LOCUS       NM_005182               1518 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens carbonic anhydrase 7 (CA7), transcript variant 1,
            mRNA.
ACCESSION   NM_005182
VERSION     NM_005182.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1518)
  AUTHORS   Maurya,N.S., Kushwaha,S., Vetukuri,R.R. and Mani,A.
  TITLE     Unlocking the Potential of the CA2, CA7, and ITM2C Gene Signatures
            for the Early Detection of Colorectal Cancer: A Comprehensive
            Analysis of RNA-Seq Data by Utilizing Machine Learning Algorithms
  JOURNAL   Genes (Basel) 14 (10), 1836 (2023)
   PUBMED   37895185
  REMARK    GeneRIF: Unlocking the Potential of the CA2, CA7, and ITM2C Gene
            Signatures for the Early Detection of Colorectal Cancer: A
            Comprehensive Analysis of RNA-Seq Data by Utilizing Machine
            Learning Algorithms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1518)
  AUTHORS   Viikila,P., Kivela,A.J., Mustonen,H., Koskensalo,S., Waheed,A.,
            Sly,W.S., Pastorek,J., Pastorekova,S., Parkkila,S. and Haglund,C.
  TITLE     Carbonic anhydrase enzymes II, VII, IX and XII in colorectal
            carcinomas
  JOURNAL   World J Gastroenterol 22 (36), 8168-8177 (2016)
   PUBMED   27688658
  REMARK    GeneRIF: CA II and CA XII, but not CA VII or CA IX, could be useful
            in predicting survival in colorectal carcinomas
REFERENCE   3  (bases 1 to 1518)
  AUTHORS   Yang,G.Z., Hu,L., Cai,J., Chen,H.Y., Zhang,Y., Feng,D., Qi,C.Y.,
            Zhai,Y.X., Gong,H., Fu,H., Cai,Q.P. and Gao,C.F.
  TITLE     Prognostic value of carbonic anhydrase VII expression in colorectal
            carcinoma
  JOURNAL   BMC Cancer 15, 209 (2015)
   PUBMED   25885898
  REMARK    GeneRIF: Our results indicate that decreased expression of CA7
            correlates with disease progression and predicts poor prognosis in
            CRC, especially for patients with early stage tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1518)
  AUTHORS   Del Giudice,R., Monti,D.M., Truppo,E., Arciello,A., Supuran,C.T.,
            De Simone,G. and Monti,S.M.
  TITLE     Human carbonic anhydrase VII protects cells from oxidative damage
  JOURNAL   Biol Chem 394 (10), 1343-1348 (2013)
   PUBMED   23851572
  REMARK    GeneRIF: native hCA VII can protect cells from oxidative damage by
            preventing the apoptosis cascade and that cysteines play a leading
            role in this process
REFERENCE   5  (bases 1 to 1518)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   6  (bases 1 to 1518)
  AUTHORS   Chagnon,P., Michaud,J., Mitchell,G., Mercier,J., Marion,J.F.,
            Drouin,E., Rasquin-Weber,A., Hudson,T.J. and Richter,A.
  TITLE     A missense mutation (R565W) in cirhin (FLJ14728) in North American
            Indian childhood cirrhosis
  JOURNAL   Am J Hum Genet 71 (6), 1443-1449 (2002)
   PUBMED   12417987
REFERENCE   7  (bases 1 to 1518)
  AUTHORS   Breton,S.
  TITLE     The cellular physiology of carbonic anhydrases
  JOURNAL   JOP 2 (4 Suppl), 159-164 (2001)
   PUBMED   11875253
  REMARK    Review article
REFERENCE   8  (bases 1 to 1518)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   9  (bases 1 to 1518)
  AUTHORS   Sly,W.S. and Hu,P.Y.
  TITLE     Human carbonic anhydrases and carbonic anhydrase deficiencies
  JOURNAL   Annu Rev Biochem 64, 375-401 (1995)
   PUBMED   7574487
  REMARK    Review article
REFERENCE   10 (bases 1 to 1518)
  AUTHORS   Montgomery,J.C., Venta,P.J., Eddy,R.L., Fukushima,Y.S., Shows,T.B.
            and Tashian,R.E.
  TITLE     Characterization of the human gene for a newly discovered carbonic
            anhydrase, CA VII, and its localization to chromosome 16
  JOURNAL   Genomics 11 (4), 835-848 (1991)
   PUBMED   1783392
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC044802.6.
            
            On Aug 17, 2018 this sequence version replaced NM_005182.2.
            
            Summary: Carbonic anhydrases are a large family of zinc
            metalloenzymes that catalyze the reversible hydration of carbon
            dioxide. They participate in a variety of biological processes,
            including respiration, calcification, acid-base balance, bone
            resorption, and the formation of aqueous humor, cerebrospinal
            fluid, saliva, and gastric acid. They show extensive diversity in
            tissue distribution and in their subcellular localization. The
            cytosolic protein encoded by this gene is predominantly expressed
            in the brain and contributes to bicarbonate driven GABAergic neuron
            excitation. Alternative splicing in the coding region results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Aug 2018].
            
            Transcript Variant: This variant (1) represents a shorter
            transcript but encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.306920.1, BC033865.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338437.7/ ENSP00000345659.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC044802.6         113757-113870
            115-312             AC044802.6         116373-116570
            313-431             AC044802.6         119884-120002
            432-527             AC044802.6         120806-120901
            528-590             AC044802.6         121007-121069
            591-746             AC044802.6         122055-122210
            747-1518            AC044802.6         122719-123490
FEATURES             Location/Qualifiers
     source          1..1518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1518
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /note="carbonic anhydrase 7"
                     /db_xref="GeneID:766"
                     /db_xref="HGNC:HGNC:1381"
                     /db_xref="MIM:114770"
     exon            1..114
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /inference="alignment:Splign:2.1.0"
     exon            115..312
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /inference="alignment:Splign:2.1.0"
     exon            313..431
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /inference="alignment:Splign:2.1.0"
     exon            432..527
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /inference="alignment:Splign:2.1.0"
     exon            528..590
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /inference="alignment:Splign:2.1.0"
     exon            591..746
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1518
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1492..1497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /note="hexamer: AATAAA"
     polyA_site      1518
                     /gene="CA7"
                     /gene_synonym="CA-VII; CAVII"
                     /note="major polyA site"
ORIGIN      
        1 ggggccggag ccgcagcccg aacgagcgga ccgagccgac cgggcaggtg cacggctgcg
       61 gggacggcag cggcatgacc ggccaccacg gctggggcta cggccaggac gacggcccct
      121 cgcattggca caagctgtat cccattgccc agggagatcg ccaatcaccc atcaatatca
      181 tctccagcca ggctgtgtac tctcccagcc tgcaaccact ggagctttcc tatgaggcct
      241 gcatgtccct cagcatcacc aacaatggcc actctgtcca ggtagacttc aatgacagcg
      301 atgaccgaac cgtggtgact gggggccccc tggaagggcc ctaccgcctc aagcagtttc
      361 acttccactg gggcaagaag cacgatgtgg gttctgagca cacggtggac ggcaagtcct
      421 tccccagcga gctgcatctg gttcactgga atgccaagaa gtacagcact tttggggagg
      481 cggcctcagc acctgatggc ctggctgtgg ttggtgtttt tttggagaca ggagacgagc
      541 accccagcat gaatcgtctg acagatgcgc tctacatggt ccggttcaag ggcaccaaag
      601 cccagttcag ctgcttcaac cccaagtgcc tcctgcctgc cagccggcac tactggacct
      661 acccgggctc tctgacgact cccccactca gtgagagtgt cacctggatt gtgctccggg
      721 agcccatctg catctctgaa aggcagatgg ggaagttccg gagcctgctt tttacctcgg
      781 aggacgatga gaggatccac atggtgaaca acttccggcc accacagcca ctgaagggcc
      841 gcgtggtaaa ggcctccttc cgggcctgag ctgcccatct gcctagccgg ccactagggc
      901 accatcttct caagggcttc catgtcagca gacaccaaac catctgaggc ttcctccctg
      961 gggggtgctg gggaccctcc ttcagccagt ttgctccttg gtcaccctgg aggcttctgg
     1021 atgggaccct tgagtctggg gcacccttca gctgccctgg ggacaggaag gacaggagct
     1081 aagcagggtc caagcctggg gctgcctctg ctctccaaga cccaaagacc ctgggaacct
     1141 cctctggtct tccccactgg cagtggcagc agccccaccc cgagcgcaca ctgtgatgga
     1201 ggagactgag ctccctgggg cgggcagctg acactaccag agagactcaa gcaataatta
     1261 gaggtgggca gagctgccct ctcggcatta cctcttctgc aggctctgcc atgcacgcac
     1321 ctcactgcca ggccattaaa atcagcaccc agcatgctgg aggtgacgtg gccttctccc
     1381 tccagccacc tgctgccacg ggcaggccct ggctatagct tatacagtat ctccccttgt
     1441 ccccacccag tcaccaaagc cacctacatg acagtccatc cctgttgaat taataaatta
     1501 atgtatccat gcaacaaa
//
