LOCUS       NM_001010905            1203 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 6 open reading frame 58 (C6orf58), mRNA.
ACCESSION   NM_001010905 XM_371847
VERSION     NM_001010905.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1203)
  AUTHORS   Saitou,M., Gaylord,E.A., Xu,E., May,A.J., Neznanova,L., Nathan,S.,
            Grawe,A., Chang,J., Ryan,W., Ruhl,S., Knox,S.M. and Gokcumen,O.
  TITLE     Functional Specialization of Human Salivary Glands and Origins of
            Proteins Intrinsic to Human Saliva
  JOURNAL   Cell Rep 33 (7), 108402 (2020)
   PUBMED   33207190
REFERENCE   2  (bases 1 to 1203)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1203)
  AUTHORS   Hu,M., Bai,Y., Zhang,C., Liu,F., Cui,Z., Chen,J. and Peng,J.
  TITLE     Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to
            FGFR and Mediates an Anti-stress Pathway to Protect Liver
            Development in Zebrafish
  JOURNAL   PLoS Genet 12 (2), e1005881 (2016)
   PUBMED   26901320
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1203)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   5  (bases 1 to 1203)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1203)
  AUTHORS   Ramachandran,P., Boontheung,P., Xie,Y., Sondej,M., Wong,D.T. and
            Loo,J.A.
  TITLE     Identification of N-linked glycoproteins in human saliva by
            glycoprotein capture and mass spectrometry
  JOURNAL   J Proteome Res 5 (6), 1493-1503 (2006)
   PUBMED   16740002
REFERENCE   7  (bases 1 to 1203)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK303850.1 and AL583806.7.
            
            On Nov 22, 2018 this sequence version replaced NM_001010905.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK303850.1, BC062712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329722.8/ ENSP00000328069.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1201              AK303850.1         1-1201
            1202-1203           AL583806.7         74204-74205
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.33"
     gene            1..1203
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /note="chromosome 6 open reading frame 58"
                     /db_xref="GeneID:352999"
                     /db_xref="HGNC:HGNC:20960"
     exon            1..313
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1005
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /note="UPF0762 protein C6orf58; protein LEG1 homolog;
                     liver enriched gene 1 homolog"
                     /codon_start=1
                     /product="protein LEG1 homolog precursor"
                     /protein_id="NP_001010905.1"
                     /db_xref="CCDS:CCDS34533.1"
                     /db_xref="GeneID:352999"
                     /db_xref="HGNC:HGNC:20960"
                     /translation="MAFLPSWVCVLVGSFSASLAGTSNLSETEPPLWKESPGQLSDYR
                     VENSMYIINPWVYLERMGMYKIILNQTARYFAKFAPDNEQNILWGLPLQYGWQYRTGR
                     LADPTRRTNCGYESGDHMCISVDSWWADLNYFLSSLPFLAAVDSGVMGISSDQVRLLP
                     PPKNERKFCYDVSSCRSSFPETMNKWNTFYQYLQSPFSKFDDLLKYLWAAHTSTLADN
                     IKSFEDRYDYYSKAEAHFERSWVLAVDHLAAVLFPTTLIRSYKFQKGMPPRILLNTDV
                     APFISDFTAFQNVVLVLLNMLDNVDKSIGYLCTEKSNVYRDHSESSSRSYGNNS"
     exon            314..400
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..585
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..686
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..925
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1203
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1166..1171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /note="hexamer: ATTAAA"
     regulatory      1179..1184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /note="hexamer: ATTAAA"
     polyA_site      1188
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /note="major polyA site"
     polyA_site      1203
                     /gene="C6orf58"
                     /gene_synonym="LEG1"
                     /note="major polyA site"
ORIGIN      
        1 agctctggca caatggcttt tcttccttcc tgggtttgtg tactagttgg ttccttttct
       61 gcttccttag cagggacttc caatctctca gagacagagc cccctctgtg gaaggagagt
      121 cctggtcagc tcagtgacta cagggtggag aacagcatgt acattattaa tccctgggta
      181 taccttgaga gaatggggat gtataaaatc atattgaatc agacagccag gtattttgca
      241 aaatttgcac cagataatga acagaatatt ttatgggggt tgcctctgca gtatggctgg
      301 caatatagga caggcagatt agctgatcca acccgaagga caaactgtgg ctatgaatct
      361 ggagatcata tgtgcatctc tgtggacagt tggtgggctg atttgaatta ttttctgtct
      421 tcattaccct ttcttgctgc ggttgattct ggtgtaatgg ggatatcatc agaccaagtc
      481 aggcttttgc ccccacccaa gaatgagagg aagttttgtt atgatgtttc tagctgtcgt
      541 tcatccttcc ctgagacaat gaacaagtgg aacacctttt accagtattt gcagtcacct
      601 tttagtaagt ttgatgatct gttgaagtac ttatgggctg cacacacttc aaccttggca
      661 gataatatca aaagttttga agacagatat gattattatt ctaaagcaga agcgcatttt
      721 gagagaagtt gggtactggc tgtggatcat ttagctgcag tcctctttcc tacaaccttg
      781 attagatcat ataagttcca gaagggcatg ccaccacgaa ttcttcttaa tactgatgta
      841 gcccctttca tcagtgactt tactgctttt cagaatgtag tcctggttct tctaaatatg
      901 cttgacaatg tggataaatc tataggttat ctttgtacag aaaaatctaa tgtatataga
      961 gatcattcgg aatctagctc tagaagttat ggaaataact cctgaaacat ttaacttcaa
     1021 acttcaggaa atgattaatg aattaaaaat gaaaaactcg aacttgacaa tcagtaattt
     1081 caaaaaatta atgtcatcat gaccatgtag tttattcttt ctgatatttt tgatttatgc
     1141 ttatttgtta agatcttgta catgtattaa aaacttaaat taaatgcatt caagttaaaa
     1201 taa
//
