LOCUS       NM_001013842            2056 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens chromosome 8 open reading frame 58 (C8orf58),
            transcript variant 1, mRNA.
ACCESSION   NM_001013842
VERSION     NM_001013842.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC037459.16, DC328974.1 and AI380311.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001013842.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.976647.1,
                                           DRR138509.8321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289989.10/ ENSP00000289989.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC037459.16        120401-120402
            3-48                DC328974.1         1-46
            49-162              AC037459.16        120449-120562
            163-638             AC037459.16        121684-122159
            639-779             AC037459.16        122514-122654
            780-888             AC037459.16        122774-122882
            889-1001            AC037459.16        123002-123114
            1002-1108           AC037459.16        123339-123445
            1109-2027           AC037459.16        123997-124915
            2028-2056           AI380311.1         10-38               c
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..2056
                     /gene="C8orf58"
                     /note="chromosome 8 open reading frame 58"
                     /db_xref="GeneID:541565"
                     /db_xref="HGNC:HGNC:32233"
     exon            1..162
                     /gene="C8orf58"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1220
                     /gene="C8orf58"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C8orf58"
                     /codon_start=1
                     /product="uncharacterized protein C8orf58 isoform 1"
                     /protein_id="NP_001013864.1"
                     /db_xref="CCDS:CCDS34862.1"
                     /db_xref="GeneID:541565"
                     /db_xref="HGNC:HGNC:32233"
                     /translation="MMGRRRAFAVDGRDGAGEGLARGCIVPGVTSTYRRIPDAAHGCS
                     SWERGDKFRGVGREALFLKLASRDSGVEMAVGDSPLAALPGLSQDSLDFESSGSSEPP
                     AQVGRLLASQKLGEVLERSRRLPTAPTSLSGQHRSLRLASKPEREVPLGAGQQESMEA
                     DTDLEAGLEEEAVGGLGPGAWACLPGQGLRYLEHLCLVLEQMARLQQLYLQLRIQRPP
                     GDPGEEESTRAPLPSPLHTPGNRGQGPWELLSQTEHTGAKAASPPKVEVPSANPPRLP
                     ETPVEPTYHLPSSQGHKRDISHWDKVKVLLNRICRRSHHHPEPPAPPDGSDPRIESRD
                     LPERPQCRPHRKTFMPSLVVKKQRAKNLSVG"
     exon            163..638
                     /gene="C8orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            639..779
                     /gene="C8orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            780..888
                     /gene="C8orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1001
                     /gene="C8orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1108
                     /gene="C8orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..2056
                     /gene="C8orf58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf58"
                     /note="hexamer: ATTAAA"
     polyA_site      2056
                     /gene="C8orf58"
                     /note="major polyA site"
ORIGIN      
        1 gtgtctgggg gccgcgccca gctgggtcgg gacgcgctcc ctgagctgcc cgagctccgc
       61 ggggactcgg gccgggatcc tcgggcggct gcattggccg gggccggggc cgggagcggg
      121 ccatgatggg ccggcggcgc gccttcgccg tggacggccg ggatggggct ggcgagggcc
      181 tggcacgggg ctgcatagtg cctggagtca ccagcaccta cagacggatc cccgacgctg
      241 cccacgggtg ctcatcctgg gagagaggtg acaagttcag aggtgtcggc agggaggcac
      301 tctttctcaa actggcctcc cgggactcag gagtggagat ggcagttggg gacagccccc
      361 tggccgcctt accgggcctt tctcaggact ccctggactt tgaatcctca gggagttctg
      421 agccccccgc ccaggtaggc cgactcctgg ccagccagaa gctgggggag gtgttggagc
      481 ggtcccgccg gctcccaaca gctcccacca gcttgtcagg acaacaccgc tccctgcggc
      541 tggcaagcaa gcctgagcgt gaagtgcccc ttggagcagg gcaacaggag tccatggagg
      601 cagacacaga cctagaggca ggcctggaag aagaggcggt ggggggcctg gggcctggag
      661 cctgggcctg cctccccggg cagggtcttc gctatctgga acacctgtgc ctggtgctgg
      721 agcagatggc aaggctccag cagctctacc tgcagctgcg gatccagagg cccccagggg
      781 atcccggcga ggaggagtcg acccgagccc ctttaccgtc cccgttacac accccaggca
      841 atcgggggca ggggccatgg gagctgctaa gccagacaga gcacacagga gcaaaggctg
      901 cttcaccccc aaaggtggag gtgcccagtg ccaaccctcc caggctgcca gaaaccccag
      961 tggagccaac gtaccacttg ccatcctccc agggacacaa gcgggatatc tcccactggg
     1021 acaaggtcaa ggtcctgctc aaccggatct gccggagaag ccaccaccac cctgagcccc
     1081 ctgcccctcc tgatggctct gaccccagga tcgagtccag ggacctccct gaaaggcctc
     1141 agtgccgccc ccaccggaag acctttatgc catcattagt ggttaagaag caacgagcaa
     1201 aaaacctttc tgtaggctga gacctctcgg tgcacctggt gaccctgggt ggaggggact
     1261 tgctgtgaag tcttcctcgc cctctgccct cttgctgctt ctccacattg ccaggaaaag
     1321 ctgctgacgc ctgccctcct ctcttgagtc gagggctgaa tctttctcct ctaagcagtc
     1381 tggtcaggaa ccttggtttc ttgagaggcc cccaagatgc cgcagctcca gggctcttcc
     1441 tcctcaccag aaatccctgg gcttccacaa tgtgaactca ctcattgtca ggtgtccgtg
     1501 gagtgttttt ggcatggtga cctgtctggg cccagcatgt tgcagatgtg tatttatgcg
     1561 caatggtatg catatctctg tgtgactgtc agtgttgcaa gctggctgga tccaaccatc
     1621 tcttctgaaa taatgcatcc aaagggttga tattctgggg gaggtcactg cagaaggatg
     1681 gaactgacct ttattcccca gtgggcagtt actgagcttt cctcctcaga gccatgctgg
     1741 cagccctggg acagagaacg gtgtggcttt ggctgcctct gcatggaatc ttgccccgga
     1801 ctcctgaaga ctgcacaagg aatgaggaag atcagggaca acctgggaac tgaataactt
     1861 tcaaagccag tgctcagctt ctctgctccg tactagcgtt tacaggtctt aattcaaacc
     1921 agatgcctgt actagttttt agaccccaag tcaacctttc tgagccacag cttcccgctg
     1981 ggaataatga tgcctgccct atctacctca cagacttgtt atgaggataa agtgagatta
     2041 aactgcctca aagtgc
//
