LOCUS       NM_005181               1721 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens carbonic anhydrase 3 (CA3), mRNA.
ACCESSION   NM_005181
VERSION     NM_005181.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1721)
  AUTHORS   Su,H., Hu,K., Liu,Z., Chen,K. and Xu,J.
  TITLE     Carbonic anhydrase 2 and 3 as risk biomarkers for dilated
            cardiomyopathy associated heart failure
  JOURNAL   Ann Palliat Med 10 (12), 12554-12565 (2021)
   PUBMED   35016406
  REMARK    GeneRIF: Carbonic anhydrase 2 and 3 as risk biomarkers for dilated
            cardiomyopathy associated heart failure.
REFERENCE   2  (bases 1 to 1721)
  AUTHORS   Okuyan,D., Aydogan Turkoglu,S. and Kockar,F.
  TITLE     Carbonic anhydrase III is a new target of HIF1alpha in prostate
            cancer model
  JOURNAL   Gene 762, 145034 (2020)
   PUBMED   32777521
  REMARK    GeneRIF: Carbonic anhydrase III is a new target of HIF1alpha in
            prostate cancer model.
REFERENCE   3  (bases 1 to 1721)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1721)
  AUTHORS   Chu,Y.H., Su,C.W., Hsieh,Y.S., Chen,P.N., Lin,C.W. and Yang,S.F.
  TITLE     Carbonic Anhydrase III Promotes Cell Migration and
            Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma
  JOURNAL   Cells 9 (3), 704 (2020)
   PUBMED   32183030
  REMARK    GeneRIF: Carbonic Anhydrase III Promotes Cell Migration and
            Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1721)
  AUTHORS   Silagi,E.S., Batista,P., Shapiro,I.M. and Risbud,M.V.
  TITLE     Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic
            Marker, is Hypoxia-responsive and Confers Protection from Oxidative
            Stress-induced Cell Death
  JOURNAL   Sci Rep 8 (1), 4856 (2018)
   PUBMED   29559661
  REMARK    GeneRIF: these data clearly suggests that CAIII serves as an
            important antioxidant critical in protecting NP cells against
            oxidative stress-induced injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1721)
  AUTHORS   Oikarinen,A., Vuori,J., Autio,P., Annala,A.P., Palatsi,R.,
            Kiistala,U. and Vaananen,K.
  TITLE     Comparison of muscle-derived serum carbonic anhydrase III and
            myoglobin in dermatological patients: effects of isotretinoin
            treatment
  JOURNAL   Acta Derm Venereol 72 (5), 352-354 (1992)
   PUBMED   1361281
REFERENCE   7  (bases 1 to 1721)
  AUTHORS   Oguni,M., Setogawa,T., Tanaka,O., Shinohara,H. and Kato,K.
  TITLE     Immunohistochemical study of carbonic anhydrase III in the
            extraocular muscles of human embryos
  JOURNAL   Acta Anat (Basel) 144 (4), 316-319 (1992)
   PUBMED   1414196
REFERENCE   8  (bases 1 to 1721)
  AUTHORS   Vuori,J., Rasi,S., Takala,T. and Vaananen,K.
  TITLE     Dual-label time-resolved fluoroimmunoassay for simultaneous
            detection of myoglobin and carbonic anhydrase III in serum
  JOURNAL   Clin Chem 37 (12), 2087-2092 (1991)
   PUBMED   1764784
REFERENCE   9  (bases 1 to 1721)
  AUTHORS   Shamsutdinov,N.Sh., Islamov,R.I. and Valuillin,V.V.
  TITLE     [Carbonic anhydrase III--a marker of the myoepithelial cells of
            human salivary glands]
  JOURNAL   Biull Eksp Biol Med 111 (3), 320-321 (1991)
   PUBMED   1905166
REFERENCE   10 (bases 1 to 1721)
  AUTHORS   Carter,N., Jeffery,S., Shiels,A., Edwards,Y., Tipler,T. and
            Hopkinson,D.A.
  TITLE     Characterization of human carbonic anhydrase III from skeletal
            muscle
  JOURNAL   Biochem Genet 17 (9-10), 837-854 (1979)
   PUBMED   120192
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA421884.1, AK313254.1 and
            AC084734.4.
            
            On Nov 23, 2018 this sequence version replaced NM_005181.3.
            
            Summary: Carbonic anhydrase III (CAIII) is a member of a multigene
            family (at least six separate genes are known) that encodes
            carbonic anhydrase isozymes. These carbonic anhydrases are a class
            of metalloenzymes that catalyze the reversible hydration of carbon
            dioxide and are differentially expressed in a number of cell types.
            The expression of the CA3 gene is strictly tissue specific and
            present at high levels in skeletal muscle and much lower levels in
            cardiac and smooth muscle. A proportion of carriers of Duchenne
            muscle dystrophy have a higher CA3 level than normal. The gene
            spans 10.3 kb and contains seven exons and six introns. [provided
            by RefSeq, Oct 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.147554.1,
                                           SRR5189667.152967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285381.3/ ENSP00000285381.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DA421884.1         33-74
            43-834              AK313254.1         44-835
            835-1721            AC084734.4         82873-83759         c
FEATURES             Location/Qualifiers
     source          1..1721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.2"
     gene            1..1721
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /note="carbonic anhydrase 3"
                     /db_xref="GeneID:761"
                     /db_xref="HGNC:HGNC:1374"
                     /db_xref="MIM:114750"
     exon            1..85
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..834
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /EC_number="4.2.1.1"
                     /note="CA-III; carbonate dehydratase III; HEL-S-167mP;
                     epididymis secretory sperm binding protein Li 167mP;
                     carbonic anhydrase III, muscle specific; carbonic
                     anhydrase IIII"
                     /codon_start=1
                     /product="carbonic anhydrase 3"
                     /protein_id="NP_005172.1"
                     /db_xref="CCDS:CCDS6238.1"
                     /db_xref="GeneID:761"
                     /db_xref="HGNC:HGNC:1374"
                     /db_xref="MIM:114750"
                     /translation="MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSL
                     QPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDD
                     HGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFL
                     DALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVS
                     SDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK"
     exon            86..283
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /inference="alignment:Splign:2.1.0"
     exon            284..402
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..495
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..558
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /inference="alignment:Splign:2.1.0"
     exon            559..714
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1721
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1701..1706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /note="hexamer: AATAAA"
     polyA_site      1721
                     /gene="CA3"
                     /gene_synonym="CAIII; Car3"
                     /note="major polyA site"
ORIGIN      
        1 ccacgcaggg gaagagaaag caggagccgt ccagcacgga ggaaggcgac catggccaag
       61 gagtggggct acgccagtca caacggtcct gaccactggc atgaactttt cccaaatgcc
      121 aagggggaaa accagtcgcc cgttgagctg catactaaag acatcaggca tgacccttct
      181 ctgcagccat ggtctgtgtc ttatgatggt ggctctgcca agaccatcct gaataatggg
      241 aagacctgcc gagttgtatt tgatgatact tatgataggt caatgctgag agggggtcct
      301 ctccctggac cctaccgact tcgccagttt catcttcact ggggctcttc ggatgatcat
      361 ggctctgagc acaccgtgga tggagtcaag tatgcagcgg agcttcattt ggttcactgg
      421 aacccgaagt ataacacttt taaagaagcc ctgaagcagc gcgatgggat cgctgtgatt
      481 ggcatttttc tgaagatagg acatgagaat ggcgagttcc agattttcct tgatgcattg
      541 gacaagatta agacaaaggg caaggaggcg cccttcacaa agtttgaccc atcctgcctg
      601 ttcccggcat gccgggacta ctggacctac cagggctcat tcaccacgcc gccctgcgag
      661 gaatgcattg tgtggctgct gctgaaggag cccatgaccg tgagctctga ccagatggcc
      721 aagctgcgga gcctcctctc cagtgctgag aacgagcccc cagtgcctct tgtgagcaac
      781 tggcgacctc cacagcctat caataacagg gtggtgagag cttccttcaa atgaggctgc
      841 tggatcttgc cctcttcagg aaaggaaacc taccattgga gagcttggtt ccttgcctcc
      901 ttctggtgct ccttactcca agtctatttc atttttccac actgagcaat gaatgtgaga
      961 gatgtggtca ccaagatcta agttacttgt tgaaagaaag ttactttcga caagatctaa
     1021 tatgaaagca tagatttcac atttgatctc tgtaataatc atctttccta taaaagtagc
     1081 atttttggta aagtttcaaa gaagaagaaa cagagatgga agagtaaaga tatttttaaa
     1141 atggctagct attgggcacc agtttttctg ttatctaaaa tttcacacaa cttcattgtt
     1201 tttattttta tattatgagt tgtccatctt aaagaaatat gagtaattct acatgtagta
     1261 gaggtgtatg aagatcatat aacaattaaa cataagccag aaattaaaat gactatagac
     1321 agcaagaatt gagctaataa tatgttttaa ctcttaacac cagcaagaag tcagtcattt
     1381 attgaagttt tagctactaa gattacttgg ttttgattac cagtgaaaag aaaacacaat
     1441 acaatcagga gttttcaaat ttttgattca gtatttgaat ttcttcttca taaatgtagt
     1501 tgaatttatc ctagtatttt tctttacctg aaggagggcc atttattttt aatttcacta
     1561 catttttctt tgcatgatta ttaaaataaa aactgcctct gttgtgtttc tcactggagg
     1621 ctggaatgaa tgatcactag aacacaaaag agtgaatgat gacacttgaa gtcaaagcag
     1681 ttgtactgat caccagaacc aataaagaca taaatggaaa a
//
