LOCUS       NM_001007090            1420 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 8 open reading frame 48 (C8orf48), mRNA.
ACCESSION   NM_001007090 NM_152567 XM_496970
VERSION     NM_001007090.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Lei,L., An,G., Zhu,Z., Liu,S., Fu,Y., Zeng,X., Cao,Q. and Yan,B.
  TITLE     C8orf48 inhibits the tumorigenesis of colorectal cancer by
            regulating the MAPK signaling pathway
  JOURNAL   Life Sci 266, 118872 (2021)
   PUBMED   33309715
  REMARK    GeneRIF: C8orf48 inhibits the tumorigenesis of colorectal cancer by
            regulating the MAPK signaling pathway.
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022832.13.
            
            On Nov 22, 2018 this sequence version replaced NM_001007090.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC031245.1, AK058131.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297324.5/ ENSP00000297324.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1420              AC022832.13        125945-127364       c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..1420
                     /gene="C8orf48"
                     /note="chromosome 8 open reading frame 48"
                     /db_xref="GeneID:157773"
                     /db_xref="HGNC:HGNC:26345"
     exon            1..1420
                     /gene="C8orf48"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1083
                     /gene="C8orf48"
                     /codon_start=1
                     /product="uncharacterized protein C8orf48"
                     /protein_id="NP_001007091.2"
                     /db_xref="CCDS:CCDS47809.1"
                     /db_xref="GeneID:157773"
                     /db_xref="HGNC:HGNC:26345"
                     /translation="MAICPELAQTDKSALANLSDETETLKNSTDEVQTSSSFSSSGGR
                     QSSPLTSGSKLEREKQTPSLEQGDTQSELLDYKNYEKKLSKKWINYLKLKDSNFERHQ
                     PDTKLPTEITRVSDEELNALQSYCTMKINLIHRRGDSKKKTSSRHKKLHLGLDVEASE
                     RDAFSCTVPDELLNRIYFKNMRTTPKQEAAAKQHISYQCPYCNRKRAELALSAFLKQK
                     KTLLESFLLQERIDEHLHTKDFLTRIGEAHQDFPRLSDDPRIIWKRLTEKSHIRYSGF
                     ERSETEQKLQRDGNSACHLPFSLPFLKRLTLIKPELVIVNDNV"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf48"
                     /note="hexamer: AATAAA"
     polyA_site      1420
                     /gene="C8orf48"
                     /note="major polyA site"
ORIGIN      
        1 aagacgacct ccgcagagct gatggcattg agatccattc ccggaggggt cagctcctga
       61 cgggttcctg agccagtctt aacctgggca aaggagatga ggagccgagc ctgatgcatt
      121 gtgatggcca tctgcccaga attggcccaa acggacaaaa gtgctcttgc aaacctttct
      181 gatgagactg agactttgaa gaactctact gatgaggtac agacttccag ctcattcagc
      241 tcctctggag gacggcagtc ctcgcccctg acctctggga gcaaactgga gagggaaaag
      301 cagactccaa gcttggaaca aggagacaca caatctgagc ttttggacta taaaaattat
      361 gaaaagaagt tgagtaaaaa atggatcaac tacctcaagc tcaaagactc taactttgaa
      421 cggcaccaac cagacaccaa acttccaaca gaaatcactc gggtatcaga tgaagaattg
      481 aatgccctgc agtcttattg caccatgaag ataaatttga ttcatcgtag aggggattct
      541 aagaagaaga cgagcagcag acataaaaag ctgcatcttg gattggatgt agaggcttca
      601 gagagagatg cctttagttg tactgtaccc gatgaacttt tgaacagaat ctactttaaa
      661 aacatgagga caacgccaaa acaggaggca gcagctaagc aacacatatc ttatcagtgt
      721 ccctattgta acaggaaaag agcggagctg gccctgtctg cctttctgaa acaaaagaag
      781 actttactgg agtcatttct actccaagag agaatagatg aacatcttca taccaaagac
      841 tttctcaccc gtattggaga agcacatcaa gactttccca ggctttcaga tgaccccaga
      901 ataatctgga aaagactgac tgagaaaagt catatcagat actctggttt tgaaagatca
      961 gagacagagc agaagttgca gcgagatgga aatagtgctt gtcatttacc attttctctg
     1021 ccatttctca agcgacttac tctaatcaaa ccagagctgg tgattgttaa tgataatgtg
     1081 taatgtggat agatgtcttt gttgtgtatt tgagtaatta ccataatttc tacaggcact
     1141 tgggaaacta acttaagact ttactatgct tccttcacag atttgaggac taagaacttt
     1201 cacttttttt ttcctattat agaaggcact gttgtagttg gaatagttat aaaaactttt
     1261 acaaaattcc aagagaacta tgttggtagt ttgggccagg atgttgatgg tacagaagca
     1321 aagtagtatg gggatgtaag agaaacttaa aaagtaataa ctgtctttgg cgatcaaatg
     1381 gctatgggga attaataaat agtagatgtt tgaaatgtta
//
