LOCUS       NM_000718               9792 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens calcium voltage-gated channel subunit alpha1 B
            (CACNA1B), transcript variant 1, mRNA.
ACCESSION   NM_000718
VERSION     NM_000718.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9792)
  AUTHORS   Kutzsche,J., Guzman,G.A., Willuweit,A., Kletke,O., Wollert,E.,
            Gering,I., Jurgens,D., Breitkreutz,J., Stark,H.,
            Beck-Sickinger,A.G., Klocker,N., Hidalgo,P. and Willbold,D.
  TITLE     An orally available Cav2.2 calcium channel inhibitor for the
            treatment of neuropathic pain
  JOURNAL   Br J Pharmacol 181 (12), 1734-1756 (2024)
   PUBMED   38157867
  REMARK    GeneRIF: An orally available Cav2.2 calcium channel inhibitor for
            the treatment of neuropathic pain.
REFERENCE   2  (bases 1 to 9792)
  AUTHORS   Xue,Y., Li,M., Hu,J., Song,Y., Guo,W., Miao,C., Ge,D., Hou,Y.,
            Wang,X., Huang,X., Liu,T., Zhang,X. and Huang,Q.
  TITLE     Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and breast
            cancer metastasis through cortactin stabilization
  JOURNAL   Cell Death Dis 13 (9), 812 (2022)
   PUBMED   36137995
  REMARK    GeneRIF: Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and
            breast cancer metastasis through cortactin stabilization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9792)
  AUTHORS   Li,G., Roy,B., Huang,X., Mu,Y., Yuan,J., Xia,Y., Song,Y. and
            Peng,Z.
  TITLE     High expression of N-type calcium channel indicates a favorable
            prognosis in gliomas
  JOURNAL   Medicine (Baltimore) 101 (26), e29782 (2022)
   PUBMED   35777045
  REMARK    GeneRIF: High expression of N-type calcium channel indicates a
            favorable prognosis in gliomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9792)
  AUTHORS   Dong,Y., Gao,Y., Xu,S., Wang,Y., Yu,Z., Li,Y., Li,B., Yuan,T.,
            Yang,B., Zhang,X.C., Jiang,D., Huang,Z. and Zhao,Y.
  TITLE     Closed-state inactivation and pore-blocker modulation mechanisms of
            human CaV2.2
  JOURNAL   Cell Rep 37 (5), 109931 (2021)
   PUBMED   34731621
  REMARK    GeneRIF: Closed-state inactivation and pore-blocker modulation
            mechanisms of human CaV2.2.
REFERENCE   5  (bases 1 to 9792)
  AUTHORS   Gao,S., Yao,X. and Yan,N.
  TITLE     Structure of human Cav2.2 channel blocked by the painkiller
            ziconotide
  JOURNAL   Nature 596 (7870), 143-147 (2021)
   PUBMED   34234349
  REMARK    GeneRIF: Structure of human Cav2.2 channel blocked by the
            painkiller ziconotide.
REFERENCE   6  (bases 1 to 9792)
  AUTHORS   Kim,D.S., Jung,H.H., Park,S.H. and Chin,H.
  TITLE     Isolation and characterization of the 5'-upstream region of the
            human N-type calcium channel alpha1B subunit gene. Chromosomal
            localization and promoter analysis
  JOURNAL   J Biol Chem 272 (8), 5098-5104 (1997)
   PUBMED   9030575
REFERENCE   7  (bases 1 to 9792)
  AUTHORS   Day,N.C., Shaw,P.J., McCormack,A.L., Craig,P.J., Smith,W.,
            Beattie,R., Williams,T.L., Ellis,S.B., Ince,P.G., Harpold,M.M.,
            Lodge,D. and Volsen,S.G.
  TITLE     Distribution of alpha 1A, alpha 1B and alpha 1E voltage-dependent
            calcium channel subunits in the human hippocampus and
            parahippocampal gyrus
  JOURNAL   Neuroscience 71 (4), 1013-1024 (1996)
   PUBMED   8684604
REFERENCE   8  (bases 1 to 9792)
  AUTHORS   Volsen,S.G., Day,N.C., McCormack,A.L., Smith,W., Craig,P.J.,
            Beattie,R., Ince,P.G., Shaw,P.J., Ellis,S.B., Gillespie,A. et al.
  TITLE     The expression of neuronal voltage-dependent calcium channels in
            human cerebellum
  JOURNAL   Brain Res Mol Brain Res 34 (2), 271-282 (1995)
   PUBMED   8750830
REFERENCE   9  (bases 1 to 9792)
  AUTHORS   Diriong,S., Lory,P., Williams,M.E., Ellis,S.B., Harpold,M.M. and
            Taviaux,S.
  TITLE     Chromosomal localization of the human genes for alpha 1A, alpha 1B,
            and alpha 1E voltage-dependent Ca2+ channel subunits
  JOURNAL   Genomics 30 (3), 605-609 (1995)
   PUBMED   8825650
REFERENCE   10 (bases 1 to 9792)
  AUTHORS   Williams,M.E., Brust,P.F., Feldman,D.H., Patthi,S., Simerson,S.,
            Maroufi,A., McCue,A.F., Velicelebi,G., Ellis,S.B. and Harpold,M.M.
  TITLE     Structure and functional expression of an omega-conotoxin-sensitive
            human N-type calcium channel
  JOURNAL   Science 257 (5068), 389-395 (1992)
   PUBMED   1321501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772363.15, M94172.1,
            AL591424.12 and BC033060.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000718.3.
            
            Summary: The protein encoded by this gene is the pore-forming
            subunit of an N-type voltage-dependent calcium channel, which
            controls neurotransmitter release from neurons. The encoded protein
            forms a complex with alpha-2, beta, and delta subunits to form the
            high-voltage activated channel. This channel is sensitive to
            omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to
            dihydropyridines. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M94172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371372.6/ ENSP00000360423.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL772363.15        6150-6156
            8-190               M94172.1           1-183
            191-191             AL772363.15        6340-6340
            192-5734            M94172.1           185-5727
            5735-5735           AL591424.12        78540-78540         c
            5736-6982           M94172.1           5729-6975
            6983-6983           AL591424.12        71154-71154         c
            6984-7251           M94172.1           6977-7244
            7252-9787           AL591424.12        68350-70885         c
            9788-9792           BC033060.1         1423-1427
FEATURES             Location/Qualifiers
     source          1..9792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..9792
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /note="calcium voltage-gated channel subunit alpha1 B"
                     /db_xref="GeneID:774"
                     /db_xref="HGNC:HGNC:1389"
                     /db_xref="MIM:601012"
     exon            1..436
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..7172
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium channel, voltage-dependent, L type, alpha 1B
                     subunit; calcium channel, voltage-dependent, N type, alpha
                     1B subunit; voltage-gated calcium channel subunit alpha
                     Cav2.2; voltage-gated calcium channel alpha subunit
                     Cav2.2; calcium channel, L type, alpha-1 polypeptide;
                     brain calcium channel III; calcium channel alpha12.2
                     subunit; Cav2.2 voltage-gated Ca2+ channel"
                     /codon_start=1
                     /product="voltage-dependent N-type calcium channel subunit
                     alpha-1B isoform 1"
                     /protein_id="NP_000709.1"
                     /db_xref="CCDS:CCDS59522.1"
                     /db_xref="GeneID:774"
                     /db_xref="HGNC:HGNC:1389"
                     /db_xref="MIM:601012"
                     /translation="MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVL
                     YKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMIL
                     ATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGS
                     YLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMK
                     AMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARL
                     CEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWL
                     YFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWI
                     FKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFAR
                     ASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPR
                     RLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAI
                     KPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFA
                     LLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKG
                     MFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKE
                     VAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLR
                     FATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAEAPEGVDPPRRHHRHRD
                     KDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPEG
                     GRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESG
                     EEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNHQPREPHCDLE
                     TSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHIPVMLTGPL
                     GEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYI
                     VTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMID
                     LGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTI
                     KRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELER
                     DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDAT
                     YEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNE
                     RACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYD
                     APYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILV
                     TEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF
                     FIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQ
                     ACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHL
                     DEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISN
                     EDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVP
                     PHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQT
                     QPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERG
                     HSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDAS
                     PMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLS
                     ADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDR
                     FGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQL
                     PQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPL
                     APGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHP
                     LRRVPNGYHCTLGLSSGGRARHSYHHPDQDHWC"
     exon            437..542
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            543..682
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            683..774
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            775..927
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1118
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1222
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1338
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1395
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1485
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1695
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1808
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1921
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2053
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2126
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2244
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2312
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2419
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..3220
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3438
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3565
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3695
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3755
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3862
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..3959
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4120
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4258
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4460
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4461..4625
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..4736
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4737..4820
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4821..4826
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4827..4943
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            4944..5009
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5010..5101
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5102..5246
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..5374
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..5471
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5472..5580
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5581..5688
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5689..5801
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5802..5929
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            5930..6065
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            6066..6182
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            6183..6390
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            6391..6641
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     exon            6642..9792
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7339..7344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /note="hexamer: AATAAA"
     polyA_site      7358
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /note="major polyA site"
     regulatory      9761..9766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
                     /note="hexamer: AATAAA"
     polyA_site      9792
                     /gene="CACNA1B"
                     /gene_synonym="BIII; CACNL1A5; CACNN; Cav2.2; DYT23;
                     NEDNEH"
ORIGIN      
        1 gggtgaggcg gcggcggctg cggcggtggg gccgggcgag gtccgctgcg gtcccggcgg
       61 ctccgtggct gctccgctct gagcgcctgg cgcgccccgc gccctccctg ccggggccgc
      121 tgggccgggg atgcacgcgg ggcccgggag ccatggtccg cttcggggac gagctgggcg
      181 gccgctatgg gggccccggc ggcggagagc gggcccgggg cggcggggcc ggcggggcgg
      241 ggggcccggg tcccgggggg ctgcagcccg gccagcgggt cctctacaag caatcgatcg
      301 cgcagcgcgc gcggaccatg gcgctgtaca accccatccc ggtcaagcag aactgcttca
      361 ccgtcaaccg ctcgctcttc gtcttcagcg aggacaacgt cgtccgcaaa tacgcgaagc
      421 gcatcaccga gtggcctcca ttcgagtata tgatcctggc caccatcatc gccaactgca
      481 tcgtgctggc cctggagcag cacctccctg atggggacaa aacgcccatg tccgagcggc
      541 tggacgacac ggagccctat ttcatcggga tcttttgctt cgaggcaggg atcaaaatca
      601 tcgctctggg ctttgtcttc cacaagggct cttacctgcg gaacggctgg aacgtcatgg
      661 acttcgtggt cgtcctcaca gggatccttg ccacggctgg aactgacttc gacctgcgaa
      721 cactgagggc tgtgcgtgtg ctgaggcccc tgaagctggt gtctgggatt ccaagtttgc
      781 aggtggtgct caagtccatc atgaaggcca tggttccact cctgcagatt gggctgcttc
      841 tcttctttgc catcctcatg tttgccatca ttggcctgga gttctacatg ggcaagttcc
      901 acaaggcctg tttccccaac agcacagatg cggagcccgt gggtgacttc ccctgtggca
      961 aggaggcccc agcccggctg tgcgagggcg acactgagtg ccgggagtac tggccaggac
     1021 ccaactttgg catcaccaac tttgacaata tcctgtttgc catcttgacg gtgttccagt
     1081 gcatcaccat ggagggctgg actgacatcc tctataatac aaacgatgcg gccggcaaca
     1141 cctggaactg gctctacttc atccctctca tcatcatcgg ctccttcttc atgctcaacc
     1201 tggtgctggg cgtgctctcg ggggagtttg ccaaggagcg agagagggtg gagaaccgcc
     1261 gcgccttcct gaagctgcgc cggcagcagc agatcgagcg agagctcaac gggtacctgg
     1321 agtggatctt caaggcggag gaagtcatgc tggccgagga ggacaggaat gcagaggaga
     1381 agtccccttt ggacgtgctg aagagagcgg ccaccaagaa gagcagaaat gacctgatcc
     1441 acgcagagga gggagaggac cggtttgcag atctctgtgc tgttggatcc cccttcgccc
     1501 gcgccagcct caagagcggg aagacagaga gctcgtcata cttccggagg aaggagaaga
     1561 tgttccggtt ttttatccgg cgcatggtga aggctcagag cttctactgg gtggtgctgt
     1621 gcgtggtggc cctgaacaca ctgtgtgtgg ccatggtgca ttacaaccag ccgcggcggc
     1681 ttaccacgac cctgtatttt gcagagtttg ttttcctggg tctcttcctc acagagatgt
     1741 ccctgaagat gtatggcctg gggcccagaa gctacttccg gtcctccttc aactgcttcg
     1801 actttggggt catcgtgggg agcgtctttg aagtggtctg ggcggccatc aagccgggaa
     1861 gctcctttgg gatcagtgtg ctgcgggccc tccgcctgct gaggatcttc aaagtcacga
     1921 agtactggag ctccctgcgg aacctggtgg tgtccctgct gaactccatg aagtccatca
     1981 tcagcctgct cttcttgctc ttcctgttca ttgtggtctt cgccctgctg gggatgcagc
     2041 tgtttggggg acagttcaac ttccaggatg agactcccac aaccaacttc gacaccttcc
     2101 ctgccgccat cctcactgtc ttccagatcc tgacgggaga ggactggaat gcagtgatgt
     2161 atcacgggat cgaatcgcaa ggcggcgtca gcaaaggcat gttctcgtcc ttttacttca
     2221 ttgtcctgac actgttcgga aactacactc tgctgaatgt ctttctggcc atcgctgtgg
     2281 acaacctggc caacgcccaa gagctgacca aggatgaaga ggagatggaa gaagcagcca
     2341 atcagaagct tgctctgcaa aaggccaaag aagtggctga agtcagcccc atgtctgccg
     2401 cgaacatctc catcgccgcc aggcagcaga actcggccaa ggcgcgctcg gtgtgggagc
     2461 agcgggccag ccagctacgg ctgcagaacc tgcgggccag ctgcgaggcg ctgtacagcg
     2521 agatggaccc cgaggagcgg ctgcgcttcg ccactacgcg ccacctgcgg cccgacatga
     2581 agacgcacct ggaccggccg ctggtggtgg agctgggccg cgacggcgcg cgggggcccg
     2641 tgggaggcaa agcccgacct gaggctgcgg aggcccccga gggcgtcgac cctccgcgca
     2701 ggcaccaccg gcaccgcgac aaggacaaga cccccgcggc gggggaccag gaccgagcag
     2761 aggccccgaa ggcggagagc ggggagcccg gtgcccggga ggagcggccg cggccgcacc
     2821 gcagccacag caaggaggcc gcggggcccc cggaggcgcg gagcgagcgc ggccgaggcc
     2881 caggccccga gggcggccgg cggcaccacc ggcgcggctc cccggaggag gcggccgagc
     2941 gggagccccg acgccaccgc gcgcaccggc accaggatcc gagcaaggag tgcgccggcg
     3001 ccaagggcga gcggcgcgcg cggcaccgcg gcggcccccg agcggggccc cgggaggcgg
     3061 agagcgggga ggagccggcg cggcggcacc gggcccggca caaggcgcag cctgctcacg
     3121 aggctgtgga gaaggagacc acggagaagg aggccacgga gaaggaggct gagatagtgg
     3181 aagccgacaa ggaaaaggag ctccggaacc accagccccg ggagccacac tgtgacctgg
     3241 agaccagtgg gactgtgact gtgggtccca tgcacacact gcccagcacc tgtctccaga
     3301 aggtggagga acagccagag gatgcagaca atcagcggaa cgtcactcgc atgggcagtc
     3361 agcccccaga cccgaacact attgtacata tcccagtgat gctgacgggc cctcttgggg
     3421 aagccacggt cgttcccagt ggtaacgtgg acctggaaag ccaagcagag gggaagaagg
     3481 aggtggaagc ggatgacgtg atgaggagcg gcccccggcc tatcgtccca tacagctcca
     3541 tgttctgttt aagccccacc aacctgctcc gccgcttctg ccactacatc gtgaccatga
     3601 ggtacttcga ggtggtcatt ctcgtggtca tcgccttgag cagcatcgcc ctggctgctg
     3661 aggacccagt gcgcacagac tcgcccagga acaacgctct gaaatacctg gattacattt
     3721 tcactggtgt ctttaccttt gagatggtga taaagatgat cgacttggga ctgctgcttc
     3781 accctggagc ctatttccgg gacttgtgga acattctgga cttcattgtg gtcagtggcg
     3841 ccctggtggc gtttgctttc tcaggatcca aagggaaaga catcaatacc atcaagtctc
     3901 tgagagtcct tcgtgtcctg cggcccctca agaccatcaa acggctgccc aagctcaagg
     3961 ctgtgtttga ctgtgtggtg aactccctga agaatgtcct caacatcttg attgtctaca
     4021 tgctcttcat gttcatattt gccgtcattg cggtgcagct cttcaaaggg aagtttttct
     4081 actgcacaga tgaatccaag gagctggaga gggactgcag gggtcagtat ttggattatg
     4141 agaaggagga agtggaagct cagcccaggc agtggaagaa atacgacttt cactacgaca
     4201 atgtgctctg ggctctgctg acgctgttca cagtgtccac gggagaaggc tggcccatgg
     4261 tgctgaaaca ctccgtggat gccacctatg aggagcaggg tccaagccct gggtaccgca
     4321 tggagctgtc catcttctac gtggtctact ttgtggtctt tcccttcttc ttcgtcaaca
     4381 tctttgtggc tttgatcatc atcaccttcc aggagcaggg ggacaaggtg atgtctgaat
     4441 gcagcctgga gaagaacgag agggcttgca ttgacttcgc catcagcgcc aaacccctga
     4501 cacggtacat gccccaaaac cggcagtcgt tccagtataa gacgtggaca tttgtggtct
     4561 ccccgccctt tgaatacttc atcatggcca tgatagccct caacactgtg gtgctgatga
     4621 tgaagttcta tgatgcaccc tatgagtacg agctgatgct gaaatgcctg aacatcgtgt
     4681 tcacatccat gttctccatg gaatgcgtgc tgaagatcat cgcctttggg gtgctgaact
     4741 atttcagaga tgcctggaat gtctttgact ttgtcactgt gttgggaagt attactgata
     4801 ttttagtaac agagattgcg gaaacgaaca atttcatcaa cctcagcttc ctccgcctct
     4861 ttcgagctgc gcggctgatc aagctgctcc gccagggcta caccatccgc atcctgctgt
     4921 ggacctttgt ccagtccttc aaggccctgc cctacgtgtg tctgctcatt gccatgctgt
     4981 tcttcatcta cgccatcatc ggcatgcagg tgtttgggaa tattgccctg gatgatgaca
     5041 ccagcatcaa ccgccacaac aacttccgga cgtttttgca agccctgatg ctgctgttca
     5101 ggagcgccac gggggaggcc tggcacgaga tcatgctgtc ctgcctgagc aaccaggcct
     5161 gtgatgagca ggccaatgcc accgagtgtg gaagtgactt tgcctacttc tacttcgtct
     5221 ccttcatctt cctgtgctcc tttctgatgt tgaacctctt tgtggctgtg atcatggaca
     5281 attttgagta cctcacgcgg gactcttcca tcctaggtcc tcaccacttg gatgagttca
     5341 tccgggtctg ggctgaatac gacccggctg cgtgtgggcg catcagttac aatgacatgt
     5401 ttgagatgct gaaacacatg tccccgcctc tggggctggg gaagaaatgc cctgctcgag
     5461 ttgcttacaa gcgcctggtt cgcatgaaca tgcccatctc caacgaggac atgactgttc
     5521 acttcacgtc cacgctgatg gccctcatcc ggacggcact ggagatcaag ctggccccag
     5581 ctgggacaaa gcagcatcag tgtgacgcgg agttgaggaa ggagatttcc gttgtgtggg
     5641 ccaatctgcc ccagaagact ttggacttgc tggtaccacc ccataagcct gatgagatga
     5701 cagtggggaa ggtttatgca gctctgatga tattcgactt ctacaagcag aacaaaacca
     5761 ccagagacca gatgcagcag gctcctggag gcctctccca gatgggtcct gtgtccctgt
     5821 tccaccctct gaaggccacc ctggagcaga cacagccggc tgtgctccga ggagcccggg
     5881 ttttccttcg acagaagagt tccacctccc tcagcaatgg cggggccata caaaaccaag
     5941 agagtggcat caaagagtct gtctcctggg gcactcaaag gacccaggat gcaccccatg
     6001 aggccaggcc acccctggag cgtggccact ccacagagat ccctgtgggg cggtcaggag
     6061 cactggctgt ggacgttcag atgcagagca taacccggag gggccctgat ggggagcccc
     6121 agcctgggct ggagagccag ggtcgagcgg cctccatgcc ccgccttgcg gccgagactc
     6181 agcccgtcac agatgccagc cccatgaagc gctccatctc cacgctggcc cagcggcccc
     6241 gtgggactca tctttgcagc accaccccgg accgcccacc ccctagccag gcgtcgtcgc
     6301 accaccacca ccaccgctgc caccgccgca gggacaggaa gcagaggtcc ctggagaagg
     6361 ggcccagcct gtctgccgat atggatggcg caccaagcag tgctgtgggg ccggggctgc
     6421 ccccgggaga ggggcctaca ggctgccggc gggaacgaga gcgccggcag gagcggggcc
     6481 ggtcccagga gcggaggcag ccctcatcct cctcctcgga gaagcagcgc ttctactcct
     6541 gcgaccgctt tgggggccgt gagcccccga agcccaagcc ctccctcagc agccacccaa
     6601 cgtcgccaac agctggccag gagccgggac cccacccaca gggcagtggt tccgtgaatg
     6661 ggagcccctt gctgtcaaca tctggtgcta gcacccccgg ccgcggtggg cggaggcagc
     6721 tcccccagac gcccctgact ccccgcccca gcatcaccta caagacggcc aactcctcac
     6781 ccatccactt cgccggggct cagaccagcc tccctgcctt ctccccaggc cggctcagcc
     6841 gtgggctttc cgaacacaac gccctgctgc agagagaccc cctcagccag cccctggccc
     6901 ctggctctcg aattggctct gacccttacc tggggcagcg tctggacagt gaggcctctg
     6961 tccacgccct gcctgaggac actctcactt tcgaggaggc tgtggccacc aactcgggcc
     7021 gctcctccag gacttcctac gtgtcctccc tgacctccca gtctcaccct ctccgccgcg
     7081 tgcccaacgg ttaccactgc accctgggac tcagctcggg tggccgagca cggcacagct
     7141 accaccaccc tgaccaagac cactggtgct agctgcaccg tgaccgctca gacgcctgca
     7201 tgcagcaggc gtgtgttcca gtggatgagt tttatcatcc acacggggca gccggccctc
     7261 gggggaggcc ttgcccacct tggtgaggct cctgtggccc ctccctcccc ctcctcccct
     7321 cttttactct agacgacgaa taaagccctg ttagaggatg cggctctctc tgtccccttc
     7381 ctgtcctgcc ttcctgggtc tcgtaccaca caccagaccc taaaccgcag gctgctgtgt
     7441 gtggctgaga aggacccagg agtccaaatc ccgtgtcctg ggactcagca tccagcatgg
     7501 gtgcttggag ccgttgtgag gagctctgcg tcctgtgggg agcacccttc acgtggccgt
     7561 gcggcacaga gaagcagggc ccacctgaaa gtgcgccgag acctcgggac ggaggggatg
     7621 gggaggggga cacagtcgtg gcttgtgcag cccgccagtg tcagcgaatg ctcactcagg
     7681 caagctctgt cctccctgga caccgtcagc cccacaggaa ccgagctggg aagtgttctt
     7741 gctgtggttg tgatttttaa ttgcaacacc tctcattctt gtcacttcta tatacgtgat
     7801 gtagaaaaaa tggaaaacca gaaaaatggg gaaggaaatg ttcacataac tttaaaaaat
     7861 caaacctgtg aaagaaagat gtcagctttt tgccacgtgt ctttgtggct tatgcgagga
     7921 gactccctgt gcagccctgt ccggtccagg tggacgtaga cggcccctgg ctctgctgct
     7981 cttgaccaag tgcctgaccg ccaggccctc acacccaggc tcctgggcac tgtggtgtga
     8041 ggcgaggcct cgggatccat caccgcagga tgctgtgaaa agtactcgcg atggcagcca
     8101 ggtagcaagc ccttgccagt ggagagcact ggatgtcatg gtggcaaaca aggcagccat
     8161 ttgctgtcct cctcccacga gtggaagggg tttccaagga agccacaggg cagctgacca
     8221 cgtgcttgtg tgaggcattt tcagtctgtt ctgcatatga ttctcagggc acactctgtg
     8281 gtatgtgaaa taggtttcct tccacataca gcagaagaga ggcaaaggct ggtaggaagg
     8341 aggaagacat tggctggggg cttggatgtg gggccgtcag ggcaggaggg aggaagcccc
     8401 agctggaatg aaactcagag caagtgaccg agggaggaca cggctcctgc cactgaggcc
     8461 gggcacctga tgcccagcac tgtcctggcg ccagacacag ggagcaggca gtcaagtgag
     8521 gtctgacccc catggccacg ctcaggagag aaagaccatg ctcaggacac tgtccaaggt
     8581 gcacaagatg ctgggaggtc ccttgtttgg tgaagaaagg gagcatttag agcagttgat
     8641 ggtggtgtgt cctccgtgtt ctgaaattcc agatgatctg tgttggattc ttggcttcta
     8701 ccccatgatt ctcctcaaag aaattgtgtg tgatgtgtgt gtgtgtgtgt gtgtgtgtgt
     8761 gtctgtgtca caggagatgc agtgcctgta caggtgtgtt cagtgtgtgg atgtcattaa
     8821 cccatagggc tatgcaacaa aagacacatt taatagaagt aaaacacaca agaccgctgc
     8881 ctggtctcgg ggttcagcat gattgtgacc aaaccttttt atagaatttc cttacctgaa
     8941 ggcacaacac tctgaaactt taaagataac agagtatttt attccaatag aataaaccag
     9001 gaatctcgga ctgtgcatgt gatcactgtg ctcctgttgc aaagtagaag gatgtgtatt
     9061 ttgacactga cgttttgtct cttgttcccc agcccccagc ccatgttatc ttgggtgtcg
     9121 aatgtgtcca ttccatgcag aaccacagcc atttccccag gcagtgttgg gtcgagaatc
     9181 cacttttcta aacccacaca gcctagctgg cttgtctaga ctcttctagg cattggaatt
     9241 gatgaaaact acagggagcg gggaaaggag acattatgtc ttgttttcct gactttgggt
     9301 tttgtttctc actgtgtctt ctccggctat catatatgtc ccctgaatct catagtgagc
     9361 tgccaaattt gaagtgcatc acccagttgt ctgcatctgg aaccagtcaa gcagtggctg
     9421 tagtttgaac aagttatgtg tgcatgtaac atatatacat atatacatat atacaagtat
     9481 gtgcatgata atgtatatct tcgtactttt tgatacaatg tattcatttg ttaattttta
     9541 attatatttg atataaatca aaggtttgtt gcaaaacttt atatttaaga agtgttaaaa
     9601 aaaaaaaaaa gtcccaacca tgcaacacaa ctgggaccta cttaaaaaga aattctgtga
     9661 ttgactagtt tgctgcctga gtcatattta tcagccaaac tttggattct gctgttgttt
     9721 ctacaatgac attttgtatg aagcaaagtc cttgaattaa aataaaaact tagcaaaaaa
     9781 tcaaaaacaa aa
//
