LOCUS       NM_001286635            6763 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 6 open reading frame 89 (C6orf89),
            transcript variant 2, mRNA.
ACCESSION   NM_001286635 XM_005248918
VERSION     NM_001286635.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6763)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6763)
  AUTHORS   Xu,Q., Chen,L.X., Ran,D.H., Xie,W.Y., Li,Q. and Zhou,X.D.
  TITLE     Bombesin receptor-activated protein regulates neutrophil
            elastase-induced mucin5AC hypersecretion in human bronchial
            epithelial cells
  JOURNAL   Exp Cell Res 357 (2), 145-154 (2017)
   PUBMED   28476309
  REMARK    GeneRIF: results suggest BRAP plays an important role in airway
            inflammation and its overexpression may regulate NE-induced MUC5AC
            hypersecretion in HBE16 cells via the EGFR/ERK/NF-kappaB signaling
            pathway
REFERENCE   3  (bases 1 to 6763)
  AUTHORS   Liu,Y., Qin,X.Q., Weber,H.C., Xiang,Y., Liu,C., Liu,H.J., Yang,H.,
            Jiang,J. and Qu,X.
  TITLE     Bombesin Receptor-Activated Protein (BRAP) Modulates NF-kappaB
            Activation in Bronchial Epithelial Cells by Enhancing HDAC Activity
  JOURNAL   J Cell Biochem 117 (5), 1069-1077 (2016)
   PUBMED   26460487
  REMARK    GeneRIF: Data indicate that bombesin receptor-activated protein
            (BRAP) might increase histone deacetylases 1/2 (HDAC) activity that
            leads to NF-kappa B (NF-kappaB) activation via its putative
            C-terminal domain.
REFERENCE   4  (bases 1 to 6763)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6763)
  AUTHORS   Lalioti,V.S., Vergarajauregui,S., Villasante,A., Pulido,D. and
            Sandoval,I.V.
  TITLE     C6orf89 encodes three distinct HDAC enhancers that function in the
            nucleolus, the golgi and the midbody
  JOURNAL   J Cell Physiol 228 (9), 1907-1921 (2013)
   PUBMED   23460338
  REMARK    GeneRIF: C60rf89 is a gene that encodes three distinct proteins
            with the capacity to enhance the activity of histone deacetylases
            (HDACs) in the nucleolus, the Golgi and the midbody
            GeneRIF: C6orf89 encodes one soluble and two type II membrane
            proteins that function as histone deacetylase enhancers. The 34sp
            is selectively targeted to the nucleolus and is retained in
            nucleolar organizer regions in mitotic cells. The 34sp is
            integrated into the ribosomal gene transcription machinery and is
            relocalized to the nucleolus upon the arrest of rDNA transcription,
            protein synthesis, and PI3K/mTORC signalling.
REFERENCE   6  (bases 1 to 6763)
  AUTHORS   Qu,X., Li,M., Liu,H.J., Xiang,Y., Tan,Y., Weber,H.C. and Qin,X.Q.
  TITLE     Role of bombesin receptor activated protein in the antigen
            presentation by human bronchial epithelial cells
  JOURNAL   J Cell Biochem 114 (1), 238-244 (2013)
   PUBMED   22930588
  REMARK    GeneRIF: Overexpression of BRAP may play a role during the antigen
            presenting process of bronchial epithelium by inhibiting the
            antigen uptake ability of bronchial epithelial cells.
REFERENCE   7  (bases 1 to 6763)
  AUTHORS   Liu,H.J., Tan,Y.R., Li,M.L., Liu,C., Xiang,Y. and Qin,X.Q.
  TITLE     Cloning of a novel protein interacting with BRS-3 and its effects
            in wound repair of bronchial epithelial cells
  JOURNAL   PLoS One 6 (8), e23072 (2011)
   PUBMED   21857995
  REMARK    GeneRIF: Data show that BRAP locates in the membrane and cytoplasm,
            suggesting that this protein is a cytoplasm protein, which promotes
            cell cycle and wound repair of HBECs.
REFERENCE   8  (bases 1 to 6763)
  AUTHORS   Zhang,J.K., Zhao,L.F., Cheng,J., Guo,J., Wang,D.Q., Hong,Y. and
            Mao,Y.
  TITLE     Screening and cloning for proteins transactivated by the PS1TP5
            protein of hepatitis B virus: a suppression subtractive
            hybridization study
  JOURNAL   World J Gastroenterol 13 (10), 1602-1607 (2007)
   PUBMED   17461456
REFERENCE   9  (bases 1 to 6763)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL122034.29, BC095423.1 and AJ420511.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001286635.1.
            
            Transcript Variant: This variant (2) includes an additional exon in
            the 5' region, resulting in differences in the 5' UTR and
            translation initiation at a downstream in-frame start codon,
            compared to variant 1. The encoded isoform (b) is shorter at the
            N-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.187208.1, BC095423.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000480824.7/ ENSP00000475947.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL122034.29        17087-17149
            64-911              BC095423.1         65-912
            912-912             AL122034.29        47600-47600
            913-1321            BC095423.1         914-1322
            1322-4540           AL122034.29        54658-57876
            4541-6763           AJ420511.1         12-2234
FEATURES             Location/Qualifiers
     source          1..6763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..6763
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /note="chromosome 6 open reading frame 89"
                     /db_xref="GeneID:221477"
                     /db_xref="HGNC:HGNC:21114"
                     /db_xref="MIM:616642"
     exon            1..77
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            78..177
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            178..385
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1240
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /note="isoform b is encoded by transcript variant 2;
                     amfion; bombesin receptor-activated protein C6orf89"
                     /codon_start=1
                     /product="bombesin receptor-activated protein C6orf89
                     isoform b"
                     /protein_id="NP_001273564.1"
                     /db_xref="CCDS:CCDS69100.1"
                     /db_xref="GeneID:221477"
                     /db_xref="HGNC:HGNC:21114"
                     /db_xref="MIM:616642"
                     /translation="MDLAANEISIYDKLSETVDLVRQTGHQCGMSEKAIEKFIRQLLE
                     KNEPQRPPPQYPLLIVVYKVLATLGLILLTAYFVIQPFSPLAPEPVLSGAHTWRSLIH
                     HIRLMSLPIAKKYMSENKGVPLHGGDEDRPFPDFDPWWTNDCEQNESEPIPANCTGCA
                     QKHLKVMLLEDAPRKFERLHPLVIKTGKPLLEEEIQHFLCQYPEATEGFSEGFFAKWW
                     RCFPERWFPFPYPWRRPLNRSQMLRELFPVFTHLPFPKDASLNKCSFLHPEPVVGSKM
                     HKMPDLFIIGSGEAMLQLIPPFQCRRHCQSVAMPIEPGDIGYVDTTHWKVYVIARGVQ
                     PLVICDGTAFSEL"
     exon            386..599
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            600..751
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..891
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1021
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1145
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..6763
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6740..6745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /note="hexamer: ATTAAA"
     polyA_site      6763
                     /gene="C6orf89"
                     /gene_synonym="BRAP; PS1TP5TP1"
                     /note="major polyA site"
ORIGIN      
        1 aggaagttgc ccatcctcct cgcccggcgg cagctgtccc cgaggcggga ggagcccgag
       61 gggcgcgagc cccgcatgaa tcattgtagt caatcatttt ccagttctca gccgctcagt
      121 tgtgatcaag ggacacgtgg tttccgaact gccagctcag aataggaaaa taacttggga
      181 ttttatattg gaagacatgg atcttgctgc caacgagatc agcatttatg acaaactttc
      241 agagactgtt gatttggtga gacagaccgg ccatcagtgt ggcatgtcag agaaggcaat
      301 tgaaaaattt atcagacagc tgctggaaaa gaatgaacct cagagacccc ccccgcagta
      361 tcctctcctt atagttgtgt ataaggttct cgcaaccttg ggattaatct tgctcactgc
      421 ctactttgtg attcaacctt tcagcccatt agcacctgag ccagtgcttt ctggagctca
      481 cacctggcgc tcactcatcc atcacattag gctgatgtcc ttgcccattg ccaagaagta
      541 catgtcagaa aataagggag ttcctctgca tgggggtgat gaagacagac cctttccaga
      601 ctttgacccc tggtggacaa acgactgtga gcagaatgag tcagagccca ttcctgccaa
      661 ctgcactggc tgtgcccaga aacacctgaa ggtgatgctc ctggaagacg ccccaaggaa
      721 atttgagagg ctccatccac tggtgatcaa gacgggaaag cccctgttgg aggaagagat
      781 tcagcatttt ttgtgccagt accctgaggc gacagaaggc ttctctgaag ggtttttcgc
      841 caagtggtgg cgctgctttc ctgagcggtg gttcccattt ccttatccat ggaggagacc
      901 tctgaacaga tcacaaatgt tacgtgagct ttttcctgtt ttcactcacc tgccatttcc
      961 aaaagatgcc tctttaaaca agtgctcctt tcttcaccca gaacctgttg tggggagtaa
     1021 gatgcataag atgcctgacc tatttatcat tggcagcggt gaggccatgt tgcagctcat
     1081 ccctcccttc cagtgccgaa gacattgtca gtctgtggcc atgccaatag agccagggga
     1141 tatcggctat gtcgacacca cccactggaa ggtctacgtt atagccagag gggtccagcc
     1201 tttggtcatc tgcgatggaa ccgctttctc agaactgtag gaaatagaac tgtgcacagg
     1261 aacagcttcc agagccgaaa accaggttga aaggggaaaa ataaaaacaa aaacgatgaa
     1321 actgctttct gggggttggt tacttagtta cctgcccttt gcatgcatgt gtgaaccagc
     1381 tgtgagctgc aaggcagtgg ccagagcctc gccctcctga ctcttcctgc aggtggctca
     1441 ggaaggattc agcctggcca cttggctagg actctgccag cacccatctg agactgacct
     1501 cttccgggcc tttggacact atgaccttga tgctgccctt caggcaggaa acagggctgg
     1561 tgcctttctt cacctgcatg gccagcttcc ttccctggca gtggagaggg cagccaacag
     1621 gttctaatgt cagagccatc ctttaccagg tgggcctgct tgtccctgtc ttgcctgcca
     1681 catcactcta ctttttggaa ggccatggct gattaaagaa gttcttgtag tttcccaagc
     1741 aaagtggaat ctagaaacag tgaaaaaagt tcagataact ttgaattgca ttcaagaagt
     1801 acacttcttt cccattgtcc gtggctcttg gagtctccgt gatgccaggc tagagtctga
     1861 ttatataata attcaaaatg gtaactccca aggtaatgct ttcttccatt tcatcaggtt
     1921 cttttatccc cactgcaccc cctccccttc tcccttgcct atctggatgg cttctcagaa
     1981 gctcggccct agtcctccct gccttggcgg ggccagagcc cactactgct gaggcagcac
     2041 tgctctcgtc agctgtgttg cctttaccaa gtgtcttcag agggttatga gttagagtag
     2101 ctggcctggg gagagggtgc ctccctgggt ttgatcttta gggtctgact ttctgcagag
     2161 aagatgtttt acagatgtgt caaagctgat gtaatgtggt tgggggagga aatccagacc
     2221 caaagtgttt gtcagctggg tgtacaactg cctatgtgat cctctgtctt aaaatgattt
     2281 ctgtctgtgc tgcgaaacaa agacaaggtg aggtgttttt cttttttgta ataatataaa
     2341 gctgtgtgtt tctgattgga tgattcacta tgtgcattgt tttctcctaa gtgcttttag
     2401 taggtagcaa tcaaatggtg taaataagga tgttcttttc ctgttccttt tatttttttc
     2461 tctctttatt attcttttat tgacaccact agatagctgg ccactggtca tgccattgcc
     2521 aagatgaaga aaaagcaaac tacactttgg cctctggttc tgaattgcag aaatcaaagg
     2581 atgcagtagg tgtctatgtc agaattatgg atcagaggca gacaatgacg agtgaagatg
     2641 gttgtgaagc cctcttcatt cctggaggag cctgcatctc atctctcagg ccctctttct
     2701 ctgtgggtct catgaacagc agtggggacc attgagcact tgaatggcct gtttgtctat
     2761 gggcttgcaa aggacaagca gagttcacag agctcaggat agaaacatca gagcctcctc
     2821 cacgggcttc agtgaaactc cgatgaactg tacctgaggg aattttttct taatcaaccc
     2881 cttgtgtgga tgaatacagg aacaacaaaa cttgtgtacg tatgaaagtc atgttgttaa
     2941 gcagttatga tttaagaggt tttaagtcag agggatcatc tggaggccgg ctttgtgcaa
     3001 gcttttacag ccttctgcag tgtccttacc ctggctgtac atggggaagg gctatgtgta
     3061 aacaagtgct ttagaggcct ctgagagttt ttaaaaatca gacccattaa caaaagagag
     3121 ggtttcttag gaacaaagca actattttga ttactgagat ctctgttttg tttctgtgag
     3181 ttactctgta ttcctttccc catttcactc ttgcccttca catcttaaat gtccataaga
     3241 aacccttgca tgtgttggta ttctgaggca tcccgtggga aagtccccta agtcccattt
     3301 tgtacttcaa caaaaaatga ctgtagcaga agataagtgg agacttttat ggatatacta
     3361 ctcattttac ttaaaatcta cccagttcag acttgaatgt aaacttgtat taggggaaaa
     3421 ttctccaaag agggttttct acatacacag aagcagttca acttctcaag ttaattttga
     3481 taagcagaat ctactactgg ccagagcgac aggagtggct aggggttgcc agccagtccc
     3541 tttctgatga tcaaggccct gcacagcagg atgccacagg atgcccctgc catctagctg
     3601 gaagcatcaa aagtccctct gtatgacccg gtgtgggaaa gagggttgtc aggatgagaa
     3661 agtggggctg cagggtgacg ataagaccac ctaaccaact ccccacctcc accaccacaa
     3721 taagaacaaa actgtagggc tctaaagaga gggggtggtt tacaagttta ttgagcattt
     3781 actaggaagt gacatggcga tgacctctgt acatgagtta ggttcacttt catgtggcct
     3841 cccactacag agatgcgtat gcccagaagt cagctctctg aggagacagg ctactttggc
     3901 cccagtttga agcattctgt ccaaatgtcc tgagctctcc agcagtcaag tagtgaatgg
     3961 ataccatact tattatggtt gatgaaaaaa ggcagagctt atcctcaatt ttttttaggg
     4021 aagagaagga ataaaataaa agtggttcaa gctgggcatg gtggctcaca cctgtaattg
     4081 cagcactttg ggaggctgag gcaggcagat cacttgaggt caggagttca agaccagcct
     4141 ggccaacagg gtgaaacccc atctctacta aaaatacaaa aattacccag gcgtgatggt
     4201 gggcgcctgt aatcccagct acacaggaag ctgaggcagg aaaattgctt gaaccgggga
     4261 ggcggagatt gcagtgagcc aagattgtgc cacttcattc cagcctgggc gacagagcga
     4321 aactctgtca aaggaaagga aagaaaagaa aaaaaaaaag agagagagaa aagaagaggg
     4381 gaggggaggg aaagggaagg gaggggaggg gaggagagga gagcagattg ggggggctca
     4441 tgttctgaga gaaaggaata atagcatttg tctagtacat tccagtttac aaagtgcctg
     4501 atatacatga tctcctttaa tcttcaccca atcctgtaaa gtaggtgtta gatccccatt
     4561 ttgcaagtaa ataagtggag gcttagagca gttaaccgct ggcaggtagg tagctggttc
     4621 catagcacat cattttcctg cggcatcacg gcatggtgcc gaagaagaca gctgtggatg
     4681 tcgttgactc agatgtgcct ccgttggggt gggagaaccc agggatgggg gtcagcaagc
     4741 caggaactcc gcagggtttg tttttaaaac tctgctggac agaagtggag gaggaaagaa
     4801 tctaaccata tgacttttat aaaaatcctt tcacttttcc cctccccatt tgaaaactct
     4861 ttttaagagt gaatgtagct gaaacacaac tgtgtccagc cattttcctg tctccacatt
     4921 cttccagatg tgtgacagag gagggactct gctcaattcc agttgtgggt ccccttggag
     4981 tttacatcac ttgtttttca attcttggtt ttctgttccc ttctaccaaa acccagcata
     5041 ggactcagtg tacacttact ttaaaacaaa aactcacatt tcttagctgc aggtgatggc
     5101 ctcagtcatt ttaatacagc ctggaatgag tttgcttatt acccagtcac tttcgtagtg
     5161 aatgttcaaa ccccaaagca aatgtttgca tctccttgtc cataaaggag aaagccaggt
     5221 tataggagaa agagagagaa aggcgcatgt ctgtttgcac agagagaggc aattttgtct
     5281 acctttcgag aatcagttat aaacagaagg gcctcttagg attttgagct ctcctgacaa
     5341 tgaaggaaaa gctctcttga gtatacaagt tccacactca ttacctttca gtggtgaccc
     5401 atcacccact acaatttgtt gaaggaaggg agtgtcagag atatgcttta aagttgtact
     5461 ttaggctgaa attctctctg tatttggacc tgcagatgtt gtgtacagaa ccgatgcatg
     5521 gcagggtcag gaagctagga gagtgaaggc gcttgtggag acagctctgt agcaaatgaa
     5581 acacggaagc ctccgggaat gtgtttgtgt caccagcagc aggcatttcc ctgtcctccc
     5641 cacccccagt ctccacatcc ccagcagcct cttccagaag catgtcaggg agacggacag
     5701 gtgctctcct tctcgtgcac cacatccaag tccacccacc gtggacgcag tgtgactaaa
     5761 tgctggcctt gaagagaaac cctcagccag cttgtctgtt gtccaggtcc ctcagtgtct
     5821 ctggtttccc tgccctgcat aatttaagca ttagtgccaa atacatctgt catattcctc
     5881 tccctggaga ctgcgaaatg tccagacttt ttcagactag tggagggaag gaatgttaca
     5941 taactaagtg gaggcctgga actgtcagga tttgacaggg ctggaccaga gacccttccg
     6001 cctctgccta gtgtgtctgt caggcaggca gcagccatca atccaagaat gagccatggc
     6061 ggcaagcact gtgtggagaa aggaacccag ccgaggtctg agtttcagac agaaactggg
     6121 gagttgggac atcttctctg tgccaggctt cattgacacc atcgctcccc acagcagctc
     6181 cttggggcag ggggctcacc tgtgcagcca cccttactca cagtagcatc ccattcttca
     6241 cactgcaacc ccccagcact gtggaccctt ccagggaggt gacaggagcc agcagacaca
     6301 tgacattccc agaaagcccc atcttatcca gacaggcttc cctccatact tctttccaca
     6361 gttttaccct cagaaaaatg ttggctgcag tcttcccttc cttcacctcc accctgggga
     6421 agggtcagta accaatgccg agggtcgggg aaggaggagt cacaggcaag acagggactc
     6481 agcgcagtgc tcccgccatc atcggggaca ggtgccaggg tcagctgcag ctctccttcc
     6541 gggagcaggg tgtggtggcc ctggatggtc ccagggagca gagggaggca ggcagctgtc
     6601 acagccacag cggctctgaa tggcttgagc ttttagtatg tgttcaagtg caggatacta
     6661 caaactggta aagacttcca ccatgtgaag aatgtatgta aattaaagtt tattgtaatg
     6721 aaggttttta ctttttgcaa ttaaaagtgt tggttgataa gaa
//
