5596
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            5597..5964
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            5965..5991
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            5992..6141
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            6142..6305
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            6306..6427
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            6428..6748
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     exon            6749..9369
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8074..8079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /note="hexamer: TATAAA"
     polyA_site      8101
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
     regulatory      9345..9350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /note="hexamer: ATTAAA"
     polyA_site      9369
                     /gene="CACNA1D"
                     /gene_synonym="CACH3; CACN4; CACNL1A2; Cav1.3; CCHL1A2;
                     PASNA; SANDD"
                     /note="major polyA site"
ORIGIN      
        1 gaagccggcg tgcggcgcgg cgcggcgggc gcggagcgag cgggcgggcg agcgcctccg
       61 tccccggatg tgagctccgg ctgcccgcgg tcccgagcca gcggcggcgc gggcggcggc
      121 ggcgggcacc gggcaccgcg gcgggcgggc agacgggcgg gcatgggggg agcgccgagc
      181 ggccccggcg gccgggccgg catcaccgcg gcgtctctcc gctagaggag gggacaagcc
      241 agttctcctt tgcagcaaaa aattacatgt atatattatt aagataatat atacattgga
      301 ttttattttt ttaaaaagtt tattttgctc catttttgaa aaagagagag cttgggtggc
      361 gagcggtttt ttttttaaat caattatcct tattttctgt tatttgtccc cgtccctccc
      421 cacccccctg ctgaagcgag aataagggca gggaccgcgg ctcctacctc ttggtgatcc
      481 ccttccccat tccgcccccg cctcaacgcc cagcacagtg ccctgcacac agtagtcgct
      541 caataaatgt tcgtggatga tgatgatgat gatgatgaaa aaaatgcagc atcaacggca
      601 gcagcaagcg gaccacgcga acgaggcaaa ctatgcaaga ggcaccagac ttcctctttc
      661 tggtgaagga ccaacttctc agccgaatag ctccaagcaa actgtcctgt cttggcaagc
      721 tgcaatcgat gctgctagac aggccaaggc tgcccaaact atgagcacct ctgcaccccc
      781 acctgtagga tctctctccc aaagaaaacg tcagcaatac gccaagagca aaaaacaggg
      841 taactcgtcc aacagccgac ctgcccgcgc ccttttctgt ttatcactca ataaccccat
      901 ccgaagagcc tgcattagta tagtggaatg gaaaccattt gacatattta tattattggc
      961 tatttttgcc aattgtgtgg ccttagctat ttacatccca ttccctgaag atgattctaa
     1021 ttcaacaaat cataacttgg aaaaagtaga atatgccttc ctgattattt ttacagtcga
     1081 gacatttttg aagattatag cgtatggatt attgctacat cctaatgctt atgttaggaa
     1141 tggatggaat ttactggatt ttgttatagt aatagtagga ttgtttagtg taattttgga
     1201 acaattaacc aaagaaacag aaggcgggaa ccactcaagc ggcaaatctg gaggctttga
     1261 tgtcaaagcc ctccgtgcct ttcgagtgtt gcgaccactt cgactagtgt caggagtgcc
     1321 cagtttacaa gttgtcctga actccattat aaaagccatg gttcccctcc ttcacatagc
     1381 ccttttggta ttatttgtaa tcataatcta tgctattata ggattggaac tttttattgg
     1441 aaaaatgcac aaaacatgtt tttttgctga ctcagatatc gtagctgaag aggacccagc
     1501 tccatgtgcg ttctcaggga atggacgcca gtgtactgcc aatggcacgg aatgtaggag
     1561 tggctgggtt ggcccgaacg gaggcatcac caactttgat aactttgcct ttgccatgct
     1621 tactgtgttt cagtgcatca ccatggaggg ctggacagat gtgctctact ggatgaatga
     1681 tgctatggga tttgaattgc cctgggtgta ttttgtcagt ctcgtcatct ttgggtcatt
     1741 tttcgtacta aatcttgtac ttggtgtatt gagcggagaa ttctcaaagg aaagagagaa
     1801 ggcaaaagca cggggagatt tccagaagct ccgggagaag cagcagctgg aggaggatct
     1861 aaagggctac ttggattgga tcacccaagc tgaggacatc gatccggaga atgaggaaga
     1921 aggaggagag gaaggcaaac gaaatactag catgcccacc agcgagactg agtctgtgaa
     1981 cacagagaac gtcagcggtg aaggcgagaa ccgaggctgc tgtggaagtc tctgtcaagc
     2041 catctcaaaa tccaaactca gccgacgctg gcgtcgctgg aaccgattca atcgcagaag
     2101 atgtagggcc gccgtgaagt ctgtcacgtt ttactggctg gttatcgtcc tggtgtttct
     2161 gaacacctta accatttcct ctgagcacta caatcagcca gattggttga cacagattca
     2221 agatattgcc aacaaagtcc tcttggctct gttcacctgc gagatgctgg taaaaatgta
     2281 cagcttgggc ctccaagcat atttcgtctc tcttttcaac cggtttgatt gcttcgtggt
     2341 gtgtggtgga atcactgaga cgatcttggt ggaactggaa atcatgtctc ccctggggat
     2401 ctctgtgttt cggtgtgtgc gcctcttaag aatcttcaaa gtgaccaggc actggacttc
     2461 cctgagcaac ttagtggcat ccttattaaa ctccatgaag tccatcgctt cgctgttgct
     2521 tctgcttttt ctcttcatta tcatcttttc cttgcttggg atgcagctgt ttggcggcaa
     2581 gtttaatttt gatgaaacgc aaaccaagcg gagcaccttt gacaatttcc ctcaagcact
     2641 tctcacagtg ttccagatcc tgacaggcga agactggaat gctgtgatgt acgatggcat
     2701 catggcttac gggggcccat cctcttcagg aatgatcgtc tgcatctact tcatcatcct
     2761 cttcatttgt ggtaactata ttctactgaa tgtcttcttg gccatcgctg tagacaattt
     2821 ggctgatgct gaaagtctga acactgctca gaaagaagaa gcggaagaaa aggagaggaa
     2881 aaagattgcc agaaaagaga gcctagaaaa taaaaagaac aacaaaccag aagtcaacca
     2941 gatagccaac agtgacaaca aggttacaat tgatgactat agagaagagg atgaagacaa
     3001 ggacccctat ccgccttgcg atgtgccagt aggggaagag gaagaggaag aggaggagga
     3061 tgaacctgag gttcctgccg gaccccgtcc tcgaaggatc tcggagttga acatgaagga
     3121 aaaaattgcc cccatccctg aagggagcgc tttcttcatt cttagcaaga ccaacccgat
     3181 ccgcgtaggc tgccacaagc tcatcaacca ccacatcttc accaacctca tccttgtctt
     3241 catcatgctg agcagcgctg ccctggccgc agaggacccc atccgcagcc actccttccg
     3301 gaacacgata ctgggttact ttgactatgc cttcacagcc atctttactg ttgagatcct
     3361 gttgaagatg acaacttttg gagctttcct ccacaaaggg gccttctgca ggaactactt
     3421 caatttgctg gatatgctgg tggttggggt gtctctggtg tcatttggga ttcaatccag
     3481 tgccatctcc gttgtgaaga ttctgagggt cttaagggtc ctgcgtcccc tcagggccat
     3541 caacagagca aaaggactta agcacgtggt ccagtgcgtc ttcgtggcca tccggaccat
     3601 cggcaacatc atgatcgtca ccaccctcct gcagttcatg tttgcctgta tcggggtcca
     3661 gttgttcaag gggaagttct atcgctgtac ggatgaagcc aaaagtaacc ctgaagaatg
     3721 caggggactt ttcatcctct acaaggatgg ggatgttgac agtcctgtgg tccgtgaacg
     3781 gatctggcaa aacagtgatt tcaacttcga caacgtcctc tctgctatga tggcgctctt
     3841 cacagtctcc acgtttgagg gctggcctgc gttgctgtat aaagccatcg actcgaatgg
     3901 agagaacatc ggcccaatct acaaccaccg cgtggagatc tccatcttct tcatcatcta
     3961 catcatcatt gtagctttct tcatgatgaa catctttgtg ggctttgtca tcgttacatt
     4021 tcaggaacaa ggagaaaaag agtataagaa ctgtgagctg gacaaaaatc agcgtcagtg
     4081 tgttgaatac gccttgaaag cacgtccctt gcggagatac atccccaaaa acccctacca
     4141 gtacaagttc tggtacgtgg tgaactcttc gcctttcgaa tacatgatgt ttgtcctcat
     4201 catgctcaac acactctgct tggccatgca gcactacgag cagtccaaga tgttcaatga
     4261 tgccatggac attctgaaca tggtcttcac cggggtgttc accgtcgaga tggttttgaa
     4321 agtcatcgca tttaagccta aggggtattt tagtgacgcc tggaacacgt ttgactccct
     4381 catcgtaatc ggcagcatta tagacgtggc cctcagcgaa gcagacccaa ctgaaagtga
     4441 aaatgtccct gtcccaactg ctacacctgg gaactctgaa gagagcaata gaatctccat
     4501 cacctttttc cgtcttttcc gagtgatgcg attggtgaag cttctcagca ggggggaagg
     4561 catccggaca ttgctgtgga cttttattaa gtcctttcag gcgctcccgt atgtggccct
     4621 cctcatagcc atgctgttct tcatctatgc ggtcattggc atgcagatgt ttgggaaagt
     4681 tgccatgaga gataacaacc agatcaatag gaacaataac ttccagacgt ttccccaggc
     4741 ggtgctgctg ctcttcaggt gtgcaacagg tgaggcctgg caggagatca tgctggcctg
     4801 tctcccaggg aagctctgtg accctgagtc agattacaac cccggggagg agtatacatg
     4861 tgggagcaac tttgccattg tctatttcat cagtttttac atgctctgtg catttctgat
     4921 catcaatctg tttgtggctg tcatcatgga taatttcgac tatctgaccc gggactggtc
     4981 tattttgggg cctcaccatt tagatgaatt caaaagaata tggtcagaat atgaccctga
     5041 ggcaaaggga aggataaaac accttgatgt ggtcactctg cttcgacgca tccagcctcc
     5101 cctggggttt gggaagttat gtccacacag ggtagcgtgc aagagattag ttgccatgaa
     5161 catgcctctc aacagtgacg ggacagtcat gtttaatgca accctgtttg ctttggttcg
     5221 aacggctctt aagatcaaga ccgaagggaa cctggagcaa gctaatgaag aacttcgggc
     5281 tgtgataaag aaaatttgga agaaaaccag catgaaatta cttgaccaag ttgtccctcc
     5341 agctggtgat gatgaggtaa ccgtggggaa gttctatgcc actttcctga tacaggacta
     5401 ctttaggaaa ttcaagaaac ggaaagaaca aggactggtg ggaaagtacc ctgcgaagaa
     5461 caccacaatt gccctacagg cgggattaag gacactgcat gacattgggc cagaaatccg
     5521 gcgtgctata tcgtgtgatt tgcaagatga cgagcctgag gaaacaaaac gagaagaaga
     5581 agatgatgtg ttcaaaagaa atggtgccct gcttggaaac catgtcaatc atgttaatag
     5641 tgataggaga gattcccttc agcagaccaa taccacccac cgtcccctgc atgtccaaag
     5701 gccttcaatt ccacctgcaa gtgatactga gaaaccgctg tttcctccag caggaaattc
     5761 ggtgtgtcat aaccatcata accataattc cataggaaag caagttccca cctcaacaaa
     5821 tgccaatctc aataatgcca atatgtccaa agctgcccat ggaaagcggc ccagcattgg
     5881 gaaccttgag catgtgtctg aaaatgggca tcattcttcc cacaagcatg accgggagcc
     5941 tcagagaagg tccagtgtga aaagaacccg ctattatgaa acttacatta ggtccgactc
     6001 aggagatgaa cagctcccaa ctatttgccg ggaagaccca gagatacatg gctatttcag
     6061 ggacccccac tgcttggggg agcaggagta tttcagtagt gaggaatgct acgaggatga
     6121 cagctcgccc acctggagca ggcaaaacta tggctactac agcagatacc caggcagaaa
     6181 catcgactct gagaggcccc gaggctacca tcatccccaa ggattcttgg aggacgatga
     6241 ctcgcccgtt tgctatgatt cacggagatc tccaaggaga cgcctactac ctcccacccc
     6301 agcatcccac cggagatcct ccttcaactt tgagtgcctg cgccggcaga gcagccagga
     6361 agaggtcccg tcgtctccca tcttccccca tcgcacggcc ctgcctctgc atctaatgca
     6421 gcaacagatc atggcagttg ccggcctaga ttcaagtaaa gcccagaagt actcaccgag
     6481 tcactcgacc cggtcgtggg ccacccctcc agcaacccct ccctaccggg actggacacc
     6541 gtgctacacc cccctgatcc aagtggagca gtcagaggcc ctggaccagg tgaacggcag
     6601 cctgccgtcc ctgcaccgca gctcctggta cacagacgag cccgacatct cctaccggac
     6661 tttcacacca gccagcctga ctgtccccag cagcttccgg aacaaaaaca gcgacaagca
     6721 gaggagtgcg gacagcttgg tggaggcagt cctgatatcc gaaggcttgg gacgctatgc
     6781 aagggaccca aaatttgtgt cagcaacaaa acacgaaatc gctgatgcct gtgacctcac
     6841 catcgacgag atggagagtg cagccagcac cctgcttaat gggaacgtgc gtccccgagc
     6901 caacggggat gtgggccccc tctcacaccg gcaggactat gagctacagg actttggtcc
     6961 tggctacagc gacgaagagc cagaccctgg gagggatgag gaggacctgg cggatgaaat
     7021 gatatgcatc accaccttgt agcccccagc gaggggcaga ctggctctgg cctcaggtgg
     7081 ggcgcaggag agccagggga aaagtgcctc atagttagga aagtttaggc actagttggg
     7141 agtaatattc aattaattag acttttgtat aagagatgtc atgcctcaag aaagccataa
     7201 acctggtagg aacaggtccc aagcggttga gcctggcaga gtaccatgcg ctcggcccca
     7261 gctgcaggaa acagcaggcc ccgccctctc acagaggatg ggtgaggagg ccagacctgc
     7321 cctgccccat tgtccagatg ggcactgctg tggagtctgc ttctcccatg taccagggca
     7381 ccaggcccac ccaactgaag gcatggcggc ggggtgcagg ggaaagttaa aggtgatgac
     7441 gatcatcaca cctgtgtcgt tacctcagcc atcggtctag catatcagtc actgggccca
     7501 acatatccat ttttaaaccc tttcccccaa atacactgcg tcctggttcc tgtttagctg
     7561 ttctgaaata cggtgtgtaa gtaagtcaga acccagctac cagtgattat tgcgagggca
     7621 atgggacctc ataaataagg ttttctgtga tgtgacgcca gtttacataa gagaatatca
     7681 ctccgatggt cggtttctga ctgtcacgct aagggcaact gtaaactgga ataataatgc
     7741 actcgcaacc aggtaaactt agatacacta gtttgtttaa aattatagat ttactgtaca
     7801 tgacttgtaa tatactataa tttgtatttg taaagagatg gtctatattt tgtaattact
     7861 gtattgtatt tgaactgcag caatatccat gggtcctaat aattgtagtt ccccactaaa
     7921 atctagaaat tattagtatt tttactcggg ctatccagaa gtagaagaaa tagagccaat
     7981 tctcatttat tcagcgaaaa tcctctgggg ttaaaatttt aagtttgaaa gaacttgaca
     8041 ctacagaaat ttttctaaaa tattttgagt cactataaac ctatcatctt tccacaagat
     8101 ataccagatg actatttgca gtcttttctt tgggcaagag ttccatgatt ttgatactgt
     8161 acctttggat ccaccatggg ttgcaactgt ctttggtttt gtttgtttga cttgaaccac
     8221 cctctggtaa gtaagtaagt gaattacaga gcaggtccag ctggctgctc tgccccttgg
     8281 gtatccatag ttacggtttt ctctgtggcc cacccagggt gttttttgca tcgctggtgc
     8341 agaaatgcat aggtggatga gatatagctg ctcttgtcct ctggggactg gtggtgctgc
     8401 ttaagaaata aggggtgctg gggacagagg agcaacgtgg tgatctatag gattggagtg
     8461 tcggggtctg tacaaatcgt attgttgcct tttacaaaac tgctgtactg tatgttctct
     8521 ttgagggctt ttatatgcaa ttgaatgagg gctgaagttt tcattagaat gcactcacac
     8581 tctgactgta cgtcctgatg aaaacccact tttggataat tagaaccgtc aaggcttcat
     8641 tttctgtcaa cagaattagg ccgactgtca ggttaccttg gcagggattc cctgcaatca
     8701 aaaagataga tgataggtag caattttggt ccaaaatttt taatagtata cagacaacct
     8761 gttaattttt tttttttttt ttttttttgt aaataacaaa caccactttg ttatgaagac
     8821 cttacaaacc tcttcttaag acattcttac tctgatccag gcaaaaacac ttcaaggttt
     8881 gtaaatgact ctttcctgac ataaatcctt ttttattaaa atgcaaaatg ttcttcagaa
     8941 taaaactgtg taataatttt tatacttggg agtgctcctt gcacagagct gtcatttgcc
     9001 agtgagagcc tccgacaggg caggtactgt gccagggcag ctctgaaatt atggatattc
     9061 ttatcctcct ggttccttcg gtgccaatgg taacctaata ccagccgcag ggagcgccat
     9121 ttctcctaaa gggctacacc actgtcaaca ttatcctgga ctctgtgtct ctctctgttg
     9181 ggtcttgtgg catcacatca ggccaaaatt gccagaccag gaccctaagt gtctgataga
     9241 ggcgatgatc ttttccaaag tcagtactta caaactggca ttcttacagg ctgcaccatt
     9301 tcctagtatg tctgctttaa gcctggttca acctctcatc gaatattaaa tttttctttg
     9361 taagaaaaa
//
