LOCUS       NM_017998               2351 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens chromosome 9 open reading frame 40 (C9orf40), mRNA.
ACCESSION   NM_017998
VERSION     NM_017998.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2351)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158825.12, AK000972.1, BC039588.1 and BM126413.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017998.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.309606.1, AK000972.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376854.6/ ENSP00000366050.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL158825.12        51367-51392         c
            27-92               AK000972.1         1-66
            93-1303             BC039588.1         1-1211
            1304-1972           AK000972.1         1278-1946
            1973-2351           BM126413.1         21-399
FEATURES             Location/Qualifiers
     source          1..2351
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..2351
                     /gene="C9orf40"
                     /note="chromosome 9 open reading frame 40"
                     /db_xref="GeneID:55071"
                     /db_xref="HGNC:HGNC:23433"
     exon            1..727
                     /gene="C9orf40"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..886
                     /gene="C9orf40"
                     /codon_start=1
                     /product="uncharacterized protein C9orf40"
                     /protein_id="NP_060468.2"
                     /db_xref="CCDS:CCDS6648.1"
                     /db_xref="GeneID:55071"
                     /db_xref="HGNC:HGNC:23433"
                     /translation="MAKRRAAEPVTFHVPWKRLLLCDFAEQPPPPPLWIRPPGVAHAG
                     QLLGVPEQHRKRKIDAGTMAEPSASPSKRRDSGDNSAPSGQEREDHGLETGDPPLPPP
                     PVLPGPGEELPGARLPGGGGDDGAGRAGPPRGDWGVASRQHNEEFWQYNTFQYWRNPL
                     PPIDLADIEDLSEDTLTEATLQGRNEGAEVDMES"
     exon            728..2351
                     /gene="C9orf40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf40"
                     /note="hexamer: AATAAA"
     polyA_site      1305
                     /gene="C9orf40"
                     /note="major polyA site"
     regulatory      1954..1959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf40"
                     /note="hexamer: AATAAA"
     polyA_site      1979
                     /gene="C9orf40"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf40"
                     /note="hexamer: AATAAA"
     polyA_site      2351
                     /gene="C9orf40"
ORIGIN      
        1 agagtgcgcg cgcgcacgtt gtgcgcaggt tcgaatctcc gccgcttcgc ggttgcttct
       61 caacgtccgg gccgcatctc ggcggcggcg agggctgagc gcgggagctg cctccgagcc
      121 ggagccccag ccctaggccc tgcgcgagct gccccgccct accccctcca gcgtcctgtc
      181 gcctcctcgc ccgacttcgg cctgtccctc tctcacgcgc tcagtcctcg ctcttcgccc
      241 cccgcagcta tcggcactcg gtctcccgcg cctggcgggc tccgcccgag cctctgggcc
      301 catggccaag cggcgtgcgg ccgagccggt gacgttccac gtgccttgga agcggctcct
      361 gctttgcgac ttcgctgagc agccgccgcc accgcctctc tggatccggc cgcccggggt
      421 cgcgcatgct gggcagctcc tcggcgtccc agagcagcac cgaaagcgca aaatcgacgc
      481 agggaccatg gcagagccct cggcttcgcc cagcaagcgc cgtgacagcg gggacaacag
      541 cgccccgagc ggccaggagc gtgaggacca cggtctggag acaggcgatc cgccgctgcc
      601 gccgccgccc gtactgccgg ggccggggga ggagctcccg ggcgcccggc tcccgggggg
      661 cggtggcgac gacggggcgg ggcgcgcagg acccccgcgg ggagactggg gggtcgcatc
      721 gcgccagcac aatgaagaat tttggcagta taataccttc cagtactgga ggaatccttt
      781 gcctcctatt gatctggcag acattgaaga tttaagtgaa gacaccctga cagaagcaac
      841 acttcagggc aggaatgaag gggctgaggt tgacatggag tcctgatgta aggagccgaa
      901 gcagtgggat tggctgattt gaggagatgt ctctaagtga attctcgtat tcttaaggga
      961 aaagttattt tccatacttg aagttatatt tccaaacctg agaaatgaag aaagattgtt
     1021 ctgacattaa atacctacag ttactactga acctcttaat aaggatttgt caaggataga
     1081 gtacagttgt aggggaagta ttttatgtat gcattcttag agcaaaaagt tttgtttaaa
     1141 ttctagaatt gaaggtactg atcttataaa aagaaattct agcagtttta gaaataggtg
     1201 ggaaaaactc aaatattcct cctatctgca ccaaaaagtt tatttgtggt atataaaatg
     1261 aatattgttt tataataact tgttaataaa gtactttcta atacattcta ttgactctgt
     1321 tagttgaaca aatagctgac ttgaacatct atgcaaactt aagatgggcg ggattgttgt
     1381 aaaagctatt gttttaaaag agctttctaa atgtaaagta gtgataattt caatttgggt
     1441 agcgtgtttg caaagcttcc aatatttgat gttggttaag ctctactatg ggcaactgaa
     1501 gatggataaa gaaaaatgaa aactgaatcg gtgcctgctt ccccctgttt tcccaggatt
     1561 agaggaaaaa atttattgta taatcagctt cttggttttg aattgcttcg aggcatggtt
     1621 ttattcctta ttactttaga cctgtagttt tcaacactga cagcacttta aaaatctttg
     1681 cctgggcctc actcttgaga gattctcatt taatagttct gaggtgggtc ttggatataa
     1741 ctattttttt aaacacctgt cctgtttccc tccattcctc tcatgtgcag acagggttga
     1801 gaaccagtag actaatggtc gtttttcctg tttaaaggag ataactaatt tgagctgaag
     1861 caatgcttct taattagctt tgtttttgtt ttgctctgtt ggtggctttg ttacaactga
     1921 attattgtgt tattactatt tcattgttaa agaaataaag taagcaattt gtgatgtgag
     1981 tatcagtgat taagttaact aacttttgta ctgcatccag aatgttggtt ttgcaattga
     2041 gtaactggtt cttgcttgca ttttttgttg ttgatgacat tagatccaaa attcaagaca
     2101 aatggtaaat gccattgaga gggaaagaga aaaacttgat tttttttgtg taatgaagga
     2161 tttaagaatg ggttgacatt aataagaatg ctttagaaca gaagacaaac tgtattgcat
     2221 tgtggtcaga catggttcaa agtcttgtac tgccacttcc tacctatgta tctttaagcc
     2281 agttattttt catctccaag cctcaaattt ctcacctgta aaatgagaaa taataaatag
     2341 tatctacctc a
//
