LOCUS       NM_007220               6837 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens carbonic anhydrase 5B (CA5B), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_007220
VERSION     NM_007220.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6837)
  AUTHORS   Aspatwar,A., Supuran,C.T., Waheed,A., Sly,W.S. and Parkkila,S.
  TITLE     Mitochondrial carbonic anhydrase VA and VB: properties and roles in
            health and disease
  JOURNAL   J Physiol 601 (2), 257-274 (2023)
   PUBMED   36464834
  REMARK    GeneRIF: Mitochondrial carbonic anhydrase VA and VB: properties and
            roles in health and disease.
            Review article
REFERENCE   2  (bases 1 to 6837)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 6837)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6837)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 6837)
  AUTHORS   Diez-Fernandez,C., Rufenacht,V., Santra,S., Lund,A.M., Santer,R.,
            Lindner,M., Tangeraas,T., Unsinn,C., de Lonlay,P., Burlina,A., van
            Karnebeek,C.D. and Haberle,J.
  TITLE     Defective hepatic bicarbonate production due to carbonic anhydrase
            VA deficiency leads to early-onset life-threatening metabolic
            crisis
  JOURNAL   Genet Med 18 (10), 991-1000 (2016)
   PUBMED   26913920
  REMARK    GeneRIF: In 10 of 96 patients, mutations in CA5A were identified on
            both alleles but none in CA5B. Exhibiting decreased enzyme activity
            or thermal stability, all CAVA mutations were proven to cause
            disease, whereas the three variants showed no relevant effect
            Erratum:[Genet Med. 2016 Jun;18(6):649. doi: 10.1038/gim.2016.46..
            PMID: 27304993]
REFERENCE   6  (bases 1 to 6837)
  AUTHORS   Vullo,D., Nishimori,I., Innocenti,A., Scozzafava,A. and
            Supuran,C.T.
  TITLE     Carbonic anhydrase activators: an activation study of the human
            mitochondrial isoforms VA and VB with amino acids and amines
  JOURNAL   Bioorg Med Chem Lett 17 (5), 1336-1340 (2007)
   PUBMED   17174092
  REMARK    GeneRIF: activators enhanced kcat, with no effect on KM, favoring
            the RDS in the catalytic cycle; the activation pattern of the two
            mitochondrial isoforms is very different from each other and as
            compared to those of the cytosolic isoforms hCA I and II.
REFERENCE   7  (bases 1 to 6837)
  AUTHORS   Shah,G.N., Hewett-Emmett,D., Grubb,J.H., Migas,M.C., Fleming,R.E.,
            Waheed,A. and Sly,W.S.
  TITLE     Mitochondrial carbonic anhydrase CA VB: differences in tissue
            distribution and pattern of evolution from those of CA VA suggest
            distinct physiological roles
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1677-1682 (2000)
   PUBMED   10677517
REFERENCE   8  (bases 1 to 6837)
  AUTHORS   Fujikawa-Adachi,K., Nishimori,I., Taguchi,T. and Onishi,S.
  TITLE     Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA
            expression, subcellular localization, and mapping to chromosome x
  JOURNAL   J Biol Chem 274 (30), 21228-21233 (1999)
   PUBMED   10409679
REFERENCE   9  (bases 1 to 6837)
  AUTHORS   Sly,W.S. and Hu,P.Y.
  TITLE     Human carbonic anhydrases and carbonic anhydrase deficiencies
  JOURNAL   Annu Rev Biochem 64, 375-401 (1995)
   PUBMED   7574487
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112497.4, BP371510.1,
            AB021660.1 and AC096510.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007220.3.
            
            Summary: Carbonic anhydrases (CAs) are a large family of zinc
            metalloenzymes that catalyze the reversible hydration of carbon
            dioxide. They participate in a variety of biological processes,
            including respiration, calcification, acid-base balance, bone
            resorption, and the formation of aqueous humor, cerebrospinal
            fluid, saliva, and gastric acid. They show extensive diversity in
            tissue distribution and in their subcellular localization. This
            gene encodes carbonic anhydrase 5B. CA5B, and the related CA5A
            gene, has its expression localized in the mitochondria though CA5B
            has a wider tissue distribution than CA5A, which is restricted to
            the liver, kidneys, and skeletal muscle. A carbonic anhydrase
            pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci
            produce CA5BP1-CA5B readthrough transcripts. [provided by RefSeq,
            Jan 2019].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291050.1, SRR1803613.157803.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000318636.8/
                                                  ENSP00000314099.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC112497.4         31182-31200         c
            20-278              BP371510.1         1-259
            279-1053            AB021660.1         280-1054
            1054-6051           AC096510.11        15160-20157
            6052-6837           AC096510.11        20158-20943
FEATURES             Location/Qualifiers
     source          1..6837
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..6837
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /note="carbonic anhydrase 5B"
                     /db_xref="GeneID:11238"
                     /db_xref="HGNC:HGNC:1378"
                     /db_xref="MIM:300230"
     exon            1..83
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /inference="alignment:Splign:2.1.0"
     exon            84..278
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1090
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /EC_number="4.2.1.1"
                     /note="carbonic dehydratase; carbonic anhydrase 5B,
                     mitochondrial; carbonate dehydratase VB; carbonic
                     anhydrase VB, mitochondrial"
                     /codon_start=1
                     /product="carbonic anhydrase 5B, mitochondrial precursor"
                     /protein_id="NP_009151.1"
                     /db_xref="CCDS:CCDS14171.1"
                     /db_xref="GeneID:11238"
                     /db_xref="HGNC:HGNC:1378"
                     /db_xref="MIM:300230"
                     /translation="MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTR
                     NRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSF
                     LVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWN
                     AVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPS
                     CLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKR
                     MVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP"
     exon            279..476
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /inference="alignment:Splign:2.1.0"
     exon            477..595
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /inference="alignment:Splign:2.1.0"
     exon            596..691
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /inference="alignment:Splign:2.1.0"
     exon            692..754
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /inference="alignment:Splign:2.1.0"
     exon            755..910
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /inference="alignment:Splign:2.1.0"
     exon            911..6837
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2942..2947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /note="hexamer: TATAAA"
     polyA_site      2971
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /note="major polyA site"
     regulatory      5016..5021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /note="hexamer: ATTAAA"
     polyA_site      5035
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
     regulatory      6033..6038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /note="hexamer: AATAAA"
     polyA_site      6056
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
     regulatory      6814..6819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /note="hexamer: AATAAA"
     polyA_site      6837
                     /gene="CA5B"
                     /gene_synonym="CA-VB; CAVB"
                     /note="major polyA site"
ORIGIN      
        1 gtagcttcga tggccggacg tgcaggctgc ggatccccgt aggcgagcga gcggctaggt
       61 tcgtgatctg gagagacgct cagattatta agttcctgca acttaactgg gaactgatca
      121 agatttcaag ctaaagatgg tggtgatgaa cagcctgagg gtcattcttc aagcctctcc
      181 aggcaaattg ctgtggagaa agttccagat tccgagattc atgccagcga ggccctgcag
      241 cctctatact tgtacttaca aaacccggaa ccgagccttg catccactct gggagagcgt
      301 ggacctggtt cctgggggcg atcgccagtc acccatcaac attcggtgga gggacagtgt
      361 ttatgatccc ggcttaaaac cactgaccat ctcttatgac ccagccacct gcctccacgt
      421 ctggaataat gggtactctt tcctcgtgga atttgaagat tctacagata aatcagtgat
      481 caagggagga cccctggaac acaactaccg attgaagcag ttccattttc actggggggc
      541 catcgatgcc tggggttctg agcacaccgt ggacagcaaa tgcttcccag cagagctgca
      601 cttagtgcat tggaacgcag tcagatttga aaactttgag gatgcagcac tggaagaaaa
      661 tggtttggct gtgataggag tatttttaaa gctaggcaaa catcataagg agctacagaa
      721 attagtggat actttgccgt caattaagca taaggacgcc cttgtggaat ttgggtcatt
      781 tgacccttcc tgcctgatgc ctacctgccc agattactgg acctactcag ggtctctgac
      841 taccccaccc ctctccgagt ctgtcacctg gatcattaag aagcaaccag tagaggttga
      901 tcatgatcag cttgagcaat ttcggaccct gcttttcact tccgaagggg agaaagagaa
      961 aagaatggtg gacaacttcc gcccccttca gccactgatg aatcgcactg ttcgttcatc
     1021 cttccggcat gattatgtgc tgaatgtaca agcgaaaccc aagccggcca ccagccaagc
     1081 aaccccctaa aacattcata tctaggcagt attttgcttt tgctttaata tatactagct
     1141 tactataaat tgttaactag actattctaa gtgcctgcat ttgataatat ttacagatgt
     1201 gcatttctta gcatgagagt gcttcatcag tctttgagga aggctattcg gtaccagcaa
     1261 gagacacaag tttctcttac agatacctgt tggtaattgt aatgcctttt ttttttcttt
     1321 aagagactag gtcttgctct gctgcccagg ctagagtgca gtggccaaat gatagctcac
     1381 tgcagccttg aactcctagg ctcaagcagt cctcctgcct tagcctctag agtagctggg
     1441 gctacaggtg ctggccgcct ggcccagctt gtaatatctt tttatgtctg acatttttga
     1501 gctatctttt tatgtttatc cattagtggt tctatagcac tatacatagg gattataatc
     1561 aaaattttta acatgtggta aggcacagac actgaccaga actcaggcct tgcagaaaca
     1621 gcctatgggc ccagactggt acttcctggc tgaatattgg ccatggtttt agatgtattt
     1681 tattttataa catgaatgtg tattctttca taagggctta tcagtcagta tatttgcccc
     1741 agtgtttagt tgttacaagg acatgatatg cttacttact atcagtttat gatgtagaaa
     1801 atatattttg taattataag aaaacaagac ttttcctata cccagaaatc cctttgcatt
     1861 tccgaagatc agatattttg cttaaaggtc tgatcatata ggaaatatat gcagaacatt
     1921 ttaaagaaaa tgcctggctg ggcacagtgg ctcacacctg taatcccagc actttgggag
     1981 gctgaggcgg gtagctcact tgaggtcagg agtttgagac cagcctggcc aacatgatga
     2041 aaccctgtca ctactacaaa taaaaaatta gccaggcatg gtggtgagca cctgtaatgc
     2101 cagctactcg ggaagctgag gctggagaat cgcttgaacc caggaggtgg tggttgtagt
     2161 gaaccaagat cacaccactg cactccagcc tgggcaacag agtgagactc tgtgtctaat
     2221 aaaaaaaaaa aaagaaaaga aaagaaaaaa tgcttaaagt gcctagaact tagaattctt
     2281 tcattgcaca tttccagaaa tatttttctt ttcttttttt tttttttttt tgagatggag
     2341 tctcgctctg tcccccaggc tggagtgcag tggcactatc ttggctcact gcaacctcca
     2401 cctcccgggt ttaagcgatt ctcctgcctc agcctcctga gtaactggga ctacaggcac
     2461 atgccaccac gcccagctaa tttttgtatt tttagtagag atggggtttc actatgttgg
     2521 ccaggctggt cttgaactcc tgacctcagg tgatccaccc gccttggcct cccaaagtgc
     2581 tgggattaca ggcgtgagcc accgtgcccg gccttccaga aatatttttc aaaggactag
     2641 taatctaata gcctatagtt tatattatta ttttgtatta tttgcacgct gttacatagt
     2701 atataatgat aatgttttct acagtgaaag agctatcccg tcttcccttt acaactgtct
     2761 gaactttatt tactcattag tcaaggttct ttgcaaggca ggtgattaac ttaaatatct
     2821 cagtttatac agtggtttaa aagacttttg ttatggtaat agggagagaa acttgtcaga
     2881 taggctaaaa tctagataat tctacatatt ctgaggaatt catgctcctg tggctcttgc
     2941 ttataaatat cttggaatgt ttctgaatgc ctctaagcct atgttcagac tctgttgcgt
     3001 caatgactgg tagtatttct ttcattaata tgtttgtcat ctggtctgca agatagggtt
     3061 ggatgaatat acttaacact actgaactgt acacttaaag atcgttagga aggaaacggg
     3121 actacatcaa acttaaaaat gtctgtgtgt caaaggaagc aatcaacaaa gtgaaaacgc
     3181 aagctctaga atgagagaaa ataattgcaa atcgtctatc ttataaggag cccaaatcca
     3241 gaatatatga ggaacttcta caactcaaca acaaaaaacc aaataactca atttttaaaa
     3301 atgggcaaag gacttgcaca gacatttctc caaagaagtt atacaattgg ccaataagaa
     3361 catgaaaata tgctcaacat tgccaattat tagggaaatg caaatcaaaa ccacaatgag
     3421 atatcgtctc acgcccatca tgatggccac tatcagaaga acaaaaaaat aacaagtatt
     3481 ggggaggatg cagagaagtt gaaacccttg tgcactgttg gtggtaatgt aaaacggtgc
     3541 agtcattacg gaaaacagta cacaggtttc ccaaataact gaaaacagaa ttaccataag
     3601 aattaccacc aaagcgggat ctcaaagaga tatttgtaca cccatgttca tagcagcatt
     3661 attcacaata gccaagaggt tctggaagca tcccaaatgt ccatcaacag atgaatagat
     3721 aaaggaaatg tggtatatac agtcaatgga atattattca gcctttaaaa agaaggaaat
     3781 cctgtcaaat gtacaatgtg gatgaacctt gaaggcatta tgccaagtga aataagccag
     3841 ccaacaaaag aacaaatgct atatgattcc tccatgtgaa gtatgcaaag tagtcaaaat
     3901 catacaatag aaagtagaaa ggtggttgcc aagcaacggt tgggggaagg ggagagggtg
     3961 aatttgtatt tagtgggtac agagcttgtg ttgcaagaat tctagagatc tgttgcaaaa
     4021 caagtgtgat tgtacttaac actactgaac tgtatacgta taagtttgag aaatatctct
     4081 tttaaaaagg gggaaatgtg aaggcttttg catgtatgcc ctaggaaatg catagaattc
     4141 ttagaaaggt aaacatggta aaaaaagaag tctttgttaa ctttctgcag ttcacctgtt
     4201 tcaaagtata gttaccttta aaagggtaaa cacacaagat atgcattttc caaagcatac
     4261 aggctttcct cctagctgtc ttgtttttta ttttttttta ttttttttat ttttttgaga
     4321 cagagtcgcg ctgtcacccg ggctggagtg cagtggcgcg atctcggctc actgcaagct
     4381 ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc tgagtagctg ggactacagg
     4441 cgcccgccac cacacccggc tattttttgt attttaagta gagacagggt ttcaccgtgt
     4501 taaccaggat ggtctcgatc tgacctcgtg atccacccgt cttggcctcc caaagtgctg
     4561 ggattacagg tgtgagccac tgtgcctggc cttcctagct gtcttgtgaa acgataagtc
     4621 aaaaccctac tgcagtgagt tttccaaact gaagggagaa gcaatgtaca gaatgcctga
     4681 cttgccctta catcttatac ctggtgttct ggcatgatta ttaaccacac tctttttcac
     4741 tttgaaccat gtcctggttt gcatggccag cttccctgca gaggtgatag aaactgactt
     4801 gaggcagttt ctttctccat gccttagtta gatgaccctc aaaggggcac agcagatttc
     4861 cctggctact gatacacctt aacaagaagc ttgtgttttt tatgccctca aaagtgtttt
     4921 acttatactt tcctagacat aaaggtggaa aatgggccta aggtctgtca aaggtcttgg
     4981 aaaagaagat tgtattaaaa ttgctgtccg tcttcattaa ataatactag atcgatacaa
     5041 tgctttcttt acagtattag tggttggtga aagacttcct tcctattgtt acagtatatg
     5101 tatatatctg taaaattaat gagatatcct ttaacttgta gattagaaag cgactaaaaa
     5161 ctcatagggg atttactaaa gaagcaacaa tgggaagaag cagccgatcc tcctcagtgc
     5221 acctttttct gttgcacagt acagtgcaca gtgtgctggc atcaccatat agggcaagct
     5281 gtgaccgcct ttctcctttc ccagggctac atggtgccaa gcaggttcag tgtacactgg
     5341 ttaccaacct gtctgattcc attgtgacag aacacactca cacccaatac attacatgaa
     5401 gcagatttat tacttacaga caggaagcaa gggacaaaag aggccctggc tccattgtga
     5461 gccagtcccc cagggctcaa gaaagctgcc cagggcgggg ctgatggagt cttgattgta
     5521 cgtgccccac ttgcaccaca gcctgccttg ggttatatac cataggagcc acataactca
     5581 ttgggcaaag ctttaaagta catcctcctt ccaggggaaa gaggaacaca acctcgctgt
     5641 ctcaaacagt tccctaaatc aagatgttac attccctagg agggacaaca acaaggccaa
     5701 cctgtttcag gcagttcctc catatcagga tattgcattc ccagtgcatt ctacagttat
     5761 tcttaagaac tacaagcaag gaagaaggga gaactgggtc agtccaaggc cacctggaga
     5821 actgtcttgt acatgggtta gggtaaagtt ggctattcta aaactaagca tccgcccaaa
     5881 agaagtcttg gaagatgtct ttccctgtta aattcagatg atggtaatta tagtttggaa
     5941 gtggaattgg cttttagagt tacttcctgt aatgaaatta acaagcaatt caggcctatt
     6001 tctgaaaatg aattcagtgg ttaattgtta aaaataaatg tctaactcct ataaaaggaa
     6061 atttacattc atttctaact cactaaaaaa tctatggccg ggtgcggtgg ctcatgcctg
     6121 taatcccagc attttgggag gccgaggcgg gcagattacc ggaggtcaag agttcgagaa
     6181 cagcctggcc aatatggtga aaccccgtct ctactaaaaa atacaaaaat tagccaggtg
     6241 gttgtggcat gcacctgtaa tcccagctac gcaggaggct gaggcagaag aatcgcttga
     6301 gcccaggagg cggaggttgc agtgagccga gatttcttag aaggaattgt tacttattgt
     6361 tctgaagtga aagtctggtc tgattcagaa gaaatgttac aacaacttaa acactgatgc
     6421 tttcagaacg ggcagcaatt ctcagcgtaa attctgatca cagggaccag caaaattggt
     6481 gagttgcata gctacaacat tctgtgccat ccagggcact ctagtttggg gatacaactg
     6541 ccaaacctcc aactagagag tttagtttaa gatttagtca agaagcagaa aggtaaaggt
     6601 gacaatgtgt agtaaaccat gatagatgtt ataaaaggtg gaatacttgt actggaaatg
     6661 catacagcgc ctcatcccct cttgaggggt caggaagttt tcacactaat gatgatggtg
     6721 atgagatgat gtaacagcta aagttttgga ggcattcact attgctaggc actgtatcag
     6781 catataacat ggcttatctt actcagtttt cacaataaaa gggttatgag atgggaa
//
