LOCUS       NM_001276366            1845 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens chromosome 9 open reading frame 153 (C9orf153),
            transcript variant 2, mRNA.
ACCESSION   NM_001276366
VERSION     NM_001276366.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137849.13.
            
            On Nov 19, 2020 this sequence version replaced NM_001276366.3.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the
            same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG772848.1, BG772974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339137.7/ ENSP00000344865.2
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AL137849.13        75449-75556         c
            109-200             AL137849.13        45437-45528         c
            201-376             AL137849.13        43754-43929         c
            377-1845            AL137849.13        36164-37632         c
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..1845
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /note="chromosome 9 open reading frame 153"
                     /db_xref="GeneID:389766"
                     /db_xref="HGNC:HGNC:31456"
     exon            1..108
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            109..200
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..422
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /codon_start=1
                     /product="uncharacterized protein C9orf153"
                     /protein_id="NP_001263295.1"
                     /db_xref="CCDS:CCDS35055.2"
                     /db_xref="GeneID:389766"
                     /db_xref="HGNC:HGNC:31456"
                     /translation="MFLTGDTSPAEDNREATLPQCSLPELYACIENFNKESKKSNLLK
                     MHGISLNEAQEVLARNLNVMSFTRGADVRGDLQPVIRKTIHESKGSGMEIF"
     exon            201..376
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..1845
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      619..624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /note="hexamer: ATTAAA"
     polyA_site      638
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /note="major polyA site"
     regulatory      1827..1832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /note="hexamer: ATTAAA"
     polyA_site      1845
                     /gene="C9orf153"
                     /gene_synonym="bA507D14.1"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgggc cttggggctg ctggatgaat gagacccagc ctctgccctg ggagtgcaga
       61 gactcaagac agatatgacc acgtgaagag acaactgtaa aacaagtgga attagagaat
      121 aaaatcccag cacgatgttc ctcactggag acaccagtcc agctgaggac aatagagaag
      181 ccacccttcc tcaatgttca cttccagaat tatatgcatg tattgagaat tttaataagg
      241 agagcaagaa atcaaatctt ctaaaaatgc atggtatttc acttaacgaa gcacaggaag
      301 tacttgctag aaacctgaat gtcatgtcat tcaccagggg cgctgatgtg agaggagatc
      361 tccaacctgt tatcaggaaa acaattcatg aatctaaggg atctggaatg gagatatttt
      421 aaggggcttg cgaagtggag gcgcactact gcaatttcat tcggagacat aaaatacaac
      481 actgagaaga gatttgtaga gagccaggac atgcctgacg ttattttccc ccctatagtt
      541 cgcaagtctt tggtcattta tcctcaaatt gattatcaaa atgaaggaag ttattctctt
      601 aaatggaata tgtagtgtat taaaatattt tggacgtaga tttttgcttt tgagagcatt
      661 gatttaatac acaaaaagta aagaagccaa gtacccaata gaacatctga agtgagtgtg
      721 tacaacacac atgaaggtat attgtaaaat taagccgtta atacagagca aaaggtccga
      781 tttaatctgc taacgtgaga agtggtttgg acggtgcaac ccatttggac cagggctaaa
      841 gcaaatatag gtcatatgaa aagaaaaggt gtaactgaag aacactcaag caagcatagc
      901 tttttaagga attttaagca cacaaggaag ttcatcatca taaagtattt ggtacattca
      961 acaaacaaat taacatctga gcatatagag atcaatatga gaacttaaat ataatctatt
     1021 aactgtccag tgacaaagaa ggaaacagca tccatgaaat aagaacagaa agatttgtaa
     1081 aagaacaaat tggaaatctt ggaaatgaaa gatatagtca ttgaaaatta taataataac
     1141 ccttgataat tatcccagtg gtagcctgga tatatctgaa gagagagggc taacaagttg
     1201 gaagacagca ttgaaaagct tagagatcat agcactgtaa gacagaaaaa taagagtatt
     1261 ggacggtaga atgagaagtt cagaaatgta tacgatggaa ttagcagaaa aaaaatagga
     1321 gaatggaaat taagtgatat gtgaaaataa aatgacagaa aaatctcaag aaacacatga
     1381 gaccttgaac tgaaaaatct cagactgatt agcaagatat tgaaaataaa tctataccca
     1441 gaaatactgt agcaaaacta tggaccacta agcagtaaag gaaaatataa tctacgaaag
     1501 agagatggat tacatacaaa gaaatgacaa attgacaata gaatgctcat taacaataga
     1561 ggtcagagga caatagtgtc atatacttac aatgctgaag gaaaatagct gtctgtaatt
     1621 ctataagcag ccaaactctc tctgaggagt agggggtaaa ataaaaatgt taaaaaatac
     1681 atgggcctaa aaatgtttac tatccataat cccttgctta aaaaaaacta ctaataaagt
     1741 atgtatttta gtaagaaccc agagggaatg caagaaataa tggcaagcaa attgttaaca
     1801 atatatgtgt gtatgattgt gtagatatta aaatacattt ccgga
//
