LOCUS       NM_016289               3829 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calcium binding protein 39 (CAB39), transcript variant
            1, mRNA.
ACCESSION   NM_016289
VERSION     NM_016289.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3829)
  AUTHORS   Wang,L., Liu,H., Wu,Q., Liu,Y., Yan,Z., Chen,G., Shang,Y., Xu,S.,
            Zhou,Q., Yan,T. and Cheng,X.
  TITLE     miR-451a was selectively sorted into exosomes and promoted the
            progression of esophageal squamous cell carcinoma through CAB39
  JOURNAL   Cancer Gene Ther 31 (7), 1060-1069 (2024)
   PUBMED   38649419
  REMARK    GeneRIF: miR-451a was selectively sorted into exosomes and promoted
            the progression of esophageal squamous cell carcinoma through
            CAB39.
REFERENCE   2  (bases 1 to 3829)
  AUTHORS   Gao,D., Wang,R., Gong,Y., Yu,X., Niu,Q., Yang,E., Fan,G., Ma,J.,
            Chen,C., Tao,Y., Lu,J. and Wang,Z.
  TITLE     CAB39 promotes cisplatin resistance in bladder cancer via the
            LKB1-AMPK-LC3 pathway
  JOURNAL   Free Radic Biol Med 208, 587-601 (2023)
   PUBMED   37726090
  REMARK    GeneRIF: CAB39 promotes cisplatin resistance in bladder cancer via
            the LKB1-AMPK-LC3 pathway.
REFERENCE   3  (bases 1 to 3829)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3829)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   5  (bases 1 to 3829)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3829)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 3829)
  AUTHORS   Milburn,C.C., Boudeau,J., Deak,M., Alessi,D.R. and van Aalten,D.M.
  TITLE     Crystal structure of MO25 alpha in complex with the C terminus of
            the pseudo kinase STE20-related adaptor
  JOURNAL   Nat Struct Mol Biol 11 (2), 193-200 (2004)
   PUBMED   14730349
REFERENCE   8  (bases 1 to 3829)
  AUTHORS   Boudeau,J., Baas,A.F., Deak,M., Morrice,N.A., Kieloch,A.,
            Schutkowski,M., Prescott,A.R., Clevers,H.C. and Alessi,D.R.
  TITLE     MO25alpha/beta interact with STRADalpha/beta enhancing their
            ability to bind, activate and localize LKB1 in the cytoplasm
  JOURNAL   EMBO J 22 (19), 5102-5114 (2003)
   PUBMED   14517248
REFERENCE   9  (bases 1 to 3829)
  AUTHORS   Hawley,S.A., Davison,M., Woods,A., Davies,S.P., Beri,R.K.,
            Carling,D. and Hardie,D.G.
  TITLE     Characterization of the AMP-activated protein kinase kinase from
            rat liver and identification of threonine 172 as the major site at
            which it phosphorylates AMP-activated protein kinase
  JOURNAL   J Biol Chem 271 (44), 27879-27887 (1996)
   PUBMED   8910387
REFERENCE   10 (bases 1 to 3829)
  AUTHORS   Miyamoto,H., Matsushiro,A. and Nozaki,M.
  TITLE     Molecular cloning of a novel mRNA sequence expressed in cleavage
            stage mouse embryos
  JOURNAL   Mol Reprod Dev 34 (1), 1-7 (1993)
   PUBMED   8418809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA886579.1, BC020570.1, BG773506.1, AK000804.1 and AF113536.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016289.3.
            
            Transcript Variant: This variant (1) represents an alternate
            non-coding exon in the 5'UTR. The same protein is encoded by
            variants 1, 2, and 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020570.1, SRR1660803.138490.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258418.10/ ENSP00000258418.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               DA886579.1         1-108
            109-200             BC020570.1         1-92
            201-651             BG773506.1         193-643
            652-1937            BC020570.1         544-1829
            1938-3827           AK000804.1         1441-3330
            3828-3829           AF113536.1         3448-3449
FEATURES             Location/Qualifiers
     source          1..3829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..3829
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /note="calcium binding protein 39"
                     /db_xref="GeneID:51719"
                     /db_xref="HGNC:HGNC:20292"
                     /db_xref="MIM:612174"
     exon            1..389
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     exon            390..546
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1458
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /note="MO25alpha"
                     /codon_start=1
                     /product="calcium-binding protein 39"
                     /protein_id="NP_057373.1"
                     /db_xref="CCDS:CCDS2478.1"
                     /db_xref="GeneID:51719"
                     /db_xref="HGNC:HGNC:20292"
                     /db_xref="MIM:612174"
                     /translation="MPFPFGKSHKSPADIVKNLKESMAVLEKQDISDKKAEKATEEVS
                     KNLVAMKEILYGTNEKEPQTEAVAQLAQELYNSGLLSTLVADLQLIDFEGKKDVAQIF
                     NNILRRQIGTRTPTVEYICTQQNILFMLLKGYESPEIALNCGIMLRECIRHEPLAKII
                     LWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYDRFFSEYEKLL
                     HSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFH
                     VFKVFVANPNKTQPILDILLKNQAKLIEFLSKFQNDRTEDEQFNDEKTYLVKQIRDLK
                     RPAQQEA"
     exon            547..711
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     exon            712..830
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     exon            831..999
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1059
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1125
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1269
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..3829
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3802..3807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /note="hexamer: ATTAAA"
     regulatory      3807..3812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /note="hexamer: AATAAA"
     polyA_site      3813
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
     polyA_site      3820
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
     polyA_site      3829
                     /gene="CAB39"
                     /gene_synonym="CGI-66; MO25"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcgca cgtcaaagcc gggctcgggc cgcaagcggg gcgaggggtt cggggagcgg
       61 cgcggcctgg gagacacaga gccttcaggc gccggggcgg gggcacaggc gaagactaag
      121 gcggcgccgg gccccacagc agcagccgca gcccaagcga gcgcagcagc gcggcggcag
      181 ccgcgggagc ccctgggcag ccgtccgccc gcgcagccgc cgccgccgcg ggagcccgtc
      241 gccgggagca ggagcgggcg gaagacaacg gaggggccga gcgtccgagc cactccgcgg
      301 ggaccgaacg agcagcccga agcggcggcg gccgaggacg gggacagcga cgacgcggag
      361 gcagagaagg gaacgcccgg cccagccccg tagcacaggc ggagtgcagc ggaggcccct
      421 gccgctgccg tcatgccgtt cccgtttggg aagtctcaca aatctccagc agacattgtg
      481 aagaatctga aggagagcat ggctgttctg gaaaagcaag acatttctga taaaaaagca
      541 gaaaaggcta cagaagaagt ttccaaaaat ctggttgcca tgaaagaaat tctgtatggc
      601 acaaatgaaa aagagcctca gacagaagca gtagctcaac ttgctcaaga actctataat
      661 agtgggctcc ttagcaccct ggtagctgat ttacagctca ttgactttga gggcaaaaaa
      721 gacgtggctc aaattttcaa caatattctc agaagacaaa ttggtacgag aactcctact
      781 gttgaataca tctgcaccca acagaatatt ttgttcatgt tattgaaagg gtatgaatct
      841 ccagaaatag ctctaaattg tggaataatg ttaagagaat gcatcagaca tgaaccactt
      901 gcaaaaatca ttttgtggtc ggaacagttt tatgatttct tcagatatgt cgaaatgtca
      961 acatttgaca tagcttcaga tgcatttgcc acattcaagg atttacttac aagacataaa
     1021 ttgctcagtg cagaattttt ggaacagcat tatgatagat ttttcagtga atatgagaag
     1081 ttacttcatt cagaaaatta tgtgacaaaa agacagtcac tgaagcttct cggtgaacta
     1141 ctactagata gacacaactt cacaattatg acaaaataca tcagtaaacc tgagaacctc
     1201 aaattaatga tgaacctgct gcgagacaaa agtcgcaaca tccagtttga ggcctttcac
     1261 gtttttaagg tgtttgtagc caatcctaac aagacgcagc ccatcctaga catcctcctc
     1321 aagaaccagg ccaaactcat agagttcctc agcaagtttc agaacgacag gacggaggat
     1381 gagcagttta acgacgagaa gacctattta gttaaacaga tcagggattt gaagagacca
     1441 gctcagcaag aagcttaatc tccaataaac atctatgtta aatccaaatt cagcatttgc
     1501 tgttagctat tcagcatcag gcactcttat tgattcatga ggaacattac tgctaatctg
     1561 ctgttaagtg aacggttttt cattttaccc ttttgttttt cagtccaggt tggagatcgt
     1621 agctgctgct gcttgcacac tagggcacat gtgggctttc tcttgatctt tgtgtcattt
     1681 cagaattcaa agactgtgct acgggagttc tgaacatggc tgggttcatg aaggcaaatg
     1741 tatggatgag agtgtggttt aggaaagagg gcactgatat cagattagac ctatgtgttt
     1801 gcacccatct ttgttggcga tctgagtgca gtgtggcaag tgcacacctg gcatccctgc
     1861 gtcagatcgc gcaccttcag gtcgcgcacc ttcgctgaag gaagatgacg cagagcttta
     1921 tctgaaatca gaggggagct atccaaaatg ggagtttggg ggcagctaaa gttgacatgc
     1981 gaataaattg atactgaaac ttagcaactt cttaaaagtg taaagaagcc tcataagatc
     2041 ataaggaaaa tgtatatatg cttttcacag ctttctagaa ttttttgaca tttgattttc
     2101 ttgagacttg taaacctgga tatgttgaag ggtatttgtt aattttactt ttcaaagata
     2161 ctttaaaaca gtagagctag caatgacacc ttgcatttca tttcaacact gcttcaaggt
     2221 ttcttttgta tataattctt agaatgctca tttcttttaa atggtttaat ttgtacagca
     2281 gaggaatgtt attgtagtag tatgtaacta ttacctaata ctgagttttt gcaaaaaaca
     2341 atgaatgctc atatgtaatt gaaatacttc agatcacatg aaaatgctga tttaacattt
     2401 aagtatcaca gcattaaaag aaaaagaaag taaaccagtc ctttgtattc agttacctaa
     2461 tggggtgcca tcaataagct gcgatacagc cctggagctc agtcagccac accttcctgc
     2521 atcctattgg ccttattcat tttaaatgag ttaatgaatc tgccagatct gtgaatgata
     2581 gagattatgc taaattaatg ctgattcttt gtgtgtgtgg gaaatctctg tagagcacct
     2641 tttctttctt agactaagta acccagtaca atagttgtga actgaataat taaaactttg
     2701 gcttctctta ggaaaagacg acttcctagt cataggtgtc ctatggggaa atttattttt
     2761 tttaatgtcc tgttccttaa tgctgcaaat tatcagtatt tataaagtaa ctgattttgc
     2821 accacttttt tgttactgtg accacggcag aacaatgtct tctagactat atctatgtaa
     2881 agttattaga atggtatctg ttcattttag tgatatgaag atcacaacta acaactgaca
     2941 aatcagagtt tgccagttca aattcagcat ggctgcagct gattaagaaa ttgatatgat
     3001 tattctttgc tagcctctct tactaatgga attatatact ggccagtaaa atgggcctcc
     3061 caattgctgt ttcagcaggt tttaaacctt caggaacacc agttaggaaa atagctccag
     3121 aaaatataga tatattttat ttttattaaa atggcagtct acatcataat tggcatttct
     3181 caagactgtc tttaccagaa tctgtgtgaa ataaggcaat ctagtctcct tgaaaaaaaa
     3241 atctcttgga tgtttaggaa ggaagacttg gccgtgatgt ggtgtcctgg ctttgtggtg
     3301 tagtgctgtg tgtatggagt tagtgtaaaa acatggatta caccaagtgg aagaaacgtc
     3361 ttcttgccaa gctcattctt agaacttaca catctagaac agcttccact ttggcagtga
     3421 ggtcgtagcc ttttaggtgg aagaagtgag ggtgcagcgt gtcagacaca acattcatgt
     3481 tactcttaca ttggaatctg aaggtagttc agacttcgtg ggttttgttt ttaagcaaaa
     3541 caatgtgaaa acatttaagt ttgaaatgtt gcatttgaag ttatgatcat ttaatatatt
     3601 catattacca agactattat actggaagtg gtttttgtgt tataaaggtt taattttaca
     3661 taaggcagtt acttaatgtg atttttaacc cttaaaaaag tggagatgta tacatttgtt
     3721 aacaatgcca tgaaagcatt ttctttctcc taaggaaaag tgaatttctt atcagaatat
     3781 ctggctggcc ctgtaattta aattaaaata aaattttgga gaaacagca
//
