LOCUS       NM_198584               3884 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens carbonic anhydrase 13 (CA13), mRNA.
ACCESSION   NM_198584 XM_352743
VERSION     NM_198584.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3884)
  AUTHORS   Yogosawa,S., Nakayama,J., Nishi,M., Ryo,A. and Yoshida,K.
  TITLE     Carbonic anhydrase 13 suppresses bone metastasis in breast cancer
  JOURNAL   Cancer Treat Res Commun 27, 100332 (2021)
   PUBMED   33588197
  REMARK    GeneRIF: Carbonic anhydrase 13 suppresses bone metastasis in breast
            cancer.
REFERENCE   2  (bases 1 to 3884)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3884)
  AUTHORS   De Simone,G., Di Fiore,A., Truppo,E., Langella,E., Vullo,D.,
            Supuran,C.T. and Monti,S.M.
  TITLE     Exploration of the residues modulating the catalytic features of
            human carbonic anhydrase XIII by a site-specific mutagenesis
            approach
  JOURNAL   J Enzyme Inhib Med Chem 34 (1), 1506-1510 (2019)
   PUBMED   31431090
  REMARK    GeneRIF: investigation of residues modulating the catalytic
            features of one of the least investigated cytosolic isoform, hCA
            XIII; results showed that residues assisting the formation of an
            ordered solvent network within the catalytic site as well as those
            forming a histidine cluster on the protein surface are important to
            guarantee an efficient proton transfer
REFERENCE   4  (bases 1 to 3884)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   5  (bases 1 to 3884)
  AUTHORS   Hilvo,M., Innocenti,A., Monti,S.M., De Simone,G., Supuran,C.T. and
            Parkkila,S.
  TITLE     Recent advances in research on the most novel carbonic anhydrases,
            CA XIII and XV
  JOURNAL   Curr Pharm Des 14 (7), 672-678 (2008)
   PUBMED   18336313
  REMARK    GeneRIF: Cytosolic carbonic anhydrase XIII may have a role in
            maintaining the acid-base balance in the kidney and the
            gastrointestinal and reproductive tracts. [review]
            Review article
REFERENCE   6  (bases 1 to 3884)
  AUTHORS   Kummola,L., Hamalainen,J.M., Kivela,J., Kivela,A.J., Saarnio,J.,
            Karttunen,T. and Parkkila,S.
  TITLE     Expression of a novel carbonic anhydrase, CA XIII, in normal and
            neoplastic colorectal mucosa
  JOURNAL   BMC Cancer 5, 41 (2005)
   PUBMED   15836783
  REMARK    GeneRIF: cytosolic CA I, II, and XIII are downregulated in
            neoplastic colorectal mucosa compared to normal colorectal mucosa
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3884)
  AUTHORS   Lehtonen,J., Shen,B., Vihinen,M., Casini,A., Scozzafava,A.,
            Supuran,C.T., Parkkila,A.K., Saarnio,J., Kivela,A.J., Waheed,A.,
            Sly,W.S. and Parkkila,S.
  TITLE     Characterization of CA XIII, a novel member of the carbonic
            anhydrase isozyme family
  JOURNAL   J Biol Chem 279 (4), 2719-2727 (2004)
   PUBMED   14600151
  REMARK    GeneRIF: a unique and widespread distribution pattern for CA XIII
            compared with the other cytosolic CA isozymes. May play important
            physiological roles in several organs
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011773.9, DB287770.1, BC052602.1 and AK095314.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198584.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095314.1, BC052602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321764.4/ ENSP00000318912.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC011773.9         147890-147918
            30-69               DB287770.1         1-40
            70-320              BC052602.1         1-251
            321-3884            AK095314.1         1-3564
FEATURES             Location/Qualifiers
     source          1..3884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.2"
     gene            1..3884
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /note="carbonic anhydrase 13"
                     /db_xref="GeneID:377677"
                     /db_xref="HGNC:HGNC:14914"
                     /db_xref="MIM:611436"
     exon            1..408
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..1160
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /EC_number="4.2.1.1"
                     /note="carbonate dehydratase XIII; CA-XIII; carbonic
                     anhydrase XIII"
                     /codon_start=1
                     /product="carbonic anhydrase 13"
                     /protein_id="NP_940986.1"
                     /db_xref="CCDS:CCDS6236.1"
                     /db_xref="GeneID:377677"
                     /db_xref="HGNC:HGNC:14914"
                     /db_xref="MIM:611436"
                     /translation="MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSS
                     LRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSAD
                     DHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQK
                     ITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPIN
                     ISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH"
     exon            409..606
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /inference="alignment:Splign:2.1.0"
     exon            607..725
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /inference="alignment:Splign:2.1.0"
     exon            726..821
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /inference="alignment:Splign:2.1.0"
     exon            822..884
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1040
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..3884
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3753..3758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /note="hexamer: ATTAAA"
     polyA_site      3773
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /note="major polyA site"
     regulatory      3861..3866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /note="hexamer: AATAAA"
     polyA_site      3884
                     /gene="CA13"
                     /gene_synonym="CAXIII"
                     /note="major polyA site"
ORIGIN      
        1 attcacttcc tggaagtcct ctaggcaaca ctttcctctc ccgagtgacg actcctcaga
       61 aggcaggaga tcccccccgg aaacctttct ctctccgtct ctccctctaa ctcaaatctc
      121 tcattcccga gtccaaacta agagagactc gcgccccagg agtcagccag cggcgcgggc
      181 gccttccccg cacgcctctg ccgtctggag gacgcaggcg ggagcgcccc ggaccgggtt
      241 cacggtctcg cactcctgcc gccggcgccc cgcggtcccg ccctagcagg ctccttcccg
      301 ggcccctccc cgctccctcc tctttctcgc tgctcagtca catctttctc ttccttccac
      361 cccgagggac catgtcgagg ctcagctggg gataccgcga gcacaacggt cctattcact
      421 ggaaggaatt tttccctatt gctgatggtg atcagcaatc tccaattgag attaaaacca
      481 aagaagtgaa atatgactct tccctccgac cacttagtat caagtatgac ccaagctcag
      541 ctaaaatcat cagcaacagc ggccattcct tcaatgttga ctttgatgac acagagaaca
      601 aatcagttct gcgtggtggt cctctcactg gaagctacag gttacggcag gttcaccttc
      661 actgggggtc cgctgatgac cacggctccg agcacatagt agatggagtg agctatgctg
      721 cagagctcca tgttgttcac tggaattcag acaaataccc cagctttgtt gaggcagctc
      781 atgaaccaga tggactggct gtcttgggag tgtttttaca gattggtgaa cctaattccc
      841 aactgcaaaa gattactgac actttggatt ccattaaaga aaagggtaaa caaactcgat
      901 tcacaaattt tgacctattg tctctgcttc caccatcctg ggactactgg acatatcctg
      961 gttctcttac agttccacct cttcttgaga gtgtcacatg gattgtttta aagcaaccta
     1021 taaacatcag ctctcaacag ctggccaaat ttcgcagtct cctgtgcaca gcggagggtg
     1081 aagcagcagc ttttctggtg agcaatcacc gcccaccaca gcctctaaag ggccgcaaag
     1141 tgagagcctc tttccattaa aaattgtcac caatgaactc ccccaaacat ggctgtggag
     1201 agacaacaaa acaaaacaaa gcacaaaagt ctctgccaac aactcttttg tggaattcta
     1261 atttatagga aacattttag tatgagcttc agtgtcacaa agaaaaccag atctctctct
     1321 cttttttttt tatttttttt agtgatagag tctcactctg tcacccaggc tggagggcag
     1381 tggtacagtc ttggctaatt gcagcctcca actcctggac tcaagtgatc ctcccacctc
     1441 agcctccaga gtaagtagga ccacaggcat gcacaagcat gcctggctaa tttttaaatt
     1501 tttttttttt aagaaatagg gtcttgctat gttgcccagg ctggtctcaa gctcctgccc
     1561 taaagtaggc ctcctgcctt tgcctctcaa agtgctggga tttcaggcat gggtcatcaa
     1621 gcccagctga cccagagctc tttactaact tatctgtctc ttatttgcac tcatggatat
     1681 tcacagtaag cattgtttga catatattaa aacccatgaa atatgtctac ttcaacctgt
     1741 gtgaaaatat agttaacatt gcaaacttta gaatgtatta aaaattttac cttgccatag
     1801 agactgaatt agtcacagct ctcagtgatg ttagatggaa acttatatct caaatgatag
     1861 gattgtgatg ctttttttgt aacaagtgat tctgcttaat attttgttat tccagttcat
     1921 aaaaagtaga ttacgttttc ctataaggat aatttttgca gtgattatat tgctaactct
     1981 cattgcatga tacctttaat aaaatgaaca atataagagt taagggcaat gggataaagc
     2041 tacttaatgt gtctcctcca ctgatcaaaa atattccata tagtcttggt gaggaattcc
     2101 ccaggatata aatggctatt tacactgtaa tgaattatac catatatgat attcactcag
     2161 taatgttaat aatgaactgg ctaataattg acaagatgca gtgcctgcca gtttatgaca
     2221 ttaacttggt ttgaaactaa catatgacat agtaccagtg cagtcagagc tgcccttagg
     2281 catgatgaac atgtggcccg tttttgcctg gtgttttggc agcaaagcag gaagcaattt
     2341 tgtgtgggtc attgttctgt caatttgtgg aaaaaattac ttcagtctca tataaatata
     2401 gaatgggtcc ataaaccctt caactcattt ccatggcaaa actcactttt ctttttatac
     2461 atgtccttca gtctcttaat tttgtcaggt ggagcttgat cttaatttta acctattatc
     2521 ttttattttt gtttgttttt ggtgaaggat aagagtggtg tttcttttgc cctttctggt
     2581 acaaacagag ggacactaag cattaactta ataatcacat ttaagacttg aacacatgct
     2641 acccttttgt catcttctga cataagttta cctgagtttc cttgatttgg aagatttgtt
     2701 tcttttatct ctcttcctct ggatgtagtt tttttttgtt ttttttttgt ttttggacgg
     2761 agtcttagtc tgtcactgag gctggagtac agtggcacga tcttggctca ctgcaacctc
     2821 catctcccgg gttcaaatga ttctcctgcc tcagcctctt gagtggctgg gattacaggc
     2881 acatgccacc acacccggct aatttttgta tttttagtag agatgggttt tgcaatgttg
     2941 gccaggctgg tctcaaactc ctgacctcaa gtgatctgcc tgcctcggcc tctcaaattg
     3001 ctggaattac agttgtgagc caccacacct ggcttgaatg tagattttaa taattgaatt
     3061 tattctgccg tgttgataga ataactgaat atcagtaaat tgtgtaacag tggtggatac
     3121 tgttgcataa gatgagctcc tgaagagtga agctaattct ttggtcaatg ttcttttccc
     3181 ctcagtgtct agtttaaggc ttttagaaga ttgatctgta gcaattattt aatgaattga
     3241 atatttaaaa aattttttat ttgctgtctt tggtaattat ctctctgctt gaaattaaat
     3301 gcactataag ttaatataac aagtaaaata cattgtcttt tgaaaatagt ttctttttaa
     3361 aggaatacta attaattgta acttgtaaaa ccaaaagttc taatggtttt taaaaaccag
     3421 tgttgagtgg aaaagtgttt ctttagtttg gaaagacctg tgaagtatcc tagtcaggga
     3481 aagaacctgt tttctggaag aatgtaagtt gctatatgtg gaggggcatg taggacaggg
     3541 gttctaatta ctgtctgtga gagttactac tttgtaactt atggtttctg cttcagtatt
     3601 gtgttggttc tgtattataa attgcacctt aatagaccaa aaatatctat acagcactga
     3661 tttccttgaa tattgtgtgt taattgatat atcttctaga ggcaaaaggt ttaaatgtgt
     3721 taaaatggtt atattgcctc ctttttaaac aaattaaaga gttgtaaata ctagtgtaga
     3781 tctcttttgt ttaccacagc aaatactgat tttatgattg ttaagcattt catattttaa
     3841 tttaaattgg attcaaccac aataaagaaa atgagaaaag cttt
//
