LOCUS       NM_001243237             684 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens chromosome 8 open reading frame 89 (C8orf89),
            transcript variant 1, mRNA.
ACCESSION   NM_001243237
VERSION     NM_001243237.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 684)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100823.3.
            
            On Jan 28, 2021 this sequence version replaced NM_001243237.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DT932667.1, DT932668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000624510.4/ ENSP00000485524.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AC100823.3         191663-191861       c
            200-353             AC100823.3         189304-189457       c
            354-409             AC100823.3         182599-182654       c
            410-684             AC100823.3         173662-173936       c
FEATURES             Location/Qualifiers
     source          1..684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..684
                     /gene="C8orf89"
                     /note="chromosome 8 open reading frame 89"
                     /db_xref="GeneID:100130301"
                     /db_xref="HGNC:HGNC:51258"
     exon            1..199
                     /gene="C8orf89"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..558
                     /gene="C8orf89"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="putative uncharacterized protein C8orf89 isoform
                     a"
                     /protein_id="NP_001230166.1"
                     /db_xref="CCDS:CCDS75752.1"
                     /db_xref="GeneID:100130301"
                     /db_xref="HGNC:HGNC:51258"
                     /translation="MSVLSPEIKCETSKFTRSSFGSCLIFESSWKKAVLETQKIKKEY
                     TTAFGLEELKECIKMPYLPGLQSCQKSVSSTPLEVPKRLPRADAEVSAVRLKKTKETC
                     SVAPLWEKSKGSGFSDPLTGAPSQYLERLSKIAILEYDTIRQETTTKSKKSKKRDLRD
                     R"
     exon            200..353
                     /gene="C8orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            354..409
                     /gene="C8orf89"
                     /inference="alignment:Splign:2.1.0"
     exon            410..684
                     /gene="C8orf89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      667..672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf89"
                     /note="hexamer: AATAAA"
     polyA_site      684
                     /gene="C8orf89"
                     /note="major polyA site"
ORIGIN      
        1 ttttttttgt attttgtgtc ctgtctctgc agcagcatct ccctctcatc agcactgttg
       61 aaagaagaaa aaatgtcagt gctatctcct gaaatcaaat gtgagacttc taaattcacc
      121 agaagttcct ttggcagttg tttgattttt gagagtagtt ggaagaaagc agttttagaa
      181 acacaaaaga ttaagaaaga atataccaca gcatttggtc tagaagagct caaggaatgt
      241 atcaaaatgc catatttacc aggactgcaa agttgccaaa aaagtgtaag ttcaactcca
      301 ctagaggttc ctaaaagact gccacgtgct gatgccgagg tgtctgcagt caggctaaag
      361 aagactaagg agacatgcag tgtggcacca ctttgggaga aatcaaaagg ttctggcttc
      421 agtgatcctc tcactggagc accatctcaa tacttagaga gactttccaa aatagccata
      481 ttggaatatg ataccattcg tcaggaaaca accacaaaat caaaaaaaag caagaaacga
      541 gacctccgag accgctgaaa aatgtcgtac agtgtgatgc tttcttcagt gacttttaag
      601 ctttatattt tcttttttta tatgatatga tgcaaaatga tttatataaa aatggaaatg
      661 taaataaata aatattttac atta
//
