LOCUS       NM_001217               1715 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens carbonic anhydrase 11 (CA11), transcript variant 1,
            mRNA.
ACCESSION   NM_001217
VERSION     NM_001217.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Tao,B., Ling,Y., Zhang,Y., Li,S., Zhou,P., Wang,X., Li,B., Jun,Z.,
            Zhang,W., Xu,C., Shi,J., Wang,L., Zhang,W. and Li,S.
  TITLE     CA10 and CA11 negatively regulate neuronal activity-dependent
            growth of gliomas
  JOURNAL   Mol Oncol 13 (5), 1018-1032 (2019)
   PUBMED   30636076
  REMARK    GeneRIF: results suggest that CA11 and CA10 negatively regulate
            neuronal activity-dependent glioma growth and inhibit glioma
            aggression. Thus, CA11/CA10 may represent a potential therapeutic
            target for the treatment of gliomas.
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Karjalainen,S.L., Haapasalo,H.K., Aspatwar,A., Barker,H.,
            Parkkila,S. and Haapasalo,J.A.
  TITLE     Carbonic anhydrase related protein expression in astrocytomas and
            oligodendroglial tumors
  JOURNAL   BMC Cancer 18 (1), 584 (2018)
   PUBMED   29792187
  REMARK    GeneRIF: The CARP VIII and XI proteins were associated to
            non-hypoxic conditions and CARP XI also to the expression of
            cytoplasmic CA II staining suggesting that the CARPs play a role in
            tumorigenesis of diffusively infiltrating gliomas
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Liang,Y., Tang,W., Huang,T., Gao,Y., Tan,A., Yang,X., Zhang,H.,
            Hu,Y., Qin,X., Li,S., Zhang,S., Mo,L., Liang,Z., Shi,D., Huang,Z.,
            Guan,Y., Zhou,J., Winkler,C., O'Brien,S.J., Xu,J., Mo,Z. and
            Peng,T.
  TITLE     Genetic variations affecting serum carcinoembryonic antigen levels
            and status of regional lymph nodes in patients with sporadic
            colorectal cancer from Southern China
  JOURNAL   PLoS One 9 (6), e97923 (2014)
   PUBMED   24941225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1715)
  AUTHORS   He,M., Wu,C., Xu,J., Guo,H., Yang,H., Zhang,X., Sun,J., Yu,D.,
            Zhou,L., Peng,T., He,Y., Gao,Y., Yuan,J., Deng,Q., Dai,X., Tan,A.,
            Feng,Y., Zhang,H., Min,X., Yang,X., Zhu,J., Zhai,K., Chang,J.,
            Qin,X., Tan,W., Hu,Y., Lang,M., Tao,S., Li,Y., Li,Y., Feng,J.,
            Li,D., Kim,S.T., Zhang,S., Zhang,H., Zheng,S.L., Gui,L., Wang,Y.,
            Wei,S., Wang,F., Fang,W., Liang,Y., Zhai,Y., Chen,W., Miao,X.,
            Zhou,G., Hu,F.B., Lin,D., Mo,Z. and Wu,T.
  TITLE     A genome wide association study of genetic loci that influence
            tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and
            alpha fetoprotein and their associations with cancer risk
  JOURNAL   Gut 63 (1), 143-151 (2014)
   PUBMED   23300138
REFERENCE   5  (bases 1 to 1715)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1715)
  AUTHORS   Taniuchi,K., Nishimori,I., Takeuchi,T., Fujikawa-Adachi,K.,
            Ohtsuki,Y. and Onishi,S.
  TITLE     Developmental expression of carbonic anhydrase-related proteins
            VIII, X, and XI in the human brain
  JOURNAL   Neuroscience 112 (1), 93-99 (2002)
   PUBMED   12044474
REFERENCE   7  (bases 1 to 1715)
  AUTHORS   Okamoto,N., Fujikawa-Adachi,K., Nishimori,I., Taniuchi,K. and
            Onishi,S.
  TITLE     cDNA sequence of human carbonic anhydrase-related protein, CA-RP X:
            mRNA expressions of CA-RP X and XI in human brain
  JOURNAL   Biochim Biophys Acta 1518 (3), 311-316 (2001)
   PUBMED   11311946
REFERENCE   8  (bases 1 to 1715)
  AUTHORS   Fujikawa-Adachi,K., Nishimori,I., Taguchi,T., Yuri,K. and Onishi,S.
  TITLE     cDNA sequence, mRNA expression, and chromosomal localization of
            human carbonic anhydrase-related protein, CA-RP XI
  JOURNAL   Biochim Biophys Acta 1431 (2), 518-524 (1999)
   PUBMED   10350627
REFERENCE   9  (bases 1 to 1715)
  AUTHORS   Bellingham,J., Gregory-Evans,K. and Gregory-Evans,C.Y.
  TITLE     Sequence and tissue expression of a novel human carbonic
            anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3
  JOURNAL   Biochem Biophys Res Commun 253 (2), 364-367 (1998)
   PUBMED   9878543
REFERENCE   10 (bases 1 to 1715)
  AUTHORS   Lovejoy,D.A., Hewett-Emmett,D., Porter,C.A., Cepoi,D.,
            Sheffield,A., Vale,W.W. and Tashian,R.E.
  TITLE     Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related
            protein XI contains a sequence motif present in the neuropeptide
            sauvagine: the human CA-RP XI gene (CA11) is embedded between the
            secretor gene cluster and the DBP gene at 19q13.3
  JOURNAL   Genomics 54 (3), 484-493 (1998)
   PUBMED   9878252
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008888.7, AY358967.2,
            DR978420.1 and AI568635.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001217.4.
            
            Summary:  Carbonic anhydrases (CAs) are a large family of zinc
            metalloenzymes that catalyze the reversible hydration of carbon
            dioxide.  They participate in a variety of biological processes,
            including respiration, calcification, acid-base balance, bone
            resorption, and the formation of aqueous humor, cerebrospinal
            fluid, saliva, and gastric acid.  They show extensive diversity in
            tissue distribution and in their subcellular localization.  CA XI
            is likely a secreted protein, however, radical changes at active
            site residues completely conserved in CA isozymes with catalytic
            activity, make it unlikely that it has carbonic anhydrase activity.
            It shares properties in common with two other acatalytic CA
            isoforms, CA VIII and CA X.  CA XI is most abundantly expressed in
            brain, and may play a general role in the central nervous system.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.681089.1,
                                           SRR3476690.1112426.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000084798.9/ ENSP00000084798.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC008888.7         25324-25581         c
            259-1639            AY358967.2         265-1645
            1640-1711           DR978420.1         111-182
            1712-1715           AI568635.1         31-34               c
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1715
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /note="carbonic anhydrase 11"
                     /db_xref="GeneID:770"
                     /db_xref="HGNC:HGNC:1370"
                     /db_xref="MIM:604644"
     exon            1..622
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..1542
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /note="carbonic anhydrase-related protein XI; carbonic
                     anhydrase-related protein 2; carbonic anhydrase-related
                     protein 11; carbonic anhydrase XI"
                     /codon_start=1
                     /product="carbonic anhydrase-related protein 11 precursor"
                     /protein_id="NP_001208.2"
                     /db_xref="CCDS:CCDS12729.1"
                     /db_xref="GeneID:770"
                     /db_xref="HGNC:HGNC:1370"
                     /db_xref="MIM:604644"
                     /translation="MGAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGN
                     FVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYN
                     TGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQL
                     IHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYF
                     LQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNP
                     PSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPERRCRGPNYRLHVDGVPHGR"
     exon            623..697
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..840
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1026
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1122
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1195
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1350
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1516
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1715
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /note="hexamer: ATTAAA"
     polyA_site      1639
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /note="major polyA site"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
                     /note="hexamer: ATTAAA"
     polyA_site      1715
                     /gene="CA11"
                     /gene_synonym="CA-RP; CA-RP II; CA-XI; CARP-2; CARPX1"
ORIGIN      
        1 aagagagaag agagactgaa acagggagaa gaggcaggag aggaggaggt ggggagagca
       61 cgaagctgga ggccgacact gagggagggc gggaggaggt gaagaaggag agaggggaga
      121 agaggcagga gctggaaagg agagagggag gaggaggagg agatgcggga tggagacctg
      181 gagttaggtg gcttgggaga gcttaatgaa aagagaacgg agaggaggtg tgggttagga
      241 accaagaggt agccctgggg gcagcagaag gctgagagga gtaggaagat caggagctag
      301 agggagactg gagggttccg ggaaaagagc agaggaaaga ggaaagacac agagagacgg
      361 gagagagaag aagagtgggt ttgaagggcg gatctcagtc cctggctgct ttggcatttg
      421 gggaactggg actccctgtg gggaggagag gaaagctgga agtcctggag ggacagggtc
      481 ccagaaggag gggacagagg agctgagaga ggggggcagg gcgttgggca ggggtccctc
      541 ggaggcctcc tggggatggg ggctgcagct cgtctgagcg cccctcgagc gctggtactc
      601 tgggctgcac tgggggcagc agctcacatc ggaccagcac ctgaccccga ggactggtgg
      661 agctacaagg ataatctcca gggaaacttc gtgccagggc ctcctttctg gggcctggtg
      721 aatgcagcgt ggagtctgtg tgctgtgggg aagcggcaga gccccgtgga tgtggagctg
      781 aagagggttc tttatgaccc ctttctgccc ccattaaggc tcagcactgg aggagagaag
      841 ctccggggaa ccttgtacaa caccggccga catgtctcct tcctgcctgc accccgacct
      901 gtggtcaatg tgtctggagg tcccctcctt tacagccacc gactcagtga actgcggctg
      961 ctgtttggag ctcgcgacgg agccggctcg gaacatcaga tcaaccacca gggcttctct
     1021 gctgaggtgc agctcattca cttcaaccag gaactctacg ggaatttcag cgctgcctcc
     1081 cgcggcccca atggcctggc cattctcagc ctctttgtca acgttgccag tacctctaac
     1141 ccattcctca gtcgcctcct taaccgcgac accatcactc gcatctccta caagaatgat
     1201 gcctactttc ttcaagacct gagcctggag ctcctgttcc ctgaatcctt cggcttcatc
     1261 acctatcagg gctctctcag caccccgccc tgctccgaga ctgtcacctg gatcctcatt
     1321 gaccgggccc tcaatatcac ctcccttcag atgcactccc tgagactcct gagccagaat
     1381 cctccatctc agatcttcca gagcctcagc ggtaacagcc ggcccctgca gcccttggcc
     1441 cacagggcac tgaggggcaa cagggacccc cggcaccccg agaggcgctg ccgaggcccc
     1501 aactaccgcc tgcatgtgga tggtgtcccc catggtcgct gagactcccc ttcgaggatt
     1561 gcacccgccc gtcctaagcc tccccacaag gcgaggggag ttacccctaa aacaaagcta
     1621 ttaaagggac agaatacttc ctgttttctc agtggtctga ttctaggcgc ggtggggaaa
     1681 catttgggta ttaaagaaca gacttcttcc ggaaa
//
