LOCUS       NM_024828               2789 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens caspase activity and apoptosis inhibitor 1 (CAAP1),
            transcript variant 1, mRNA.
ACCESSION   NM_024828
VERSION     NM_024828.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2789)
  AUTHORS   Ni,M., Zhou,J., Gong,W., Jiang,R., Li,X., Dai,W., Yin,Z., Chen,Z.,
            Zheng,Z. and Zhu,J.
  TITLE     Proteomic analysis reveals CAAP1 negatively correlates with
            platinum resistance in ovarian cancer
  JOURNAL   J Proteomics 277, 104864 (2023)
   PUBMED   36870674
  REMARK    GeneRIF: Proteomic analysis reveals CAAP1 negatively correlates
            with platinum resistance in ovarian cancer.
REFERENCE   2  (bases 1 to 2789)
  AUTHORS   Chen,J.Y., Chen,H., Li,T., Yang,L., Ye,X.M., Gao,W.Y., Zhang,S.P.
            and Zong,L.
  TITLE     LncRNA LncOGD-1006 alleviates OGD-induced ischemic brain injury
            regulating apoptosis through miR-184-5p/CAAP1 axis
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (23), 12324-12333 (2020)
   PUBMED   33336752
  REMARK    GeneRIF: LncRNA LncOGD-1006 alleviates OGD-induced ischemic brain
            injury regulating apoptosis through miR-184-5p/CAAP1 axis.
REFERENCE   3  (bases 1 to 2789)
  AUTHORS   Zhang,H.M., Li,H., Wang,G.X., Wang,J., Xiang,Y., Huang,Y., Shen,C.,
            Dai,Z.T., Li,J.P., Zhang,T.C. and Liao,X.H.
  TITLE     MKL1/miR-5100/CAAP1 loop regulates autophagy and apoptosis in
            gastric cancer cells
  JOURNAL   Neoplasia 22 (5), 220-230 (2020)
   PUBMED   32315812
  REMARK    GeneRIF: MKL1/miR-5100/CAAP1 loop regulates autophagy and apoptosis
            in gastric cancer cells.
REFERENCE   4  (bases 1 to 2789)
  AUTHORS   Zhang,Y., Johansson,E., Miller,M.L., Janicke,R.U., Ferguson,D.J.,
            Plas,D., Meller,J. and Anderson,M.W.
  TITLE     Identification of a conserved anti-apoptotic protein that modulates
            the mitochondrial apoptosis pathway
  JOURNAL   PLoS One 6 (9), e25284 (2011)
   PUBMED   21980415
  REMARK    GeneRIF: The data suggest that C9orf82 functions as an
            anti-apoptotic protein that modulates a caspase-10 dependent
            mitochondrial caspase-3/9 feedback amplification loop. It is
            designated as Conserved Anti-Apoptotic Protein (CAAP).
REFERENCE   5  (bases 1 to 2789)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2789)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 2789)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP228742.1, BC071953.1 and AF131768.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024828.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071953.1, SRR1660809.10313.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMN03267764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333916.8/ ENSP00000369431.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BP228742.1         27-101
            76-960              BC071953.1         1-885
            961-2789            AF131768.1         120-1948
FEATURES             Location/Qualifiers
     source          1..2789
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.2"
     gene            1..2789
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /note="caspase activity and apoptosis inhibitor 1"
                     /db_xref="GeneID:79886"
                     /db_xref="HGNC:HGNC:25834"
     exon            1..390
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1173
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     conserved anti-apoptotic protein"
                     /codon_start=1
                     /product="caspase activity and apoptosis inhibitor 1
                     isoform 1"
                     /protein_id="NP_079104.3"
                     /db_xref="CCDS:CCDS6516.1"
                     /db_xref="GeneID:79886"
                     /db_xref="HGNC:HGNC:25834"
                     /translation="MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCG
                     SAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRSTDSSSVSGSLQQE
                     TKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQ
                     KMLPDVLKNCSIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSD
                     LVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINADAYDSDIEGPCNEEAAA
                     PEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQ
                     QLELLELEMRARAIKALMKAGDIKKPA"
     exon            391..591
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..676
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /inference="alignment:Splign:2.1.0"
     exon            677..752
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /inference="alignment:Splign:2.1.0"
     exon            753..826
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /inference="alignment:Splign:2.1.0"
     exon            827..2789
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1976..1981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /note="hexamer: AATAAA"
     polyA_site      1997
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
     regulatory      2198..2203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /note="hexamer: AATAAA"
     polyA_site      2220
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /note="major polyA site"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /note="hexamer: AATAAA"
     polyA_site      2528
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
                     /note="hexamer: ATTAAA"
     polyA_site      2789
                     /gene="CAAP1"
                     /gene_synonym="C9orf82; CAAP"
ORIGIN      
        1 agtgcctgcc gcccacggcc gcaggagtcg ggcttcggtc gcaccagaga cagcggactt
       61 tcctccgatg gttgcagcag agggatcatg acggggaaaa agtcctcccg ggagaaacgg
      121 cgcaaacgta gcagtcagga ggcggccgca gcgctcgcgg ccccggacat cgtacccgcg
      181 ttggccagcg gcagcagtgg aagcactagc ggctgcggga gcgccggggg ctgcgggagc
      241 gtcagctgct gtgggaacgc caattttagt ggaagtgtca ccggcggtgg gagcggcggc
      301 agctgttggg gcgggagcag cgtggagcgc agcgagcgcc ggaagcggag gagtaccgac
      361 tcttccagcg tctcgggctc cttgcagcag gaaactaaat atattttgcc aactttggaa
      421 aaagaattat tcttggcaga gcacagtgac cttgaagaag gtggactgga cctgactgtg
      481 tcattgaaac cagttagttt ctatatatca gacaaaaaag aaatgcttca gcagtgcttc
      541 tgtattatag gagagaaaaa gttacagaag atgcttcctg atgtgttaaa gaactgttca
      601 atagaagaaa ttaaaaaact atgccaggaa cagttagagc tcctgtctga aaaaaaaatt
      661 ttgaagattc ttgagggtga caatggaatg gactctgata tggaagagga agcagatgat
      721 ggttctaaga tgggatctga tttagtcagt cagcaagaca tctgtataga ttctgcttca
      781 tccgtgagag agaataagca acctgaaggt ttggaattaa aacaaggaaa aggggaagat
      841 agtgatgtac tcagtataaa tgcagatgct tatgacagcg acatagaagg cccatgcaac
      901 gaagaagcag ctgctcccga ggcaccagaa aatacagtcc aaagtgaagc tggtcagata
      961 gatgacctgg agaaagacat tgagaaaagt gtgaatgaga ttctaggact ggcagagtct
     1021 agcccaaacg aacccaaagc agccaccctg gctgttcctc caccagaaga tgttcaacct
     1081 tctgcacagc aactggagct gctagaactt gagatgaggg caagagcgat taaagcccta
     1141 atgaaagctg gtgatataaa aaagccagcc taggtattta acttgatttt gaattttagg
     1201 tatgtttgaa caaagccaca tcatttaatt ttgtatctaa aatttatttg gggtcttata
     1261 tgttatttct catgtaaccc ttattaggac tcattttagc cctaaattac ctgtggctgt
     1321 ttctttttat ttttttgact acttttatat tataaatgtg tgttactgtc ttatgaattc
     1381 atggcaatat agttggatag cctggatact ttgttagatg agtatttagc tgtgtctgca
     1441 aatcttaaaa gccattagca aagagtcgtg gtattttttt ctttattttt aaatgtttgg
     1501 gcaccaaacc taaaagcaaa agattgacga agcatgtttc tcttaaggct acttgtattt
     1561 tacaatacaa tattaaatta tttaatttga gaaatttagt tttgcttata tgcacttttt
     1621 aaatatatac tattttgaag attccttatg taaatgcaaa tttcctagtt aaaaccgaat
     1681 aacagagatc tgaaatgact gagaaaaact tttttattaa aggaaggaat taatttaagg
     1741 caatttttaa ctatgtagaa ctaattgccc atgtttaatt atagcagaca cgccattcta
     1801 acaggtattt gataccattg gatgcattat tctaggtttt ttctttaata aaaatggaac
     1861 aagttttcat ttacattcca agctgtcagg aaatgaagaa tattttatta tctaggattt
     1921 tatctgatgt agttgcttaa agatctgatg tgctataatt ccatgaatca gaaataataa
     1981 aatgctatca ttctggatct gaagactttt gatacttttt caaaagcaaa attaatttca
     2041 ggaacctttg ataagttgtt gttataatta atctaatttt gtatagtttt tgtaaataaa
     2101 ttaccatcct tccacaatta gggatgcttt tatcccccca tcactaattg cagttgtttg
     2161 ataccaaaat aaatttacgt agagatcctt aacttaaaat aaattaattt tttcaaaaaa
     2221 cataaatctg gaactgttgt ttctatattt gataacaaat acagtatatt ttatttataa
     2281 gccatggtct actgatactg tatgaggact ttccttatat ataaaagttg cagggattgt
     2341 gttttattag ctgctttaat tatgttaatt ttagagagtt tttaaatgga aatagaggac
     2401 atttatgaaa cgctggaatt gcagttacaa attctttttg ttgttgttgt tcctgaacat
     2461 gccttggaat aattctacca ttttttcccc ctccataaat ctttctaata aagcatagaa
     2521 aaagcctata tgattttaaa tgcttctctt aagctggtaa acagatttga gttatgagtt
     2581 cattgttatt gcttcaagat gaaaagacag tgatataatt tttctatttc aacttaaaag
     2641 taatagttaa tatgctaaag tagtacagaa taaactttat tgctgcttac taactacaaa
     2701 atactgtaga tggcatctgt atgattaaac atataaagta aaacaggtct gagggctttg
     2761 tagatgatta aagtctccac cttcatgaa
//
