LOCUS       NM_019855               1853 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens calcium binding protein 5 (CABP5), mRNA.
ACCESSION   NM_019855
VERSION     NM_019855.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Di Jeso,B., Morishita,Y., Treglia,A.S., Lofrumento,D.D.,
            Nicolardi,G., Beguinot,F., Kellogg,A.P. and Arvan,P.
  TITLE     Transient covalent interactions of newly synthesized thyroglobulin
            with oxidoreductases of the endoplasmic reticulum
  JOURNAL   J Biol Chem 289 (16), 11488-11496 (2014)
   PUBMED   24599957
  REMARK    GeneRIF: the faster migrating Tg adduct C primarily engages the
            CaBP1/P5 oxidoreductase, whereas the slower migrating Tg adduct A
            primarily engages ERp72.
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   McCue,H.V., Burgoyne,R.D. and Haynes,L.P.
  TITLE     Membrane targeting of the EF-hand containing calcium-sensing
            proteins CaBP7 and CaBP8
  JOURNAL   Biochem Biophys Res Commun 380 (4), 825-831 (2009)
   PUBMED   19338761
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Haeseleer,F., Imanishi,Y., Sokal,I., Filipek,S. and Palczewski,K.
  TITLE     Calcium-binding proteins: intracellular sensors from the calmodulin
            superfamily
  JOURNAL   Biochem Biophys Res Commun 290 (2), 615-623 (2002)
   PUBMED   11785943
  REMARK    Review article
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010458.6, AA318398.1,
            AF169159.1, AC010330.7 and BU734136.1.
            
            On May 17, 2019 this sequence version replaced NM_019855.4.
            
            Summary: The product of this gene belongs to a subfamily of calcium
            binding proteins, which share similarity to calmodulin. Calcium
            binding proteins are an important component of calcium mediated
            cellular signal transduction. Expression of this gene is
            retina-specific. The mouse homolog of this protein has been shown
            to express in the inner nuclear layer of the retina, suggested its
            role in neuronal functioning. The specific function of this gene is
            unknown. [provided by RefSeq, Oct 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169159.1, BC126135.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN03465415
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293255.3/ ENSP00000293255.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC010458.6         86751-86775
            26-179              AA318398.1         1-154
            180-394             AF169159.1         148-362
            395-395             AC010458.6         90225-90225
            396-880             AF169159.1         364-848
            881-1400            AC010330.7         9305-9824
            1401-1853           BU734136.1         18-470              c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1853
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /note="calcium binding protein 5"
                     /db_xref="GeneID:56344"
                     /db_xref="HGNC:HGNC:13714"
                     /db_xref="MIM:607315"
     exon            1..220
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..679
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /note="calcium-binding protein 3"
                     /codon_start=1
                     /product="calcium-binding protein 5"
                     /protein_id="NP_062829.1"
                     /db_xref="CCDS:CCDS12709.1"
                     /db_xref="GeneID:56344"
                     /db_xref="HGNC:HGNC:13714"
                     /db_xref="MIM:607315"
                     /translation="MQFPMGPACIFLRKGIAEKQRERPLGQDEIEELREAFLEFDKDR
                     DGFISCKDLGNLMRTMGYMPTEMELIELGQQIRMNLGGRVDFDDFVELMTPKLLAETA
                     GMIGVQEMRDAFKEFDTNGDGEITLVELQQAMQRLLGERLTPREISEVVREADVNGDG
                     TVDFEEFVKMMSR"
     exon            221..251
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /inference="alignment:Splign:2.1.0"
     exon            252..395
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /inference="alignment:Splign:2.1.0"
     exon            396..505
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..653
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..1853
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /note="hexamer: AATAAA"
     polyA_site      1299
                     /gene="CABP5"
                     /gene_synonym="CABP3"
                     /note="major polyA site"
ORIGIN      
        1 acagctctaa gacaccggga ccgaaggaga agccaagaga ggcaggaaga ggtggcaaag
       61 gagtgctgga gaagataagg aggctgagct ccgacaggga gcagggagga ggggccatct
      121 tgagactggt gccctgcgag ctccacccca cccctccatg cagttcccca tgggccccgc
      181 ctgcatcttc ttgaggaaag gcattgctga gaaacagcgg gaaagaccac tgggacaaga
      241 tgagattgaa gagctgcggg aagcatttct tgagttcgat aaggaccgag atgggttcat
      301 ctcttgtaag gatctgggga atctcatgag gacgatgggt tacatgccca cggagatgga
      361 actgattgag ctcggccagc aaatccgcat gaacctgggt ggccgtgtag actttgatga
      421 ctttgtggag ctgatgaccc ccaaattgct tgcagaaaca gctgggatga tcggtgtcca
      481 ggagatgcgg gatgccttca aggagtttga cacgaatgga gatggggaga tcaccctggt
      541 ggagctacag caggccatgc agagactcct gggggagcgg ctcacccccc gggagatctc
      601 tgaggttgtc cgggaggctg atgttaatgg agacggcaca gttgactttg aagagtttgt
      661 gaagatgatg tctcgctgag gaggtcctgg aagctccaga ccctctccac ctggtcaaca
      721 tggagcaagc gcttgtggag aaccaaagcc caaaagcccc agatcccctt aaagcagaga
      781 gggagggcag gcgggaggga gggcattggc atgcggcgct gtgcatgggg tgagacccag
      841 agcggtatct ttgccaggat gggggcgtct gcagaactag attaagaagg aagagtctgt
      901 ggatggaaat aggaagcgtg ggagggtcca gttgccaccc ccaaaaattc caatgattct
      961 tgacatcttt tcacttcacg tagtcctaag tccctgtgac ctgccagagt ctcttcccca
     1021 gcttcccctt gggtgaaaat agtctcttct cctgttgggt atcaaaaggt tcagaacgta
     1081 gtctctactc ttcccctgcc tgcatcaact gttgcaaatc ccgtttctct ctcccggtaa
     1141 ggggacaaat tatactttat tcaggtgatg gttacatgaa cagcccagac ttcaccacta
     1201 cgcaatatat ccatgtaaca aaaccgcact tgtactccct aaatctatag aaatacaaaa
     1261 tgaaataaaa aggatgcaaa tcagtcacag agctggaaac agagttgttg ttgaggctgg
     1321 gcttggaaat ggctcgtgca agtggcattc aaagtcaact ccttcctttt cctgatttcc
     1381 tggaagcact gtctggtttc tctctctctc tctctctctc tctctctctc tctctctgtc
     1441 tgtctgtctc tgtctcccct cccacatccc ttcctttgtg taagatactc aggggactga
     1501 attaaaccac aaatctggat tatcaaggtt tagagctagc tgatccttgg ggaattaatc
     1561 ccctgaaaaa atgtcatcat gcaaagagag agatgacagg atcccccaaa tccccagttc
     1621 agccaggttg ttgcaaagtc tttcctagaa gcctcctacc tccgcgctgg tctgtcctgg
     1681 accacccaga ggctgtgtct ctgttagatg ggtcgtctgt tccgtccctc acgtcctgac
     1741 atcgatctgt gccatgaaac agaaaagaga gattcctcct gacctccgcc caaagcaaga
     1801 cactccagca atgcaaaggt taaaataaaa gtcaaaataa agaattaact tca
//
