LOCUS       NM_001099858            1805 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chromosome 7 open reading frame 25 (C7orf25),
            transcript variant 1, mRNA.
ACCESSION   NM_001099858
VERSION     NM_001099858.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Matelska,D., Steczkiewicz,K. and Ginalski,K.
  TITLE     Comprehensive classification of the PIN domain-like superfamily
  JOURNAL   Nucleic Acids Res 45 (12), 6995-7020 (2017)
   PUBMED   28575517
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Bommel,H., Xie,G., Rossoll,W., Wiese,S., Jablonka,S., Boehm,T. and
            Sendtner,M.
  TITLE     Missense mutation in the tubulin-specific chaperone E (Tbce) gene
            in the mouse mutant progressive motor neuronopathy, a model of
            human motoneuron disease
  JOURNAL   J Cell Biol 159 (4), 563-569 (2002)
   PUBMED   12446740
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010132.5.
            
            On Dec 23, 2020 this sequence version replaced NM_001099858.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024820.1, SRR18074968.3222002.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000350427.5/
                                                ENSP00000343364.4
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC010132.5         55619-55774
            157-1805            AC010132.5         56768-58416
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..1805
                     /gene="C7orf25"
                     /note="chromosome 7 open reading frame 25"
                     /db_xref="GeneID:79020"
                     /db_xref="HGNC:HGNC:21703"
     exon            1..156
                     /gene="C7orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            157..1805
                     /gene="C7orf25"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1443
                     /gene="C7orf25"
                     /codon_start=1
                     /product="UPF0415 protein C7orf25"
                     /protein_id="NP_001093328.2"
                     /db_xref="CCDS:CCDS5466.1"
                     /db_xref="GeneID:79020"
                     /db_xref="HGNC:HGNC:21703"
                     /translation="MSAHSMLCERIAIAKELIKRAESLSRSRKGGIEGGAKLCSKLKA
                     ELKFLQKVEAGKVAIKESHLQSTNLTHLRAIVESAENLEEVVSVLHVFGYTDTLGEKQ
                     TLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKSIIEQAEDFLQASHQQPVQY
                     SNPHIIFAFYNSVSSPMAEKLKEMGISVRGDIVAVNALLDHPEELQPSESESDDEGPE
                     LLQVTRVDRENILASVAFPTEIKVDVCKRVNLDITTLITYVSALSYGGCHFIFKEKVL
                     TEQAEQERKEQVLPQLEAFMKDKELFACESAVKDFQSILDTLGGPGERERATVLIKRI
                     NVVPDQPSERALRLVASSKINSRSLTIFGTGDTLKAITMTANSGFVRAANNQGVKFSV
                     FIHQPRALTESKEALATPLPKDYTTDSEH"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C7orf25"
                     /note="hexamer: ATTAAA"
     polyA_site      1805
                     /gene="C7orf25"
                     /note="major polyA site"
ORIGIN      
        1 gtgatgcagg aggtgcccga ggcggcgggg ctcgcgcggg tggagccgcc tcggcgttcg
       61 agcggggtgg gggctgcccg gttgagattt cccggcgggt cccggcctct gcgtgcacgc
      121 gcctgcgtgc tcgcgctcgc ggttctggcg ctgccggaaa ggaataatgc tgacagcatg
      181 tctgcacatt ccatgctctg tgaacgaatc gccatagcca aggaactgat caagagagca
      241 gaatcacttt ctagatcaag aaaaggtggc atagaaggtg gtgcaaagct gtgcagcaaa
      301 ttgaaggcag aattaaaatt cttgcagaaa gtagaagctg ggaaagtagc tattaaagag
      361 tctcatttac agagcactaa cctaacacac ctgagagcca ttgtggaatc agcagaaaac
      421 ctggaagaag ttgttagtgt tcttcatgtc tttggttata cagatacctt aggagaaaag
      481 caaacccttg tggtagatgt agttgcaaat ggtggtcata cttgggtgaa agccattggc
      541 cggaaggctg aagctcttca taacatctgg ctgggcaggg gccaatatgg tgacaaaagc
      601 atcattgagc aggctgaaga cttcctccag gccagtcacc agcagccagt gcagtatagc
      661 aaccctcaca tcatctttgc attttacaac agtgtctcca gccccatggc agagaagctg
      721 aaagaaatgg gcatatctgt gagaggagac atagtagcag tcaacgctct gttagatcac
      781 cctgaagagc ttcaaccaag tgagagtgaa tcagatgatg agggccctga acttttgcag
      841 gtgaccagag ttgaccgaga aaatatacta gcaagtgttg cgtttccaac agaaattaag
      901 gtcgatgtgt gcaaaagagt aaatctggac attactactt taatcacata tgtatctgcc
      961 ctcagctatg gaggctgcca ctttattttc aaagagaaag tgctcacaga acaagcagag
     1021 caagagagga aagagcaggt tctacctcag ctggaggcct ttatgaagga caaggagttg
     1081 tttgcttgtg aatctgctgt caaggacttt cagtctattt tagatacctt aggaggacct
     1141 ggggagagag agagggccac tgtgttaatt aagcgaatta atgtggtacc agaccagcct
     1201 tctgagcgtg ccttgagact agtggccagt tcaaaaatta atagccgctc attaacaatt
     1261 tttgggacgg gagacaccct aaaagccatc acaatgactg ctaatagtgg ttttgtcaga
     1321 gctgcaaaca accagggtgt taaatttagt gtgtttatcc atcagcccag agcacttact
     1381 gagagtaaag aggctctagc caccccctta ccaaaagact acacaactga cagtgaacac
     1441 taaagatacc ctttaaatat ttttgtggaa gtaagttatt tataccaaag gctgggtctt
     1501 cccatctaaa ctggtgggaa aaaaggtcta tagtaaaagt aaaactgaga actcttaaac
     1561 cagtagagtt tctttgtctc tcatctaaag tatataacct cccaaagtag aaaaagcaca
     1621 agagagaagc ttatctatca aactgtctgc attagtgcaa ttaagaaccg aaatacgtct
     1681 atataaagct ttcagctgta ttgtaatact ttgattcgat agggctacaa ctcccctact
     1741 gctaaccaca tttcatggaa tatggctaca ttgcatcttg cattaaatat ctggagaaaa
     1801 ttcaa
//
