LOCUS       NM_033122               1517 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens calcium binding protein, spermatid associated 1
            (CABS1), mRNA.
ACCESSION   NM_033122
VERSION     NM_033122.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1517)
  AUTHORS   Ritz,T., Rosenfield,D., St Laurent,C.D., Trueba,A.F., Werchan,C.A.,
            Vogel,P.D., Auchus,R.J., Reyes-Serratos,E. and Befus,A.D.
  TITLE     A novel biomarker associated with distress in humans:
            calcium-binding protein, spermatid-specific 1 (CABS1)
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 312 (6), R1004-R1016 (2017)
   PUBMED   28381457
  REMARK    GeneRIF: CABS1 is readily detected in human saliva and is
            associated with psychological and physiological indicators of
            stress.
REFERENCE   2  (bases 1 to 1517)
  AUTHORS   St Laurent,C.D., St Laurent,K.E., Mathison,R.D. and Befus,A.D.
  TITLE     Calcium-binding protein, spermatid-specific 1 is expressed in human
            salivary glands and contains an anti-inflammatory motif
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 308 (7), R569-R575 (2015)
   PUBMED   25632019
  REMARK    GeneRIF: Human CABS1 has a peptide motif homologous to the
            anti-inflammatory peptide sequence of rat SMR1.
REFERENCE   3  (bases 1 to 1517)
  AUTHORS   Calvel,P., Kervarrec,C., Lavigne,R., Vallet-Erdtmann,V.,
            Guerrois,M., Rolland,A.D., Chalmel,F., Jegou,B. and Pineau,C.
  TITLE     CLPH, a novel casein kinase 2-phosphorylated disordered protein, is
            specifically associated with postmeiotic germ cells in rat
            spermatogenesis
  JOURNAL   J Proteome Res 8 (6), 2953-2965 (2009)
   PUBMED   19271754
REFERENCE   4  (bases 1 to 1517)
  AUTHORS   Kawashima,A., Osman,B.A., Takashima,M., Kikuchi,A., Kohchi,S.,
            Satoh,E., Tamba,M., Matsuda,M. and Okamura,N.
  TITLE     CABS1 is a novel calcium-binding protein specifically expressed in
            elongate spermatids of mice
  JOURNAL   Biol Reprod 80 (6), 1293-1304 (2009)
   PUBMED   19208547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB027445.1, AF380838.1 and BX098854.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033122.3.
            
            CCDS Note: This CCDS ID represents the human ortholog of the
            protein described in PMIDs: 19208547 and 19271754. This transcript
            is supported by AK057459.1. It should be noted this transcript is
            predicted to undergo nonsense-mediated mRNA decay (NMD). However,
            the protein is represented because it was detected endogenously in
            mouse and rat (PMIDs: 19208547 and 19271754, respectively). It is
            likely that the majority of transcripts representing this variant
            will undergo NMD, while some low level of NMD escape may allow for
            the expression of this protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.194722.1,
                                           SRR5189667.25865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273936.6/ ENSP00000273936.4
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               DB027445.1         39-588
            551-1513            AF380838.1         548-1510
            1514-1517           BX098854.1         479-482
FEATURES             Location/Qualifiers
     source          1..1517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1517
                     /gene="CABS1"
                     /gene_synonym="C4orf35; CLPH; NYD-SP26"
                     /note="calcium binding protein, spermatid associated 1"
                     /db_xref="GeneID:85438"
                     /db_xref="HGNC:HGNC:30710"
                     /db_xref="MIM:618600"
     exon            1..1366
                     /gene="CABS1"
                     /gene_synonym="C4orf35; CLPH; NYD-SP26"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1247
                     /gene="CABS1"
                     /gene_synonym="C4orf35; CLPH; NYD-SP26"
                     /note="casein-like phosphoprotein; calcium-binding
                     protein, sperm-specific 1; testis development protein
                     NYD-SP26; calcium-binding protein, spermatid-specific 1"
                     /codon_start=1
                     /product="calcium-binding and spermatid-specific protein
                     1"
                     /protein_id="NP_149113.3"
                     /db_xref="CCDS:CCDS3539.1"
                     /db_xref="GeneID:85438"
                     /db_xref="HGNC:HGNC:30710"
                     /db_xref="MIM:618600"
                     /translation="MAEDGLPKIYSHPPTESSKTPTAATIFFGADNAIPKSETTITSE
                     GDHVTSVNEYMLESDFSTTTDNKLTAKKEKLKSEDDMGTDFIKSTTHLQKEITSLTGT
                     TNSITRDSITEHFMPVKIGNISSPVTTVSLIDFSTDIAKEDILLATIDTGDAEISITS
                     EVSGTLKDSSAGVADAPAFPRKKDEADMSNYNSSIKSNVPADEAVQVTDSTIPEAEIP
                     PAPEESFTTIPDITALEEEKITEIDLSVLEDDTSAVATLTDSDEKFITVFELTTSAEK
                     DKDKREDTLLTDEETTEGASIWMERDTANEAETHSVLLTAVESRYDFVVPASIATNLV
                     EESSTEEDLSETDNTETVPKITEPFSGTTSVLDTPDYKEDTSTTETDIFELLKEEPDE
                     FMI"
     exon            1367..1517
                     /gene="CABS1"
                     /gene_synonym="C4orf35; CLPH; NYD-SP26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1492..1497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABS1"
                     /gene_synonym="C4orf35; CLPH; NYD-SP26"
                     /note="hexamer: AATAAA"
     polyA_site      1517
                     /gene="CABS1"
                     /gene_synonym="C4orf35; CLPH; NYD-SP26"
                     /note="major polyA site"
ORIGIN      
        1 agagatacca ctgagtccag aagcaagacc tgtgagagtg cacagtgcca cttcgcccca
       61 tggctgaaga tggtttgccc aaaatttatt ctcatcctcc aacagaaagc agtaaaacac
      121 caactgcagc aaccattttc tttggggctg acaatgctat tcccaaatca gaaacaacta
      181 ttacttcaga aggagaccac gtcacttcag taaatgaata tatgctagaa agcgattttt
      241 caacaactac agacaacaaa ctgacagcta aaaaggaaaa actcaaatca gaagatgata
      301 tggggaccga ctttattaag tcaacaactc acctacagaa agaaattacc tctctgactg
      361 gcactacaaa ctccataaca agagactcta ttaccgaaca tttcatgcca gtgaaaattg
      421 ggaatatttc atcaccagtt actactgttt ctttaataga tttttccact gacatagcaa
      481 aagaagatat cctcttagct accattgaca caggagatgc agagatctca ataacctctg
      541 aagtctctgg cacactaaag gacagcagtg ctggtgttgc tgacgctcct gcctttccac
      601 gtaaaaagga tgaagctgat atgagcaatt ataattcctc catcaaatcc aatgtccctg
      661 ctgatgaggc tgtccaggtc actgattcca ctattcctga ggctgaaatc cctcctgctc
      721 ctgaagaaag cttcactact attccagaca taactgccct tgaagaagag aaaataaccg
      781 aaattgacct aagtgtttta gaagatgaca ccagtgctgt ggctacatta actgactctg
      841 atgagaagtt tatcactgtg tttgaactca ctacctctgc tgaaaaagac aaagataaac
      901 gggaagatac tctgctaact gatgaagaaa ctaccgaggg agccagtatt tggatggaga
      961 gagatactgc aaatgaagca gagacccatt ctgttttgct tactgctgtt gaatccagat
     1021 atgacttcgt tgtccctgca tcaatagcta caaacctagt ggaagaatca tctacagaag
     1081 aagatttgtc tgaaactgat aatacagaga ctgtacctaa gatcactgag ccattttctg
     1141 gaactacctc tgtattagat accccagact ataaggaaga cacctccaca actgaaacgg
     1201 atatctttga actactgaaa gaagaacccg atgagttcat gatttaaaag caacaaaagg
     1261 gataccatgt agaattgtgc aatagtctag ccagctagcc ttaacatcta agaaattttt
     1321 ccaacaagca aaaaccttta gaaatgaaag aatgtgggca tttaaggtct taaacactga
     1381 atatcacact cttcttatga ctcttgttag cgattcaagg acataaatct tcattctttt
     1441 ctggcacaga ctacttaaat gggtctgttt tcactttgct catttttctt caataaatct
     1501 ttttggcaag caactga
//
