LOCUS       NM_032847               1310 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 8 open reading frame 76 (C8orf76), mRNA.
ACCESSION   NM_032847
VERSION     NM_032847.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Li,D., Pan,J., Zhang,Y., Li,Y., Jin,S., Zhong,C., Chen,P., Ma,J.,
            Hu,W., Fan,X. and Lin,H.
  TITLE     C8orf76 Modulates Ferroptosis in Liver Cancer via Transcriptionally
            Up-Regulating SLC7A11
  JOURNAL   Cancers (Basel) 14 (14), 3410 (2022)
   PUBMED   35884471
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Wang,Y. and Dong,X.
  TITLE     High Expression of C8orf76 Is an Independent Predictive Factor of
            Poor Prognosis in Patients with Breast Cancer
  JOURNAL   Adv Ther 39 (6), 2946-2960 (2022)
   PUBMED   35482249
  REMARK    GeneRIF: High Expression of C8orf76 Is an Independent Predictive
            Factor of Poor Prognosis in Patients with Breast Cancer.
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Wang,X., Liang,Q., Zhang,L., Gou,H., Li,Z., Chen,H., Dong,Y., Ji,J.
            and Yu,J.
  TITLE     C8orf76 Promotes Gastric Tumorigenicity and Metastasis by Directly
            Inducing lncRNA DUSP5P1 and Associates with Patient Outcomes
  JOURNAL   Clin Cancer Res 25 (10), 3128-3140 (2019)
   PUBMED   30733230
  REMARK    GeneRIF: C8orf76 amplication or overexpression plays a pivotal
            oncogenic role in gastric carcinogenesis and is an independent
            prognostic factor for gastric cancer patients.
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Kim,Y.C., Wu,Q., Chen,J., Xuan,Z., Jung,Y.C., Zhang,M.Q.,
            Rowley,J.D. and Wang,S.M.
  TITLE     The transcriptome of human CD34+ hematopoietic stem-progenitor
            cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8278-8283 (2009)
   PUBMED   19416867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR156993.1 and BC067796.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032847.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.218279.1,
                                           SRR5189667.407709.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276704.6/ ENSP00000276704.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DR156993.1         22-26
            6-1310              BC067796.1         1-1305
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..1310
                     /gene="C8orf76"
                     /note="chromosome 8 open reading frame 76"
                     /db_xref="GeneID:84933"
                     /db_xref="HGNC:HGNC:25924"
     exon            1..148
                     /gene="C8orf76"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1174
                     /gene="C8orf76"
                     /codon_start=1
                     /product="uncharacterized protein C8orf76"
                     /protein_id="NP_116236.1"
                     /db_xref="CCDS:CCDS6341.1"
                     /db_xref="GeneID:84933"
                     /db_xref="HGNC:HGNC:25924"
                     /translation="MDSGCWLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEE
                     TESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLSSTNFAMKRDVQEGQARC
                     LAHLGRHMEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLH
                     PFNPWNWGKLAEAYLNLGPALSAALASSQKQHSFTSSDKTIKSFFPHSGKDCLLCFPE
                     TLPESSLFSVEANSSNSQKNEKALTNIQNCMAEKRETVLIETQLKACASFIRTRLLLQ
                     FTQPQQTSFALERNLRTQQEIEDKMKGFSFKEDTLLLIAEVMGEDIPEKIKDEVHPEV
                     KCVGSVALTALVTVSSEEFEDKWFRKIKDHFCPFENQFHTEIQILA"
     exon            149..244
                     /gene="C8orf76"
                     /inference="alignment:Splign:2.1.0"
     exon            245..388
                     /gene="C8orf76"
                     /inference="alignment:Splign:2.1.0"
     exon            389..846
                     /gene="C8orf76"
                     /inference="alignment:Splign:2.1.0"
     exon            847..979
                     /gene="C8orf76"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1310
                     /gene="C8orf76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1263..1268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf76"
                     /note="hexamer: TATAAA"
     regulatory      1284..1289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf76"
                     /note="hexamer: TATAAA"
     polyA_site      1290
                     /gene="C8orf76"
                     /note="major polyA site"
     polyA_site      1310
                     /gene="C8orf76"
                     /note="major polyA site"
ORIGIN      
        1 gcttcctcgt tgcccccgcc gcgggcgcga gatggattcc gggtgctggt tgttcggcgg
       61 cgagttcgag gactcggtgt tcgaggagag gccggagcgg cggtcaggac cgcccgcgtc
      121 ctactgcgcc aagctctgcg agccgcagtg gttttatgaa gaaacagaaa gcagtgatga
      181 tgttgaagtg ctgactctca agaaattcaa aggagacctg gcctacagac gacaagagta
      241 tcagaaagca ctgcaggagt attccagtat ctctgaaaaa ttgtcatcaa ccaattttgc
      301 catgaaaagg gatgtccagg aaggtcaggc tcggtgtctg gctcacctgg gtaggcatat
      361 ggaggcgctg gagattgctg caaacttgga aaataaagca accaacacag accatttaac
      421 cacggtactc tacctccagc ttgctatttg ttcaagtttg cagaacttgg agaaaacaat
      481 tttctgcctg cagaaactga tttctttgca tccttttaat ccttggaact ggggcaaatt
      541 ggcagaggct tacctgaatc tggggccagc tctttcagca gcacttgcgt catctcagaa
      601 acagcacagt ttcacctcaa gtgacaaaac tatcaaatcc ttctttccac actcaggaaa
      661 agactgtctt ttgtgttttc ctgaaacctt gcctgagagc tctttatttt ctgtggaagc
      721 gaatagcagt aatagccaga aaaatgagaa agctctgaca aatatccaaa actgtatggc
      781 agaaaagaga gaaacagtgt tgatagagac tcagctgaaa gcatgtgcct cttttatacg
      841 aaccaggctt ctgcttcagt ttacccaacc tcagcaaaca tcgtttgctt tggagaggaa
      901 cttaaggact cagcaggaaa ttgaagataa aatgaaaggg ttcagcttca aagaagacac
      961 tttgctgttg atagctgagg ttatgggaga agatatccca gaaaaaataa aagatgaagt
     1021 tcacccagag gtgaagtgtg ttggctccgt agccctgact gccttggtga ctgtatcctc
     1081 agaagaattt gaagacaagt ggttcagaaa gatcaaagac catttctgtc catttgaaaa
     1141 tcagttccat acagagatac aaatcttggc ttagtgggtt ataaaaaaca aaaccacaaa
     1201 tatcttgtac tgtattaatt gtccttgttt acttcagaca ggatccattg ctaatcatgg
     1261 agtataaatg attatttatg ttttataaaa ctggcttctg tctcaaatga
//
