LOCUS       NM_012295               7233 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calcineurin binding protein 1 (CABIN1), transcript
            variant 2, mRNA.
ACCESSION   NM_012295 XM_005261418
VERSION     NM_012295.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7233)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7233)
  AUTHORS   Ray-Gallet,D., Ricketts,M.D., Sato,Y., Gupta,K., Boyarchuk,E.,
            Senda,T., Marmorstein,R. and Almouzni,G.
  TITLE     Functional activity of the H3.3 histone chaperone complex HIRA
            requires trimerization of the HIRA subunit
  JOURNAL   Nat Commun 9 (1), 3103 (2018)
   PUBMED   30082790
  REMARK    GeneRIF: analysis of the trimeric HIRA, UBN1 and CABIN1 H3.3
            histone chaperone complex
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7233)
  AUTHORS   Ricketts,M.D. and Marmorstein,R.
  TITLE     A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific
            Histone Chaperone Function
  JOURNAL   J Mol Biol 429 (13), 1924-1933 (2017)
   PUBMED   27871933
  REMARK    Review article
REFERENCE   4  (bases 1 to 7233)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 7233)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7233)
  AUTHORS   Youn,H.D., Grozinger,C.M. and Liu,J.O.
  TITLE     Calcium regulates transcriptional repression of myocyte enhancer
            factor 2 by histone deacetylase 4
  JOURNAL   J Biol Chem 275 (29), 22563-22567 (2000)
   PUBMED   10825153
REFERENCE   7  (bases 1 to 7233)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   8  (bases 1 to 7233)
  AUTHORS   Youn,H.D., Sun,L., Prywes,R. and Liu,J.O.
  TITLE     Apoptosis of T cells mediated by Ca2+-induced release of the
            transcription factor MEF2
  JOURNAL   Science 286 (5440), 790-793 (1999)
   PUBMED   10531067
REFERENCE   9  (bases 1 to 7233)
  AUTHORS   Sun,L., Youn,H.D., Loh,C., Stolow,M., He,W. and Liu,J.O.
  TITLE     Cabin 1, a negative regulator for calcineurin signaling in T
            lymphocytes
  JOURNAL   Immunity 8 (6), 703-711 (1998)
   PUBMED   9655484
REFERENCE   10 (bases 1 to 7233)
  AUTHORS   Laherty,C.D., Yang,W.M., Sun,J.M., Davie,J.R., Seto,E. and
            Eisenman,R.N.
  TITLE     Histone deacetylases associated with the mSin3 corepressor mediate
            mad transcriptional repression
  JOURNAL   Cell 89 (3), 349-356 (1997)
   PUBMED   9150134
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC253536.1 and AF072441.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012295.3.
            
            Summary: Calcineurin plays an important role in the T-cell
            receptor-mediated signal transduction pathway. The protein encoded
            by this gene binds specifically to the activated form of
            calcineurin and inhibits calcineurin-mediated signal transduction.
            The encoded protein is found in the nucleus and contains a leucine
            zipper domain as well as several PEST motifs, sequences which
            confer targeted degradation to those proteins which contain them.
            Alternative splicing results in multiple transcript variants
            encoding two different isoforms. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF072441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263119.10/ ENSP00000263119.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC253536.1         55272-55282
            12-7233             AF072441.1         2-7223
FEATURES             Location/Qualifiers
     source          1..7233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..7233
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /note="calcineurin binding protein 1"
                     /db_xref="GeneID:23523"
                     /db_xref="HGNC:HGNC:24187"
                     /db_xref="MIM:604251"
     exon            1..64
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            65..141
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..6801
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /note="isoform a is encoded by transcript variant 2;
                     calcineurin binding protein cabin 1; calcineurin
                     inhibitor"
                     /codon_start=1
                     /product="calcineurin-binding protein cabin-1 isoform a"
                     /protein_id="NP_036427.1"
                     /db_xref="CCDS:CCDS13823.1"
                     /db_xref="GeneID:23523"
                     /db_xref="HGNC:HGNC:24187"
                     /db_xref="MIM:604251"
                     /translation="MIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKAL
                     DLQKHDRFEESAKAYHELLEASLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQ
                     REDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPC
                     LDNLITVLYTLSDYTTCLYFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLK
                     CDMSIHDVSVSAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGES
                     LLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQPLESSMVVTPVNVIQPSTVSTNPAVA
                     VAEPVVSYTSVATTSFPLHSPGLLETGAPVGDISGGDKSKKGVKRKKISEESGETAKR
                     RSARVRNTKCKKEEKVDFQELLMKFLPSRLRKLDPEEEDDSFNNYEVQSEAKLESFPS
                     IGPQRLSFDSATFMESEKQDVHEFLLENLTNGGILELMMRYLKAMGHKFLVRWPPGLA
                     EVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSAV
                     SPRNCPAGMVNGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARF
                     LALQGDMEQALENYDICTEMLQSSTAIQVEAGAERRDIVIRLPNLHNDSVVSLEEIDK
                     NLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCTSGFDRAKHLEFMTSIPERPAQL
                     LLLQDSLLRLKDYRQCFECSDVALNEAVQQMVNSGEAAAKEEWVATVTQLLMGIEQAL
                     SADSSGSILKVSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEPHVSSVLPWIILHRIIW
                     QEEDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLR
                     FYVRVLQKELAASTSEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVD
                     LIWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTERPALSLDKVS
                     AYIEGTSTEVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFYMHDICICPNR
                     FDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNLSLWIEY
                     GTMSYALHSFASRQLKQWRGELPPELVQQMEGRRDSMLETAKHCFTSAARCEGDGDEE
                     EWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALE
                     VYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTPKASEKEKACLVD
                     EDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPHQQATPDDRSQDS
                     TAVALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQGATEERGKN
                     EESLESTEGFRAAEQGVQKPAAETPASACIPGKPSASTPTLWDGKKRGDLPGEPVAFP
                     QGLPAGAEEQRQFLTEQCIASFRLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDV
                     LLGSSIPWQQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLL
                     KVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELA
                     EGSERPGPKVCGLPGARMTTDVSHKASPEDGQEGLPQPKKPPLADGSGPGPEPGGKVG
                     LLNHRPVAMDAGDSADQSGERKDKESPRAGPTEPMDTSEATVCHSDLERTPPLLPGRP
                     ARDRGPESRPTELSLEELSISARQQPTPLTPAQPAPAPAPATTTGTRAGGHPEEPLSR
                     LSRKRKLLEDTESGKTLLLDAYRVWQQGQKGVAYDLGRVERIMSETYMLIKQVDEEAA
                     LEQAVKFCQVHLGAAAQRQASGDTPTTPKHPKDSRENFFPVTVVPTAPDPVPADSVQR
                     PSDAHTKPRPALAAATTIITCPPSASASTLDQSKDPGPPRPHRPEATPSMASLGPEGE
                     ELARVAEGTSFPPQEPRHSPQVKMAPTSSPAEPHCWPAEAALGTGAEPTCSQEGKLRP
                     EPRRDGEAQEAASETQPLSSPPTAASSKAPSSGSAQPPEGHPGKPEPSRAKSRPLPNM
                     PKLVIPSAATKFPPEITVTPPTPTLLSPKGSISEETKQKLKSAILSAQSAANVRKESL
                     CQPALEVLETSSQESSLESETDEDDDYMDI"
     exon            142..234
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            235..348
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            349..483
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            484..664
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            665..794
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            795..944
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1231
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1400
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1537
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1755
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1834
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2022
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2175
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2370
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2613
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2770
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2886
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3048
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3255
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3401
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3663
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3924
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4076
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4255
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            4256..4438
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4770
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            4771..4884
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            4885..5048
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5145
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            5146..5820
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            5821..5895
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            5896..6178
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            6179..6343
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            6344..6657
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     exon            6658..7233
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7216..7221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /note="hexamer: AATAAA"
     polyA_site      7233
                     /gene="CABIN1"
                     /gene_synonym="CAIN; KB-318B8.7; PPP3IN"
                     /note="major polyA site"
ORIGIN      
        1 gtcaggcgcg cagccggacg gcgcggtggt cgggacagac tggccgttgc tgtggagacg
       61 cctggagagt tgtggactgg ggcaaccttt gccagtgatg agaagtgatg ctcgtggcag
      121 tgctgaatct ctctgaatat gattcgaatt gcagccttaa atgccagctc caccattgag
      181 gatgatcatg aaggaagctt taaaagtcac aaaacccaga caaaggaggc tcaggaagca
      241 gaggcttttg cattgtacca caaggccctt gatctgcaga aacatgaccg gtttgaggag
      301 tctgccaaag cctaccatga gctcttggag gcgagcctgc tgcgggaggc agtttcatcc
      361 ggtgatgaga aagaggggtt gaaacaccct gggctgatac tgaaatattc cacttataag
      421 aacttggccc agctggcagc ccagcgggag gatctggaga cagccatgga gttctactta
      481 gaggcagtga tgctggactc cacagatgtc aacctctggt ataagattgg acatgtggcc
      541 ctgaggctca tccggatccc cctggctcgc catgcttttg aggaagggct gcggtgcaat
      601 cctgaccact ggccctgttt ggataaccta atcactgtcc tgtacaccct cagtgattac
      661 acaacatgtc tgtacttcat ctgcaaagct ttggagaagg attgccggta cagcaaaggg
      721 ctggtcctca aggagaagat ttttgaggag cagccttgtc tccggaagga ctctctcaga
      781 atgttcctca aatgtgacat gtcgattcac gatgtttcgg tgagtgcagc tgagacacag
      841 gcgattgtag atgaggcctt ggggctgcga aaaaagaggc aagcgctgat tgtgcgggag
      901 aaggagccgg acctgaaact tgtgcagccc attcctttct tcacctggaa gtgcctcgga
      961 gagagcttgc tggccatgta caatcatctc accacctgtg agcccccacg tcccagcctt
     1021 ggcaaaagga ttgatttgtc ggactaccag gaccccagcc agcctcttga gtcctccatg
     1081 gtggtgacgc cagttaacgt gatccagcca agcactgtca gcaccaaccc agctgtggct
     1141 gtcgccgagc ctgtggtctc ctacacctct gtggctacaa ccagcttccc actgcacagt
     1201 cctggtctgt tggagacagg cgctcctgtg ggtgatattt ctgggggaga taaatccaag
     1261 aaaggggtaa aacggaagaa gatttcagaa gagagtggag aaacagcaaa gcggcggtct
     1321 gcccgtgtcc gaaacaccaa gtgcaaaaaa gaagagaaag tagacttcca ggagcttctg
     1381 atgaagttct tgccgtccag gttaagaaag ctggaccctg aggaggaaga tgattccttt
     1441 aataactatg aagtccagtc agaagccaaa ctggaaagct tcccaagcat tgggcctcaa
     1501 aggctgtcat ttgactcagc cacattcatg gaatctgaaa agcaggacgt gcatgagttc
     1561 ctgctggaga acctaaccaa cgggggcatc ctggagctga tgatgcgcta cctgaaagcc
     1621 atgggccaca agttcttggt aaggtggcct ccaggcttgg cggaggtcgt gctcagcgtc
     1681 taccacagct ggaggaggca cagcaccagc ctgcccaacc cgctgctgag ggactgcagc
     1741 aacaagcaca tcaaggacat gatgctgatg tctctctcct gcatggaact ccagctggac
     1801 cagtggctgc tgaccaaagg cagaagctct gcagtgtctc ctcggaactg ccctgctggt
     1861 atggtgaatg gcagatttgg acctgacttc ccagggaccc actgcctggg tgacctccta
     1921 cagctgtcat ttgcctcgtc ccagcgcgac ctgttcgagg atggttggct ggagtttgtg
     1981 gtccgtgttt actggctgaa ggctcgcttc ctggcgctgc agggagacat ggagcaggcc
     2041 ctggagaact atgacatctg cacagaaatg ctccagagtt ccaccgccat ccaggtggag
     2101 gcaggggctg aacgaagaga cattgtcatc cggctgccca acctccataa tgactctgtg
     2161 gtttccctgg aggagattga taagaacctg aagtcgctgg agcggtgcca gtccctggag
     2221 gagattcagc ggctgtatga agcaggcgac tacaaggctg ttgtgcatct gctccgcccc
     2281 actttgtgca ccagtgggtt tgaccgggcc aaacacctgg agtttatgac ttccattcct
     2341 gagaggccag cccagctgct tcttctgcag gactccttgc tccggctgaa ggactatcgg
     2401 cagtgttttg agtgttccga tgtggctctg aacgaggctg tccagcagat ggtgaactca
     2461 ggtgaggctg ccgccaagga ggagtgggtg gccacagtga cccaactgct gatgggcatc
     2521 gagcaggccc tctctgcgga cagcagtggt agcatcctga aggtatcatc ctccaccact
     2581 ggccttgtgc ggctcaccaa caacctcatc caggtcattg actgcagcat ggctgtgcag
     2641 gaggaggcca aggagcccca cgtctcttca gtgctaccct ggatcattct acaccggatc
     2701 atctggcagg aggaagacac cttccattct ctgtgccacc agcagcagct ccaaaaccca
     2761 gcggaggaag ggatgtcaga gacgcccatg ctcccatcct ccctcatgct gctgaacaca
     2821 gcccacgagt atttgggcag aaggtcctgg tgctgcaatt cagatggggc tctgctgcga
     2881 ttctatgtgc gagtactcca gaaggaactg gctgcatcca cctctgaaga cacgcaccct
     2941 tacaaggagg agctggagac agccttggag cagtgcttct actgcctgta cagcttcccc
     3001 agcaagaaga gtaaggccag gtacctggag gaacactcgg cccagcaggt ggatcttata
     3061 tgggaggatg cactgttcat gtttgagtat tttaagccca agacccttcc tgaatttgac
     3121 agctataaga ccagcaccgt gtctgctgac ttggccaacc tactgaagag aattgccacc
     3181 attgtgcctc gcacagagag gccagccctt agcctggaca aagtctctgc ctacattgag
     3241 ggaacttcaa ctgaggtacc ctgcctccca gagggggctg acccctcccc tccagtggtg
     3301 aacgagcttt actacctcct ggctgattat catttcaaaa acaaggagca gtccaaggcc
     3361 atcaagttct acatgcatga catctgcatc tgccccaata ggtttgattc ctgggcaggc
     3421 atggctctgg cccgggccag ccgcattcag gacaagctga actccaatga gctgaagagt
     3481 gatgggccca tttggaagca tgccacgccc gtcttgaact gcttccgtcg ggccctggag
     3541 attgacagct ccaacttgtc cctatggatt gagtatggca ccatgtccta tgccttgcac
     3601 tcattcgcct cacgtcaatt gaagcagtgg agaggcgagc tgccccctga gctcgtgcag
     3661 cagatggagg gccggcgcga cagcatgcta gagacagcca agcactgttt cacatcagca
     3721 gcccgctgcg agggtgatgg tgacgaggag gagtggctca tccactacat gctgggcaag
     3781 gtggctgaga agcagcagca gccacccacc gtttacttgc tgcactacag gcaggctggc
     3841 cactacctgc acgaggaggc tgcccgctac cccaagaaga tccactacca caacccacct
     3901 gagctggcca tggaggccct ggaggtgtac tttcggctcc atgcttccat cctgaagctc
     3961 ctggggaagc ccgattctgg ggttggtgca gaggtcctgg tcaactttat gaaggaggct
     4021 gcagaaggac cctttgccag gggcgaggag aagaacacac ccaaagcttc agaaaaggag
     4081 aaggcctgcc tggtggacga ggactcccac tcttcagctg ggacactgcc gggccccgga
     4141 gcctccctcc cctcctcctc tggcccaggt ctgacatccc caccttacac agccactccg
     4201 attgaccacg attacgtcaa atgtaaaaaa ccccaccagc aggcaacgcc ggacgaccga
     4261 agccaggaca gcacagccgt agcactctca gactctagct caacgcagga cttctttaat
     4321 gagcccacca gcttactgga aggctccagg aaatcctaca cagagaagag gctgcccatt
     4381 ctcagttccc aagcaggagc gacgggtaaa gatcttcagg gggccacaga agaaagagga
     4441 aaaaacgagg agtcattgga gagtacagaa ggcttccggg ctgcagagca aggtgtccag
     4501 aagcctgctg cagaaacccc agcctctgct tgcatccctg gcaagccctc agcatccaca
     4561 cccaccctgt gggatgggaa gaagagaggg gacctcccag gggagccagt ggccttcccc
     4621 caggggctgc cggctggtgc tgaggagcag cggcagtttc tcacagagca gtgcatcgcc
     4681 tccttccgcc tgtgcctgag ccgcttcccc cagcactata agagtctcta ccgtctggcc
     4741 ttcctctaca cctacagcaa gacccaccgg aacctccagt gggcccgcga cgtgttgcta
     4801 ggcagcagta tcccgtggca acaactgcag cacatgccgg cacaggggct cttctgcgag
     4861 aggaacaaga ccaatttctt caacggcatc tggcggatcc ccgtggacga gattgaccgg
     4921 ccgggcagct ttgcctggca catgaaccgc tccatcgtgc tgctgctcaa ggtgctggcc
     4981 cagctgcggg accacagcac cctgctgaag gtgtcctcca tgcttcagcg gaccccagac
     5041 cagggcaaga agtatctgcg agatgctgac cgccaggtcc tggcgcagcg ggccttcatc
     5101 ctcactgtga aggtgctcga agacacgctg agcgagctcg cagaggggtc agaacgccca
     5161 gggcccaagg tctgtggcct ccccggagcc aggatgacca ccgatgtctc acacaaggcc
     5221 agtcctgagg atggccagga gggcctcccc cagccgaaga agccccctct ggctgatggc
     5281 tcagggccag ggcccgagcc aggaggcaaa gtgggcctcc tcaaccaccg gcctgtggcc
     5341 atggatgcag gagacagtgc agaccaaagc ggggagcgga aggataaaga gagcccacgg
     5401 gcagggccca ctgagcccat ggacacgagt gaggccactg tttgccactc agacttggag
     5461 cggacaccac ccctgctgcc aggtcgcccc gcaagggacc ggggccccga gagccggccc
     5521 actgagctgt ccctggagga gctgagcatc agtgcccggc agcagcccac cccgctcacc
     5581 ccagcccagc cagcccccgc ccccgccccc gccaccacca cagggaccag ggcagggggc
     5641 cacccggagg agccgctctc ccggctcagc cgcaagagga agctcctgga ggacacagag
     5701 tcaggcaaga cacttctgtt ggatgcctac cgtgtgtggc agcagggcca gaagggtgtg
     5761 gcctatgacc tgggccgtgt ggagaggatc atgtcggaga cctacatgct catcaagcag
     5821 gtggatgagg aggctgcgct ggagcaggct gtgaagttct gccaggtcca tcttggggct
     5881 gccgcccaga gacaggcctc gggggacacc cccaccactc caaagcaccc caaagacagc
     5941 cgagagaact tctttcctgt gacagtggtg cccacagccc ctgaccctgt gccagctgac
     6001 tctgtccagc ggcccagtga tgctcacacc aagcctcgcc ctgcactagc tgccgccaca
     6061 actattatca cctgccctcc gtcagcatca gcttccaccc tggaccagtc caaggaccct
     6121 gggcctcccc ggccacacag gcctgaagct acccccagca tggcctctct gggcccagag
     6181 ggagaagagc tggcgagagt ggcagagggc accagcttcc cgcctcagga gccacggcac
     6241 agtccgcagg tgaagatggc ccccacaagt tccccggcag agccacactg ctggccggca
     6301 gaggctgccc tgggcacagg cgctgagccc acctgcagcc aggaggggaa actgaggcct
     6361 gagccgagaa gggatgggga ggctcaggag gctgcgagtg agactcagcc cctgagctct
     6421 cccccaacag ctgccagctc caaggccccc agcagtggga gtgcccagcc accagagggt
     6481 cacccaggca agcctgagcc cagccgggct aagtcccgcc ccctgcccaa catgccaaag
     6541 ctggtcatcc cctccgccgc caccaagttc ccccctgaga tcaccgtcac gccacccacc
     6601 ccaaccctgc tctcccccaa aggcagcatc tcggaggaga ccaagcagaa gctgaagtca
     6661 gccatccttt ctgcccagtc tgctgccaac gtgaggaagg agagcctatg ccagccagcc
     6721 ctggaggtcc tggagacatc cagccaggag tcctcgctgg agagcgagac agacgaggac
     6781 gacgactaca tggacatttg aggggccact gcagccccac cgccacgccc caggggacca
     6841 gccaggcctg gaatgccccc tgggcaggac cctgggcagg accagaggcc cacatggatg
     6901 ccactcccca cacagccccc aggcctgccc agcccacctc ctcatggcat cctccctgta
     6961 cccaggtcag gctgtccaca ccacatggga gcccagagga ggaggggccc gccttagcca
     7021 tgtgaaggtg gattggtcgc catctgcacg ccaggcggca tccttttcta tgaagtgttg
     7081 actttgtaaa tctgcccaca cccagctggc catatccacc cctcgacgcc gggatgagcc
     7141 ggctctgcct gtgtcacagt ggaggggtcc tttagggcca ggctcacccc tcaccctttt
     7201 tttggttgct tttctaataa agatggaaca gtt
//
