LOCUS       NM_001195639            7814 bp    mRNA    linear   PRI 05-JUN-2024
DEFINITION  Homo sapiens chromosome 8 open reading frame 34 (C8orf34),
            transcript variant 2, mRNA.
ACCESSION   NM_001195639
VERSION     NM_001195639.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7814)
  AUTHORS   Stransky,N., Cerami,E., Schalm,S., Kim,J.L. and Lengauer,C.
  TITLE     The landscape of kinase fusions in cancer
  JOURNAL   Nat Commun 5, 4846 (2014)
   PUBMED   25204415
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7814)
  AUTHORS   Han,J.Y., Shin,E.S., Lee,Y.S., Ghang,H.Y., Kim,S.Y., Hwang,J.A.,
            Kim,J.Y. and Lee,J.S.
  TITLE     A genome-wide association study for irinotecan-related severe
            toxicities in patients with advanced non-small-cell lung cancer
  JOURNAL   Pharmacogenomics J 13 (5), 417-422 (2013)
   PUBMED   22664479
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067871.6, BC041961.1,
            AL834454.1, AC090096.5 and T89089.1.
            
            On Mar 18, 2017 this sequence version replaced NM_001195639.1.
            
            Summary: This gene encodes a protein that is related to the cyclic
            AMP dependent protein kinase regulators. Naturally occurring
            mutations in this gene are associated with an increased risk for
            severe toxicities, such as diarrhea and neutropenia, in patients
            undergoing chemotherapeutic treatment. [provided by RefSeq, Mar
            2017].
            
            Transcript Variant: This variant (2) lacks several exons and
            includes an alternate 3' terminal exon, compared to variant 1. The
            encoded isoform (2) has a shorter and distinct C-terminus, compared
            to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.194860.1,
                                           SRR1803616.139739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AC067871.6         25656-26004
            350-852             BC041961.1         1-503
            853-3188            AL834454.1         1-2336
            3189-3189           AC090096.5         110345-110345       c
            3190-4423           AL834454.1         2338-3571
            4424-7803           AC090096.5         105731-109110       c
            7804-7814           T89089.1           1-11                c
FEATURES             Location/Qualifiers
     source          1..7814
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.2"
     gene            1..7814
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="chromosome 8 open reading frame 34"
                     /db_xref="GeneID:116328"
                     /db_xref="HGNC:HGNC:30905"
     exon            1..967
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             641..1762
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     vestibule-1 protein; protein VEST-1; uncharacterized
                     protein C8orf34"
                     /codon_start=1
                     /product="uncharacterized protein C8orf34 isoform 2"
                     /protein_id="NP_001182568.1"
                     /db_xref="GeneID:116328"
                     /db_xref="HGNC:HGNC:30905"
                     /translation="MSSPLASELSELAALRPGFRLSAPHARVAPRAATHARGRGRASH
                     AGQPRLRSSCPGPSPGKRRVVPSGGAQPRVLPALSSRSHLFPMASHPQTRIQAYLEKN
                     KIGPLFEELMTKLITETPDQPIPFLIDHLQSKQGNRGQLQRTLSGSAALWAESEKSES
                     KGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKP
                     QSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGR
                     EENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLL
                     AAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLGNFKN"
     exon            968..1115
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1247
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1376
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1405
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1578
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..7804
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="hexamer: AATAAA"
     polyA_site      4117
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="major polyA site"
     regulatory      4404..4409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="hexamer: AATAAA"
     polyA_site      4426
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
     regulatory      5575..5580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="hexamer: AATAAA"
     polyA_site      5598
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
     regulatory      5867..5872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="hexamer: AATAAA"
     polyA_site      5894
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
     regulatory      6452..6457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="hexamer: AATACA"
     polyA_site      6476
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
     regulatory      7610..7615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
                     /note="hexamer: TATAAA"
     polyA_site      7626
                     /gene="C8orf34"
                     /gene_synonym="VEST-1; VEST1"
ORIGIN      
        1 gcactttgag agttttcagc tgggttctca ggctgcgttc acccgtcgac ttgctccagg
       61 ccaaaccaga ttttgaaaag gaaggcaact tctttttcgc ggcaaaccct taaacccacg
      121 caccttctca aaactctgcc cttctcaacc cctgcgctag agtaggcagg gcagaaggtg
      181 ctgaggagag gctcagaagg ggcggtgggg acgatcccct ttcgaactgc atttgtagct
      241 gccaaggagt agccaacaag caccagattt atgtgcactt tgaaagaagc accttcacca
      301 ttggcttttt aagcggcgct gtcgctaggg agcggctggt agggcgagca gcctcgggga
      361 gcagcccggg ctgtttgttc cgtcaccggg gaaaggaggt acacacagtc gcgcgcgcac
      421 ggacacacac acacacgcac gcacgcacac acaccggtgg cgagttcgag ccccgcggcc
      481 cctgtccgcc cgcgtgcgcc cctcgacaca gctcgcctcc cgccccctga ttcctgctgc
      541 tgccgcccag aggagaaagg aacctctgcc tcgaatttcc ccactgcgcc gggcgctgcg
      601 gagagcggcg agggtgggcg cgaggcggag aacgcgatga atgagttctc ccctcgcctc
      661 ggagttgtct gagttggcgg cgctgcgccc aggcttccgg ctctcagcgc cccacgcgcg
      721 cgtggctccc cgggctgcca cccacgcccg cggccggggc cgagccagcc acgcagggca
      781 gccgaggctc cggagctcct gtcccggccc cagtccgggt aaaaggaggg ttgtccccag
      841 cggaggcgca cagccgcgcg ttctccctgc actctcttcg cggtcccatc tgttccccat
      901 ggcgtctcat ccgcaaaccc ggatccaggc ttacctggag aagaacaaga tcggtcccct
      961 gtttgaggaa ttaatgacca agttaataac tgagacacct gaccagccaa tcccatttct
     1021 cattgaccat cttcagtcta aacaagggaa ccgtggacaa cttcaaagaa ctttgtctgg
     1081 atctgcagct ctatgggcag aaagtgaaaa atcagaatcc aaaggaacaa gaagggattt
     1141 cagaagctat gataaacctt ggcaattaaa tgcaaagaag cctaaaaaat caaaaagtga
     1201 ccttgctgtg tctaatattt ctccaccatc accggactcc aaatcattgc caaggtcagt
     1261 agagcatcca aagtggaact ggaggactaa accacaaagc cgtgattttg atgaattgaa
     1321 tcacatcctt caggagagca agaagctggg gaaagccctt gagaatctct ctcgaagtat
     1381 tgcaatttca gatgaactcg ataaggaaac agtgacattt aattcttctc ttctgaggcc
     1441 ccgtgtgatt ggagaatgga ttggtagaga agaaaatgat gctgatcccc tagctgctga
     1501 aatgctacag cctccaattc caagaagcaa aaatgaccaa tgggaaagtg aagatagtgg
     1561 ctctagtcct gcaggaagct taaagatgga gcctaagaac aaaggattaa aacagcagca
     1621 acagcaacat aagaaactcc tggccgcaat gctctctcaa gattcttttg agtccatcca
     1681 cagccctacc ccatctgtaa cagaagaaga tattgataat gaagatgatg caatggaatt
     1741 gctgggtaat tttaaaaatt aataatttct cattttcttc tttgacattg taaaaaaaac
     1801 gtgtggtgat taagagattt taaaagtttt gaatagcctt gtcttaggga aaagaaacca
     1861 tttagtacat attttattta cattagactc acataaagtt gcatgtaaga actaaattga
     1921 aataccctaa gcatatgaat atttattaga ctgtattttg tgctttgtgt atgctgcact
     1981 ttaccttctg actacgtaat gaagcgttat tctgtgtgca actgtgatca aaattcaagt
     2041 ctgtctgctt tattctctga taataattgc cttgtttaca tctattgtct ataaaatata
     2101 cccaaagtac atatttcagc cctcactcca aaatgtctac cttttatttt gaggatgctt
     2161 tagaaaaata gaataaagtt gaaaggggca gatagtaaat tcaggtttta tgttttccgt
     2221 aaatgacggg aaagtttgca gagatttcaa agtttcttca ggcctgttac tttcatgaaa
     2281 ccttattaat cttgtatatg taggatatct ttttatattt tttaatgtag tatatgtatg
     2341 tttttgcttc atcagaaatc tcttcatata aatttttaaa ctgaacttct ctttggaaca
     2401 tcatttttct gaagaaagaa aatgaaatgt tatttcagag tgatccacat ataaaacaat
     2461 gagttttgaa gtcagtggta tcaattattc tgctacaaat aaagagtatg attttcaaat
     2521 actttataac aatatgctgt tgtattttat ttagaaagag aataaataat ataattattt
     2581 gaaagcctta aacacgtttt acatatagaa tatggaatct cagaaaaata taggccattt
     2641 tctgaagttt ttgttaaaaa tgagattcct tggttttaag tgtttatggc agtaaaatac
     2701 tatcattata aaaaatgata tattgcttat catttttgca taggcctaca aaggtgttat
     2761 ttggtcaatg gtgacaggtt tgaaagatgt tttctgatgc tgtaaaaact gcattcatgc
     2821 taacattaag gagattgtat catggcgttt tcattacatg ctgttggtcc cttccaattg
     2881 ggtcttttcc tcacctccaa atcattaaca tggcagacgt gccctatgtg gcagtggtag
     2941 cttcattcaa caaacattta ctgagcactt actctatgct aagcacttgg ctggggtctg
     3001 ggaacataaa aataaaatca ttgtgatctg tgtttgaagg aattttacat tgtaatgttc
     3061 aagatacaat acgtcactac ctgtgctaac tgcgctaatt ggatgaagca cacagttgtg
     3121 tataggggta acacctaaag cagaggtaag ggacagtgac ccaggaatgt ttcctagaga
     3181 agccgattac tctggctagt cctgaaaagc aaatagatgt aagctcagca ggtggggtgt
     3241 ggtcattgta ggtttgctca cgtaggtatg ggctgttttg cgattgtgct ccataactat
     3301 acctgtaaat ggttcctctg ctttggacag taacagggaa ggggcaactg agatccaggg
     3361 tttctttcag gagatgcagt tgtccactcc atgctggtac tccctagatc tcagctgccc
     3421 tgactgaagg ttctagtctc ccaagctgaa gaccgaggat tgagtcttgg agactatcta
     3481 atgatgagca attaataact agtcctcatt aattcttttt ttagacattt tagcctgtgg
     3541 tctgagcaag tttaataata agagatagtt gaaggtttgg actttcttca tgtaattcca
     3601 catatctcag cacaggtggc aagcagtgta ataatgttgg tctctaggtc atgagattat
     3661 cctcttatag cttggaatgt tacaagtcca ctggacttta tcttaaaata atgccatatt
     3721 caatttcttg tttttgaaat ggattccagc aaaatgtatg tgattgtgtc tatttcagaa
     3781 aaatataaat gctaagttct tggaaattta tgtgaaatct aattttatag agtttatata
     3841 gaatcattgt aagatgcaat agagacatct ggtatttaaa atctttttga atctacattt
     3901 tgtagatgtg tgtgctatag cttatgtgtt tgtaaatgtt taacttgtct ttgttatcta
     3961 taccaagata taactggctg aaaaatattt attatgcatg gaaagcactc tgtaaacctt
     4021 gtgaagtgat aaataagtga aaggtataat tgttagttga cattaatata aaaaaggatt
     4081 attcttcaat aaaattggtt gatttgaagg gaaaaaatcc ttttagttga actagtagaa
     4141 gttagtaata actattgact cttgttttgt ttattaagga aactagcatt gttaatatat
     4201 actgattaat atttaattat tcacagttgt ttaattatat atttgtggat ttcttttcta
     4261 aatgttttag gcatatgaaa atattatagt acaacacctg taatttttaa gtagatcaaa
     4321 tattttctgt aagattgctt taaatgctcc ttataaattc acattgcaaa agtaacttaa
     4381 tatggaatta acacttgtca gataataaaa cagccaaact tgtgaatttt taagatataa
     4441 tcattttaag cacctctgaa attggtgctg taattataga agatactgag taaagtatct
     4501 gccaagtcat ctcatgctca aatataagat attttcaaat attttagtac aaatatttta
     4561 gtaatcgttc tggcaattaa tgaccactat gaaaaaaagg ttatagaaaa tcttcacata
     4621 ttttttaaaa ttaataaaat aaatgatttt caaaaatgga atgacaagtt acaatggtag
     4681 aatgagagat ttattgctgg gcatagtggc ttaagcctgt aataccagca ctttgggagg
     4741 ctgaggtggg tggattgctt gagcccagga atttgagacc agcctgggaa acatgacgaa
     4801 acctcgtctc tacaaaaaat acttatatta gtcaagtgtg gttgcatgca cctatagtcc
     4861 cagctactgg actgagtctg gaaggtcgag tctgcagtga gctgtggtca tgccactgta
     4921 gtccagcctg ggtgacagag ggagacccta tctcaaaaaa aaaaaaaaaa aaaaaaaaag
     4981 aagaaaaaga aaagatctat aaaaatccct gtatatttta ctacattaat tatcagagaa
     5041 catttgagga acttcgttag tttaaaagat atttcacctt ggaaacatgt gcccattttt
     5101 cttacattag atgcatttta atcttattct tgttgaaagg cgagtttcag tcacgttttt
     5161 gattattctc tttatgattg atattcattt aaaaatatca gtattatttg aaagatataa
     5221 ctacttttct tatacattct aatatgggta ttactatccc atacaatttg taaaagttta
     5281 taaaaaatgt attatgcttt ctcagaattg atgatgaggc aagtatataa aaatcaaatt
     5341 ccaaagatgc taaaaaggaa aacaatatta attatgtttt atactttttg gtcttagcct
     5401 ataattatat aaaatccaaa atcaaaagta aaattacatt gcgacaaggt gattgcaagt
     5461 acattttatc tgttttaaaa tgaataatca agaacaagtg taattatact gggattcttt
     5521 gctgaatata gtcattgagt ttctattacc tcaatatgtt accaaatttt gtaaaataaa
     5581 aacaatttac tagaaggagt taatacatta aggtgatcat ttgacacttt ctttcttata
     5641 ttctgatcaa cttttataaa gtaaatattc actctttgtt ctgtttttta aattggaggc
     5701 ttcttaaaga agaatgtgcc cacattggca aaataagaac aagcattttg cctaatgaga
     5761 aatgaatgct gtcactgaat gatgtaaaat ttctttaaaa aggagagaga gggagcacta
     5821 aatgtttaaa gaaaaatcta cctacctatc catgtaccta tattttaata aagtatgtaa
     5881 aataatctaa aacacaaggg actatacata gaaactcttt ttatctcttt gtttcttttg
     5941 atctttagaa tattgctcat tggaagtaat caggataaca gaaaagttat caccttaaaa
     6001 tgaatgttct tcataaaaaa gattattcat aagaaatcta aggactttct ttttattttc
     6061 tttttttttt taaagagatc aagtcttgct ttggctaatg cagtttgtat cactttctta
     6121 tgtcctcctt cctgatatat tttataggag cacttgaaaa atgaactgct tagagtagaa
     6181 aaaatcacat aaattataaa gtaattctag catagacttg agaaaatggt ttctttatga
     6241 ttcattttca tcatattatc atgttaaaaa gctttattta ggattctttc tttgcttttg
     6301 ctaaatgtat ctcagtccct tttattacct tctagattta cttgttttgt gtttagaatt
     6361 gttttgtttt tcataccctt cattcttcac ttttgttttt ttcagcaaaa tatcaaaaca
     6421 tttgcaaatc gtagagatta tcctttaaat aaatacaaat ctgcatgcca ccaaaatata
     6481 tacatcatcc tatgtgattt acttttatgg tgtttagtaa gaaatattgc tttattttct
     6541 tgtaaaaaat ttccagtggt aaaaataaat caacatagta gaataaacgt caatagtttg
     6601 aaaatgaaat ctaaacccat aaacaaatta ttgacaaatg ccttttatct caattataca
     6661 cctattggaa aatttcttta taagacacag ccatttccaa tatatttgtg aaaagagttg
     6721 tttaaaacct atttatcact ttgaataagt tccacgtttt ttgacacata ccaataacat
     6781 agaataatat attttttctt gtttatgtta tagcttttca ctgagtacct tgtaaaggca
     6841 tgagacacag tgtgattggc atatgtggtg gtgttagtgg tatatggcca aagcaccagc
     6901 ttatactcta atgacccagg tctagacctc atgctacctc ttgctaatat tgtcccctca
     6961 ggtacacgta attaattgta aagtgctggt gactacatat gaccttccta ctcaacaggg
     7021 atgttgagag gataaaaaaa aaatgagata tttctctaaa gtgctttttt tttttctttt
     7081 tgtcatggct aacaggaata tttgacaaaa gacaatagaa tttctataca aaacttttct
     7141 tctagataaa tttatatcct tgaacccaga tacattttgt atgctacaga caaaggaaaa
     7201 aaaaagcttt ctttagcttt gggaagttgc ctaaaaacag caaaaatgta tgtttcccac
     7261 aacacaataa aattaaaggc ttgaaaagat aagaggtaaa gctatatgtt tttgcaagcc
     7321 aaaatgttgg ctataccaac acaaagcact aaatttttca tttttaactt ggatattaaa
     7381 gcaaggatag atgatttggt taaggatgta tagaaaatta ttctactgtc tttcattttc
     7441 ctctgtgtaa atgtataatt cctaggagga aaagaaaaat gttttctgcc tacatatgta
     7501 tctctagtag caaaagttgg gcttagggta ggaataaggt ggaaagacaa ggagatatag
     7561 agaaattaga aatttgtact atatgtttac atgcttatgt aaataaaatt ataaaagtgt
     7621 tgaaaatctg ttcttaaaaa tttcttgaat tatatttata aatatgaaaa tgtttgaagc
     7681 agcacaattt gatggtttca cattaattca ctgtgtaaac aaacctaaac taaattgaaa
     7741 agcagtgtta catattatta aggtattgtt gcttttgaaa taaacttgcc cacttcaaat
     7801 gcttaaaaaa aaaa
//
