LOCUS       NM_001100619            5283 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens Cdk5 and Abl enzyme substrate 1 (CABLES1), transcript
            variant 2, mRNA.
ACCESSION   NM_001100619
VERSION     NM_001100619.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5283)
  AUTHORS   Hetty,S., Vranic,M., Kamble,P.G., Lundqvist,M.H., Pereira,M.J. and
            Eriksson,J.W.
  TITLE     CABLES1 expression is reduced in human subcutaneous adipose tissue
            in obesity and type 2 diabetes but may not directly impact
            adipocyte glucose and lipid metabolism
  JOURNAL   Adipocyte 12 (1), 2242997 (2023)
   PUBMED   37555665
  REMARK    GeneRIF: CABLES1 expression is reduced in human subcutaneous
            adipose tissue in obesity and type 2 diabetes but may not directly
            impact adipocyte glucose and lipid metabolism.
REFERENCE   2  (bases 1 to 5283)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5283)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 5283)
  AUTHORS   Liu,J., Wang,Y., Cui,J., Sun,M., Pu,Z., Wang,C., Du,W., Liu,X.,
            Wu,J., Hou,J., Zhang,S. and Yu,B.
  TITLE     miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac
            c-kit+ cells to promote proliferation and inhibit apoptosis through
            a negative feedback loop
  JOURNAL   Stem Cell Res Ther 8 (1), 127 (2017)
   PUBMED   28583208
  REMARK    GeneRIF: miR199a-3p and P53 are coupled through CABLES1 and
            comprise a novel negative feedback loop that likely contributes to
            cardiac c-kit(+) cell proliferation and apoptosis.
            Erratum:[Stem Cell Res Ther. 2019 Dec 20;10(1):404. doi:
            10.1186/s13287-019-1514-4.. PMID: 31862017]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5283)
  AUTHORS   Zhang,H., Duan,H.O., Kirley,S.D., Zukerberg,L.R. and Wu,C.L.
  TITLE     Aberrant splicing of cables gene, a CDK regulator, in human cancers
  JOURNAL   Cancer Biol Ther 4 (11), 1211-1215 (2005)
   PUBMED   16177568
  REMARK    GeneRIF: Analysis of the RT-PCR prducts of the CABLES1 gene showed
            eight intragenic deletions in its mRNA transcripts; 5/8 are the
            result of RNA splicing.
REFERENCE   6  (bases 1 to 5283)
  AUTHORS   Tsuji,K., Mizumoto,K., Yamochi,T., Nishimoto,I. and Matsuoka,M.
  TITLE     Differential effect of ik3-1/cables on p53- and p73-induced cell
            death
  JOURNAL   J Biol Chem 277 (4), 2951-2957 (2002)
   PUBMED   11706030
  REMARK    Erratum:[J Biol Chem 2002 May 10;277(19):17374]
REFERENCE   7  (bases 1 to 5283)
  AUTHORS   Wu,C.L., Kirley,S.D., Xiao,H., Chuang,Y., Chung,D.C. and
            Zukerberg,L.R.
  TITLE     Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits
            cell growth, and is lost in many human colon and squamous cancers
  JOURNAL   Cancer Res 61 (19), 7325-7332 (2001)
   PUBMED   11585773
REFERENCE   8  (bases 1 to 5283)
  AUTHORS   Yamochi,T., Nishimoto,I., Okuda,T. and Matsuoka,M.
  TITLE     ik3-1/Cables is associated with Trap and Pctaire2
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1045-1050 (2001)
   PUBMED   11527406
REFERENCE   9  (bases 1 to 5283)
  AUTHORS   Matsuoka,M., Matsuura,Y., Semba,K. and Nishimoto,I.
  TITLE     Molecular cloning of a cyclin-like protein associated with
            cyclin-dependent kinase 3 (cdk 3) in vivo
  JOURNAL   Biochem Biophys Res Commun 273 (2), 442-447 (2000)
   PUBMED   10873625
  REMARK    Erratum:[Biochem Biophys Res Commun 2000 Aug 11;274(3):880]
REFERENCE   10 (bases 1 to 5283)
  AUTHORS   Zukerberg,L.R., Patrick,G.N., Nikolic,M., Humbert,S., Wu,C.L.,
            Lanier,L.M., Gertler,F.B., Vidal,M., Van Etten,R.A. and Tsai,L.H.
  TITLE     Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine
            phosphorylation, kinase upregulation, and neurite outgrowth
  JOURNAL   Neuron 26 (3), 633-646 (2000)
   PUBMED   10896159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105247.16 and AC011731.8.
            
            On Sep 24, 2020 this sequence version replaced NM_001100619.2.
            
            Summary: This gene encodes a protein involved in regulation of the
            cell cycle through interactions with several cyclin-dependent
            kinases. One study (PMID: 16177568) reported aberrant splicing of
            transcripts from this gene which results in removal of the cyclin
            binding domain only in human cancer cells, and reduction in gene
            expression was shown in colorectal cancers (PMID:
            17982127).Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (2) uses an alternate first exon
            that contains the translation initiation site, resulting in an
            isoform (2) with a distinct N-terminus.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.403543.1,
                                           SRR14372079.2577418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256925.12/ ENSP00000256925.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1123              AC105247.16        103856-104978
            1124-1195           AC105247.16        157209-157280
            1196-1288           AC105247.16        162819-162911
            1289-1366           AC011731.8         23510-23587
            1367-1463           AC011731.8         44141-44237
            1464-1620           AC011731.8         45428-45584
            1621-1724           AC011731.8         46675-46778
            1725-1831           AC011731.8         62493-62599
            1832-2039           AC011731.8         63262-63469
            2040-5283           AC011731.8         66760-70003
FEATURES             Location/Qualifiers
     source          1..5283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..5283
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /note="Cdk5 and Abl enzyme substrate 1"
                     /db_xref="GeneID:91768"
                     /db_xref="HGNC:HGNC:25097"
                     /db_xref="MIM:609194"
     exon            1..1123
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..2180
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /note="isoform 2 is encoded by transcript variant 2; CDK5
                     and ABL1 enzyme substrate 1; interactor with CDK3 1"
                     /codon_start=1
                     /product="CDK5 and ABL1 enzyme substrate 1 isoform 2"
                     /protein_id="NP_001094089.1"
                     /db_xref="CCDS:CCDS42417.1"
                     /db_xref="GeneID:91768"
                     /db_xref="HGNC:HGNC:25097"
                     /db_xref="MIM:609194"
                     /translation="MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAP
                     AQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEEGGAAKPGAGGAC
                     GARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGP
                     GVARGFASPLGAGRASGEQWQPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQ
                     VPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGGSTSAFE
                     QLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTR
                     NGRIVLISGRRSFCSIFSVLPYRDSTQVGDLKLDGGRQSTGAVSLKEIIGLEGVELGA
                     DGKTVSYTQFLLPTNAFGARRNTIDSTSSFSQFRNLSHRSLSIGRASGTQGSLDTGSD
                     LGDFMDYDPNLLDDPQWPCGKHKRVLIFPSYMTTVIDYVKPSDLKKDMNETFKEKFPH
                     IKLTLSKIRSLKREMRKLAQEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGAC
                     VLLAAKIGSDLKKHEVKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMP
                     HYRRLVQSS"
     exon            1124..1195
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1288
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1366
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1463
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1620
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1724
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1831
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2039
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..5283
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3443..3448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3466
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /note="major polyA site"
     regulatory      5262..5267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /note="hexamer: AATAAA"
     polyA_site      5283
                     /gene="CABLES1"
                     /gene_synonym="CABL1; CABLES; HsT2563; IK3-1"
                     /note="major polyA site"
ORIGIN      
        1 gcgagccagc ggccaggcga ccggcgggcg gccagccagc gagccgaact agccgagcta
       61 ggtagcgagg cgtgcgcgtg ggccggggcg gcggcgcccc catccccagc accgaggggc
      121 gagcatggcc cgcccgcggg ggggctggac cgccgcgcac gccgcccgat ccccgcgccc
      181 tacccagccc gggtcgccgc cgctcgcgcc cgccgcttag cgctcgggcg ccgctcgctt
      241 ctccgggcat cgcggaaatc ccgccgcaga cggacacaat ggcggcggcg gcggcggccg
      301 ccaccacggc cgcctgcagc agcggcagcg ccggcaccga cgccgcgggc gccagcggat
      361 tgcagcagcc gccgccgcag ccccagcctc agcccgcggc cgccgcgccg gcccagccgc
      421 cgcccgaacc cccccggaag ccgcgcatgg acccgcggcg ccgccaggct gccctctcct
      481 tcctcaccaa catctcgctg gacggccggc tgccgccgca ggacgcggag tggggcggtg
      541 gcgaggaggg cggcgcggcc aagccgggcg ccggcggcgc ctgcggcgcg aggactcggt
      601 tcagcttgct cgccgctgcc gagcggggcg gctgcatcgc gctcgccgcg ccgggcacgc
      661 cggctgcggg gttagccgct gggtccggcc cctgcctccc acagccctcg tcgctgccgc
      721 ccttgattcc tggcggccat gcgaccgtgt ccggccccgg ggtggcgcgg gggttcgcga
      781 gtcccctggg cgccggccgg gcgtcggggg agcagtggca gccgccccgg ccggcgcctc
      841 tcgccgcctg tgcccaactg cagctgctcg acgggtccgg ggccgccggg caggaggagt
      901 tggaggagga cgatgccttt atcagcgtgc aggtgccggc ggccgccttt ttgggctccg
      961 ggacccccgg gagtgggagc ggcagtcggg gacgcctcaa ctcgttcact cagggaatcc
     1021 tgcccatcgc cttctccagg ccgacttcgc agaactactg ctccctggag cagccaggcc
     1081 agggcggcag caccagcgcc ttcgagcagc tgcagaggtc ccgacggcgc ctcatctccc
     1141 agagatcttc cttggagacc ctggaagata ttgaggagaa cgcccctctc cggagatgtc
     1201 gaactctctc aggttcaccc agaccaaaga attttaagaa gattcatttt atcaagaaca
     1261 tgcggcaaca cgataccagg aatggcagaa tagtccttat cagtggcaga agatccttct
     1321 gtagtatatt ttcagtgctg ccgtatcgcg acagtaccca agtcggggac ttgaagttgg
     1381 acggaggaag acaatcaact ggtgcagtga gtttgaaaga gatcattggt ctggaaggtg
     1441 tggagctggg tgctgatggg aagactgttt cctataccca atttctgtta cccacaaatg
     1501 cctttggagc ccggagaaat accatagact ccacctcctc tttctcccag ttccgtaacc
     1561 tgagccaccg cagcctctcc ataggccggg caagcggcac ccaggggagc ctcgacacag
     1621 gtagtgacct gggagacttt atggactatg acccaaatct cttggatgac ccccagtggc
     1681 cttgtggcaa acacaaacgc gttctgatct tcccttccta catgacaaca gtgattgact
     1741 acgtgaagcc ctcggatctc aagaaggaca tgaacgagac cttcaaggag aagtttcctc
     1801 acattaagct gacactcagc aaaattagga gtctgaaacg agagatgcgg aagcttgcgc
     1861 aggaggactg tggccttgag gagcccacgg tggccatggc cttcgtctac tttgaaaagc
     1921 tcgccctcaa ggggaaactc aacaaacaga accggaagct gtgtgctggg gcatgtgtgc
     1981 tgttagcagc caaaattgga agtgacctca aaaaacacga agtcaagcat ttaattgaca
     2041 aactggaaga gaagttccgg ctgaacaggc gagaactgat tgcctttgaa ttcccggtgt
     2101 tagtggcctt ggaattcgcc ctccacttgc ccgagcacga agtcatgccc cactacagac
     2161 ggctggtcca gagttcctag cactggcccc gaggacagcc aagggccatt tcttctcagc
     2221 ttggtggagc agcacttact tactactgga aatgaaaaaa agtagaactc agaataccag
     2281 acttttcttc ctctcgacat agtttgggga gaagcagtac tagaaacttt ccaaggagtc
     2341 ttgggtgtgt agccaagagg agccatgagc tatggactcc tcaagcacgg gaagaggagg
     2401 tgtgtgctga gaacagagag gccctgccct ctgtccacta gcgagaatcc ctagctgccc
     2461 cagcccagtc tttctccccg gcattcacaa actttgcaag cgtggtccag ggccttctcc
     2521 agatctgttc caacttggag tgtgaagggc ttgagcatac gggggaagag agtctgcaga
     2581 agttggggga aaacttttaa aagataccct cattgtgtca aagagtgtgc caatctattt
     2641 ttgtatcagc attggaagtg cactttcccc tggggcgtgt gggtgtgtga atgtgcaagt
     2701 gtctgagaga tactgcatca gccctagacc cccagagcca gtcccgccct ttacagagca
     2761 gcccttagcc tggggccatg ggtcaggctg accttcaaca attatttcta gatgatttct
     2821 ggataagaat tgctctctcg gtaccagaca gtttgacatc ctccaccctt agaaaatgac
     2881 tgacattgtt ttgttactgc tcctacccac caaggggata aagaaggcga gttctgagtg
     2941 ttggatgagt cagtcgcgtg gaaggacgtg gagcgtggcg ctctgtaact tcctgccgtc
     3001 tgccaccccg ccacgtgtat ttaaccctcg cactttctcc actgtggaga tggctggggc
     3061 ggcgccccac agtgtgtatt cctgtcctct atgttagagt gcatcagaag cacatttact
     3121 gtgctatcta tatcgctata taaaagtgtt ttataaaaac ccagaatagg agcacgacgc
     3181 atgattggtg tttgaggcgt ttgccagctg ggacaaactg cgtttggagc tgtggttaag
     3241 ctgactaagg aggcggtggc tctttcttaa cattcccacg tgcccagggc tgttcatgca
     3301 agattttaat ggtgacttgt cctggcttac tgggacagtc tgtatgaggc atgtcaccac
     3361 actgtcgcct catagctgca agagagaggc accagctgaa gttcccctga ctgaagagag
     3421 cctgtggcca tgtaaaaaga gaattaaact cttgttgctt tttgtatacc tgtatgcgtt
     3481 tgtgtagacg tgtgtctcac cagtcacctt tgccctgcat tgctgatccc cttgcgcaca
     3541 ctgattctag tgaggtcaca gattcggagc ttcacacacc agcccagaga aagggcgatg
     3601 gaaccgaacc gagggtctgc agctttcgtt agcagagctg tcagattctt gacagtcttg
     3661 gaggatggag aaattcaagc agcagctggt gagggccaaa acagaatact tggcttcttc
     3721 agaatcttag attgcactga gtttagtcct aaatattttg ctaacaaatt tccttggcca
     3781 gaatcagttg taagacagtg atttgggtgg tggggggagg gaggagggag aggatatgat
     3841 taatgtggtc tctttggctg atcgaaagct agatcaactg gtacttaggg cacttgctgt
     3901 ttataaagca aaattgagaa aatattcaag gtgcctccat cgcctgaact acaaaatgcc
     3961 cttggccttc ctcacatggg gtctgtcacc ttgcatctct gataagccat ccaccttcct
     4021 ggtcagtgcc tacaggggga gagcctttct gagaagcagg tcctgtggta tctgagaatg
     4081 gtctagagag ctccccactg cccatctgcc cccgaatttc ctgccaagct ctggggagtg
     4141 gggtgggggg agggacgtcc gatggatgac aggccgccag cccagacgtg gggagagaag
     4201 cctgagtcct ttcctgtgtg ataaaatcag gctaatttac ttggatttgg ggtgatttgt
     4261 ttggttttta gcatttatga ggtgagccca tgaagttagt ggtccattac tttttaaaga
     4321 tgcattttca ttttaaactg tctcctggcc tgtggatttg tggaatggac agttttgtgg
     4381 gttttaattt atttgtgagg agtcggggct gagaaggcat tttatcagga ggtctccttt
     4441 tgcacgtcca tgacatgagc ttttcggagg caaaggaagt ggaggagggt gagagatgca
     4501 ggtcactgcc agaggcacct ctgtgacacg gaacattcca gacacgtcgc agccttgggc
     4561 ttcggcgagg aggaagtctg agcctgtgaa gcgagaaggc caggcagtag actggctctg
     4621 aggttttgcc ctttgacctc ctccacagag ggcagcttca gccccttgta agccctgccc
     4681 cctctcagga ctgccctgag gcctctccag tcctccccac actcagagat ctgtggggaa
     4741 gctccgccca gccacactcc ttgggataat actagccggt tctgcctgat tccttttccc
     4801 ccggagccag cctagggggc ccgggactcc tctagtgagc cttgactgtt aggtaagaga
     4861 caggaagcag acaagccaag aggttgctgc agctgccccc aggaggaaac gggcagcagg
     4921 gagtgtggcc cagcccccac tgtacccctc caggggcccg agcccttgcc agcccaatga
     4981 caccttgaag tcaccacttt tcctttcttg cccgctaata aaacctattt aaacaggaaa
     5041 ttcataccaa atgcaaatgg gttttgtttt ccttggcatt ttgttgttcc gatcacagat
     5101 ttccctgcca gggtgtctgt ggttatcagc tgcaggctca gcttggggcg gccgcttcac
     5161 acaagccact ctgtaccacg tgccctacct tagtgacggg agtaaggagc ttccttcccc
     5221 tccatgtcat tccttcctgt tcccttcatt ccccaacagc aaataaaact gttgaatgct
     5281 ctg
//
