LOCUS       NM_001033677            1597 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens calcium binding protein 1 (CABP1), transcript variant
            3, mRNA.
ACCESSION   NM_001033677
VERSION     NM_001033677.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1597)
  AUTHORS   Di Jeso,B., Morishita,Y., Treglia,A.S., Lofrumento,D.D.,
            Nicolardi,G., Beguinot,F., Kellogg,A.P. and Arvan,P.
  TITLE     Transient covalent interactions of newly synthesized thyroglobulin
            with oxidoreductases of the endoplasmic reticulum
  JOURNAL   J Biol Chem 289 (16), 11488-11496 (2014)
   PUBMED   24599957
  REMARK    GeneRIF: the faster migrating Tg adduct C primarily engages the
            CaBP1/P5 oxidoreductase, whereas the slower migrating Tg adduct A
            primarily engages ERp72.
REFERENCE   2  (bases 1 to 1597)
  AUTHORS   Seeger,C., Gorny,X., Reddy,P.P., Seidenbecher,C. and Danielson,U.H.
  TITLE     Kinetic and mechanistic differences in the interactions between
            caldendrin and calmodulin with AKAP79 suggest different roles in
            synaptic function
  JOURNAL   J Mol Recognit 25 (10), 495-503 (2012)
   PUBMED   22996592
  REMARK    GeneRIF: Different kinetics of Ca-dependent binding step between
            caldendrin and calmodulin with AKAP79 suggest their different roles
            in synaptic function.
REFERENCE   3  (bases 1 to 1597)
  AUTHORS   Gorny,X., Mikhaylova,M., Seeger,C., Reddy,P.P., Reissner,C.,
            Schott,B.H., Helena Danielson,U., Kreutz,M.R. and Seidenbecher,C.
  TITLE     AKAP79/150 interacts with the neuronal calcium-binding protein
            caldendrin
  JOURNAL   J Neurochem 122 (4), 714-726 (2012)
   PUBMED   22693956
  REMARK    GeneRIF: We demonstrate that calmodulin and caldendrin compete for
            a partially overlapping binding site on AKAP79 and that their
            binding is differentially dependent on calcium
REFERENCE   4  (bases 1 to 1597)
  AUTHORS   Park,S., Li,C. and Ames,J.B.
  TITLE     Nuclear magnetic resonance structure of calcium-binding protein 1
            in a Ca(2+) -bound closed state: implications for target
            recognition
  JOURNAL   Protein Sci 20 (8), 1356-1366 (2011)
   PUBMED   21608059
  REMARK    GeneRIF: Present the NMR structure of full-length CaBP1 with Ca(2+)
            bound at the first, third, and fourth EF-hands.
REFERENCE   5  (bases 1 to 1597)
  AUTHORS   Oz,S., Tsemakhovich,V., Christel,C.J., Lee,A. and Dascal,N.
  TITLE     CaBP1 regulates voltage-dependent inactivation and activation of
            Ca(V)1.2 (L-type) calcium channels
  JOURNAL   J Biol Chem 286 (16), 13945-13953 (2011)
   PUBMED   21383011
  REMARK    GeneRIF: CaBP1 regulates voltage-dependent inactivation and
            activation of Ca(V)1.2 (L-type) calcium channels
REFERENCE   6  (bases 1 to 1597)
  AUTHORS   Zhou,H., Kim,S.A., Kirk,E.A., Tippens,A.L., Sun,H., Haeseleer,F.
            and Lee,A.
  TITLE     Ca2+-binding protein-1 facilitates and forms a postsynaptic complex
            with Cav1.2 (L-type) Ca2+ channels
  JOURNAL   J Neurosci 24 (19), 4698-4708 (2004)
   PUBMED   15140941
  REMARK    GeneRIF: We describe a new role for CaBP1 in regulation of Ca2+
            influx through Ca(v)1.2 (L-type) Ca2+ channels. CaBP1 interacts
            directly with the alpha1 subunit of Ca(v)1.2 at sites that also
            bind Calmodulin
REFERENCE   7  (bases 1 to 1597)
  AUTHORS   Haynes,L.P., Tepikin,A.V. and Burgoyne,R.D.
  TITLE     Calcium-binding protein 1 is an inhibitor of agonist-evoked,
            inositol 1,4,5-trisphosphate-mediated calcium signaling
  JOURNAL   J Biol Chem 279 (1), 547-555 (2004)
   PUBMED   14570872
  REMARK    GeneRIF: CaBP1 is able to specifically regulate InsP3
            receptor-mediated alterations in [Ca2+]i during agonist
            stimulation.
REFERENCE   8  (bases 1 to 1597)
  AUTHORS   Lee,A., Westenbroek,R.E., Haeseleer,F., Palczewski,K., Scheuer,T.
            and Catterall,W.A.
  TITLE     Differential modulation of Ca(v)2.1 channels by calmodulin and
            Ca2+-binding protein 1
  JOURNAL   Nat Neurosci 5 (3), 210-217 (2002)
   PUBMED   11865310
  REMARK    GeneRIF: enhances inactivation, causes a depolarizing shift in the
            voltage dependence of activation, and does not support
            Ca2+-dependent facilitation of Ca(v)2.1 channels
REFERENCE   9  (bases 1 to 1597)
  AUTHORS   Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
            Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
  TITLE     Five members of a novel Ca(2+)-binding protein (CABP) subfamily
            with similarity to calmodulin
  JOURNAL   J Biol Chem 275 (2), 1247-1260 (2000)
   PUBMED   10625670
REFERENCE   10 (bases 1 to 1597)
  AUTHORS   Yamaguchi,K., Yamaguchi,F., Miyamoto,O., Sugimoto,K., Konishi,R.,
            Hatase,O. and Tokuda,M.
  TITLE     Calbrain, a novel two EF-hand calcium-binding protein that
            suppresses Ca2+/calmodulin-dependent protein kinase II activity in
            the brain
  JOURNAL   J Biol Chem 274 (6), 3610-3616 (1999)
   PUBMED   9920909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030201.1 and AL533429.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 8, 2021 this sequence version replaced NM_001033677.1.
            
            Summary: Calcium binding proteins are an important component of
            calcium mediated cellular signal transduction. This gene encodes a
            protein that belongs to a subfamily of calcium binding proteins
            which share similarity to calmodulin. The protein encoded by this
            gene regulates the gating of voltage-gated calcium ion channels.
            This protein inhibits calcium-dependent inactivation and supports
            calcium-dependent facilitation of ion channels containing
            voltage-dependent L-type calcium channel subunit alpha-1C. This
            protein also regulates calcium-dependent activity of inositol
            1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium
            channels, and transient receptor potential channel TRPC5. This gene
            is predominantly expressed in retina and brain. Alternative
            splicing results in multiple transcript variants encoding disinct
            isoforms. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (3) is the longest transcript and
            encodes the longest isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030201.1, AL565119.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316803.8/ ENSP00000317310.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               BC030201.1         8-485
            479-893             AL533429.3         455-869
            894-1597            BC030201.1         901-1604
FEATURES             Location/Qualifiers
     source          1..1597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1597
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /note="calcium binding protein 1"
                     /db_xref="GeneID:9478"
                     /db_xref="HGNC:HGNC:1384"
                     /db_xref="MIM:605563"
     exon            1..714
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1173
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /note="isoform 3 is encoded by transcript variant 3;
                     calcium binding protein 5; caldendrin"
                     /codon_start=1
                     /product="calcium-binding protein 1 isoform 3"
                     /protein_id="NP_001028849.1"
                     /db_xref="CCDS:CCDS31913.1"
                     /db_xref="GeneID:9478"
                     /db_xref="HGNC:HGNC:1384"
                     /db_xref="MIM:605563"
                     /translation="MGGGDGAAFKRPGDGARLQRVLGLGSRREPRSLPAGGPAPRRTA
                     PPPPGHASAGPAAMSSHIAKSESKTSLLKAAAAAASGGSRAPRHGPARDPGLPSRRLP
                     GSCPATPQSSGDPSSRRPLCRPAPREEGARGSQRVLPQAHCRPREALPAAASRPSPSS
                     PLPPARGRDGEERGLSPALGLRGSLRARGRGDSVPAAASEADPFLHRLRPMLSSAFGQ
                     DRSLRPEEIEELREAFREFDKDKDGYINCRDLGNCMRTMGYMPTEMELIELSQQINMN
                     LGGHVDFDDFVELMGPKLLAETADMIGVKELRDAFREFDTNGDGEISTSELREAMRKL
                     LGHQVGHRDIEEIIRDVDLNGDGRVDFEEFVRMMSR"
     exon            715..745
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /inference="alignment:Splign:2.1.0"
     exon            746..889
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /inference="alignment:Splign:2.1.0"
     exon            890..999
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1147
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1597
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1575..1580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /note="hexamer: AATAAA"
     polyA_site      1597
                     /gene="CABP1"
                     /gene_synonym="CALBRAIN; HCALB_BR"
                     /note="major polyA site"
ORIGIN      
        1 agatctgcac cgccagccgc cgggagctcc gggctccggg cgtagaggct gcgctgtcac
       61 atgggcggcg gcgacggggc cgcatttaag cggccggggg acggcgcccg cctccagcgc
      121 gtcctcgggc ttggctcccg ccgggagccc cgttctctgc ccgccggggg ccccgcgccg
      181 cgccgcaccg cgccgccccc gccgggccat gcgagcgcgg gccccgccgc gatgagctcg
      241 cacatcgcca aaagcgagtc caagacgtcg ctgctgaagg cggcggcggc ggcggcgagc
      301 gggggcagcc gggctccccg ccacggccct gcccgggacc cggggctgcc tagccgccgg
      361 ctacccggct cctgcccggc gacgccgcag tcgtccgggg accccagttc gcggaggccc
      421 ctgtgccggc cggcgccgcg agaggagggc gcgcggggga gccagcgtgt gctcccccag
      481 gcgcactgca ggccccggga ggcgctgccg gccgcggcgt cccgaccttc gccgtcgtcg
      541 ccgctgccgc cggcccgcgg gcgggatggg gaggaacggg gactgtcccc ggcgctcggc
      601 ctccggggct ctctgcgagc ccggggccgc ggggactccg ttccagccgc cgcgtccgag
      661 gcggacccgt tcctccaccg gctgcgcccc atgctcagct ccgcctttgg ccaggataga
      721 tcactgcgac cagaggaaat tgaagagctc cgagaggcct tcagagaatt cgacaaggac
      781 aaggatggct acatcaactg ccgggatctg ggcaactgca tgcgcaccat gggctacatg
      841 cccaccgaga tggagctcat cgaactgtcc cagcagatca acatgaacct gggtggccat
      901 gtagattttg atgacttcgt ggagctaatg gggcctaaac tcctggcaga gacagcagat
      961 atgattggtg taaaggaact gcgagatgct ttccgagagt ttgacaccaa tggtgatggg
     1021 gaaataagca ccagtgagct gcgagaggct atgaggaagc tcctgggtca tcaggtggga
     1081 caccgagaca tagaggaaat tatccgagat gtggacctca atggggatgg acgagtggac
     1141 tttgaagagt ttgtccggat gatgtcccgc tgaggccgcg agggcccctc caggactgcc
     1201 aagctcccaa aggcggggct aagaggagct agagcttgcc tcacccgctg tagccgccga
     1261 gagcccagga tgtactggcg gatggggcct gcctgcaccc cggggaggcg cccaccccgg
     1321 acccccaccc ctccgcactg tgaaagacta actcctgcaa ctggaaagcg ggggcgcccg
     1381 ccgacgagga ggccaccgtg ccaagccggc agaggtcatg ccaggcgcca agggccatgt
     1441 gcccagctgc tgctggctgg gtgggccagg gagcccgcca gcagacccca cacagcatgt
     1501 ccgccccagg gcaaagcctc ccaccttcgc tctgcgcccg tcccagctcg cctcagccct
     1561 gttatctcag aaccaataaa aatatttcca agagcaa
//
