LOCUS       NM_182527               3334 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens calcium binding protein 7 (CABP7), mRNA.
ACCESSION   NM_182527
VERSION     NM_182527.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Rajamanoharan,D., McCue,H.V., Burgoyne,R.D. and Haynes,L.P.
  TITLE     Modulation of phosphatidylinositol 4-phosphate levels by CaBP7
            controls cytokinesis in mammalian cells
  JOURNAL   Mol Biol Cell 26 (8), 1428-1439 (2015)
   PUBMED   25717182
  REMARK    GeneRIF: CaBP7 regulates lysosome clustering at the intercellular
            bridge during cytokinesis in HeLa cells. CaBP7 depletion induces
            lysosome mislocalization, extension of intercellular bridge
            lifetime, and cytokinesis failure.
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   McCue,H.V., Patel,P., Herbert,A.P., Lian,L.Y., Burgoyne,R.D. and
            Haynes,L.P.
  TITLE     Solution NMR structure of the Ca2+-bound N-terminal domain of
            CaBP7: a regulator of golgi trafficking
  JOURNAL   J Biol Chem 287 (45), 38231-38243 (2012)
   PUBMED   22989873
  REMARK    GeneRIF: Data indicate that the Ca(2+)-bound form of
            calcium-binding protein 7 (CaBP7) N-terminal domain (NTD) is
            monomeric and exhibits an open conformation.
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   McCue,H.V., Burgoyne,R.D. and Haynes,L.P.
  TITLE     Membrane targeting of the EF-hand containing calcium-sensing
            proteins CaBP7 and CaBP8
  JOURNAL   Biochem Biophys Res Commun 380 (4), 825-831 (2009)
   PUBMED   19338761
  REMARK    GeneRIF: CaBP7 and 8 possess a targeting mechanism that is unique
            amongst the CaBPs that may contribute to differential functional
            Ca(2+)-sensing by these family members.
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Haeseleer,F., Imanishi,Y., Sokal,I., Filipek,S. and Palczewski,K.
  TITLE     Calcium-binding proteins: intracellular sensors from the calmodulin
            superfamily
  JOURNAL   Biochem Biophys Res Commun 290 (2), 615-623 (2002)
   PUBMED   11785943
  REMARK    Review article
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004882.3, BC051805.1, AA351919.1 and BX488512.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182527.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051805.1, EL734620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216144.4/ ENSP00000216144.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               AC004882.3         66609-66960
            353-1688            BC051805.1         1-1336
            1689-1711           AA351919.1         136-158             c
            1712-2155           BC051805.1         1359-1802
            2156-2337           BX488512.1         376-557
            2338-3334           BC051805.1         1985-2981
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..3334
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /note="calcium binding protein 7"
                     /db_xref="GeneID:164633"
                     /db_xref="HGNC:HGNC:20834"
                     /db_xref="MIM:618759"
     exon            1..531
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1070
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /note="calneuron 2; calneuron II"
                     /codon_start=1
                     /product="calcium-binding protein 7"
                     /protein_id="NP_872333.1"
                     /db_xref="CCDS:CCDS13867.1"
                     /db_xref="GeneID:164633"
                     /db_xref="HGNC:HGNC:20834"
                     /db_xref="MIM:618759"
                     /translation="MPFHPVTAALMYRGIYTVPNLLSEQRPVDIPEDELEEIREAFKV
                     FDRDGNGFISKQELGTAMRSLGYMPNEVELEVIIQRLDMDGDGQVDFEEFVTLLGPKL
                     STSGIPEKFHGTDFDTVFWKCDMQKLTVDELKRLLYDTFCEHLSMKDIENIIMTEEES
                     HLGTAEECPVDVETCSNQQIRQTCVRKSLICAFAIAFIISVMLIAANQVLRSGMK"
     exon            532..675
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..788
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..942
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..3334
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3305..3310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /note="hexamer: CATAAA"
     polyA_site      3334
                     /gene="CABP7"
                     /gene_synonym="CALN2"
                     /note="major polyA site"
ORIGIN      
        1 acagaacgag cgagcgagcg agcggagagg cggctacagc ctgagcgccg ggccggtagc
       61 ggccgcgccg gcgagcggac tagcgggcgg cgagcagcgc ggagcgcgcg gggcaccgag
      121 gagcgggcgc ggcgggcacc gcgcgaggca gccggagctc tcggaaaggc cagagcggcg
      181 ccgcccccgc tgcccctgcg gggccccggc tgggagcccg acgagggagc gggcggcatg
      241 gcccggcggc ccggggcgcg ggggcgctag gcccccggag gggcgtcccc agcctcgccg
      301 ctgccgccgc cgccctccgc agccgcgcgc cccgcccgct ccagccgccc ccggggccgc
      361 caccggccca tgagccccgg cctcaaagtt tgcggcgggc gggcgggcgc ggagcctcca
      421 agatgccgtt ccacccggtg acggcggcgt tgatgtaccg gggcatctac accgtgccca
      481 acctgctgtc ggagcagcgc ccggtggaca tcccggagga cgagctggag gagatccgag
      541 aggccttcaa ggtgtttgac cgtgacggca atggcttcat ctccaagcag gagctgggca
      601 cagccatgcg ctcactgggt tacatgccca acgaggtgga gctggaggtc atcatccagc
      661 ggctggacat ggatggtgat ggtcaagtgg actttgagga gtttgtgacc cttctgggac
      721 ccaaactctc cacctcaggg atcccagaga agttccatgg caccgacttt gatactgtct
      781 tctggaagtg cgacatgcag aagctgacgg tggatgagct gaagcggctg ctctacgaca
      841 ccttctgcga gcacctgtcc atgaaggaca tagagaacat catcatgacg gaggaggaga
      901 gccacctggg cacagccgag gagtgtcccg tggatgtgga gacctgctcc aaccagcaga
      961 tccgccagac ttgcgtgcgc aagagtctca tctgcgcctt cgccatcgcc ttcatcatca
     1021 gtgtcatgct cattgcggcc aaccaggtgc tgcgcagtgg catgaagtag acgccacctg
     1081 gatgccccat ccaccgcatg cggtgcccgt ggcccgcccc acaccaccgc cgcctgcaga
     1141 cctctccctt ggccggctcc ctgggccgcc atctgcgtgt acttcagggc ctgggtatcc
     1201 agcgagccct ccccacccac ccacggtcct cacctggagc tgtggcctgg ctgtggaggg
     1261 ccgggtggtg gctctgagga tggtccccag ccccaccctg tccccaccct ggcctgtaag
     1321 gagcactcac tcttcctacc atccaggggc tcctgggaaa ttaaggaggg atttgcacag
     1381 gaacccccag gacccagtcg ctgctgtggt cccttgggca ggagcgggca ccctgtgcct
     1441 tgagacagca gcctatctgg ggccacacag ccaacccagc cctggtccct gaggtctgcc
     1501 cagggcacag ggcacaggca gggacagaaa gccttctcct gggggagggt gggaagccag
     1561 ggtgtcctgg gccttgctgc ctggcatagc ctgaggaggc ccctggtctt ctccttgggc
     1621 cccttcctct gaccctcgtt ggaccccaac ccagaccccc ttttctccat gtacctgctg
     1681 ggccagccca tttcacaggt gaggaacccg aggctcaggg ccccgagact tggcctcagt
     1741 tcttccttcc acagggattt tcaggaaagg cagaagctcg tggaggatgg gcatctgagg
     1801 tggccctgca gccccccacc ttctggccct cccaccagag gcccagctac caaggccaca
     1861 ttgtccacca ccccagccta gagcctagaa ctgtagtcca gctgaggaag gaggcagagc
     1921 tggggcctga aggctctgag cagcctccag ccagggggct cctccagggc tgaactttgg
     1981 gagggcccct gtactacctc ctgggccaag aaactggcac agccccacac tgtcagtgcc
     2041 aagaggctgc gccaggccac tctctcagcc cagggcctgc cctcctgtcc tcccacttct
     2101 ctacgccctc aaggttggag accccgctcc catgccccag ctgtgccatc ccaaatactt
     2161 gggcagcagc tcagcatggg cagacatggg ggctgtggat tcttccaggg cggggatggc
     2221 agatggagcc cttgggctcc ttgggcctag agccacttct taccaggcaa cgggcacagc
     2281 caccctggca caccctctgc ctggccgtgc tgaacctctg ctggtcccaa gggagaaggg
     2341 agtgagcgtg ggtcacctgg ggaaaatctc atctgattcc ctccttgccc gacctctgct
     2401 aggggctgga gaacagagct cagagcaccc agtgtaggga aacacagcca gaccactgtg
     2461 gtgacagact ttctttataa acatttggaa gttttctccc ccatcttctt aagaagcagg
     2521 ggggcaggtg gaggagagtg aggggagagc tgcccggtgc agacccagga cgagggctgc
     2581 acttggtgtg gccgtgtcct gagcctcagt gaggctgggc agatggtctc ggagcctcca
     2641 tggggcgtag caggaaccgg gcttggcttc ctattgtgac tgatgagaaa agtgaccacg
     2701 tgggggtcag tcgggggcaa ggggctcagc cccactggac tctgggctgc agaggccacc
     2761 ccccaggtgg gggtgcccgc agggatggag gcagctcctg aactggtggc cagcccacgg
     2821 ggtactggaa gacagtggtt ctgatgggtt cagccctaga gagagagaga gaagcgggga
     2881 gaataagagt gcactacagc ccaggcttat gccaccccca gcccacctgc ctcaccaccc
     2941 tggctgtggg gagggtcagc tgcctgcatg acttttctgg aaggcagagc ctcgaaaata
     3001 ggcagaccgt ttgagccagc gacctcacct ctaggaactg agcccaagga aatagcgggg
     3061 ttgcaggcag acattgagct gcgagacaat gggaataacc ttcgtgtcca cctgtggggg
     3121 actgattcaa tacatatgca cgtccacagc agagaatgcc atgcggcctg tgtaagaatt
     3181 aaggcagatt tatatgcact gatgaggaaa gacatactgt gtgataggga gaaaaagcag
     3241 cttataaaat aatgtatata gcatgatact atttttgttt aaaaatatat aaaatatata
     3301 aatgcataaa aaaatcctgg aagacacagc aaaa
//
