LOCUS       NM_031215               3783 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens Cdk5 and Abl enzyme substrate 2 (CABLES2), mRNA.
ACCESSION   NM_031215 XM_496479
VERSION     NM_031215.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3783)
  AUTHORS   Whiffin,N., Hosking,F.J., Farrington,S.M., Palles,C., Dobbins,S.E.,
            Zgaga,L., Lloyd,A., Kinnersley,B., Gorman,M., Tenesa,A.,
            Broderick,P., Wang,Y., Barclay,E., Hayward,C., Martin,L.,
            Buchanan,D.D., Win,A.K., Hopper,J., Jenkins,M., Lindor,N.M.,
            Newcomb,P.A., Gallinger,S., Conti,D., Schumacher,F., Casey,G.,
            Liu,T., Campbell,H., Lindblom,A., Houlston,R.S., Tomlinson,I.P. and
            Dunlop,M.G.
  CONSRTM   Swedish Low-Risk Colorectal Cancer Study Group
  TITLE     Identification of susceptibility loci for colorectal cancer in a
            genome-wide meta-analysis
  JOURNAL   Hum Mol Genet 23 (17), 4729-4737 (2014)
   PUBMED   24737748
REFERENCE   2  (bases 1 to 3783)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   3  (bases 1 to 3783)
  AUTHORS   Couch,F.J., Wang,X., Bamlet,W.R., de Andrade,M., Petersen,G.M. and
            McWilliams,R.R.
  TITLE     Association of mitotic regulation pathway polymorphisms with
            pancreatic cancer risk and outcome
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (1), 251-257 (2010)
   PUBMED   20056645
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 3783)
  AUTHORS   Matsuoka,M., Sudo,H., Tsuji,K., Sato,H., Kurita,M., Suzuki,H.,
            Nishimoto,I. and Ogata,E.
  TITLE     ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated
            and p53-independent apoptotic pathways
  JOURNAL   Biochem Biophys Res Commun 312 (2), 520-529 (2003)
   PUBMED   14637168
  REMARK    GeneRIF: We thus identified ik3-2 as a proapoptotic factor involved
            in both p53-mediated and p53-independent apoptotic pathways.
REFERENCE   5  (bases 1 to 3783)
  AUTHORS   Sato,H., Nishimoto,I. and Matsuoka,M.
  TITLE     ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5,
            and c-abl
  JOURNAL   Biochim Biophys Acta 1574 (2), 157-163 (2002)
   PUBMED   11955625
REFERENCE   6  (bases 1 to 3783)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121832.56.
            
            On Mar 24, 2021 this sequence version replaced NM_031215.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4188638.1,
                                           SRR11853560.18852.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279101.10/ ENSP00000279101.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-371               AL121832.56        30384-30754         c
            372-443             AL121832.56        19990-20061         c
            444-536             AL121832.56        19784-19876         c
            537-614             AL121832.56        18406-18483         c
            615-723             AL121832.56        17626-17734         c
            724-889             AL121832.56        16909-17074         c
            890-993             AL121832.56        16389-16492         c
            994-1100            AL121832.56        15858-15964         c
            1101-1305           AL121832.56        14718-14922         c
            1306-3783           AL121832.56        12103-14580         c
FEATURES             Location/Qualifiers
     source          1..3783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..3783
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /note="Cdk5 and Abl enzyme substrate 2"
                     /db_xref="GeneID:81928"
                     /db_xref="HGNC:HGNC:16143"
                     /db_xref="MIM:618772"
     exon            1..371
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1446
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /note="interactor with CDK3 2"
                     /codon_start=1
                     /product="CDK5 and ABL1 enzyme substrate 2"
                     /protein_id="NP_112492.2"
                     /db_xref="CCDS:CCDS33503.1"
                     /db_xref="GeneID:81928"
                     /db_xref="HGNC:HGNC:16143"
                     /db_xref="MIM:618772"
                     /translation="MAAAAAGGAPGPAPGPAGPPPPAAPTSAARAPPQALRRRGDSRR
                     RQAALFFLNNISLDGRPPSLGPGGEKPPPPPAEAREPPAPPPPEPPTGLPARTPAPQG
                     LLSPTQVPTGLGLDGQRQRKRVTSQRCSLEFLEDAVGCAPAQRTKHTSGSPRHKGLKK
                     THFIKNMRQYDTRNSRIVLICAKRSLCAAFSVLPYGEGLRISDLRVDSQKQRHPSGGV
                     SVSSEMVFELEGVELGADGKVVSYAKFLYPTNALVTHKSDSHGLLPTPRPSVPRTLPG
                     SRHKPAPTKSAPASTELGSDVGDTLEYNPNLLDDPQWPCGKHKRVLIFASYMTTVIEY
                     VKPSDLKKDMNETFREKFPHVKLTLSKIRSLKREMRSLSEECSLEPVTVAMAYVYFEK
                     LVLQGKLSKQNRKLCAGACVLLAAKISSDLRKSGVTQLIDKLEERFRFNRRDLIGFEF
                     TVLVALELALYLPENQVLPHYRRLTQQF"
     exon            372..443
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..536
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..614
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..723
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..889
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..993
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1100
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1305
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..3783
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3529..3534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /note="hexamer: AACAAA"
     polyA_site      3552
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
                     /note="major polyA site"
     polyA_site      3783
                     /gene="CABLES2"
                     /gene_synonym="C20orf150; dJ908M14.2; ik3-2"
ORIGIN      
        1 agtctgagga tggccgcggc cgcggccggt ggagccccgg gcccggcccc cggccccgcc
       61 gggcccccgc cacccgccgc gccgacctcg gccgctcggg ccccgccgca ggcgctgcgg
      121 aggcgcgggg actcgcggcg ccgccaggcc gcgcttttct tcctcaacaa catctccctg
      181 gacgggcggc ccccgagcct gggcccgggc ggagagaagc ccccgccgcc gcccgccgag
      241 gcccgcgaac cgccagcgcc gccgccgccg gagcccccca ccgggctgcc cgccaggacc
      301 cccgcgcccc agggcctgct cagccccacg caggtgccca ccggcctcgg cctggatggg
      361 cagcgccaga ggaagcgagt cacgtcccag cgctgctccc tggagtttct ggaagatgcc
      421 gtgggatgcg ctccagcaca gagaaccaaa cacacatctg gatcaccgag acataaaggc
      481 ctgaagaaga cccacttcat caagaacatg aggcagtacg acaccaggaa cagcaggatc
      541 gtgctcatct gtgccaagcg gtccctgtgc gcggccttct cggtcctgcc ctatggggaa
      601 ggcctgcgga tcagtgacct gagggtggac agccagaagc agaggcaccc gtccggcggc
      661 gtctctgtgt cttccgagat ggtctttgag ctagaaggtg tggagctagg agcagacggg
      721 aaggtcgtgt cttatgcgaa gttcctgtat cccaccaacg ccctggtcac acacaagagt
      781 gacagccatg gcctgctgcc cacacctcgg cccagtgtcc cccggactct gccagggtca
      841 agacataaac ctgcccccac caagtcggca ccagccagca cagaactagg gagtgacgtg
      901 ggggacaccc tggagtacaa ccccaacctc ctggatgacc cgcagtggcc ctgcggcaag
      961 cacaaacgtg tcctcatctt tgcgtcgtac atgaccacag tgatagaata cgtgaagccc
     1021 tcagacctca aaaaggacat gaacgagacc ttcagggaga agttccccca tgtcaaactg
     1081 acgctgagca aaatcaggag cttaaagcgg gagatgcgga gcctgtcgga ggagtgcagc
     1141 ctggagcccg tgacggtggc catggcctac gtgtactttg agaagctggt cctgcagggc
     1201 aagctcagca aacagaaccg caagctgtgc gctggcgcct gcgtgctgct ggctgccaag
     1261 atcagcagtg acctgcgcaa gagcggcgtg acgcagctca tcgataagtt agaagaaagg
     1321 tttcgattca acaggcgcga cctgataggg tttgagttca cagtgctcgt ggccttggag
     1381 ctggccctgt atcttcccga gaaccaagtg ttacctcatt acaggcgcct cacccagcag
     1441 ttctagcaga ggccccacag aaggctcagg gcaccgaggt gcacttgccg gcctgggagg
     1501 tgtcccactg aagccccgcg cctcctcctg ccagcacccc cagcacctgc tagcaggagg
     1561 cacctggcct ccgctggtgc agctttcctt tttgcctctt tgccatttcc ttggaaagag
     1621 acgtcgcttt catccccaag tgcaccgtcc ctccgagggg atttctgaga attctcctgc
     1681 atttttacat aaactaaatg tgaggtttgt tactggtatt tttttcacgt gcctgagacc
     1741 agcctggtac caggaccttt tgttcacagc gtgcagcagc gagccggctg cagtgtgtct
     1801 cccctggcct cgccttctgc aaaccaccgc agccaccaca gcgtcagggt ggagatctgg
     1861 gtttctagac ctcactgaac acactggaat ggctgagttt aacttattta ggcattcatc
     1921 ttggagatgt ggtttttcgg gttccccagc agcatctccc gacaccaact gtgccgctgg
     1981 ctccctgcca cctgaagccg agctcctcca gagctttctc cgcccacctc actgcatccc
     2041 aagtggagct tttggtgtcc agttaggcca gcgggagcag tctcctgatt tattttgatc
     2101 tcattcttgg actcttggac ctctctgttc ttcaagcatc gtgtcactgt gaaatcctaa
     2161 cgcccctgtg tcctacagac cgacggcaca acagacagct gcccatccca tgccatgctc
     2221 taccctctgc ctctcaccag gagacactct gggcctccag gacaattgct gcttgccggc
     2281 tcttattttt ctaagcaata ttgtgatgga gaaaaataac atatttattg ggatttggtt
     2341 ttttgggtct ttttttttta agggaacaaa aaatggttaa atgaggtctg ctgaagttga
     2401 cttgaaaaca cacttgaccc tcaggcagga gggcactgac cacaccccac acaacctcaa
     2461 agggtcagtg cgtcagtgcc ttttcttctg aggcaggaaa caggtgccat cttggccacc
     2521 tcggccaggg cagcccacca tgctaaaagg accccaaatg gtggtcgttg tcccttctgt
     2581 gcaggccagc agggccccat ctctagtttt tccacgtctg tctgaagttc ttgcaacaaa
     2641 ttctgcatgg tccagcgctc cagctagctg cctcatcaaa aacactgaat aaccaaggac
     2701 tgctgagttt ttcttcatgg ggggtcagct ggtctcaaaa ctggccactg cctcagccac
     2761 caagcttttt cctaccacta ccttataaac ctgcctggcc ctggaggggc tctgggacga
     2821 ctttgtctct agcccattaa tacaatacat cctatgcttt ctgtgcagac tggtgcttcc
     2881 gcagaaagga gatgccaatt ctgctatcac agaactccac cagcaactcc acccgacccc
     2941 agcagtggtg caggacagct gccagcaccc acctggccct cctccttttc cacagccact
     3001 cactggggcc accaaaaccc agagatggca ggtgtgtggg acagactgga ggatgaggac
     3061 aaaccaaagc ctttgttctt tcttattgtg gagcgtcccc ttccatcaag cagcctgccc
     3121 tcaagccaag gatcatcccc tggaacccag tatgcaccca gaggggactc agcttcaaag
     3181 ctgctccacc atgctgggtc ccaggcagct ttcctctgaa aagcaacctc tcctgccacc
     3241 cagatcccat ctcaagagct cgcccatgtt acgagcatgt aaaggactga cttcctagta
     3301 actgttgcag tttacaacct gccctccagg gacacgtctc catggttttt cctacacatg
     3361 aatgcgagaa atggctgata agcacagtaa tttaagattg cgtattcatg tagtgagatt
     3421 tagtcattaa ccaacccggt ctttgtgatg tgtgaagcct tcccttcagt tatgtcccat
     3481 ttttatgatg ccaaaagctg ccactgtgtg gtattcgagg attattgcaa caaagccagt
     3541 agttaaacca aactacagtc tcagcctgtc attctctaga acacatccag gtgtcggagc
     3601 taaggtgttc agctcggctg tgactataca gaaccaggcc tggcgttgct tccgcaccgg
     3661 tagcagttgt ggatgtcagt gtgcataagc aagtatcaga cctcagaatg tttgagttat
     3721 tttgtcttag atatctgttt ttaaatggat aatgtatttg tcctttaaac ctcagttttg
     3781 caa
//
