LOCUS       NM_023080               2588 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens chromosome 8 open reading frame 33 (C8orf33), mRNA.
ACCESSION   NM_023080
VERSION     NM_023080.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2588)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2588)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 2588)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2588)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2588)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   6  (bases 1 to 2588)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA467518.1 and BC010001.2.
            
            On Nov 22, 2018 this sequence version replaced NM_023080.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024642.1, SRR1660805.43468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331434.7/ ENSP00000330361.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA467518.1         30-40
            12-2588             BC010001.2         1-2577
FEATURES             Location/Qualifiers
     source          1..2588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2588
                     /gene="C8orf33"
                     /note="chromosome 8 open reading frame 33"
                     /db_xref="GeneID:65265"
                     /db_xref="HGNC:HGNC:26104"
     exon            1..31
                     /gene="C8orf33"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..715
                     /gene="C8orf33"
                     /codon_start=1
                     /product="UPF0488 protein C8orf33"
                     /protein_id="NP_075568.1"
                     /db_xref="CCDS:CCDS34974.1"
                     /db_xref="GeneID:65265"
                     /db_xref="HGNC:HGNC:26104"
                     /translation="MAALGHLAGEAAAAPGPGTPCASRGARLPGPVSSARNPSTVCLC
                     PEQPTCSNADSRAHPLGDEGGTASKKQKNKKKTRNRASVANGGEKASEKLAPEEVPLS
                     AEAQAQQLAQELAWCVEQLELGLKRQKPTPKQKEQAIGAIRTLRSKRTPLPRKRQLMH
                     SLFGDYRAQMEAEWREALRALRAAAYSAQVQPVDGATRKKSQRVCRPRSIWRAKATLD
                     MPDEEFRFNFF"
     exon            32..343
                     /gene="C8orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            344..428
                     /gene="C8orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            429..575
                     /gene="C8orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            576..2588
                     /gene="C8orf33"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2588
                     /gene="C8orf33"
                     /note="major polyA site"
ORIGIN      
        1 gtagttccgg tggcgactgc ggcgcatggc ggccctggga catcttgctg gggaggcagc
       61 ggcggcccca ggcccgggta ctccctgcgc gtcccgcgga gcccggcttc ccggcccagt
      121 ttccagcgcc cggaatcctt ccactgtctg tctctgccca gagcaaccta cgtgcagtaa
      181 cgctgactcc agagcgcacc cgttgggcga tgaaggcggc acagcgtcga aaaaacaaaa
      241 gaataagaag aaaacgcgga acagggcctc tgtggcaaat ggaggcgaga aggcctcaga
      301 gaaactcgcc ccagaagaag ttcccctaag cgctgaggcc caggcacaac agttggccca
      361 ggaattggct tggtgtgtgg agcaactgga gctgggcctc aagaggcaga aacccacccc
      421 gaaacagaaa gagcaggcta ttggagcaat ccgaaccctg cgcagcaaaa gaacgccctt
      481 gccccggaag aggcagctga tgcactcctt gtttggagac tatagggctc agatggaagc
      541 cgaatggcgt gaggccctgc gggctctcag agctgctgct tattcagccc aggtgcaacc
      601 tgtagatgga gccaccagaa agaagagcca aagggtctgc aggcctcgct ctatatggag
      661 agccaaagcc actctggaca tgcctgatga agagtttagg ttcaatttct tttagcgtct
      721 ccccgaacct gaaacaatcc ccctcccttg gggtggtgta ggggtttgtt ttgagtgcag
      781 agcctttcca ggacttctgt tgtcagagaa ccctggagtt ggtctgtccc tggctggtcc
      841 aaggatttgt agctgttgtg aaggtgtgag accatcagat aggcaaaaga ccccgttcgt
      901 tttctgatga aatgttctct ctttcagaag agagagagag gtgcatttag aaaatatgca
      961 ataaattgaa gtgagtgttc aaagtattgt agaaggaata ttgtactcag tctttaggat
     1021 tagattaagt ggctgttggt aacaaagatt agtggagaag ctgtataatc gtacactggt
     1081 tttcactttt gaaaggaatc cctgtcaaat ggtttagtgc ttaatgctgt tatgtcatat
     1141 tgccctaatc tctatttttg ataaaattgg ataaggagtg aaagagtatg ctgaccacct
     1201 atgttagagg aagtacagaa gatgcagggg tgtggtatcc ctgggtccag tccctcacct
     1261 ggtacctttg tgcatgttgc cttcattcct gagcaggtat catcctcagg gaaccagcat
     1321 ggcacctacc aggccaggct ctgttcttag gagcaaggag cttcttgcgc taacagttct
     1381 ggcctgagac ctggattgag ccttggcaga cttcttgtct aaatgttggc cattcagtct
     1441 caggccctct gttccatgga attgggaatc tccaggtgac ctaatcctca ttggtggctt
     1501 gatgtttgct ggtatcttcc aaactcagtt cccagactag attgatacct ggagcccagc
     1561 tgcctactca gcatttccac ttgggtgctt cataggcatt tcaaacctga tgtgtttaaa
     1621 acacttgatt aggctccggt tttcctttgg cttctgcttt tcagtgaatg gcatgactgc
     1681 ctatgtgggt ggcaagccac ccaggtgccg aggaaagaga ctgagggcac gagctgttcc
     1741 agtataataa aatatataaa ataagaagag ttatactaga tctagatcat agacatgatt
     1801 atatgtgagt atcattaatc attagtttat agcaattact ctttattcca atattataat
     1861 aatcctcact ctacaatcat aacctaggaa aaaccaggcc atacagagat aggagccgag
     1921 gggacatagt gcgaagtggc cagaagacaa gagtgtgagc cttctcttat gcccggacag
     1981 ggccaccaga gggcttggtc tagcagtaac accagtgtct gggaagatgc ctgttgcaaa
     2041 gtggaccatg gtctagcagt agcatcagtg tcaaggaaaa acacccacta cttagcagac
     2101 tgggaaaagg agcctccctt tccccggggg agtttagaga agactactcc tccacctctt
     2161 gtggagggcc tgacatcagt caggcccgcc cgcagttatc cagaggcctg tctccctgtg
     2221 atgctgtgct tcagtggtca cgctcctagt ccgctttcat gttccatcct gtatacctgg
     2281 ctctgccttt tagatagcag gagcaaatta gtgaaagtac taaatgtctg atatgcagaa
     2341 ataatggcat aagctgtctc tctctcttct ctctctctct gcctctgctg ccaggcaggg
     2401 aagggccccc tgtccagtgg acacatgacc catgtgacct tacctattat tggagatggt
     2461 tcacattcct taccctgccc ctttgtctta tatccaataa atatcagtgc agcctggcat
     2521 ttggggccac tactggtctc cgcgtcttgg tggtagtggt cccccaggcc caggtgtctt
     2581 ttctttta
//
