LOCUS       NM_001079670            3502 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens calcium binding protein 39 like (CAB39L), transcript
            variant 2, mRNA.
ACCESSION   NM_001079670
VERSION     NM_001079670.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3502)
  AUTHORS   Lee,S., Bondaruk,J., Wang,Y., Chen,H., Lee,J.G., Majewski,T.,
            Mullen,R.D., Cogdell,D., Chen,J., Wang,Z., Yao,H., Kus,P.,
            Jeong,J., Lee,I., Choi,W., Navai,N., Guo,C., Dinney,C.,
            Baggerly,K., Mendelsohn,C., McConkey,D., Behringer,R.R., Kimmel,M.,
            Wei,P. and Czerniak,B.
  TITLE     Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal
            urothelial differentiation program, contributing to bladder
            carcinogenesis
  JOURNAL   Cell Rep 43 (5), 114146 (2024)
   PUBMED   38676926
  REMARK    GeneRIF: Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal
            urothelial differentiation program, contributing to bladder
            carcinogenesis.
REFERENCE   2  (bases 1 to 3502)
  AUTHORS   Wu,Y., Xu,Z., Chen,X., Fu,G., Tian,J., Shi,Y., Sun,J. and Jin,B.
  TITLE     Bioinformatics Prediction and Experimental Verification Identify
            CAB39L as a Diagnostic and Prognostic Biomarker of Kidney Renal
            Clear Cell Carcinoma
  JOURNAL   Medicina (Kaunas) 59 (4), 716 (2023)
   PUBMED   37109674
  REMARK    GeneRIF: Bioinformatics Prediction and Experimental Verification
            Identify CAB39L as a Diagnostic and Prognostic Biomarker of Kidney
            Renal Clear Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3502)
  AUTHORS   Bai,J., Wang,J., Yang,Y., Wang,F., He,A. and Zhang,W.
  TITLE     Identification of HLA-A*0201-restricted CTL Epitopes for
            MLAA-34-specific Immunotherapy for Acute Monocytic Leukemia
  JOURNAL   J Immunother 44 (4), 141-150 (2021)
   PUBMED   33596023
  REMARK    GeneRIF: Identification of HLA-A*0201-restricted CTL Epitopes for
            MLAA-34-specific Immunotherapy for Acute Monocytic Leukemia.
REFERENCE   4  (bases 1 to 3502)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3502)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3502)
  AUTHORS   Zhao,J., He,A., Zhang,W., Meng,X. and Gu,L.
  TITLE     Quantitative assessment of MLAA-34 expression in diagnosis and
            prognosis of acute monocytic leukemia
  JOURNAL   Cancer Immunol Immunother 60 (4), 587-597 (2011)
   PUBMED   21240483
  REMARK    GeneRIF: our data indicate that MLAA-34 may be used as a prognostic
            marker for treatment decision-making in acute monocytic leukemia
REFERENCE   7  (bases 1 to 3502)
  AUTHORS   Zhang,P.Y., Zhang,W.G., He,A.L., Wang,J.L. and Li,W.B.
  TITLE     Identification and functional characterization of the novel acute
            monocytic leukemia associated antigen MLAA-34
  JOURNAL   Cancer Immunol Immunother 58 (2), 281-290 (2009)
   PUBMED   18592235
  REMARK    GeneRIF: It was proposed that a splice variant MLAA-34 of CAB39L
            associated with acute monocytic leukemia.  MLAA-34 was identified
            and characterized.  Identification and functional characterization
            of the novel acute monocytic leukemia associated antigen MLAA-34
REFERENCE   8  (bases 1 to 3502)
  AUTHORS   Kahn,B.B., Alquier,T., Carling,D. and Hardie,D.G.
  TITLE     AMP-activated protein kinase: ancient energy gauge provides clues
            to modern understanding of metabolism
  JOURNAL   Cell Metab 1 (1), 15-25 (2005)
   PUBMED   16054041
  REMARK    Review article
REFERENCE   9  (bases 1 to 3502)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   10 (bases 1 to 3502)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB051338.1, BX647518.1, BC010993.2, AL138875.8 and AW134845.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001079670.2.
            
            Transcript Variant: This variant (2) lacks a 5' non-coding exon
            compared to variant 1. Variants 1-5 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.211827.1,
                                           SRR1660803.23513.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409308.6/ ENSP00000386375.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB051338.1         285-285
            2-598               BX647518.1         1-597
            599-599             BC010993.2         537-537
            600-2354            BX647518.1         599-2353
            2355-3219           AL138875.8         69759-70623         c
            3220-3502           AW134845.1         17-299              c
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..3502
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /note="calcium binding protein 39 like"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
     exon            1..79
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            80..217
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            218..293
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            294..435
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1338
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /note="sarcoma antigen NY-SAR-79; antigen MLAA-34;
                     U937-associated antigen; mo25-like protein; MO25beta"
                     /codon_start=1
                     /product="calcium-binding protein 39-like"
                     /protein_id="NP_001073138.1"
                     /db_xref="CCDS:CCDS9416.2"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
                     /translation="MKKMPLFSKSHKNPAEIVKILKDNLAILEKQDKKTDKASEEVSK
                     SLQAMKEILCGTNEKEPPTEAVAQLAQELYSSGLLVTLIADLQLIDFEGKKDVTQIFN
                     NILRRQIGTRSPTVEYISAHPHILFMLLKGYEAPQIALRCGIMLRECIRHEPLAKIIL
                     FSNQFRDFFKYVELSTFDIASDAFATFKDLLTRHKVLVADFLEQNYDTIFEDYEKLLQ
                     SENYVTKRQSLKLLGELILDRHNFAIMTKYISKPENLKLMMNLLRDKSPNIQFEAFHV
                     FKVFVASPHKTQPIVEILLKNQPKLIEFLSSFQKERTDDEQFADEKNYLIKQIRDLKK
                     TAP"
     exon            436..600
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            601..719
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            720..888
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            889..948
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1014
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1158
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..3502
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1477..1482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /note="hexamer: TATAAA"
     polyA_site      1500
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /note="major polyA site"
     regulatory      2329..2334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /note="hexamer: AATAAA"
     polyA_site      2354
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /note="major polyA site"
     regulatory      3485..3490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /note="hexamer: AATAAA"
     polyA_site      3502
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /note="major polyA site"
ORIGIN      
        1 gcactgtagc tgagccaatg gagttactcg tagtcgagag gccggcatca ctggagtggt
       61 ggcgcagctg tttcctccgg atatccatca aatattgaga agaaagaata tcaggagcaa
      121 agtgttctaa gttgctgttc agaacgtaaa gatgcgaacc ccaaatcagt ggtttgttca
      181 ttcttcatgc aagagcaatg cactaaagga gagaagcaag ctgtggtgat cagtgacttt
      241 ggtgaaagct aagaaggttc aaacaaattt gcaaatgata tacaacttct aagcattcca
      301 tattggaaga agagatttct acacatgaaa aaaatgcctt tgtttagtaa atcacacaaa
      361 aatccagcag aaattgtgaa aatcctgaaa gacaatttgg ccattttgga aaagcaagac
      421 aaaaagacag acaaggcttc agaagaagtg tctaaatcac tgcaagcaat gaaagaaatt
      481 ctgtgtggta caaacgagaa agaaccccca acagaagcag tggctcagct agcacaagaa
      541 ctctacagca gtggcctgct agtgacactg atagctgacc tgcagctgat agactttgag
      601 ggaaaaaaag atgtgaccca gatatttaac aacatcttga gaagacagat aggcactcgg
      661 agtcctactg tggagtatat tagtgctcat cctcatatcc tgtttatgct cctcaaagga
      721 tatgaagccc cacagattgc cttacgttgt gggattatgc tgagagaatg tattcgacat
      781 gaaccacttg ccaaaatcat cctcttttct aatcaattca gagatttctt taagtacgtg
      841 gagttgtcaa catttgatat tgcttcagat gcctttgcta ctttcaagga tttactaacc
      901 agacataaag tgttggtagc agacttctta gaacaaaatt acgacactat ttttgaagac
      961 tatgagaaat tgcttcagtc tgagaattat gttactaaga gacagtcttt aaagctgcta
     1021 ggggagctga tcctggaccg tcacaacttt gccatcatga caaagtatat cagcaagccg
     1081 gagaacctga aactcatgat gaacctcctt cgggataaaa gtcccaacat ccagtttgaa
     1141 gcctttcatg tttttaaggt gtttgtggcc agtcctcaca aaacacagcc tattgtggag
     1201 atcctgttaa aaaatcagcc caaactcatt gagtttctga gcagcttcca aaaagaaagg
     1261 acggatgatg agcagttcgc tgacgagaag aactacttga ttaaacagat ccgagacttg
     1321 aagaaaacgg ccccttgaag agctccccgg cccctgtcac agtcagtcgt ctcatttgtc
     1381 cagtttgtac agtgtgtcat ttcagaaagt catcattctt gggaagactt tggaggtgcc
     1441 tattttttct gctgtaattg ttctgggtag atggagtata aacatttgaa tggaaaaaaa
     1501 ttaacctaga ataatatatt cattttagtc aagtctgtga ttatttatgt gaaatgagaa
     1561 ccattgtatc agatgttgat aaaagcaatt ttaacttgca gatgtgagcc cctgggcaca
     1621 atgagccgct aaatgggagc tcaattgaca ggcatcacca agtcttcaag gaggactgag
     1681 ttctcagggg agaactggga atggggccag ggtgcaaaaa tgctttgccc atctgtaggt
     1741 agacacacag atcgctcagg gcactgagag atcccagaag gtaacgttaa tgttttcagt
     1801 cattgtgtgt cctttgttgc tgccaatgtc tttggactgt aatcagtgca tccacacctc
     1861 ccaggatcca gtgctccctc tcagctcagt ctcccctctc tccctgtcct gcattccatc
     1921 ccagctcctc agcatggcct cagtgggcgc acccatgcct cccgcagtcc aggtgagcag
     1981 gggagcaact gagcaggaag aggatggatc aacaagggtc acggggaata ggggacccac
     2041 ggggtgtgac ctgcttgcta gagaactgtg aacatgtggc tctggataga gtgactgctg
     2101 ctccatatta gcttccagag ggtgagtgag ggacagaata tttccttcat aatggtcatg
     2161 ggtgaatgct ttctgctgta agtgtctttt agagtaggaa tcagcatagt gggatgccca
     2221 gcaggcacaa accatgggtc cagggagtct cagcggggaa cttctatcag tatcaataac
     2281 cattggaagg agaaatgatt catgtgtgaa aaaattctca gatccatcaa taaatttttt
     2341 tcagagccat tgtatcagat gttgataaaa gcaatttttt tctaataagc tgtcattcta
     2401 taattgccca tcacagtctt tagtgaacac atagaaagcc tatacagttt tggtcctgaa
     2461 tagtctcttg tgactaggat gattgaggtg ttaattcctc ttccttataa aaaggcttgg
     2521 aatcaaaaat attttaaaag gccgtggttt cgtttcagac atcaaccatc taaaacggga
     2581 ttttaaagcg atattttaca agaatgaaag gcacaattgt tgatctgtat tttttacact
     2641 tcagtttcta aatcatgaat cgttgccttc cacaggaacc ctcccttata cattacttga
     2701 gtgttgtgta gtttttcttc agccaggtat ttctctgcct agagagggga agagaaatgt
     2761 gttctccagg actgatcccc tttgtagatt ttgtacctga agagttacct ggcagggcac
     2821 cacccttggc taggcccagg tgtgtgtttc tttcttgcct ggcatggacc ccgaggcagg
     2881 tgatgtgggg cctggcgcac ctccccgctt tggcagctgt ggcctccctg gccagtgccc
     2941 ttgcaggagg ccggccggca gcctgatgac ccgtactctt tagtcactga cgtcagatta
     3001 tttttataac gttccctgac agttcagagt cccttcgaat tgcacttttc tggtttcgct
     3061 tatttaatta aaagagatga gtgtaagtat aaaaaatgaa ggtgaaataa ccattggaat
     3121 tgtatttggt tacttaatac tgttccacaa catcttggga cgtctgtttt cctttggaga
     3181 gtgaggcctt gttattattc ttttctgata aagaaaacat tttatttcct ttgggcttgc
     3241 attagctctt tcctagcaac ccattatccc agctcagtac ctttcaaaca gaaaactaga
     3301 gtctggggtt ttgttgtgat ctgaatttgt aagttattaa tgtgaaaggg ggagcaggaa
     3361 gctccccctt tgcacaaagg gggatttgtt tgcacaaagt tcactgtaaa tactgtgaga
     3421 attgaattct gaaaaggtca tatttagtga tttcaaaagc acacatttaa atgaagactg
     3481 actaaataaa aggtaccaca ca
//
