LOCUS       NM_001128618            1510 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome 9 open reading frame 57 (C9orf57),
            transcript variant 1, mRNA.
ACCESSION   NM_001128618 XM_001714846 XM_059954 XM_937019
VERSION     NM_001128618.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138751.18.
            
            On Jul 19, 2019 this sequence version replaced NM_001128618.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036255.1, SRR5189667.346529.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000651200.2/
                                                ENSP00000498279.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AL138751.18        188394-188510       c
            118-267             AL138751.18        187132-187281       c
            268-327             AL138751.18        184681-184740       c
            328-450             AL138751.18        183971-184093       c
            451-1510            AL138751.18        179273-180332       c
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..1510
                     /gene="C9orf57"
                     /note="chromosome 9 open reading frame 57"
                     /db_xref="GeneID:138240"
                     /db_xref="HGNC:HGNC:27037"
     exon            1..117
                     /gene="C9orf57"
                     /inference="alignment:Splign:2.1.0"
     exon            118..267
                     /gene="C9orf57"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..590
                     /gene="C9orf57"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C9orf57"
                     /codon_start=1
                     /product="uncharacterized protein C9orf57 isoform 1"
                     /protein_id="NP_001122090.2"
                     /db_xref="CCDS:CCDS47980.2"
                     /db_xref="GeneID:138240"
                     /db_xref="HGNC:HGNC:27037"
                     /translation="MRRIVFAGVILFRLLGVILFRLLGVILFGRLGDLGTCQTKPGQY
                     WKEEVHIQDVGGLICRACNLSLPFHGCLLDLGTCQAEPGQYCKEEVHIQGGIQWYSVK
                     GCTKNTSECFKSTLVKRILQLHELVTTHCCNHSLCNF"
     exon            268..327
                     /gene="C9orf57"
                     /inference="alignment:Splign:2.1.0"
     exon            328..450
                     /gene="C9orf57"
                     /inference="alignment:Splign:2.1.0"
     exon            451..1510
                     /gene="C9orf57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1487..1492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf57"
                     /note="hexamer: AATAAA"
     regulatory      1494..1499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf57"
                     /note="hexamer: AATAAA"
     polyA_site      1505
                     /gene="C9orf57"
                     /note="major polyA site"
     polyA_site      1510
                     /gene="C9orf57"
                     /note="major polyA site"
ORIGIN      
        1 agagtgtcgc tttcagttgt aacggacttc atcacatcac aaattgtact cgttctcatc
       61 cttttaagaa agttcagacc caggaaaatt tccatagtac cttaatgaaa aagatagaaa
      121 tcagtgggac gtgtctttcc tttcatctcc ttttcggctt ggaaatcaga atgagaagga
      181 ttgtttttgc tggtgttatc ttattccgcc tcttaggtgt tatcttattc cgcctcttag
      241 gtgttatctt attcggccgc ttaggtgacc tgggaacctg ccagacaaaa cctggtcagt
      301 actggaaaga agaggtccac attcaagatg ttggaggttt gatttgcaga gcatgcaatc
      361 tttcactgcc cttccatgga tgtcttttag acctgggaac ctgccaggca gaacctggtc
      421 agtactgtaa agaagaggtc cacattcaag gtggcattca atggtattca gtcaaaggct
      481 gcacaaagaa cacatcagag tgcttcaaga gtactctcgt caagagaatt ctgcaactgc
      541 atgaacttgt aactactcac tgctgcaatc attctttgtg caatttctga gtcagtggcc
      601 catatctaaa atgcttggca gatcaatcag tctcgaagcc tgacctggct atcacaaaat
      661 gatggctatt gtcaattagc ccacttcaga aacctcagac ccttgtaggt agaaggaatt
      721 ttgatctgaa attgactttg gttttcaata ttcccaatat ctcccccacc acctccaact
      781 catctgagaa atagcccttt caacaccatt tctctcctct cctccttctg cttaatttac
      841 cttcctacca caaggctaca aagaaggaaa aatgttagtg attctccaag tcaaactagg
      901 catgtcacct ctaactactt tcatttccct caataattcc atactccaaa atatggttac
      961 aaatgtttca caagacagca agtgacctga gaatattcat ttggtttcca aagcaaactg
     1021 ccttgctcct ttggggtgat ttatggtata gaagaaactg acttaacata tactataggg
     1081 aaaaaataag ccatgaatca gcaagccagg cctgcgggaa aagtatgaac ccaaacagga
     1141 aagggctgag gcaggtggta gggctggcac ttatttcttc catctgcctc agagtttatc
     1201 caaattttga attttccgta ccttaaccat gcctaaatgc tttggcttgt tcaattttgg
     1261 cagattaagc agttcaaggt aagcagagaa gtaagttccc aaccacaagg aatttaaaag
     1321 gagtaggaac gtactttgaa ctacatttcc cattttgcga tcattacgtc ttctattaca
     1381 atgccctact ttggcagcat gaagagtact gcattaattt aatttaattt aaaatttaat
     1441 ttaaaactgt ctttctctgt attttcagga gtttgaaaat tcaaaaaata aataataaat
     1501 gtcaataaaa
//
