LOCUS       NM_000719              13744 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens calcium voltage-gated channel subunit alpha1 C
            (CACNA1C), transcript variant 18, mRNA.
ACCESSION   NM_000719
VERSION     NM_000719.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13744)
  AUTHORS   Zhang,X., Liang,X., Cheng,X., Chen,J., Deng,W., Zhang,Y., Cui,L.,
            Cheng,X., Li,X., Yang,C., Ye,B. and Cao,L.
  TITLE     [CACNA1C rs58619945 genotype influences the cortical thickness of
            attention network among patients with Bipolar disorder]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 41 (9), 1045-1052 (2024)
   PUBMED   39217481
  REMARK    GeneRIF: [CACNA1C rs58619945 genotype influences the cortical
            thickness of attention network among patients with Bipolar
            disorder].
REFERENCE   2  (bases 1 to 13744)
  AUTHORS   Yang,Y., Zhu,Z., Hui,L. and Sun,P.
  TITLE     Effects of CACNA1C and ANK3 on cognitive function in patients with
            bipolar disorder
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 133, 111016 (2024)
   PUBMED   38657895
  REMARK    GeneRIF: Effects of CACNA1C and ANK3 on cognitive function in
            patients with bipolar disorder.
REFERENCE   3  (bases 1 to 13744)
  AUTHORS   Almodovar-Paya,C., Guardiola-Ripoll,M., Giralt-Lopez,M.,
            Oscoz-Irurozqui,M., Canales-Rodriguez,E.J., Madre,M.,
            Soler-Vidal,J., Ramiro,N., Callado,L.F., Arias,B., Gallego,C.,
            Pomarol-Clotet,E. and Fatjo-Vilas,M.
  TITLE     NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom
            severity through neuroanatomical changes in schizophrenia
  JOURNAL   Brain Struct Funct 229 (5), 1299-1315 (2024)
   PUBMED   38720004
  REMARK    GeneRIF: NRN1 epistasis with BDNF and CACNA1C: mediation effects on
            symptom severity through neuroanatomical changes in schizophrenia.
REFERENCE   4  (bases 1 to 13744)
  AUTHORS   Gao,S., Yao,X., Chen,J., Huang,G., Fan,X., Xue,L., Li,Z., Wu,T.,
            Zheng,Y., Huang,J., Jin,X., Wang,Y., Wang,Z., Yu,Y., Liu,L.,
            Pan,X., Song,C. and Yan,N.
  TITLE     Structural basis for human Cav1.2 inhibition by multiple drugs and
            the neurotoxin calciseptine
  JOURNAL   Cell 186 (24), 5363-5374 (2023)
   PUBMED   37972591
  REMARK    GeneRIF: Structural basis for human Cav1.2 inhibition by multiple
            drugs and the neurotoxin calciseptine.
REFERENCE   5  (bases 1 to 13744)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
REFERENCE   6  (bases 1 to 13744)
  AUTHORS   Napolitano,C. and Priori,S.G.
  TITLE     CACNA1C-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301577
REFERENCE   7  (bases 1 to 13744)
  AUTHORS   Groffen,A.J., Bikker,H. and Christiaans,I.
  TITLE     Long QT Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301308
REFERENCE   8  (bases 1 to 13744)
  AUTHORS   Sun,W., McPherson,J.D., Hoang,D.Q., Wasmuth,J.J., Evans,G.A. and
            Montal,M.
  TITLE     Mapping of a human brain voltage-gated calcium channel to human
            chromosome 12p13-pter
  JOURNAL   Genomics 14 (4), 1092-1094 (1992)
   PUBMED   1335957
REFERENCE   9  (bases 1 to 13744)
  AUTHORS   Powers,P.A., Gregg,R.G. and Hogan,K.
  TITLE     Linkage mapping of the human gene for the alpha 1 subunit of the
            cardiac DHP-sensitive Ca2+ channel (CACNL1A1) to chromosome
            12p13.2-pter using a dinucleotide repeat
  JOURNAL   Genomics 14 (1), 206-207 (1992)
   PUBMED   1330882
REFERENCE   10 (bases 1 to 13744)
  AUTHORS   Soldatov,N.M.
  TITLE     Molecular diversity of L-type Ca2+ channel transcripts in human
            fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4628-4632 (1992)
   PUBMED   1316612
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005342.1, Z34810.1 and
            AC007618.21.
            
            On May 2, 2019 this sequence version replaced NM_000719.6.
            
            Summary: This gene encodes an alpha-1 subunit of a
            voltage-dependent calcium channel. Calcium channels mediate the
            influx of calcium ions into the cell upon membrane polarization.
            The alpha-1 subunit consists of 24 transmembrane segments and forms
            the pore through which ions pass into the cell. The calcium channel
            consists of a complex of alpha-1, alpha-2/delta, beta, and gamma
            subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of
            these proteins, either encoded by different genes or the result of
            alternative splicing of transcripts. The protein encoded by this
            gene binds to and is inhibited by dihydropyridine. Alternative
            splicing results in many transcript variants encoding different
            proteins. Some of the predicted proteins may not produce functional
            ion channel subunits. [provided by RefSeq, Oct 2012].
            
            Transcript Variant: This variant (18), also referred to as HLCC70,
            lacks three alternate in-frame exons, compared to variant 1,
            resulting in a shorter protein (isoform 18), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF465484.1, Z34810.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399655.6/ ENSP00000382563.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               AC005342.1         177303-177878
            577-6908            Z34810.1           1-6332
            6909-13744          AC007618.21        773-7608            c
FEATURES             Location/Qualifiers
     source          1..13744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..13744
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="calcium voltage-gated channel subunit alpha1 C"
                     /db_xref="GeneID:775"
                     /db_xref="HGNC:HGNC:1390"
                     /db_xref="MIM:114205"
     exon            1..625
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..6993
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="isoform 18 is encoded by transcript variant 18;
                     calcium channel, cardic dihydropyridine-sensitive, alpha-1
                     subunit; DHPR, alpha-1 subunit; voltage-dependent L-type
                     Ca2+ channel alpha 1 subunit; calcium channel,
                     voltage-dependent, L type, alpha 1C subunit; CACNA1C
                     intronic transcript 2; CACNA1C intronic transcript 2
                     (non-protein coding)"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     alpha-1C isoform 18"
                     /protein_id="NP_000710.5"
                     /db_xref="CCDS:CCDS44794.1"
                     /db_xref="GeneID:775"
                     /db_xref="HGNC:HGNC:1390"
                     /db_xref="MIM:114205"
                     /translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
                     TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
                     ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
                     RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
                     DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
                     FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
                     GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
                     SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
                     NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
                     WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
                     FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
                     LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
                     QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
                     NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
                     SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
                     PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
                     ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL
                     DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
                     NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
                     RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
                     IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
                     KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
                     TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN
                     SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG
                     MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE
                     PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL
                     DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS
                     DGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD
                     DEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRA
                     ISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQR
                     PLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGY
                     PSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMN
                     HDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFH
                     LECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPAT
                     PGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSL
                     MVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEM
                     ESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSR
                     VYVSSL"
     exon            626..947
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1053
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1193
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1333
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1492
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1689
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1793
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1966
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2057
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2084
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2245
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2471
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2679
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2800
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2915
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3036
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3106
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3239
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3369
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3429
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3536
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3624
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3732
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3733..3785
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3932
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4134
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4293
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4294..4404
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4488
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4521
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4522..4650
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4651..4716
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4717..4808
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4809..4974
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            4975..5102
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5103..5199
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5200..5302
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5303..5404
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5405..5532
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5533..5667
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            5668..6020
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6021..6149
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6150..6256
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6257..6360
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6361..6693
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     exon            6694..13744
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7923..7928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="hexamer: AATAGA"
     polyA_site      7953
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="major polyA site"
     regulatory      8637..8642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="hexamer: AATATA"
     polyA_site      8656
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
     regulatory      8700..8705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="hexamer: AGTAAA"
     polyA_site      8736
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
     regulatory      13722..13727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="hexamer: AATAAA"
     polyA_site      13744
                     /gene="CACNA1C"
                     /gene_synonym="CACH2; CACN2; CACNA1C-IT2; CACNL1A1;
                     CaV1.2; CCHL1A1; LQT8; NEDHLSS; TS; TS. LQT8"
                     /note="major polyA site"
ORIGIN      
        1 gtctccctct cgctgcctct gcagaaacag ctcctgccag agcggcgctc ggcgcggcgc
       61 ggcgggcccg gagcggcggc ggcggctctt cctgcctccg cgcccaggag ttgccggctc
      121 cctttgacag cagagagccg ggcaggggcc tcaggaggac tcgctgggag tgggcagagg
      181 cgcctcggcc cctgccggcc caggcgggcc ccgcgcgccc cccgcccctc ctctccgcct
      241 cttctcgccc tgcctctccc gatttatttt ttcaaatggt gtagccgccg gaggtgcggt
      301 gctcagttct tggaaggggc ccggatgtac tgaggatgcg ttacagtttc actcgaggag
      361 gcagtagtgg aaaggagcag tttttggggt ttgatgccat aatgggaatc aggtaatcgt
      421 cggcggggaa gaagaaacgc tgcagaccac ggcttcctcg aatcttgcgc gaaagccgcc
      481 ggcctcggag gagggattaa tccagacccg ccggggggtg ttttcacatt tcttcctctt
      541 cgtggctgct cctcctatta aaaccatttt tggtccatgg tcaatgagaa tacgaggatg
      601 tacattccag aggaaaacca ccaaggttcc aactatggga gcccacgccc cgcccatgcc
      661 aacatgaatg ccaatgcggc agcggggctg gcccctgagc acatccccac cccgggggct
      721 gccctgtcgt ggcaggcggc catcgacgca gcccggcagg ctaagctgat gggcagcgct
      781 ggcaatgcga ccatctccac agtcagctcc acgcagcgga agcggcagca atatgggaaa
      841 cccaagaagc agggcagcac cacggccaca cgcccgcccc gagccctgct ctgcctgacc
      901 ctgaagaacc ccatccggag ggcctgcatc agcattgtcg aatggaaacc atttgaaata
      961 attattttac tgactatttt tgccaattgt gtggccttag cgatctatat tccctttcca
     1021 gaagatgatt ccaacgccac caattccaac ctggaacgag tggaatatct ctttctcata
     1081 atttttacgg tggaagcgtt tttaaaagta atcgcctatg gactcctctt tcaccccaat
     1141 gcctacctcc gcaacggctg gaacctacta gattttataa ttgtggttgt ggggcttttt
     1201 agtgcaattt tagaacaagc aaccaaagca gatggggcaa acgctctcgg agggaaaggg
     1261 gccggatttg atgtgaaggc gctgagggcc ttccgcgtgc tgcgccccct gcggctggtg
     1321 tccggagtcc caagtctcca ggtggtcctg aattccatca tcaaggccat ggtccccctg
     1381 ctgcacatcg ccctgcttgt gctgtttgtc atcatcatct acgccatcat cggcttggag
     1441 ctcttcatgg ggaagatgca caagacctgc tacaaccagg agggcatagc agatgttcca
     1501 gcagaagatg acccttcccc ttgtgcgctg gaaacgggcc acgggcggca gtgccagaac
     1561 ggcacggtgt gcaagcccgg ctgggatggt cccaagcacg gcatcaccaa ctttgacaac
     1621 tttgccttcg ccatgctcac ggtgttccag tgcatcacca tggagggctg gacggacgtg
     1681 ctgtactggg tcaatgatgc cgtaggaagg gactggccct ggatctattt tgttacacta
     1741 atcatcatag ggtcattttt tgtacttaac ttggttctcg gtgtgcttag cggagagttt
     1801 tccaaagaga gggagaaggc caaggcccgg ggagatttcc agaagctgcg ggagaagcag
     1861 cagctagaag aggatctcaa aggctacctg gattggatca ctcaggccga agacatcgat
     1921 cctgagaatg aggacgaagg catggatgag gagaagcccc gaaacatgag catgcccacc
     1981 agtgagaccg agtccgtcaa caccgaaaac gtggctggag gtgacatcga gggagaaaac
     2041 tgcggggcca ggctggccca ccggatctcc aagtcaaagt tcagccgcta ctggcgccgg
     2101 tggaatcggt tctgcagaag gaagtgccgc gccgcagtca agtctaatgt cttctactgg
     2161 ctggtgattt tcctggtgtt cctcaacacg ctcaccattg cctctgagca ctacaaccag
     2221 cccaactggc tcacagaagt ccaagacacg gcaaacaagg ccctgctggc cctgttcacg
     2281 gcagagatgc tcctgaagat gtacagcctg ggcctgcagg cctacttcgt gtccctcttc
     2341 aaccgctttg actgcttcgt cgtgtgtggc ggcatcctgg agaccatcct ggtggagacc
     2401 aagatcatgt ccccactggg catctccgtg ctcagatgcg tccggctgct gaggattttc
     2461 aagatcacga ggtactggaa ctccttgagc aacctggtgg catccttgct gaactctgtg
     2521 cgctccatcg cctccctgct ccttctcctc ttcctcttca tcatcatctt ctccctcctg
     2581 gggatgcagc tctttggagg aaagttcaac tttgatgaga tgcagacccg gaggagcaca
     2641 ttcgataact tcccccagtc cctcctcact gtgtttcaga tcctgaccgg ggaggactgg
     2701 aattcggtga tgtatgatgg gatcatggct tatggcggcc cctcttttcc agggatgtta
     2761 gtctgtattt acttcatcat cctcttcatc tgtggaaact atatcctact gaatgtgttc
     2821 ttggccattg ctgtggacaa cctggctgat gctgagagcc tcacatctgc ccaaaaggag
     2881 gaggaagagg agaaggagag aaagaagctg gccaggactg ccagcccaga gaagaaacaa
     2941 gagttggtgg agaagccggc agtgggggaa tccaaggagg agaagattga gctgaaatcc
     3001 atcacggctg acggagagtc tccacccgcc accaagatca acatggatga cctccagccc
     3061 aatgaaaatg aggataagag cccctacccc aacccagaaa ctacaggaga agaggatgag
     3121 gaggagccag agatgcctgt cggccctcgc ccacgaccac tctctgagct tcaccttaag
     3181 gaaaaggcag tgcccatgcc agaagccagc gcgtttttca tcttcagctc taacaacagg
     3241 tttcgcctcc agtgccaccg cattgtcaat gacacgatct tcaccaacct gatcctcttc
     3301 ttcattctgc tcagcagcat ttccctggct gctgaggacc cggtccagca cacctccttc
     3361 aggaaccata ttctgtttta ttttgatatt gtttttacca ccattttcac cattgaaatt
     3421 gctctgaaga tgactgctta tggggctttc ttgcacaagg gttctttctg ccggaactac
     3481 ttcaacatcc tggacctgct ggtggtcagc gtgtccctca tctcctttgg catccagtcc
     3541 agtgcaatca atgtcgtgaa gatcttgcga gtcctgcgag tactcaggcc cctgagggcc
     3601 atcaacaggg ccaaggggct aaagcatgtg gttcagtgtg tgtttgtcgc catccggacc
     3661 atcgggaaca tcgtgattgt caccaccctg ctgcagttca tgtttgcctg catcggggtc
     3721 cagctcttca agggaaagct gtacacctgt tcagacagtt ccaagcagac agaggcggaa
     3781 tgcaagggca actacatcac gtacaaagac ggggaggttg accaccccat catccaaccc
     3841 cgcagctggg agaacagcaa gtttgacttt gacaatgttc tggcagccat gatggccctc
     3901 ttcaccgtct ccaccttcga agggtggcca gagctgctgt accgctccat cgactcccac
     3961 acggaagaca agggccccat ctacaactac cgtgtggaga tctccatctt cttcatcatc
     4021 tacatcatca tcatcgcctt cttcatgatg aacatcttcg tgggcttcgt catcgtcacc
     4081 tttcaggagc agggggagca ggagtacaag aactgtgagc tggacaagaa ccagcgacag
     4141 tgcgtggaat acgccctcaa ggcccggccc ctgcggaggt acatccccaa gaaccagcac
     4201 cagtacaaag tgtggtacgt ggtcaactcc acctacttcg agtacctgat gttcgtcctc
     4261 atcctgctca acaccatctg cctggccatg cagcactacg gccagagctg cctgttcaaa
     4321 atcgccatga acatcctcaa catgctcttc actggcctct tcaccgtgga gatgatcctg
     4381 aagctcattg ccttcaaacc caagcactat ttctgtgatg catggaatac atttgacgcc
     4441 ttgattgttg tgggtagcat tgttgatata gcaatcaccg aggtaaaccc agctgaacat
     4501 acccaatgct ctccctctat gaacgcagag gaaaactccc gcatctccat caccttcttc
     4561 cgcctgttcc gggtcatgcg tctggtgaag ctgctgagcc gtggggaggg catccggacg
     4621 ctgctgtgga ccttcatcaa gtccttccag gccctgccct atgtggccct cctgatcgtg
     4681 atgctgttct tcatctacgc ggtgatcggg atgcaggtgt ttgggaaaat tgccctgaat
     4741 gataccacag agatcaaccg gaacaacaac tttcagacct tcccccaggc cgtgctgctc
     4801 ctcttcaggt gtgccaccgg ggaggcctgg caggacatca tgctggcctg catgccaggc
     4861 aagaagtgtg ccccagagtc cgagcccagc aacagcacgg agggtgaaac accctgtggt
     4921 agcagctttg ctgtcttcta cttcatcagc ttctacatgc tctgtgcctt cctgatcatc
     4981 aacctctttg tagctgtcat catggacaac tttgactacc tgacaaggga ctggtccatc
     5041 cttggtcccc accacctgga tgagtttaaa agaatctggg cagagtatga ccctgaagcc
     5101 aagggtcgta tcaaacacct ggatgtggtg accctcctcc ggcggattca gccgccacta
     5161 ggttttggga agctgtgccc tcaccgcgtg gcttgcaaac gcctggtctc catgaacatg
     5221 cctctgaaca gcgacgggac agtcatgttc aatgccaccc tgtttgccct ggtcaggacg
     5281 gccctgagga tcaaaacaga agggaaccta gaacaagcca atgaggagct gcgggcgatc
     5341 atcaagaaga tctggaagcg gaccagcatg aagctgctgg accaggtggt gccccctgca
     5401 ggtgatgatg aggtcaccgt tggcaagttc tacgccacgt tcctgatcca ggagtacttc
     5461 cggaagttca agaagcgcaa agagcagggc cttgtgggca agccctccca gaggaacgcg
     5521 ctgtctctgc aggctggctt gcgcacactg catgacatcg ggcctgagat ccgacgggcc
     5581 atctctggag atctcaccgc tgaggaggag ctggacaagg ccatgaagga ggctgtgtcc
     5641 gctgcttctg aagatgacat cttcaggagg gccggtggcc tgttcggcaa ccacgtcagc
     5701 tactaccaaa gcgacggccg gagcgccttc ccccagacct tcaccactca gcgcccgctg
     5761 cacatcaaca aggcgggcag cagccagggc gacactgagt cgccatccca cgagaagctg
     5821 gtggactcca ccttcacccc gagcagctac tcgtccaccg gctccaacgc caacatcaac
     5881 aacgccaaca acaccgccct gggtcgcctc cctcgccccg ccggctaccc cagcacggtc
     5941 agcactgtgg agggccacgg gccccccttg tcccctgcca tccgggtgca ggaggtggcg
     6001 tggaagctca gctccaacag gtgccactcc cgggagagcc aggcagccat ggcgggtcag
     6061 gaggagacgt ctcaggatga gacctatgaa gtgaagatga accatgacac ggaggcctgc
     6121 agtgagccca gcctgctctc cacagagatg ctctcctacc aggatgacga aaatcggcaa
     6181 ctgacgctcc cagaggagga caagagggac atccggcaat ctccgaagag gggtttcctc
     6241 cgctctgcct cactaggtcg aagggcctcc ttccacctgg aatgtctgaa gcgacagaag
     6301 gaccgagggg gagacatctc tcagaagaca gtcctgccct tgcatctggt tcatcatcag
     6361 gcattggcag tggcaggcct gagccccctc ctccagagaa gccattcccc tgcctcattc
     6421 cctaggcctt ttgccacccc accagccaca cctggcagcc gaggctggcc cccacagccc
     6481 gtccccaccc tgcggcttga gggggtcgag tccagtgaga aactcaacag cagcttccca
     6541 tccatccact gcggctcctg ggctgagacc acccccggtg gcgggggcag cagcgccgcc
     6601 cggagagtcc ggcccgtctc cctcatggtg cccagccagg ctggggcccc agggaggcag
     6661 ttccacggca gtgccagcag cctggtggaa gcggtcttga tttcagaagg actggggcag
     6721 tttgctcaag atcccaagtt catcgaggtc accacccagg agctggccga cgcctgcgac
     6781 atgaccatag aggagatgga gagcgcggcc gacaacatcc tcagcggggg cgccccacag
     6841 agccccaatg gcgccctctt accctttgtg aactgcaggg acgcggggca ggaccgagcc
     6901 gggggcgaag aggacgcggg ctgtgtgcgc gcgcggggtc gaccgagtga ggaggagctc
     6961 caggacagca gggtctacgt cagcagcctg tagtgggcgc tgccagatgc gggctttttt
     7021 ttatttgttt caatgttcct aatgggttcg tttcagaagt gcctcactgt tctcgtgacc
     7081 tggagttaac cggaacagcg tcttcattca tttctgttgg gaccagacgc ggagcctggg
     7141 tgcgcgagcc gccctccggg aggaaggcgc ccggctgcgt ctgcagaggc ggggagagga
     7201 ggcggcgagg gtcccggggc gcgaggaagg cgcctgccct ctcccagctc gcaggccccg
     7261 ggcccggccg cgcctccgcg gggagagcac cccggcttcc cgcgcgccct caccaaaagg
     7321 accctacagc aaacgggtgt ctttcgactc tgcttgtaga aaccatttgc acatattctg
     7381 tacgagcctc gctgtctccc tagagccagg gccctgcgga tttggagaag ggagcggggc
     7441 aggacttcca ggaggacccc aacccggccc ggagagggag gaggaggcct ccaggggcgc
     7501 ggagctctgg ggatgggcgt cgggccggca gtggtgcggc tcactccgtc cctgcccacc
     7561 tgcgacggga tcccccgacc ggcacgggcc acgccgagct cccggccagc cgccggcccg
     7621 caggcagcgc gagggaggag ctgcgccgcc ggctccgccc aaccaggtgg tgctgagctt
     7681 ccgctgagcg ctcttttgtt ttgtggtttg acacttttct tgacagcatg ttgcagtttc
     7741 ttttcggttt tggttttttt taaatgtttt attttgcttt cccagcggga ggggaggaag
     7801 aagagtgttt acaaagtcct gtagccccct cacctttctg ttttcacttt tgccaatgta
     7861 catcgggttt ggttttcttg tattatttaa acggttgtgg tttccttttt ccacggaggt
     7921 tcaatagaag ccgctgcagg agagttttac caaccattgt gtatgcccaa taatttgtta
     7981 tcatttcctt aggtagtaac ctatttttgt tctggtttgg ttcggttatc taatggaaag
     8041 gtaactggca atgcacttga tgtggtcttg cacatgtggg tgatagagtt gggttccttt
     8101 ttatgctggg tgtacaggtg ggtttgggag agaggagcat gcgcgagaga gtctccgagt
     8161 gtgtgcgacg cgtgtgtgtg tggtgggttg tctgtgtgca tatgtcctgc ccgtgtatat
     8221 gcacccacac catgtgcccg tgcacaccag tgactacgca gtcccccctt tctggtttag
     8281 ctgtgggaag atctgaatct ggggccgttt gaaagcaaaa acaaaccact gtctctgctt
     8341 ctgaaacggg aatcagtaac tctttgcatt ttctgtccca caagatatgc aaaaacaatg
     8401 caataatatt catttaaaaa tacaattgtg agttgtgttg gcattaaaac tgtattttaa
     8461 aaaaagacag aaatttaagg gaaaaacaca agaaggcatt ttgcttcaat atattccgtg
     8521 taatgtttta ttgcattgat aatgtttctg ttgaagaaac cgttatactt gaattcaggt
     8581 cagtttcagt atttttcaaa tattttttta aaactgaatt gcaattgtgc caagcgaata
     8641 taatgaattg aattaagttg gttttcggat tcacttcttg tatattttgc tgcatgtaaa
     8701 gtaaatcatt ttgtatttgg agtgtgacaa gctttacctt tgaactcaag tgcttttcta
     8761 tatgtggttg ggggaaaggg aacaagtttt ctttagtttg cacaatgagc aaaggtatca
     8821 ccagtgtagt cattattctg ctctccacaa acaggtttgg acattactgt tttgcatatc
     8881 ttgtgtttgc ttacatttcc ctcaattttt ccaaaatcgt ttgctgggta tgtttgtacc
     8941 gcctcttgct gtgagagacc aggacctatt ttattccagt cttcactctg tccactctgc
     9001 tctggtcatc tgatttggta cttctccaag aacagccctt cactgtgagg tgcagggagg
     9061 cgttctgatg agccctcagt cactgggccg tcatccgcat cccccatgga agaggtagct
     9121 ggctttccct tcccttccac cacacggaat tttctctttg gcttccttag gaaagtgtac
     9181 actaaccggg aggataaaat taaagtcagg ctgcttggag ggaggggcat cctcacttcc
     9241 ggattcttgt tgctctaccc aacaaggaca gcaggggctc gagaaaggaa ctggtgaaac
     9301 cctgatccat ctgaaagtca actctgcgtg ctcctttctc catcccttcc tcactctgga
     9361 gcagcctttc cttcaggctt gccctaatgt ttgggctgcc ggggaggggg ccaggacaag
     9421 ggaagaggca tccggagctc acagtggggg tgggaacaga tttttgtggg ggcatctcta
     9481 atgctcactt atatctccct agaacatcac tcttttggtg ctgtgtcctt caaatgtatg
     9541 tcaacagtgg tggctgaaaa gggactgctt tggggaaaac aggacccaac cattcaccca
     9601 gaattgaccc attaaatctc ttccagtcct agtgttccct gagcccctct tggcacatat
     9661 ataagtaagc tagaaattac aataagggac agtccattcc tctatgacag cttgctggac
     9721 tgattcatga caaagtggag aaatgtactc aatactcccc ggttaacaca gtctagaaac
     9781 agagtttctt tatggatatc cacacccaag tcatccaaac tttcttgatt ccttttcact
     9841 gccatcaagg tcctctagaa attgagttta ggtatcatcc tttgaaaagt tcccaagatt
     9901 tctaccagga ggtacacaca ggcgttccct gtctagggca ggaggactat cctagcttga
     9961 ccttctgatc cactagaata agactggcgt atgatgcctg tcatcagaac agactggcac
    10021 aagtagtgac atcaatgaac cacagcacaa tcttccaagt gatgtctact ctccacctaa
    10081 aatggaattt tccccatgac cttgtaaaac ataattgtca catcttccat acccctcctg
    10141 acagccccca agtgtcagga gaaaacagtc aggggctaag ggcccaaggg acttgaagaa
    10201 acaacagttt aaggtctgca gtttggtcaa cttaattctt gtcctccgac cagccctgcc
    10261 tctttcattt ccagaccttg gagaattttt cccagctttg attcagaagg tactagttat
    10321 aacccctttc cttcttctta atccaatagg cctcactctc actgggaaat ccactcaaag
    10381 gaacaaggca atgtctctca ttctatttcc cagttccaaa ttccaggtgc ttgtctggag
    10441 tgaagctacc cgttactttc tcccagcttt tctccaccca gcatgtctcc tgcccatgca
    10501 gctgaagaca gtggggcaac ctcaggagaa gcagaccttt ccatgcccaa gttcatctcc
    10561 tgagcaacag tgacacctag aaaatgagga ctttggaagt cacccaaaag atggtggcta
    10621 ctttatggag tcctgaagat acacagccac cactcctaaa ggcaaagaaa gaaaacacga
    10681 atgtaggtca gggatagagt ggaaccctgg tcatcggggt ttttagcctc atcgtgggaa
    10741 aggtggtaaa ggaggatgat ggcatctcca tccctagagg ccaagaattg aaatatcatt
    10801 gtcaaggatt agaaacaatt cagcaaagag gccacaaaaa gggcctgctg actcccagaa
    10861 gacctcttta aaccccaggg gaggcaaata cttgctgatg gagtctgggc cgtttccata
    10921 ttttaaagaa gacctgcctc tggggcaaat gtcagcacag agaggactgg gaggagaatg
    10981 gaggcaagaa aagggcatat tttgactccc tctgtgcctc ttcccagttc atggaaggat
    11041 gtgttcagct tacccaccca cagtgaccag tgtggtggag ccgctgacat ctcaaggatc
    11101 tatttgggaa ggtgagaaga gtactcattc catctggggg tgttgttcca gccacatcag
    11161 cctacctggt gggatgtggg ggtgtctgcc accctgtccc ccctctgctg atgtccctcc
    11221 cctcaggctg tccaggtgcc acctgacaca ggctgctgtg caaagacagg cggggaagcc
    11281 caaacctcac tcccagggag gccctcagcc gccagagtcc aggttctcca gaggctacga
    11341 tttgaggagg ttgaggggga agacaggagg gaaagaaaag tcctacaact gtcaggaatg
    11401 gggcaccttt ccctgtccct aagcaaagct ccctcttccc actgccctcc ccagccccag
    11461 ctccctgtcc tccccaacac ctagtgagaa agacggtgcg tggaagggag tcccatgggc
    11521 agatgcttac acgacctctt tgtgaagcct cttctgggtt taacttcatt catcaattta
    11581 ttcttatgtc aaagcaatga aacttttctt tctggagcca gataccaata caacaggtga
    11641 acgggtttct gccacatctc tacattgacg ggggatgctt gaacaacccc cctcactaca
    11701 cagacacaca ccgttaaggc acaagggctg gggttgagct ctagatgagg gactttcctg
    11761 ctcctgcaag ggtgagcact gtatacacag acaaggaggg tgcagtagag tgactccctt
    11821 ggatggaagt agtaccatca gaacctacta ttattatgac ataaattcta tttacataca
    11881 ttgagagaat actacaatca acactttttc ctgggatgac tttaagaggt ttgagccaca
    11941 gcacctgaag tggcaaagat ccatggtctt tgtagggtat tagagaactc ttccagtcac
    12001 ctctgaaagc actctagatc ttgcagctga gtggatgaag tgtaacaaat ctgttgcacg
    12061 ctgagaggag tcagaattag catttttcat gaaagttccc cacgtctcta ctaagaatga
    12121 ggaagaaaag actaagacta ggtaattaca cagaggcttg aaatgttaca tcaccagagc
    12181 caagtcctct cccttcagat cagttactgg ctgctacaca gggacacccc caccttttca
    12241 gggcatccca tgcactccac ttctcaggat ctaaggaatt tgactttgta gggatcccag
    12301 aaagggcact gtgccacttc ccctggtgtg aatcagacat acattgtaca ttcatttcta
    12361 aaattcactc atgcacctca aaccaaggtc attatccaaa aaaaaaaaaa aaaagctctg
    12421 ggtggaagag tttgtaagtt ttaagagagg gtcatttcta tgtgaggaaa tgcagaaatg
    12481 gacagaatga ttcttattca ctgtttgggt ctggagaatt cccattgtgg aaatcttaga
    12541 gatctcaagt ttattaccaa gggaataagg aaaaaaaggt gagcaggcac caggccaagc
    12601 agtggctccc ttgccaagga acctgaggct gcaggtttca gggaccccct tgaagaaacc
    12661 tctcctggcc attggccagg agaaaagaga agtctctcct gtagagtcac aagagaagca
    12721 aaagagggtg ggtcactggg tcctggacat agcccccaac cccaagactt cccaatatgg
    12781 agaaactaca ccaatgttta aaaggggaaa aggaaagaac ttgtacatca agggaagatg
    12841 atttgtaaac acacagtcct gtgcagaaag atccccttca ggaggtgtct ccagcatccc
    12901 aaagctgtgc gcaccttctc ttttcctgcc tcaggccacc tatgcatcca gctgcagccc
    12961 atacccacac ctgaaatcca tctcttgaat cccagccagg ttatatacca ccccattgcc
    13021 atgtcctgtc ctggccagaa tgcatgctgt tcccccaagc ctcgtgggag tgaggccatg
    13081 ggaaacagag atgagcatgt ctggacaagt ctgtgatggt agtggatgag aataacccat
    13141 ggcaaaacac gcacattcat taagaaatag ggcgacagat tccccgttgg tgaagcactg
    13201 aaaggtctat tactctcata atattgctgt tttattttaa tccaccagag ctaccatgca
    13261 aaactttcct cctgtgaaac gctccagata aagctcctct aatctcccct tccctcatgt
    13321 cctccagctc aaacccacct tcatccccca aaccaatctg tatcatgcct gttatcagag
    13381 aggcacagaa agatgggcag tgcctccgtt gtcaccattc cccacacccc tacacacccc
    13441 cacaccctcc cctccaggct ccacgacttc acagtcttac tgttgtaaat atcattgtac
    13501 agtttgtaat cctcaaataa tcccattgtc agaggcctcg cctgatgggc cttctcaccc
    13561 tcgagaaagg ccagggaatc tagaaggggc aacccttcaa ggagagcttc agggtcatct
    13621 ctgtgtgaga cactattgta tattcctgta agattgcatt tttatctaag gaatgatgtt
    13681 atttaaaaaa caaacaaaaa acacaaaaaa taagaattgc aaataaattt cttaacaatg
    13741 tcta
//
