LOCUS       NM_182505               1185 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens chromosome 9 open reading frame 85 (C9orf85),
            transcript variant 2, mRNA.
ACCESSION   NM_182505
VERSION     NM_182505.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Tan,H.W., Xu,Y.M., Liang,Z.L., Cai,N.L., Wu,Y.Y. and Lau,A.T.Y.
  TITLE     Single-gene knockout-coupled omics analysis identifies C9orf85 and
            CXorf38 as two uncharacterized human proteins associated with ZIP8
            malfunction
  JOURNAL   Front Mol Biosci 9, 991308 (2022)
   PUBMED   36330220
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010179.2, BC052375.1, CB113688.1, BQ431408.1 and BQ020559.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182505.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.104612.1,
                                           SRR5189658.70843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334731.7/ ENSP00000334289.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               BC010179.2         129-326
            199-765             BC052375.1         170-736
            766-880             BC010179.2         787-901
            881-900             CB113688.1         509-528
            901-904             BQ431408.1         835-838
            905-973             CB113688.1         533-601
            974-1185            BQ020559.1         12-223              c
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..1185
                     /gene="C9orf85"
                     /note="chromosome 9 open reading frame 85"
                     /db_xref="GeneID:138241"
                     /db_xref="HGNC:HGNC:28784"
                     /db_xref="MIM:620761"
     exon            1..198
                     /gene="C9orf85"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..570
                     /gene="C9orf85"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C9orf85"
                     /codon_start=1
                     /product="uncharacterized protein C9orf85 isoform 2"
                     /protein_id="NP_872311.2"
                     /db_xref="CCDS:CCDS6639.1"
                     /db_xref="GeneID:138241"
                     /db_xref="HGNC:HGNC:28784"
                     /db_xref="MIM:620761"
                     /translation="MSSQKGNVARSRPQKHQNTFSFKNDKFDKSVQTKKINAKLHDGV
                     CQRCKEVLEWRVKYSKYKPLSKPKKCVKCLQKTVKDSYHIMCRPCACELEVCAKCGKK
                     EDIVIPLNKETEKIEHTENNLSSNHRRSCRRNEESDDDLDFDIDLEDTGGDHQMN"
     exon            199..305
                     /gene="C9orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            306..419
                     /gene="C9orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            420..1185
                     /gene="C9orf85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1165..1170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf85"
                     /note="hexamer: AATAAA"
     polyA_site      1185
                     /gene="C9orf85"
                     /note="major polyA site"
ORIGIN      
        1 attgacagaa gcgtcaattc ctgggagtag ttcgttggtt ttctttcccc tcatcctttt
       61 gcctgctccc ggcgaggggt ggctttgatt tcggcgatga gctcccagaa aggcaacgtg
      121 gctcgttcca gacctcagaa gcaccagaat acgtttagct tcaaaaatga caagttcgat
      181 aaaagtgtgc agaccaagaa aattaatgca aaacttcatg atggagtatg tcagcgctgt
      241 aaagaagttc ttgagtggcg tgtaaaatac agcaaataca aaccattatc aaaacctaaa
      301 aagtgtgtta aatgtttaca aaagacagtg aaggattctt atcacataat gtgcaggcca
      361 tgtgcctgtg aacttgaagt ttgcgcaaaa tgtggaaaga aagaagacat tgttattccg
      421 ttgaataaag aaacagaaaa aatagaacat actgaaaata atctaagttc caaccataga
      481 agaagctgca gaagaaatga agaaagtgat gatgatttag attttgatat tgatttagaa
      541 gacacaggag gagaccatca aatgaattaa tatcactgta ttaaaagtct gccgggcaca
      601 gtggctcacg cctgtaatcc caacactttg ggaggccaag gagggtggat cacctgaggt
      661 caggagttcg agaccagcct ggccaacatg gcggaacccc atctccacta aaagtacaaa
      721 aaattagctg ggcgtggtgg ctcatgcctg taatcccagc tactcaggag gctgaggcag
      781 gaggattgct tgaaccctgg aggcggagat tgaagtgagc tgagttcgtg ccattacact
      841 ccagcctggg tgacagagtg agactctgtc tcaaaaaaaa taaaataaaa agtcaattta
      901 gaatgtgaaa ttctgaccac cttttggctt tgagtatttt ccaaaagata tttgaaatcc
      961 taatgaggaa atcagaaaaa gctatggaaa aatagacaaa tttcatacat gaacaatata
     1021 aattgtgtat attacttaac atcaaactaa acaagattca gaattgatgg ttgtataaga
     1081 actagctcat gtaaaaataa aataacatta ttacattgcc tcaaaaattg gtcctcggta
     1141 agtgcctttt gataaatgat ctcaaataaa tgactcatag caaaa
//
