LOCUS       NM_020178               3179 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens carbonic anhydrase 10 (CA10), transcript variant 2,
            mRNA.
ACCESSION   NM_020178
VERSION     NM_020178.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3179)
  AUTHORS   Li,Q., Zhang,L., Zhang,Z., Fan,Y. and Zhang,Q.
  TITLE     Carbonic anhydrase 10 functions as a tumor suppressor in renal cell
            carcinoma and its methylation is a risk factor for survival outcome
  JOURNAL   Urol Oncol 40 (4), 168 (2022)
   PUBMED   34980544
  REMARK    GeneRIF: Carbonic anhydrase 10 functions as a tumor suppressor in
            renal cell carcinoma and its methylation is a risk factor for
            survival outcome.
REFERENCE   2  (bases 1 to 3179)
  AUTHORS   Kreuzer,M., Banerjee,A., Birts,C.N., Darley,M., Tavassoli,A.,
            Ivan,M. and Blaydes,J.P.
  TITLE     Glycolysis, via NADH-dependent dimerisation of CtBPs, regulates
            hypoxia-induced expression of CAIX and stem-like breast cancer cell
            survival
  JOURNAL   FEBS Lett 594 (18), 2988-3001 (2020)
   PUBMED   32618367
  REMARK    GeneRIF: Glycolysis, via NADH-dependent dimerisation of CtBPs,
            regulates hypoxia-induced expression of CAIX and stem-like breast
            cancer cell survival.
REFERENCE   3  (bases 1 to 3179)
  AUTHORS   Ge,A., Gao,S., Liu,Y., Zhang,H., Wang,X., Zhang,L., Pang,D. and
            Zhao,Y.
  TITLE     Methylation of WT1, CA10 in peripheral blood leukocyte is
            associated with breast cancer risk: a case-control study
  JOURNAL   BMC Cancer 20 (1), 713 (2020)
   PUBMED   32736539
  REMARK    GeneRIF: Methylation of WT1, CA10 in peripheral blood leukocyte is
            associated with breast cancer risk: a case-control study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3179)
  AUTHORS   Tao,B., Ling,Y., Zhang,Y., Li,S., Zhou,P., Wang,X., Li,B., Jun,Z.,
            Zhang,W., Xu,C., Shi,J., Wang,L., Zhang,W. and Li,S.
  TITLE     CA10 and CA11 negatively regulate neuronal activity-dependent
            growth of gliomas
  JOURNAL   Mol Oncol 13 (5), 1018-1032 (2019)
   PUBMED   30636076
  REMARK    GeneRIF: results suggest that CA11 and CA10 negatively regulate
            neuronal activity-dependent glioma growth and inhibit glioma
            aggression. Thus, CA11/CA10 may represent a potential therapeutic
            target for the treatment of gliomas.
REFERENCE   5  (bases 1 to 3179)
  AUTHORS   Gao,H.L., Wang,X., Sun,H.R., Zhou,J.D., Lin,S.Q., Xing,Y.H.,
            Zhu,L., Zhou,H.B., Zhao,Y.S., Chi,Q. and Liu,Y.P.
  TITLE     Methylation Status of Transcriptional Modulatory Genes Associated
            with Colorectal Cancer in Northeast China
  JOURNAL   Gut Liver 12 (2), 173-182 (2018)
   PUBMED   29291617
  REMARK    GeneRIF: Total heterogeneous methylation of CA10 conferred a
            significantly higher risk of Colorectal Cancer.The gene methylation
            status of blood leukocytes may be associated with CRC risk.
REFERENCE   6  (bases 1 to 3179)
  AUTHORS   Supuran,C.T., Scozzafava,A. and Casini,A.
  TITLE     Carbonic anhydrase inhibitors
  JOURNAL   Med Res Rev 23 (2), 146-189 (2003)
   PUBMED   12500287
  REMARK    Review article
REFERENCE   7  (bases 1 to 3179)
  AUTHORS   Taniuchi,K., Nishimori,I., Takeuchi,T., Fujikawa-Adachi,K.,
            Ohtsuki,Y. and Onishi,S.
  TITLE     Developmental expression of carbonic anhydrase-related proteins
            VIII, X, and XI in the human brain
  JOURNAL   Neuroscience 112 (1), 93-99 (2002)
   PUBMED   12044474
REFERENCE   8  (bases 1 to 3179)
  AUTHORS   Okamoto,N., Fujikawa-Adachi,K., Nishimori,I., Taniuchi,K. and
            Onishi,S.
  TITLE     cDNA sequence of human carbonic anhydrase-related protein, CA-RP X:
            mRNA expressions of CA-RP X and XI in human brain
  JOURNAL   Biochim Biophys Acta 1518 (3), 311-316 (2001)
   PUBMED   11311946
REFERENCE   9  (bases 1 to 3179)
  AUTHORS   Kleiderlein,J.J., Nisson,P.E., Jessee,J., Li,W.B., Becker,K.G.,
            Derby,M.L., Ross,C.A. and Margolis,R.L.
  TITLE     CCG repeats in cDNAs from human brain
  JOURNAL   Hum Genet 103 (6), 666-673 (1998)
   PUBMED   9921901
  REMARK    GeneRIF: Identifies a string of seven CCG repeats in the 5' UTR of
            a carbonic anhydrase X cDNA from human brain.
            Erratum:[Hum Genet 1999 Jan;104(1):113]
REFERENCE   10 (bases 1 to 3179)
  AUTHORS   Hewett-Emmett,D. and Tashian,R.E.
  TITLE     Functional diversity, conservation, and convergence in the
            evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene
            families
  JOURNAL   Mol Phylogenet Evol 5 (1), 50-77 (1996)
   PUBMED   8673298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA128892.1, BC047456.1,
            AW135066.1 and AC005883.14.
            
            On Nov 23, 2018 this sequence version replaced NM_020178.4.
            
            Summary: This gene encodes a protein that belongs to the carbonic
            anhydrase family of zinc metalloenzymes, which catalyze the
            reversible hydration of carbon dioxide in various biological
            processes. The protein encoded by this gene is an acatalytic member
            of the alpha-carbonic anhydrase subgroup, and it is thought to play
            a role in the central nervous system, especially in brain
            development. Multiple transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.459666.1, BC068462.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451037.7/ ENSP00000405388.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               DA128892.1         59-215
            158-2731            BC047456.1         129-2702
            2732-2875           AW135066.1         328-471             c
            2876-2876           AC005883.14        6499-6499
            2877-3179           AW135066.1         24-326              c
FEATURES             Location/Qualifiers
     source          1..3179
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33-q22"
     gene            1..3179
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /note="carbonic anhydrase 10"
                     /db_xref="GeneID:56934"
                     /db_xref="HGNC:HGNC:1369"
                     /db_xref="MIM:604642"
     exon            1..989
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             929..1915
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /note="carbonic anhydrase-related protein 10; carbonic
                     anhydrase-related protein X; cerebral protein-15; CARP X;
                     CA-RP X; carbonic anhydrase X; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="carbonic anhydrase-related protein 10 precursor"
                     /protein_id="NP_064563.1"
                     /db_xref="CCDS:CCDS32684.1"
                     /db_xref="GeneID:56934"
                     /db_xref="HGNC:HGNC:1369"
                     /db_xref="MIM:604642"
                     /translation="MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFV
                     PVPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTG
                     RHVSLRLDKEHLVNISGGPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIH
                     YNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQ
                     GLNIEELYPETSSFITYDGSMTIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPS
                     QIFLSMSDNFRPVQPLNNRCIRTNINFSLQGKDCPNNRAQKLQYRVNEWLLK"
     exon            990..1064
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1207
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1393
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1489
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1562
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1717
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1892
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..3179
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2704..2709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /note="hexamer: AATAAA"
     polyA_site      2726
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /note="major polyA site"
     regulatory      3158..3163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /note="hexamer: AATAAA"
     polyA_site      3179
                     /gene="CA10"
                     /gene_synonym="CA-RPX; CARPX; HUCEP-15"
                     /note="major polyA site"
ORIGIN      
        1 gtattgcgga aaatctcgac agcggcgcta gttgcgggcg atggaagcca ggcaactggg
       61 ggttctgggg agttcaggaa aatagcagag gagcaggaag ggcgcgcgcg acctggagag
      121 tctgtgtgcc cccaccgcgc cccagtcccc ggggcccagc ccttcccctc ggcgccctgg
      181 acgcactgcc ggaacccggc tgagaggctg caggctgcgc gcggacctgg ggagcaggga
      241 gggtcggcgg aggctgccgg cggctggcgg tttcgggcaa taatccctgc ctctctttct
      301 ctgtgtgtct gctgtgtctg ctccttcccc gccccccgga agcaggagaa gaactgcccc
      361 ggagcgcagc agccaccctc cgaccatgcc ccggtgaggg gggcggactt cgagggcaac
      421 ttgccgcgga ctgcctgggc ttagccagcg agctacgcgc tcccgggagc ccggaattgc
      481 acggcgcagc ccggcggggg gctatcgtct atgtcttctt ggggcgccag acgaatcggg
      541 gtctcgtttt tgctggaaga gcccagtgtt ggtggcttca ggtggctgct gccgccgccg
      601 ccgccgccgc cgctgctagt gcggtttccg ccgctggtgc gaagagaaga gacacgcgag
      661 cggggagacc tccaaggcag cgaggcatcg gacatgtgtc agcacatctg gggcgcacat
      721 ccgtcgagcc cgaggggaga tttgccggaa caattcaaac tgcgatattg atcttggggg
      781 tgactgtccc tggccggctg tcgggtggga gtgcgagtgt gcactcgctc ggaagtgtgt
      841 gcgagtgtgt atgtgtgtgt gccgtgtcgg gctcccccct tccccccgtt ttcccgtcga
      901 gtgatgcact tggaatgaga atcagaggat ggaaatagtc tgggaggtgc tttttcttct
      961 tcaagccaat ttcatcgtct gcatatcagc tcaacagaat tcaccaaaaa tccatgaagg
     1021 ctggtgggca tacaaggagg tggtccaggg aagctttgtt ccagttcctt ctttctgggg
     1081 attggtgaac tcagcttgga atctttgctc tgtggggaaa cggcagtcgc cagtcaacat
     1141 agagaccagt cacatgatct tcgacccctt tctgacacct cttcgcatca acacgggggg
     1201 caggaaggtc agtgggacca tgtacaacac tggaagacac gtatcccttc gcctggacaa
     1261 ggagcacttg gtcaacatat ctggagggcc catgacatac agccaccggc tggaggagat
     1321 ccgactacac tttgggagtg aggacagcca agggtcggag cacctcctca atggacaggc
     1381 cttctctggg gaggtgcagc tcatccacta taaccatgag ctatatacga atgtcacaga
     1441 agctgcaaag agtccaaatg gattggtggt agtttctata tttataaaag tttctgattc
     1501 atcaaaccca tttcttaatc gaatgctcaa cagagatact atcacaagaa taacatataa
     1561 aaatgatgca tatttactac aggggcttaa tatagaggaa ctatatccag agacctctag
     1621 tttcatcact tacgatgggt cgatgactat cccaccctgc tatgagacag caagttggat
     1681 cataatgaac aaacctgtct atataaccag gatgcagatg cattccttgc gcctgctcag
     1741 ccagaaccag ccatctcaga tctttctgag catgagtgac aacttcaggc ctgtccagcc
     1801 actcaacaac cgctgcatcc gcaccaatat caacttcagt ttacagggga aggactgtcc
     1861 aaacaaccga gcccagaagc ttcagtatag agtaaatgaa tggctcctca agtagggaac
     1921 aaagccaaga agaatcccac ctcagtgaaa tgctacaact gtgaattgac gtaacctaga
     1981 atgtccccct tcttgcttct ctctccttct ttcccccaag cctcattcat tcttgggatt
     2041 ggccctttct tcatgaaaag tgtctgcaaa accatggcag aggaatacat ctctcacaca
     2101 tactcacaaa cacacacaca agcacttgca catacataca aacacatgca aacataccta
     2161 cacacacaca cactcttaca acctccatca tgggaagtca agtttcagaa acaaaagtct
     2221 cattcataag aggtcttaga agaaaataac cagttaacct gatttcaatt ttgataccgt
     2281 tttcctgaac taataaatct acccaatgag acttttcagc ctttgtacat acaaaattct
     2341 tccaaaagag agaggagaaa atacagctct gatggcatca aacggacttt gcatcaagta
     2401 atttcagata gtgtcctagg atcctttgag ggtgctggta gcaggtgagc aggacaaagt
     2461 tgaccaagga cacttatttc tagattatga ttcttctgtt tactcaacaa tttacaaaga
     2521 aaaaaaggac agacattgaa gagctacaca ttgtatatat atcaccacag actataagga
     2581 aatggaatta tttccctctt tgtcacatat ctgtagtagg atttgccaag atcagaaatg
     2641 atccatttgc tgtttcttgt tttccaaagg tcatacattg tgtttggtta ttgttaccag
     2701 ctcaataaat gtgtttaacg agttaatttc atttttctgg ctttggtctg ttctccttcc
     2761 ttacaggcta agccctggct ccatgcaact gcattctttg atttcacttg ttccttcatc
     2821 tacatgtttt gttcatttgc agccagtttt tactgagttt gtggcaatca ggaatgcatt
     2881 tgctaagcaa gtatgacttt aattccactc catggctcaa tcattcacat gaggtgagct
     2941 tcagcctgag atagcaggcg acagacttct tgcgtttcaa aactgccatg cccccctgtg
     3001 atgctcccgt gaaggaatgc actttgcctt gtaagttcct gggaaagggg tatgttttct
     3061 ctccaggtgc agccagatct cacaaagtac aaaacgaatg cctttctttt cttgtttata
     3121 atggtcactc actgtgtttg gttactgtca agaaatcaat aaatgtgttt aacaagtta
//
