LOCUS       NM_199460              13993 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens calcium voltage-gated channel subunit alpha1 C
            (CACNA1C), transcript variant 1, mRNA.
ACCESSION   NM_199460
VERSION     NM_199460.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13993)
  AUTHORS   Zhang,X., Liang,X., Cheng,X., Chen,J., Deng,W., Zhang,Y., Cui,L.,
            Cheng,X., Li,X., Yang,C., Ye,B. and Cao,L.
  TITLE     [CACNA1C rs58619945 genotype influences the cortical thickness of
            attention network among patients with Bipolar disorder]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 41 (9), 1045-1052 (2024)
   PUBMED   39217481
  REMARK    GeneRIF: [CACNA1C rs58619945 genotype influences the cortical
            thickness of attention network among patients with Bipolar
            disorder].
REFERENCE   2  (bases 1 to 13993)
  AUTHORS   Yang,Y., Zhu,Z., Hui,L. and Sun,P.
  TITLE     Effects of CACNA1C and ANK3 on cognitive function in patients with
            bipolar disorder
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 133, 111016 (2024)
   PUBMED   38657895
  REMARK    GeneRIF: Effects of CACNA1C and ANK3 on cognitive function in
            patients with bipolar disorder.
REFERENCE   3  (bases 1 to 13993)
  AUTHORS   Almodovar-Paya,C., Guardiola-Ripoll,M., Giralt-Lopez,M.,
            Oscoz-Irurozqui,M., Canales-Rodriguez,E.J., Madre,M.,
            Soler-Vidal,J., Ramiro,N., Callado,L.F., Arias,B., Gallego,C.,
            Pomarol-Clotet,E. and Fatjo-Vilas,M.
  TITLE     NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom
            severity through neuroanatomical changes in schizophrenia
  JOURNAL   Brain Struct Funct 229 (5), 1299-1315 (2024)
   PUBMED   38720004
  REMARK    GeneRIF: NRN1 epistasis with BDNF and CACNA1C: mediation effects on
            symptom severity through neuroanatomical changes in schizophrenia.
REFERENCE   4  (bases 1 to 13993)
  AUTHORS   Gao,S., Yao,X., Chen,J., Huang,G., Fan,X., Xue,L., Li,Z., Wu,T.,
            Zheng,Y., Huang,J., Jin,X., Wang,Y., Wang,Z., Yu,Y., Liu,L.,
            Pan,X., Song,C. and Yan,N.
  TITLE     Structural basis for human Cav1.2 inhibition by multiple drugs and
            the neurotoxin calciseptine
  JOURNAL   Cell 186 (24), 5363-5374 (2023)
   PUBMED   37972591
  REMARK    GeneRIF: Structural basis for human Cav1.2 inhibition by multiple
            drugs and the neurotoxin calciseptine.
REFERENCE   5  (bases 1 to 13993)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
REFERENCE   6  (bases 1 to 13993)
  AUTHORS   Napolitano,C. and Priori,S.G.
  TITLE     CACNA1C-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301577
REFERENCE   7  (bases 1 to 13993)
  AUTHORS   Groffen,A.J., Bikker,H. and Christiaans,I.
  TITLE     Long QT Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301308
REFERENCE   8  (bases 1 to 13993)
  AUTHORS   Sun,W., McPherson,J.D., Hoang,D.Q., Wasmuth,J.J., Evans,G.A. and
            Montal,M.
  TITLE     Mapping of a human brain voltage-gated calcium channel to human
            chromosome 12p13-pter
  JOURNAL   Genomics 14 (4), 1092-1094 (1992)
   PUBMED   1335957
REFERENCE   9  (bases 1 to 13993)
  AUTHORS   Powers,P.A., Gregg,R.G. and Hogan,K.
  TITLE     Linkage mapping of the human gene for the alpha 1 subunit of the
            cardiac DHP-sensitive Ca2+ channel (CACNL1A1) to chromosome
            12p13.2-pter using a dinucleotide repeat
  JOURNAL   Genomics 14 (1), 206-207 (1992)
   PUBMED   1330882
REFERENCE   10 (bases 1 to 13993)
  AUTHORS   Soldatov,N.M.
  TITLE     Molecular diversity of L-type Ca2+ channel transcripts in human
            fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4628-4632 (1992)
   PUBMED   1316612
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005342.1, AK309111.1,
            AF465484.1, L29534.1, AY562395.1, AB209016.1, Z34816.1, L29536.1,
            Z34822.1, KF455578.2 and AC007618.21.
            
            On Aug 14, 2020 this sequence version replaced NM_199460.3.
            
            Summary: This gene encodes an alpha-1 subunit of a
            voltage-dependent calcium channel. Calcium channels mediate the
            influx of calcium ions into the cell upon membrane polarization.
            The alpha-1 subunit consists of 24 transmembrane segments and forms
            the pore through which ions pass into the cell. The calcium channel
            consists of a complex of alpha-1, alpha-2/delta, beta, and gamma
            subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of
            these proteins, either encoded by different genes or the result of
            alternative splicing of transcripts. The protein encoded by this
            gene binds to and is inhibited by dihydropyridine. Alternative
            splicing results in many transcript variants encoding different
            proteins. Some of the predicted proteins may not produce functional
            ion channel subunits. [provided by RefSeq, Oct 2012].
            
            Transcript Variant: This variant (1), also referred to as HFCC,
            encodes the longest isoform (1). This isoform (1) is predicted to
            form a non-functional calcium channel subunit because it contains
            an aberrant number of transmembrane domains.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AC005342.1         177303-177600
            299-311             AK309111.1         1-13
            312-827             AF465484.1         1-516
            828-1689            L29534.1           178-1039
            1690-1793           AY562395.1         1-104
            1794-3429           L29534.1           1144-2779
            3430-3489           AB209016.1         2542-2601
            3490-4421           L29534.1           2780-3711
            4422-4464           Z34816.1           3786-3828
            4465-4548           L29536.1           3755-3838
            4549-6180           Z34822.1           3829-5460
            6181-6269           KF455578.2         102-190
            6270-7157           Z34822.1           5550-6437
            7158-13993          AC007618.21        773-7608            c
FEATURES             Location/Qualifiers
     source          1..13993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..13993
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="calcium voltage-gated channel subunit alpha1 C"
                     /db_xref="GeneID:775"
                     /db_xref="HGNC:HGNC:1390"
                     /db_xref="MIM:114205"
     exon            1..625
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..7242
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium channel, cardic dihydropyridine-sensitive, alpha-1
                     subunit; DHPR, alpha-1 subunit; voltage-dependent L-type
                     Ca2+ channel alpha 1 subunit; calcium channel,
                     voltage-dependent, L type, alpha 1C subunit; CACNA1C
                     intronic transcript 2; CACNA1C intronic transcript 2
                     (non-protein coding)"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     alpha-1C isoform 1"
                     /protein_id="NP_955630.3"
                     /db_xref="GeneID:775"
                     /db_xref="HGNC:HGNC:1390"
                     /db_xref="MIM:114205"
                     /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
                     TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
                     ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
                     RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
                     DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
                     FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
                     GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
                     SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
                     NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
                     WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
                     FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
                     LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
                     QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
                     NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
                     SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
                     PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
                     ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM
                     TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAIN
                     RAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE
                     CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSID
                     SHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDK
                     NQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYG
                     QSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVIL
                     SETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRL
                     FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN
                     DTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETP
                     CGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY
                     DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATL
                     FALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYA
                     TFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEE
                     LDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSS
                     QGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGH
                     GPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCLLLRRANPSRCH
                     SRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEED
                     KRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVA
                     GLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIH
                     CGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQF
                     AQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDR
                     AGGEEDAGCVRARGRPSEEELQDSRVYVSSL"
     exon            626..947
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1053
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1193
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1333
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1492
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1689
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1793
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1966
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2057
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2084
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2245
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2471
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2679
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2800
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2915
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3036
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3106
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3239
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3369
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3429
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3489
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3596
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3684
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3792
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3845
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3992
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4194
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4353
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4464
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4465..4548
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4549..4632
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4665
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4666..4794
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4795..4860
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4861..4952
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4953..5118
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5119..5246
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..5343
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5344..5446
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5447..5548
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5549..5676
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5677..5811
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5812..6164
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6165..6269
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6270..6398
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6399..6505
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6506..6609
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6610..6942
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6943..13993
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8172..8177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="hexamer: AATAGA"
     polyA_site      8202
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="major polyA site"
     regulatory      8886..8891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="hexamer: AATATA"
     polyA_site      8905
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
     regulatory      8949..8954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="hexamer: AGTAAA"
     polyA_site      8985
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
     regulatory      13971..13976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="hexamer: AATAAA"
     polyA_site      13993
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="major polyA site"
ORIGIN      
        1 gtctccctct cgctgcctct gcagaaacag ctcctgccag agcggcgctc ggcgcggcgc
       61 ggcgggcccg gagcggcggc ggcggctctt cctgcctccg cgcccaggag ttgccggctc
      121 cctttgacag cagagagccg ggcaggggcc tcaggaggac tcgctgggag tgggcagagg
      181 cgcctcggcc cctgccggcc caggcgggcc ccgcgcgccc cccgcccctc ctctccgcct
      241 cttctcgccc tgcctctccc gatttatttt ttcaaatggt gtagccgccg gaggtgcggt
      301 gctcagttct tggaaggggc ccggatgtac tgaggatgcg ttacagtttc actcgaggag
      361 gcagtagtgg aaaggagcag tttttggggt ttgatgccat aatgggaatc aggtaatcgt
      421 cggcggggaa gaagaaacgc tgcagaccac ggcttcctcg aatcttgcgc gaaagccgcc
      481 ggcctcggag gagggattaa tccagacccg ccggggggtg ttttcacatt tcttcctctt
      541 cgtggctgct cctcctatta aaaccatttt tggtccatgg tcaatgagaa tacgaggatg
      601 tacattccag aggaaaacca ccaaggttcc aactatggga gcccacgccc cgcccatgcc
      661 aacatgaatg ccaatgcggc agcggggctg gcccctgagc acatccccac cccgggggct
      721 gccctgtcgt ggcaggcggc catcgacgca gcccggcagg ctaagctgat gggcagcgct
      781 ggcaatgcga ccatctccac agtcagctcc acgcagcgga agcggcagca atatgggaaa
      841 cccaagaagc agggcagcac cacggccaca cgcccgcccc gagccctgct ctgcctgacc
      901 ctgaagaacc ccatccggag ggcctgcatc agcattgtcg aatggaaacc atttgaaata
      961 attattttac tgactatttt tgccaattgt gtggccttag cgatctatat tccctttcca
     1021 gaagatgatt ccaacgccac caattccaac ctggaacgag tggaatatct ctttctcata
     1081 atttttacgg tggaagcgtt tttaaaagta atcgcctatg gactcctctt tcaccccaat
     1141 gcctacctcc gcaacggctg gaacctacta gattttataa ttgtggttgt ggggcttttt
     1201 agtgcaattt tagaacaagc aaccaaagca gatggggcaa acgctctcgg agggaaaggg
     1261 gccggatttg atgtgaaggc gctgagggcc ttccgcgtgc tgcgccccct gcggctggtg
     1321 tccggagtcc caagtctcca ggtggtcctg aattccatca tcaaggccat ggtccccctg
     1381 ctgcacatcg ccctgcttgt gctgtttgtc atcatcatct acgccatcat cggcttggag
     1441 ctcttcatgg ggaagatgca caagacctgc tacaaccagg agggcatagc agatgttcca
     1501 gcagaagatg acccttcccc ttgtgcgctg gaaacgggcc acgggcggca gtgccagaac
     1561 ggcacggtgt gcaagcccgg ctgggatggt cccaagcacg gcatcaccaa ctttgacaac
     1621 tttgccttcg ccatgctcac ggtgttccag tgcatcacca tggagggctg gacggacgtg
     1681 ctgtactggg tcaatgatgc cgtaggaagg gactggccct ggatctattt tgttacacta
     1741 atcatcatag ggtcattttt tgtacttaac ttggttctcg gtgtgcttag cggagagttt
     1801 tccaaagaga gggagaaggc caaggcccgg ggagatttcc agaagctgcg ggagaagcag
     1861 cagctagaag aggatctcaa aggctacctg gattggatca ctcaggccga agacatcgat
     1921 cctgagaatg aggacgaagg catggatgag gagaagcccc gaaacatgag catgcccacc
     1981 agtgagaccg agtccgtcaa caccgaaaac gtggctggag gtgacatcga gggagaaaac
     2041 tgcggggcca ggctggccca ccggatctcc aagtcaaagt tcagccgcta ctggcgccgg
     2101 tggaatcggt tctgcagaag gaagtgccgc gccgcagtca agtctaatgt cttctactgg
     2161 ctggtgattt tcctggtgtt cctcaacacg ctcaccattg cctctgagca ctacaaccag
     2221 cccaactggc tcacagaagt ccaagacacg gcaaacaagg ccctgctggc cctgttcacg
     2281 gcagagatgc tcctgaagat gtacagcctg ggcctgcagg cctacttcgt gtccctcttc
     2341 aaccgctttg actgcttcgt cgtgtgtggc ggcatcctgg agaccatcct ggtggagacc
     2401 aagatcatgt ccccactggg catctccgtg ctcagatgcg tccggctgct gaggattttc
     2461 aagatcacga ggtactggaa ctccttgagc aacctggtgg catccttgct gaactctgtg
     2521 cgctccatcg cctccctgct ccttctcctc ttcctcttca tcatcatctt ctccctcctg
     2581 gggatgcagc tctttggagg aaagttcaac tttgatgaga tgcagacccg gaggagcaca
     2641 ttcgataact tcccccagtc cctcctcact gtgtttcaga tcctgaccgg ggaggactgg
     2701 aattcggtga tgtatgatgg gatcatggct tatggcggcc cctcttttcc agggatgtta
     2761 gtctgtattt acttcatcat cctcttcatc tgtggaaact atatcctact gaatgtgttc
     2821 ttggccattg ctgtggacaa cctggctgat gctgagagcc tcacatctgc ccaaaaggag
     2881 gaggaagagg agaaggagag aaagaagctg gccaggactg ccagcccaga gaagaaacaa
     2941 gagttggtgg agaagccggc agtgggggaa tccaaggagg agaagattga gctgaaatcc
     3001 atcacggctg acggagagtc tccacccgcc accaagatca acatggatga cctccagccc
     3061 aatgaaaatg aggataagag cccctacccc aacccagaaa ctacaggaga agaggatgag
     3121 gaggagccag agatgcctgt cggccctcgc ccacgaccac tctctgagct tcaccttaag
     3181 gaaaaggcag tgcccatgcc agaagccagc gcgtttttca tcttcagctc taacaacagg
     3241 tttcgcctcc agtgccaccg cattgtcaat gacacgatct tcaccaacct gatcctcttc
     3301 ttcattctgc tcagcagcat ttccctggct gctgaggacc cggtccagca cacctccttc
     3361 aggaaccata ttctgtttta ttttgatatt gtttttacca ccattttcac cattgaaatt
     3421 gctctgaaga tcctaggcaa tgcagactat gtcttcacta gtatctttac attagaaatt
     3481 atccttaaga tgactgctta tggggctttc ttgcacaagg gttctttctg ccggaactac
     3541 ttcaacatcc tggacctgct ggtggtcagc gtgtccctca tctcctttgg catccagtcc
     3601 agtgcaatca atgtcgtgaa gatcttgcga gtcctgcgag tactcaggcc cctgagggcc
     3661 atcaacaggg ccaaggggct aaagcatgtg gttcagtgtg tgtttgtcgc catccggacc
     3721 atcgggaaca tcgtgattgt caccaccctg ctgcagttca tgtttgcctg catcggggtc
     3781 cagctcttca agggaaagct gtacacctgt tcagacagtt ccaagcagac agaggcggaa
     3841 tgcaagggca actacatcac gtacaaagac ggggaggttg accaccccat catccaaccc
     3901 cgcagctggg agaacagcaa gtttgacttt gacaatgttc tggcagccat gatggccctc
     3961 ttcaccgtct ccaccttcga agggtggcca gagctgctgt accgctccat cgactcccac
     4021 acggaagaca agggccccat ctacaactac cgtgtggaga tctccatctt cttcatcatc
     4081 tacatcatca tcatcgcctt cttcatgatg aacatcttcg tgggcttcgt catcgtcacc
     4141 tttcaggagc agggggagca ggagtacaag aactgtgagc tggacaagaa ccagcgacag
     4201 tgcgtggaat acgccctcaa ggcccggccc ctgcggaggt acatccccaa gaaccagcac
     4261 cagtacaaag tgtggtacgt ggtcaactcc acctacttcg agtacctgat gttcgtcctc
     4321 atcctgctca acaccatctg cctggccatg cagcactacg gccagagctg cctgttcaaa
     4381 atcgccatga acatcctcaa catgctcttc actggcctct tcaccgtgga gatgatcctg
     4441 aagctcattg ccttcaaacc caagggttac tttagtgatc cctggaatgt ttttgacttc
     4501 ctcatcgtaa ttggcagcat aattgacgtc attctcagtg agactaatca ctatttctgt
     4561 gatgcatgga atacatttga cgccttgatt gttgtgggta gcattgttga tatagcaatc
     4621 accgaggtaa acccagctga acatacccaa tgctctccct ctatgaacgc agaggaaaac
     4681 tcccgcatct ccatcacctt cttccgcctg ttccgggtca tgcgtctggt gaagctgctg
     4741 agccgtgggg agggcatccg gacgctgctg tggaccttca tcaagtcctt ccaggccctg
     4801 ccctatgtgg ccctcctgat cgtgatgctg ttcttcatct acgcggtgat cgggatgcag
     4861 gtgtttggga aaattgccct gaatgatacc acagagatca accggaacaa caactttcag
     4921 accttccccc aggccgtgct gctcctcttc aggtgtgcca ccggggaggc ctggcaggac
     4981 atcatgctgg cctgcatgcc aggcaagaag tgtgccccag agtccgagcc cagcaacagc
     5041 acggagggtg aaacaccctg tggtagcagc tttgctgtct tctacttcat cagcttctac
     5101 atgctctgtg ccttcctgat catcaacctc tttgtagctg tcatcatgga caactttgac
     5161 tacctgacaa gggactggtc catccttggt ccccaccacc tggatgagtt taaaagaatc
     5221 tgggcagagt atgaccctga agccaagggt cgtatcaaac acctggatgt ggtgaccctc
     5281 ctccggcgga ttcagccgcc actaggtttt gggaagctgt gccctcaccg cgtggcttgc
     5341 aaacgcctgg tctccatgaa catgcctctg aacagcgacg ggacagtcat gttcaatgcc
     5401 accctgtttg ccctggtcag gacggccctg aggatcaaaa cagaagggaa cctagaacaa
     5461 gccaatgagg agctgcgggc gatcatcaag aagatctgga agcggaccag catgaagctg
     5521 ctggaccagg tggtgccccc tgcaggtgat gatgaggtca ccgttggcaa gttctacgcc
     5581 acgttcctga tccaggagta cttccggaag ttcaagaagc gcaaagagca gggccttgtg
     5641 ggcaagccct cccagaggaa cgcgctgtct ctgcaggctg gcttgcgcac actgcatgac
     5701 atcgggcctg agatccgacg ggccatctct ggagatctca ccgctgagga ggagctggac
     5761 aaggccatga aggaggctgt gtccgctgct tctgaagatg acatcttcag gagggccggt
     5821 ggcctgttcg gcaaccacgt cagctactac caaagcgacg gccggagcgc cttcccccag
     5881 accttcacca ctcagcgccc gctgcacatc aacaaggcgg gcagcagcca gggcgacact
     5941 gagtcgccat cccacgagaa gctggtggac tccaccttca ccccgagcag ctactcgtcc
     6001 accggctcca acgccaacat caacaacgcc aacaacaccg ccctgggtcg cctccctcgc
     6061 cccgccggct accccagcac ggtcagcact gtggagggcc acgggccccc cttgtcccct
     6121 gccatccggg tgcaggaggt ggcgtggaag ctcagctcca acagggaaag gcacgttccg
     6181 atgtgtgagg atctggagct caggagggat tcaggctcag cagggactca ggctcactgc
     6241 cttctgctca ggagagcaaa cccctctagg tgccactccc gggagagcca ggcagccatg
     6301 gcgggtcagg aggagacgtc tcaggatgag acctatgaag tgaagatgaa ccatgacacg
     6361 gaggcctgca gtgagcccag cctgctctcc acagagatgc tctcctacca ggatgacgaa
     6421 aatcggcaac tgacgctccc agaggaggac aagagggaca tccggcaatc tccgaagagg
     6481 ggtttcctcc gctctgcctc actaggtcga agggcctcct tccacctgga atgtctgaag
     6541 cgacagaagg accgaggggg agacatctct cagaagacag tcctgccctt gcatctggtt
     6601 catcatcagg cattggcagt ggcaggcctg agccccctcc tccagagaag ccattcccct
     6661 gcctcattcc ctaggccttt tgccacccca ccagccacac ctggcagccg aggctggccc
     6721 ccacagcccg tccccaccct gcggcttgag ggggtcgagt ccagtgagaa actcaacagc
     6781 agcttcccat ccatccactg cggctcctgg gctgagacca cccccggtgg cgggggcagc
     6841 agcgccgccc ggagagtccg gcccgtctcc ctcatggtgc ccagccaggc tggggcccca
     6901 gggaggcagt tccacggcag tgccagcagc ctggtggaag cggtcttgat ttcagaagga
     6961 ctggggcagt ttgctcaaga tcccaagttc atcgaggtca ccacccagga gctggccgac
     7021 gcctgcgaca tgaccataga ggagatggag agcgcggccg acaacatcct cagcgggggc
     7081 gccccacaga gccccaatgg cgccctctta ccctttgtga actgcaggga cgcggggcag
     7141 gaccgagccg ggggcgaaga ggacgcgggc tgtgtgcgcg cgcggggtcg accgagtgag
     7201 gaggagctcc aggacagcag ggtctacgtc agcagcctgt agtgggcgct gccagatgcg
     7261 ggcttttttt tatttgtttc aatgttccta atgggttcgt ttcagaagtg cctcactgtt
     7321 ctcgtgacct ggagttaacc ggaacagcgt cttcattcat ttctgttggg accagacgcg
     7381 gagcctgggt gcgcgagccg ccctccggga ggaaggcgcc cggctgcgtc tgcagaggcg
     7441 gggagaggag gcggcgaggg tcccggggcg cgaggaaggc gcctgccctc tcccagctcg
     7501 caggccccgg gcccggccgc gcctccgcgg ggagagcacc ccggcttccc gcgcgccctc
     7561 accaaaagga ccctacagca aacgggtgtc tttcgactct gcttgtagaa accatttgca
     7621 catattctgt acgagcctcg ctgtctccct agagccaggg ccctgcggat ttggagaagg
     7681 gagcggggca ggacttccag gaggacccca acccggcccg gagagggagg aggaggcctc
     7741 caggggcgcg gagctctggg gatgggcgtc gggccggcag tggtgcggct cactccgtcc
     7801 ctgcccacct gcgacgggat cccccgaccg gcacgggcca cgccgagctc ccggccagcc
     7861 gccggcccgc aggcagcgcg agggaggagc tgcgccgccg gctccgccca accaggtggt
     7921 gctgagcttc cgctgagcgc tcttttgttt tgtggtttga cacttttctt gacagcatgt
     7981 tgcagtttct tttcggtttt ggtttttttt aaatgtttta ttttgctttc ccagcgggag
     8041 gggaggaaga agagtgttta caaagtcctg tagccccctc acctttctgt tttcactttt
     8101 gccaatgtac atcgggtttg gttttcttgt attatttaaa cggttgtggt ttcctttttc
     8161 cacggaggtt caatagaagc cgctgcagga gagttttacc aaccattgtg tatgcccaat
     8221 aatttgttat catttcctta ggtagtaacc tatttttgtt ctggtttggt tcggttatct
     8281 aatggaaagg taactggcaa tgcacttgat gtggtcttgc acatgtgggt gatagagttg
     8341 ggttcctttt tatgctgggt gtacaggtgg gtttgggaga gaggagcatg cgcgagagag
     8401 tctccgagtg tgtgcgacgc gtgtgtgtgt ggtgggttgt ctgtgtgcat atgtcctgcc
     8461 cgtgtatatg cacccacacc atgtgcccgt gcacaccagt gactacgcag tccccccttt
     8521 ctggtttagc tgtgggaaga tctgaatctg gggccgtttg aaagcaaaaa caaaccactg
     8581 tctctgcttc tgaaacggga atcagtaact ctttgcattt tctgtcccac aagatatgca
     8641 aaaacaatgc aataatattc atttaaaaat acaattgtga gttgtgttgg cattaaaact
     8701 gtattttaaa aaaagacaga aatttaaggg aaaaacacaa gaaggcattt tgcttcaata
     8761 tattccgtgt aatgttttat tgcattgata atgtttctgt tgaagaaacc gttatacttg
     8821 aattcaggtc agtttcagta tttttcaaat atttttttaa aactgaattg caattgtgcc
     8881 aagcgaatat aatgaattga attaagttgg ttttcggatt cacttcttgt atattttgct
     8941 gcatgtaaag taaatcattt tgtatttgga gtgtgacaag ctttaccttt gaactcaagt
     9001 gcttttctat atgtggttgg gggaaaggga acaagttttc tttagtttgc acaatgagca
     9061 aaggtatcac cagtgtagtc attattctgc tctccacaaa caggtttgga cattactgtt
     9121 ttgcatatct tgtgtttgct tacatttccc tcaatttttc caaaatcgtt tgctgggtat
     9181 gtttgtaccg cctcttgctg tgagagacca ggacctattt tattccagtc ttcactctgt
     9241 ccactctgct ctggtcatct gatttggtac ttctccaaga acagcccttc actgtgaggt
     9301 gcagggaggc gttctgatga gccctcagtc actgggccgt catccgcatc ccccatggaa
     9361 gaggtagctg gctttccctt cccttccacc acacggaatt ttctctttgg cttccttagg
     9421 aaagtgtaca ctaaccggga ggataaaatt aaagtcaggc tgcttggagg gaggggcatc
     9481 ctcacttccg gattcttgtt gctctaccca acaaggacag caggggctcg agaaaggaac
     9541 tggtgaaacc ctgatccatc tgaaagtcaa ctctgcgtgc tcctttctcc atcccttcct
     9601 cactctggag cagcctttcc ttcaggcttg ccctaatgtt tgggctgccg gggagggggc
     9661 caggacaagg gaagaggcat ccggagctca cagtgggggt gggaacagat ttttgtgggg
     9721 gcatctctaa tgctcactta tatctcccta gaacatcact cttttggtgc tgtgtccttc
     9781 aaatgtatgt caacagtggt ggctgaaaag ggactgcttt ggggaaaaca ggacccaacc
     9841 attcacccag aattgaccca ttaaatctct tccagtccta gtgttccctg agcccctctt
     9901 ggcacatata taagtaagct agaaattaca ataagggaca gtccattcct ctatgacagc
     9961 ttgctggact gattcatgac aaagtggaga aatgtactca atactccccg gttaacacag
    10021 tctagaaaca gagtttcttt atggatatcc acacccaagt catccaaact ttcttgattc
    10081 cttttcactg ccatcaaggt cctctagaaa ttgagtttag gtatcatcct ttgaaaagtt
    10141 cccaagattt ctaccaggag gtacacacag gcgttccctg tctagggcag gaggactatc
    10201 ctagcttgac cttctgatcc actagaataa gactggcgta tgatgcctgt catcagaaca
    10261 gactggcaca agtagtgaca tcaatgaacc acagcacaat cttccaagtg atgtctactc
    10321 tccacctaaa atggaatttt ccccatgacc ttgtaaaaca taattgtcac atcttccata
    10381 cccctcctga cagcccccaa gtgtcaggag aaaacagtca ggggctaagg gcccaaggga
    10441 cttgaagaaa caacagttta aggtctgcag tttggtcaac ttaattcttg tcctccgacc
    10501 agccctgcct ctttcatttc cagaccttgg agaatttttc ccagctttga ttcagaaggt
    10561 actagttata acccctttcc ttcttcttaa tccaataggc ctcactctca ctgggaaatc
    10621 cactcaaagg aacaaggcaa tgtctctcat tctatttccc agttccaaat tccaggtgct
    10681 tgtctggagt gaagctaccc gttactttct cccagctttt ctccacccag catgtctcct
    10741 gcccatgcag ctgaagacag tggggcaacc tcaggagaag cagacctttc catgcccaag
    10801 ttcatctcct gagcaacagt gacacctaga aaatgaggac tttggaagtc acccaaaaga
    10861 tggtggctac tttatggagt cctgaagata cacagccacc actcctaaag gcaaagaaag
    10921 aaaacacgaa tgtaggtcag ggatagagtg gaaccctggt catcggggtt tttagcctca
    10981 tcgtgggaaa ggtggtaaag gaggatgatg gcatctccat ccctagaggc caagaattga
    11041 aatatcattg tcaaggatta gaaacaattc agcaaagagg ccacaaaaag ggcctgctga
    11101 ctcccagaag acctctttaa accccagggg aggcaaatac ttgctgatgg agtctgggcc
    11161 gtttccatat tttaaagaag acctgcctct ggggcaaatg tcagcacaga gaggactggg
    11221 aggagaatgg aggcaagaaa agggcatatt ttgactccct ctgtgcctct tcccagttca
    11281 tggaaggatg tgttcagctt acccacccac agtgaccagt gtggtggagc cgctgacatc
    11341 tcaaggatct atttgggaag gtgagaagag tactcattcc atctgggggt gttgttccag
    11401 ccacatcagc ctacctggtg ggatgtgggg gtgtctgcca ccctgtcccc cctctgctga
    11461 tgtccctccc ctcaggctgt ccaggtgcca cctgacacag gctgctgtgc aaagacaggc
    11521 ggggaagccc aaacctcact cccagggagg ccctcagccg ccagagtcca ggttctccag
    11581 aggctacgat ttgaggaggt tgagggggaa gacaggaggg aaagaaaagt cctacaactg
    11641 tcaggaatgg ggcacctttc cctgtcccta agcaaagctc cctcttccca ctgccctccc
    11701 cagccccagc tccctgtcct ccccaacacc tagtgagaaa gacggtgcgt ggaagggagt
    11761 cccatgggca gatgcttaca cgacctcttt gtgaagcctc ttctgggttt aacttcattc
    11821 atcaatttat tcttatgtca aagcaatgaa acttttcttt ctggagccag ataccaatac
    11881 aacaggtgaa cgggtttctg ccacatctct acattgacgg gggatgcttg aacaaccccc
    11941 ctcactacac agacacacac cgttaaggca caagggctgg ggttgagctc tagatgaggg
    12001 actttcctgc tcctgcaagg gtgagcactg tatacacaga caaggagggt gcagtagagt
    12061 gactcccttg gatggaagta gtaccatcag aacctactat tattatgaca taaattctat
    12121 ttacatacat tgagagaata ctacaatcaa cactttttcc tgggatgact ttaagaggtt
    12181 tgagccacag cacctgaagt ggcaaagatc catggtcttt gtagggtatt agagaactct
    12241 tccagtcacc tctgaaagca ctctagatct tgcagctgag tggatgaagt gtaacaaatc
    12301 tgttgcacgc tgagaggagt cagaattagc atttttcatg aaagttcccc acgtctctac
    12361 taagaatgag gaagaaaaga ctaagactag gtaattacac agaggcttga aatgttacat
    12421 caccagagcc aagtcctctc ccttcagatc agttactggc tgctacacag ggacaccccc
    12481 accttttcag ggcatcccat gcactccact tctcaggatc taaggaattt gactttgtag
    12541 ggatcccaga aagggcactg tgccacttcc cctggtgtga atcagacata cattgtacat
    12601 tcatttctaa aattcactca tgcacctcaa accaaggtca ttatccaaaa aaaaaaaaaa
    12661 aaagctctgg gtggaagagt ttgtaagttt taagagaggg tcatttctat gtgaggaaat
    12721 gcagaaatgg acagaatgat tcttattcac tgtttgggtc tggagaattc ccattgtgga
    12781 aatcttagag atctcaagtt tattaccaag ggaataagga aaaaaaggtg agcaggcacc
    12841 aggccaagca gtggctccct tgccaaggaa cctgaggctg caggtttcag ggaccccctt
    12901 gaagaaacct ctcctggcca ttggccagga gaaaagagaa gtctctcctg tagagtcaca
    12961 agagaagcaa aagagggtgg gtcactgggt cctggacata gcccccaacc ccaagacttc
    13021 ccaatatgga gaaactacac caatgtttaa aaggggaaaa ggaaagaact tgtacatcaa
    13081 gggaagatga tttgtaaaca cacagtcctg tgcagaaaga tccccttcag gaggtgtctc
    13141 cagcatccca aagctgtgcg caccttctct tttcctgcct caggccacct atgcatccag
    13201 ctgcagccca tacccacacc tgaaatccat ctcttgaatc ccagccaggt tatataccac
    13261 cccattgcca tgtcctgtcc tggccagaat gcatgctgtt cccccaagcc tcgtgggagt
    13321 gaggccatgg gaaacagaga tgagcatgtc tggacaagtc tgtgatggta gtggatgaga
    13381 ataacccatg gcaaaacacg cacattcatt aagaaatagg gcgacagatt ccccgttggt
    13441 gaagcactga aaggtctatt actctcataa tattgctgtt ttattttaat ccaccagagc
    13501 taccatgcaa aactttcctc ctgtgaaacg ctccagataa agctcctcta atctcccctt
    13561 ccctcatgtc ctccagctca aacccacctt catcccccaa accaatctgt atcatgcctg
    13621 ttatcagaga ggcacagaaa gatgggcagt gcctccgttg tcaccattcc ccacacccct
    13681 acacaccccc acaccctccc ctccaggctc cacgacttca cagtcttact gttgtaaata
    13741 tcattgtaca gtttgtaatc ctcaaataat cccattgtca gaggcctcgc ctgatgggcc
    13801 ttctcaccct cgagaaaggc cagggaatct agaaggggca acccttcaag gagagcttca
    13861 gggtcatctc tgtgtgagac actattgtat attcctgtaa gattgcattt ttatctaagg
    13921 aatgatgtta tttaaaaaac aaacaaaaaa cacaaaaaat aagaattgca aataaatttc
    13981 ttaacaatgt cta
//
