LOCUS       NM_001366906            1688 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ciliary associated calcium binding coiled-coil 1
            (CABCOCO1), transcript variant 3, mRNA.
ACCESSION   NM_001366906 XM_006717690
VERSION     NM_001366906.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1688)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1688)
  AUTHORS   Ngoc,P.C.T., Tan,S.H., Tan,T.K., Chan,M.M., Li,Z., Yeoh,A.E.J.,
            Tenen,D.G. and Sanda,T.
  TITLE     Identification of novel lncRNAs regulated by the TAL1 complex in
            T-cell acute lymphoblastic leukemia
  JOURNAL   Leukemia 32 (10), 2138-2151 (2018)
   PUBMED   29654272
REFERENCE   3  (bases 1 to 1688)
  AUTHORS   Kawashima,A., Kigoshi,T., Katoh,Y., Ishikawa,Y., Shawki,H.H.,
            Inoue,N., Tamba,M., Matsuda,M. and Okamura,N.
  TITLE     CABCOCO1, a novel coiled-coil protein With calcium-binding
            activity, is localized in the sperm flagellum
  JOURNAL   Mol Reprod Dev 83 (10), 912-926 (2016)
   PUBMED   26990073
REFERENCE   4  (bases 1 to 1688)
  AUTHORS   Niu,N., Schaid,D.J., Abo,R.P., Kalari,K., Fridley,B.L., Feng,Q.,
            Jenkins,G., Batzler,A., Brisbin,A.G., Cunningham,J.M., Li,L.,
            Sun,Z., Yang,P. and Wang,L.
  TITLE     Genetic association with overall survival of taxane-treated lung
            cancer patients - a genome-wide association study in human
            lymphoblastoid cell lines followed by a clinical association study
  JOURNAL   BMC Cancer 12, 422 (2012)
   PUBMED   23006423
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1688)
  AUTHORS   Wain,L.V., Verwoert,G.C., O'Reilly,P.F., Shi,G., Johnson,T.,
            Johnson,A.D., Bochud,M., Rice,K.M., Henneman,P., Smith,A.V.,
            Ehret,G.B., Amin,N., Larson,M.G., Mooser,V., Hadley,D., Dorr,M.,
            Bis,J.C., Aspelund,T., Esko,T., Janssens,A.C., Zhao,J.H., Heath,S.,
            Laan,M., Fu,J., Pistis,G., Luan,J., Arora,P., Lucas,G., Pirastu,N.,
            Pichler,I., Jackson,A.U., Webster,R.J., Zhang,F., Peden,J.F.,
            Schmidt,H., Tanaka,T., Campbell,H., Igl,W., Milaneschi,Y.,
            Hottenga,J.J., Vitart,V., Chasman,D.I., Trompet,S.,
            Bragg-Gresham,J.L., Alizadeh,B.Z., Chambers,J.C., Guo,X.,
            Lehtimaki,T., Kuhnel,B., Lopez,L.M., Polasek,O., Boban,M.,
            Nelson,C.P., Morrison,A.C., Pihur,V., Ganesh,S.K., Hofman,A.,
            Kundu,S., Mattace-Raso,F.U., Rivadeneira,F., Sijbrands,E.J.,
            Uitterlinden,A.G., Hwang,S.J., Vasan,R.S., Wang,T.J., Bergmann,S.,
            Vollenweider,P., Waeber,G., Laitinen,J., Pouta,A., Zitting,P.,
            McArdle,W.L., Kroemer,H.K., Volker,U., Volzke,H., Glazer,N.L.,
            Taylor,K.D., Harris,T.B., Alavere,H., Haller,T., Keis,A.,
            Tammesoo,M.L., Aulchenko,Y., Barroso,I., Khaw,K.T., Galan,P.,
            Hercberg,S., Lathrop,M., Eyheramendy,S., Org,E., Sober,S., Lu,X.,
            Nolte,I.M., Penninx,B.W., Corre,T., Masciullo,C., Sala,C.,
            Groop,L., Voight,B.F., Melander,O., O'Donnell,C.J., Salomaa,V.,
            d'Adamo,A.P., Fabretto,A., Faletra,F., Ulivi,S., Del Greco,F.,
            Facheris,M., Collins,F.S., Bergman,R.N., Beilby,J.P., Hung,J.,
            Musk,A.W., Mangino,M., Shin,S.Y., Soranzo,N., Watkins,H., Goel,A.,
            Hamsten,A., Gider,P., Loitfelder,M., Zeginigg,M., Hernandez,D.,
            Najjar,S.S., Navarro,P., Wild,S.H., Corsi,A.M., Singleton,A., de
            Geus,E.J., Willemsen,G., Parker,A.N., Rose,L.M., Buckley,B.,
            Stott,D., Orru,M., Uda,M., van der Klauw,M.M., Zhang,W., Li,X.,
            Scott,J., Chen,Y.D., Burke,G.L., Kahonen,M., Viikari,J., Doring,A.,
            Meitinger,T., Davies,G., Starr,J.M., Emilsson,V., Plump,A.,
            Lindeman,J.H., Hoen,P.A., Konig,I.R., Felix,J.F., Clarke,R.,
            Hopewell,J.C., Ongen,H., Breteler,M., Debette,S., Destefano,A.L.,
            Fornage,M., Mitchell,G.F., Smith,N.L., Holm,H., Stefansson,K.,
            Thorleifsson,G., Thorsteinsdottir,U., Samani,N.J., Preuss,M.,
            Rudan,I., Hayward,C., Deary,I.J., Wichmann,H.E., Raitakari,O.T.,
            Palmas,W., Kooner,J.S., Stolk,R.P., Jukema,J.W., Wright,A.F.,
            Boomsma,D.I., Bandinelli,S., Gyllensten,U.B., Wilson,J.F.,
            Ferrucci,L., Schmidt,R., Farrall,M., Spector,T.D., Palmer,L.J.,
            Tuomilehto,J., Pfeufer,A., Gasparini,P., Siscovick,D.,
            Altshuler,D., Loos,R.J., Toniolo,D., Snieder,H., Gieger,C.,
            Meneton,P., Wareham,N.J., Oostra,B.A., Metspalu,A., Launer,L.,
            Rettig,R., Strachan,D.P., Beckmann,J.S., Witteman,J.C., Erdmann,J.,
            van Dijk,K.W., Boerwinkle,E., Boehnke,M., Ridker,P.M.,
            Jarvelin,M.R., Chakravarti,A., Abecasis,G.R., Gudnason,V.,
            Newton-Cheh,C., Levy,D., Munroe,P.B., Psaty,B.M., Caulfield,M.J.,
            Rao,D.C., Tobin,M.D., Elliott,P. and van Duijn,C.M.
  CONSRTM   LifeLines Cohort Study; EchoGen consortium; AortaGen Consortium;
            CHARGE Consortium Heart Failure Working Group; KidneyGen
            consortium; CKDGen consortium; Cardiogenics consortium; CardioGram
  TITLE     Genome-wide association study identifies six new loci influencing
            pulse pressure and mean arterial pressure
  JOURNAL   Nat Genet 43 (10), 1005-1011 (2011)
   PUBMED   21909110
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1688)
  AUTHORS   Ho,J.E., Levy,D., Rose,L., Johnson,A.D., Ridker,P.M. and
            Chasman,D.I.
  TITLE     Discovery and replication of novel blood pressure genetic loci in
            the Women's Genome Health Study
  JOURNAL   J Hypertens 29 (1), 62-69 (2011)
   PUBMED   21045733
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1688)
  AUTHORS   Liu,C., Li,H., Qi,Q., Lu,L., Gan,W., Loos,R.J. and Lin,X.
  TITLE     Common variants in or near FGF5, CYP17A1 and MTHFR genes are
            associated with blood pressure and hypertension in Chinese Hans
  JOURNAL   J Hypertens 29 (1), 70-75 (2011)
   PUBMED   20852445
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 1688)
  AUTHORS   Niu,W., Zhang,Y., Ji,K., Gu,M., Gao,P. and Zhu,D.
  TITLE     Confirmation of top polymorphisms in hypertension genome wide
            association study among Han Chinese
  JOURNAL   Clin Chim Acta 411 (19-20), 1491-1495 (2010)
   PUBMED   20542020
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1688)
  AUTHORS   Newton-Cheh,C., Johnson,T., Gateva,V., Tobin,M.D., Bochud,M.,
            Coin,L., Najjar,S.S., Zhao,J.H., Heath,S.C., Eyheramendy,S.,
            Papadakis,K., Voight,B.F., Scott,L.J., Zhang,F., Farrall,M.,
            Tanaka,T., Wallace,C., Chambers,J.C., Khaw,K.T., Nilsson,P., van
            der Harst,P., Polidoro,S., Grobbee,D.E., Onland-Moret,N.C.,
            Bots,M.L., Wain,L.V., Elliott,K.S., Teumer,A., Luan,J., Lucas,G.,
            Kuusisto,J., Burton,P.R., Hadley,D., McArdle,W.L., Brown,M.,
            Dominiczak,A., Newhouse,S.J., Samani,N.J., Webster,J., Zeggini,E.,
            Beckmann,J.S., Bergmann,S., Lim,N., Song,K., Vollenweider,P.,
            Waeber,G., Waterworth,D.M., Yuan,X., Groop,L., Orho-Melander,M.,
            Allione,A., Di Gregorio,A., Guarrera,S., Panico,S., Ricceri,F.,
            Romanazzi,V., Sacerdote,C., Vineis,P., Barroso,I., Sandhu,M.S.,
            Luben,R.N., Crawford,G.J., Jousilahti,P., Perola,M., Boehnke,M.,
            Bonnycastle,L.L., Collins,F.S., Jackson,A.U., Mohlke,K.L.,
            Stringham,H.M., Valle,T.T., Willer,C.J., Bergman,R.N., Morken,M.A.,
            Doring,A., Gieger,C., Illig,T., Meitinger,T., Org,E., Pfeufer,A.,
            Wichmann,H.E., Kathiresan,S., Marrugat,J., O'Donnell,C.J.,
            Schwartz,S.M., Siscovick,D.S., Subirana,I., Freimer,N.B.,
            Hartikainen,A.L., McCarthy,M.I., O'Reilly,P.F., Peltonen,L.,
            Pouta,A., de Jong,P.E., Snieder,H., van Gilst,W.H., Clarke,R.,
            Goel,A., Hamsten,A., Peden,J.F., Seedorf,U., Syvanen,A.C.,
            Tognoni,G., Lakatta,E.G., Sanna,S., Scheet,P., Schlessinger,D.,
            Scuteri,A., Dorr,M., Ernst,F., Felix,S.B., Homuth,G., Lorbeer,R.,
            Reffelmann,T., Rettig,R., Volker,U., Galan,P., Gut,I.G.,
            Hercberg,S., Lathrop,G.M., Zelenika,D., Deloukas,P., Soranzo,N.,
            Williams,F.M., Zhai,G., Salomaa,V., Laakso,M., Elosua,R.,
            Forouhi,N.G., Volzke,H., Uiterwaal,C.S., van der Schouw,Y.T.,
            Numans,M.E., Matullo,G., Navis,G., Berglund,G., Bingham,S.A.,
            Kooner,J.S., Connell,J.M., Bandinelli,S., Ferrucci,L., Watkins,H.,
            Spector,T.D., Tuomilehto,J., Altshuler,D., Strachan,D.P., Laan,M.,
            Meneton,P., Wareham,N.J., Uda,M., Jarvelin,M.R., Mooser,V.,
            Melander,O., Loos,R.J., Elliott,P., Abecasis,G.R., Caulfield,M. and
            Munroe,P.B.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study identifies eight loci associated with
            blood pressure
  JOURNAL   Nat Genet 41 (6), 666-676 (2009)
   PUBMED   19430483
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL451049.11 and AC022398.7.
            
            On May 21, 2020 this sequence version replaced NM_001366906.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14243140.10435206.1,
                                           SRR5189667.102486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648843.3/ ENSP00000496918.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AL451049.11        98591-98694
            105-208             AL451049.11        108294-108397
            209-378             AL451049.11        116805-116974
            379-523             AL451049.11        121703-121847
            524-596             AL451049.11        126211-126283
            597-719             AC022398.7         72292-72414         c
            720-860             AC022398.7         71470-71610         c
            861-1688            AC022398.7         65707-66534         c
FEATURES             Location/Qualifiers
     source          1..1688
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..1688
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /note="ciliary associated calcium binding coiled-coil 1"
                     /db_xref="GeneID:219621"
                     /db_xref="HGNC:HGNC:28678"
     exon            1..104
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..935
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /note="isoform 2 is encoded by transcript variant 3;
                     uncharacterized protein C10orf107; ciliary-associated
                     calcium-binding coiled-coil protein 1; ARID5B-inducing
                     enhancer associated long noncoding RNA"
                     /codon_start=1
                     /product="ciliary-associated calcium-binding coiled-coil
                     protein 1 isoform 2"
                     /protein_id="NP_001353835.1"
                     /db_xref="CCDS:CCDS91247.1"
                     /db_xref="GeneID:219621"
                     /db_xref="HGNC:HGNC:28678"
                     /translation="MSQGTTPWGPTPAGTTPESERDTEFQEHEKILSPDFLSVAQITD
                     LLMEDIDGVQEKLRIFLNFKNLETCLKDAILLDYYVSGFLWARGMDFSIIQYSKFMTL
                     LAMSLQNLKTLHMSLEESIKWLGEVMAEIGPTHSQKSEDWNIFDVKQANAIIDYLKIS
                     LFQHYKLYEFMFYSAREEIVIGTEQVIEVVKSACGPFPNPLEEGISFDIYSTFIEPPT
                     ILDTEMKRLDQEQGPEESQPETDTSDMDPLVGFTIEDVKSVLDQVTDDILIGIQTEIN
                     EKLQIQEEAFNARIEKLKKA"
     exon            105..208
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /inference="alignment:Splign:2.1.0"
     exon            209..378
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /inference="alignment:Splign:2.1.0"
     exon            379..523
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /inference="alignment:Splign:2.1.0"
     exon            524..596
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /inference="alignment:Splign:2.1.0"
     exon            597..719
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /inference="alignment:Splign:2.1.0"
     exon            720..860
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1688
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1234..1239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /note="hexamer: AATAAA"
     polyA_site      1255
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /note="major polyA site"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /note="hexamer: AAGAAA"
     polyA_site      1329
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
     regulatory      1500..1505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
                     /note="hexamer: ATTATA"
     polyA_site      1528
                     /gene="CABCOCO1"
                     /gene_synonym="ARIEL; C10orf107"
ORIGIN      
        1 gcctaggtga cgaggggccg cttctctcgg ccgagattgc ggcgatgtcg caggggacga
       61 ctccctgggg gccgaccccg gcgggaacca cgcccgaatc ggagagagac actgaattcc
      121 aggagcatga aaagattctg tctccggatt ttctttcagt tgcccaaatc actgatttgt
      181 taatggagga catcgatgga gttcaagaaa aactgagaat atttttgaat ttcaaaaacc
      241 ttgaaacttg tttaaaggat gccattctac tagattatta tgtatctgga tttttgtggg
      301 ctagaggaat ggatttctct attattcagt attcaaaatt tatgacttta ctagctatgt
      361 cacttcaaaa tcttaaaaca ctacatatgt ccttagagga aagcataaaa tggcttggag
      421 aagttatggc tgaaatagga ccaacacatt cgcaaaagag tgaggactgg aatatctttg
      481 atgtaaaaca agccaatgct atcattgatt acttaaaaat cagcttattt caacactaca
      541 agctatacga gtttatgttc tactctgcca gggaagaaat tgtgatagga actgagcaag
      601 tgatagaggt tgtcaagtct gcatgtggcc ctttcccaaa tcctctggaa gaaggaatct
      661 catttgatat ttattcaaca ttcatagagc cccccacaat attggatacg gaaatgaaga
      721 ggttggatca agaacaaggc cctgaggagt ctcagccaga aactgacacc tcagacatgg
      781 atcctttagt tggttttacc attgaagatg taaaatcagt gctggatcaa gtcacagatg
      841 acattttaat cggcattcag accgagataa acgaaaaact gcaaatacag gaagaggcct
      901 ttaatgcacg aatagaaaaa ttgaaaaagg cctaaggact tggtacaagg agagtgatgc
      961 taaacttcac agaaacaaac aaaaccagcc agaataacag actctctgga gcgtcgtgtc
     1021 tccatcactt agttgtgaaa ggaaaaccaa gccccacttt ttattttcct aagtaattag
     1081 aaaagtattg gtcccaattt tgctatctcc catcccataa cagcctctga atttattgca
     1141 ccaagtgtaa tgagaacatt ttgtatacaa gagtttgaaa aattatatat aaaaatacaa
     1201 ttacttttat gatagtcctt tgacgttttg actaataaat cctattcatc ttcaaggaga
     1261 atgaagtcaa ctttttaaat aaccagaaat aaagaaagat gataataact tcatccattt
     1321 tgacccaaac ggactgccac gttactggaa cactgtgaaa acataccagt accacactat
     1381 tgaggataaa atttgttaaa caatagcaat tcaaatgcat atatgaggtt tttttttttt
     1441 ttactgaaat catttggttt tcttatttaa acgtttcagt gtgaaaccaa ttttctgaaa
     1501 ttatataatg cagtttgaag cactttaatt tattctgtac tgtatttgtt atttctaatc
     1561 ttgttactct cccaggagaa tacatgacct atataaaaag aagcaatgta taaatggtta
     1621 ttaaagacca acctatatat agattgtaaa aatcttaaat acaaatcaaa ctcatagagt
     1681 tcccagaa
//
