LOCUS       NM_199350               1945 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens chromosome 9 open reading frame 50 (C9orf50), mRNA.
ACCESSION   NM_199350 XM_351852
VERSION     NM_199350.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Pineau,C., Hikmet,F., Zhang,C., Oksvold,P., Chen,S., Fagerberg,L.,
            Uhlen,M. and Lindskog,C.
  TITLE     Cell Type-Specific Expression of Testis Elevated Genes Based on
            Transcriptomics and Antibody-Based Proteomics
  JOURNAL   J Proteome Res 18 (12), 4215-4230 (2019)
   PUBMED   31429579
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Yu,B., Zheng,Y., Alexander,D., Manolio,T.A., Alonso,A.,
            Nettleton,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association study of a heart failure related
            metabolomic profile among African Americans in the Atherosclerosis
            Risk in Communities (ARIC) study
  JOURNAL   Genet Epidemiol 37 (8), 840-845 (2013)
   PUBMED   23934736
REFERENCE   3  (bases 1 to 1945)
  AUTHORS   Clark,S.L., Adkins,D.E., Aberg,K., Hettema,J.M., McClay,J.L.,
            Souza,R.P. and van den Oord,E.J.
  TITLE     Pharmacogenomic study of side-effects for antidepressant treatment
            options in STAR*D
  JOURNAL   Psychol Med 42 (6), 1151-1162 (2012)
   PUBMED   22041458
REFERENCE   4  (bases 1 to 1945)
  AUTHORS   Fardilha,M., Esteves,S.L., Korrodi-Gregorio,L., Vintem,A.P.,
            Domingues,S.C., Rebelo,S., Morrice,N., Cohen,P.T., da Cruz e
            Silva,O.A. and da Cruz e Silva,E.F.
  TITLE     Identification of the human testis protein phosphatase 1
            interactome
  JOURNAL   Biochem Pharmacol 82 (10), 1403-1415 (2011)
   PUBMED   21382349
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590369.18 and AL391056.25.
            
            On Jul 26, 2021 this sequence version replaced NM_199350.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093122.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372478.5/ ENSP00000361556.4
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1035              AL590369.18        4482-5516           c
            1036-1126           AL590369.18        4155-4245           c
            1127-1243           AL590369.18        3935-4051           c
            1244-1407           AL391056.25        127361-127524       c
            1408-1570           AL391056.25        125312-125474       c
            1571-1715           AL391056.25        124984-125128       c
            1716-1945           AL391056.25        124102-124331       c
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..1945
                     /gene="C9orf50"
                     /note="chromosome 9 open reading frame 50"
                     /db_xref="GeneID:375759"
                     /db_xref="HGNC:HGNC:23677"
     exon            1..1035
                     /gene="C9orf50"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..1823
                     /gene="C9orf50"
                     /codon_start=1
                     /product="uncharacterized protein C9orf50"
                     /protein_id="NP_955382.3"
                     /db_xref="CCDS:CCDS35159.1"
                     /db_xref="GeneID:375759"
                     /db_xref="HGNC:HGNC:23677"
                     /translation="MFWRRLRPGAQDLAPKGLPGDGDFRRSSDPRLPKLTPPALRAAL
                     GARGSGDWRIPGGGAAWWPEGDAKPGVGVGRLPPRLPALLTATRRAVRKRGLLRSLLP
                     PPLLSAGASRESAPRQPGPGERERPRRRVAREDPDFLGAFLGELLPSRFREFLHQLQE
                     KCAEEPEPLTSPAPQHQRGVLEHCPGSPRCPNCSFLPDLWGQSSHLQDSLTKISLQQT
                     PILGPLKGDHSQFTTVRKANHRPHGAQVPRLKAALTHNPSGEGSRPCRQRCPFRVRFA
                     DETLQDTTLRYWERRRSVQQSVIVNQKAALPVASERVFGSVGKRLESLPKALYPGAKE
                     ETLASSSCWDCAGLSTQKTQGYLSEDTSMNSSLPFCSWKKAAAQRPRSSLRAFLDPHR
                     NLEQESLLPNRVLQSVLKQGCPKGYHLLLASATLQPDKR"
     exon            1036..1126
                     /gene="C9orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1243
                     /gene="C9orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1407
                     /gene="C9orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1570
                     /gene="C9orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1715
                     /gene="C9orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1945
                     /gene="C9orf50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf50"
                     /note="hexamer: AATAAA"
     polyA_site      1927
                     /gene="C9orf50"
                     /note="major polyA site"
     polyA_site      1945
                     /gene="C9orf50"
                     /note="major polyA site"
ORIGIN      
        1 ctctaccagc ggtgatgcgg tgatgccgtt tcacggctgc agagaggcag gtgctgctat
       61 tatccccatt ctgcagacca gagcccccag ggaaggcaga gggaagttaa ttggcttggc
      121 caaggttaca aagctaataa gtggtggagc tgggactaaa tcctaaataa taataacttt
      181 gaaatactaa gaatggcagc tagtctatgt gtaagcttgg ccagcgtgcc tggcactgta
      241 ccgagcttgc tgttctaaga ctggcatgta cttgctcatt taaacgtcac agcaaccccc
      301 aaagttggct actcttgctg tcaccatttt tcaggtgagg aaacagaggc tctgggagct
      361 ctcgcctgaa gccactcgct gtccgccggg ccggtggcgt tcaccccgca ccgcgctgcc
      421 ccgcccgggg cactatggcc tggggctgga ctatgccctc cccacctcag ccggcgcccc
      481 ccacccacgc gcgctgaggg tgcggtgagc tgagtgcggg gccaagcatg ttctggcgtc
      541 gacttcgccc aggggcccag gacctggcgc ccaaggggct ccctggcgac ggagacttcc
      601 gacgcagcag cgacccgcgg ctgcccaagc tgaccccgcc cgcgctccga gcggctctgg
      661 gcgcgcgggg ctccggggac tggaggatcc cggggggcgg cgccgcgtgg tggccggaag
      721 gggacgccaa gcccggggtg ggcgtcggac gcctcccgcc gcgcctgccc gccttgctca
      781 ccgcgacccg gcgggccgtg cggaagcggg ggctgctgcg gtccctgctg ccgcctcccc
      841 tgctgtcggc cggcgcgtcc cgggaatcgg cgcccaggca gccagggcct ggagagcgcg
      901 agcgcccccg gaggcgcgtg gccagggagg accccgactt cttgggcgcc ttcctaggag
      961 agctcctccc cagcaggttc cgtgagttcc tgcaccagct ccaggagaag tgcgccgagg
     1021 agccggagcc actgacatcc ccagcaccgc aacatcaaag gggtgtatta gagcactgcc
     1081 cagggtctcc gcggtgtccc aactgttcat tcctcccaga cctgtggggc cagtcatcgc
     1141 acctccagga tagtcttacg aagatttcgc tccagcagac acctattctg gggcccctga
     1201 agggtgatca ctcacaattc accactgtca gaaaggccaa ccacaggccc cacggtgcac
     1261 aggtccccag gctcaaggct gcgctgaccc acaacccctc gggggaaggc tctaggccct
     1321 gcaggcagcg ttgccctttc cgggtgcgat tcgctgacga gaccctgcag gacacaacgc
     1381 tccgctactg ggagcgcaga cgctcagtcc aacagagcgt cattgtgaac cagaaggccg
     1441 ccctgccagt ggcgtccgag cgggtgtttg ggagtgtcgg aaaacggctg gagagtttgc
     1501 ccaaagccct gtaccctggg gccaaggagg agaccctggc cagctcctcg tgttgggact
     1561 gcgctggcct gtccacccag aagacacagg gctacctttc tgaggacacc tccatgaaca
     1621 gcagcctgcc cttctgttca tggaagaagg ccgctgctca gaggccgcga agcagcctcc
     1681 gagccttctt ggacccgcac agaaacctgg agcaggagtc cctcctgccc aaccgggtgc
     1741 tgcagtcggt cctgaagcaa ggctgcccta aggggtacca tctcctcctg gcctccgcaa
     1801 cactgcagcc agataagagg tgaacactcg cgaacccaag gccaggggca cacatgggcc
     1861 aggcaatgag gagcgtcctt ccttgcccca caaataaagg cacatcccag gtggctggga
     1921 cctgccagta ggtgtcacac cacaa
//
