LOCUS       NM_001190972            1041 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 8 open reading frame 88 (C8orf88),
            transcript variant 1, mRNA.
ACCESSION   NM_001190972 XM_001722508 XM_001722530 XM_001722571
VERSION     NM_001190972.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1041)
  AUTHORS   Pugsley,L., Naineni,S.K., Amiri,M., Yanagiya,A., Cencic,R.,
            Sonenberg,N. and Pelletier,J.
  TITLE     C8ORF88: A Novel eIF4E-Binding Protein
  JOURNAL   Genes (Basel) 14 (11), 2076 (2023)
   PUBMED   38003019
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI562585.1, DA838443.1 and AC103770.5.
            
            On Nov 23, 2018 this sequence version replaced NM_001190972.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.351401.1,
                                           SRR1803614.333674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517562.3/ ENSP00000454561.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BI562585.1         15-32
            19-567              DA838443.1         1-549
            568-1041            AC103770.5         3327-3800
FEATURES             Location/Qualifiers
     source          1..1041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..1041
                     /gene="C8orf88"
                     /note="chromosome 8 open reading frame 88"
                     /db_xref="GeneID:100127983"
                     /db_xref="HGNC:HGNC:44672"
     exon            1..125
                     /gene="C8orf88"
                     /inference="alignment:Splign:2.1.0"
     exon            126..224
                     /gene="C8orf88"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..505
                     /gene="C8orf88"
                     /codon_start=1
                     /product="uncharacterized protein C8orf88"
                     /protein_id="NP_001177901.1"
                     /db_xref="CCDS:CCDS59105.1"
                     /db_xref="GeneID:100127983"
                     /db_xref="HGNC:HGNC:44672"
                     /translation="METKKLIGKPLQPARPVRHLTSPPGAVFPFNFQNEYPCNTQCIQ
                     SGVSRCKTNGMQAFSQGLNEQQQQQSPVKKERIKYSRDFLLKLSSVSICRKKPDFLPD
                     HPIVLQKPENNQSFK"
     exon            225..298
                     /gene="C8orf88"
                     /inference="alignment:Splign:2.1.0"
     exon            299..374
                     /gene="C8orf88"
                     /inference="alignment:Splign:2.1.0"
     exon            375..481
                     /gene="C8orf88"
                     /inference="alignment:Splign:2.1.0"
     exon            482..1041
                     /gene="C8orf88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      853..858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf88"
                     /note="hexamer: TATAAA"
     polyA_site      875
                     /gene="C8orf88"
                     /note="major polyA site"
     regulatory      1017..1022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf88"
                     /note="hexamer: AATAAA"
     polyA_site      1041
                     /gene="C8orf88"
ORIGIN      
        1 accgcggtca gccagcggac cagcggcagg agccgttccc cgacgggcag cagggcgctc
       61 ggcctccgcg tgtgggctga gcgcggcgac gctgctgccc cgaaatcccc gtggattttg
      121 agtcgtatgg aacctcaaag tctttgtgac aatggaaacc aaaaaattaa ttggtaaacc
      181 gcttcaacca gcaagacctg ttcgtcatct gacttctccc ccaggagcag tgttcccttt
      241 caactttcaa aacgaatatc catgcaacac tcagtgcata caaagtggag ttagcagatg
      301 taagacgaat ggaatgcaag ccttttctca aggtcttaat gagcaacagc aacagcagtc
      361 tccagttaag aaagagagaa ttaaatacag cagagatttc ctgttgaagc tctcaagtgt
      421 ttccatctgc agaaaaaaac cagactttct gcctgatcat cccattgtac tgcaaaaacc
      481 agaaaacaac caaagtttta agtagcattt taagaacaga tgaatttaag tttggacatc
      541 tgcaaatgag gtggatctag caacaataac tgtaatggac tgtgacaatt caatttattc
      601 ttaattttga tggttggcta tttgacttct ctaaaaatga gaaagagcta ttttaaaata
      661 taaagaattt tctaatcagt ttcagctttg caggaggttt cctgcataaa ttgggaagta
      721 acactggaaa gtaggaattt ggttagtgaa gtgggaagac tgtatattta taatttgcat
      781 actacttgca attttttgtt tttcatcact tgtaataatg gaatggaaat gtaagctgta
      841 aagactctca aatataaaat atttgctaca gtgtatatat ggtacataat tgcttgttgc
      901 ttttaaagtt ccttctgttg ttctgcttcc cactgatttc ataccagctc atgaatggat
      961 cattacagtc tctccagagg cttagaatga ttcagaatgt tcaatgcata gttctcaata
     1021 aacaggaggc agaattttta a
//
