LOCUS       NM_014070               1156 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens chromosome 6 open reading frame 15 (C6orf15), mRNA.
ACCESSION   NM_014070
VERSION     NM_014070.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Liu,L., Wang,X., He,Q., Yu,B., Wang,J. and Shen,H.
  TITLE     Differential diagnosis of gastric low- and high grade dysplasia
            using C6orf15 protein
  JOURNAL   Ann Diagn Pathol 71, 152298 (2024)
   PUBMED   38547762
  REMARK    GeneRIF: Differential diagnosis of gastric low- and high grade
            dysplasia using C6orf15 protein.
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Xiong,X., Wang,S., Gao,Z. and Ye,Y.
  TITLE     C6orf15 acts as a potential novel marker of adverse pathological
            features and prognosis for colon cancer
  JOURNAL   Pathol Res Pract 245, 154426 (2023)
   PUBMED   37054577
  REMARK    GeneRIF: C6orf15 acts as a potential novel marker of adverse
            pathological features and prognosis for colon cancer.
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   Li,J., Glessner,J.T., Zhang,H., Hou,C., Wei,Z., Bradfield,J.P.,
            Mentch,F.D., Guo,Y., Kim,C., Xia,Q., Chiavacci,R.M., Thomas,K.A.,
            Qiu,H., Grant,S.F., Furth,S.L., Hakonarson,H. and Sleiman,P.M.
  TITLE     GWAS of blood cell traits identifies novel associated loci and
            epistatic interactions in Caucasian and African-American children
  JOURNAL   Hum Mol Genet 22 (7), 1457-1464 (2013)
   PUBMED   23263863
REFERENCE   5  (bases 1 to 1156)
  AUTHORS   Rubicz,R., Yolken,R., Drigalenko,E., Carless,M.A., Dyer,T.D.,
            Bauman,L., Melton,P.E., Kent,J.W. Jr., Harley,J.B., Curran,J.E.,
            Johnson,M.P., Cole,S.A., Almasy,L., Moses,E.K., Dhurandhar,N.V.,
            Kraig,E., Blangero,J., Leach,C.T. and Goring,H.H.
  TITLE     A genome-wide integrative genomic study localizes genetic factors
            influencing antibodies against Epstein-Barr virus nuclear antigen 1
            (EBNA-1)
  JOURNAL   PLoS Genet 9 (1), e1003147 (2013)
   PUBMED   23326239
REFERENCE   6  (bases 1 to 1156)
  AUTHORS   Sanchez,F., Holm,S.J., Mallbris,L., O'Brien,K.P. and Stahle,M.
  TITLE     STG does not associate with psoriasis in the Swedish population
  JOURNAL   Exp Dermatol 13 (7), 413-418 (2004)
   PUBMED   15217361
  REMARK    GeneRIF: STG is expressed in taste buds, skin and tonsils, and does
            not associate with psoriasis in the Swedish population
REFERENCE   7  (bases 1 to 1156)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 1156)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1156)
  AUTHORS   Neira,M., Danilova,V., Hellekant,G. and Azen,E.A.
  TITLE     A new gene (rmSTG) specific for taste buds is found by laser
            capture microdissection
  JOURNAL   Mamm Genome 12 (1), 60-66 (2001)
   PUBMED   11178745
REFERENCE   10 (bases 1 to 1156)
  AUTHORS   Oka,A., Tamiya,G., Tomizawa,M., Ota,M., Katsuyama,Y., Makino,S.,
            Shiina,T., Yoshitome,M., Iizuka,M., Sasao,Y., Iwashita,K.,
            Kawakubo,Y., Sugai,J., Ozawa,A., Ohkido,M., Kimura,M., Bahram,S.
            and Inoko,H.
  TITLE     Association analysis using refined microsatellite markers localizes
            a susceptibility locus for psoriasis vulgaris within a 111 kb
            segment telomeric to the HLA-C gene
  JOURNAL   Hum Mol Genet 8 (12), 2165-2170 (1999)
   PUBMED   10545595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662844.12 and AB031481.1.
            
            On May 17, 2019 this sequence version replaced NM_014070.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031481.1, AY358438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259870.4/ ENSP00000259870.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL662844.12        52044-52063         c
            21-512              AB031481.1         1-492
            513-1082            AL662844.12        50785-51354         c
            1083-1156           AB031481.1         1063-1136
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1156
                     /gene="C6orf15"
                     /gene_synonym="STG"
                     /note="chromosome 6 open reading frame 15"
                     /db_xref="GeneID:29113"
                     /db_xref="HGNC:HGNC:13927"
                     /db_xref="MIM:611401"
     exon            1..87
                     /gene="C6orf15"
                     /gene_synonym="STG"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..998
                     /gene="C6orf15"
                     /gene_synonym="STG"
                     /note="taste bud-specific protein; uncharacterized protein
                     C6orf15; simian taste bud-specific"
                     /codon_start=1
                     /product="uncharacterized protein C6orf15 precursor"
                     /protein_id="NP_054789.2"
                     /db_xref="CCDS:CCDS4693.1"
                     /db_xref="GeneID:29113"
                     /db_xref="HGNC:HGNC:13927"
                     /db_xref="MIM:611401"
                     /translation="MQGRVAGSCAPLGLLLVCLHLPGLFARSIGVVEEKVSQNLGTNL
                     PQLGQPSSTGPSNSEHPQPALDPRSNDLARVPLKLSVPASDGFPPAGGSAVQRWPPSW
                     GLPAMDSWPPEDPWQMMAAAAEDRLGEALPEELSYLSSAAALAPGSGPLPGESSPDAT
                     GLSPKASLLHQDSESRRLPRSNSLGAGGKILSQRPPWSLIHRVLPDHPWGTLNPSVSW
                     GGGGPGTGWGTRPMPHPEGIWGINNQPPGTSWGNINRYPGGSWGNINRYPGGSWGNIN
                     RYPGGSWGNIHLYPGINNPFPPGVLRPPGSSWNIPAGFPNPPSPRLQWG"
     exon            88..1156
                     /gene="C6orf15"
                     /gene_synonym="STG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf15"
                     /gene_synonym="STG"
                     /note="hexamer: AATAAA"
     polyA_site      1156
                     /gene="C6orf15"
                     /gene_synonym="STG"
                     /note="major polyA site"
ORIGIN      
        1 gagatcgggt gctgagcagg atgcagggcc gcgtggcagg gagctgcgct cctctgggcc
       61 tgctcctggt ctgtcttcat ctcccaggcc tctttgcccg gagcatcggt gttgtggagg
      121 agaaagtttc ccaaaacttg gggaccaact tgcctcagct cggacaacct tcctccactg
      181 gcccctctaa ctctgaacat ccgcagcccg ctctggaccc taggtctaat gacttggcaa
      241 gggttcctct gaagctcagc gtgcctgcat cagatggctt cccacctgca ggaggttctg
      301 cagtgcagag gtggcctcca tcgtgggggc tgcctgccat ggattcctgg ccccctgagg
      361 atccttggca gatgatggct gctgcggctg aggaccgcct gggggaagcg ctgcctgaag
      421 aactctctta cctctccagt gctgcggccc tcgctccggg cagtggccct ttgcctgggg
      481 agtcttctcc cgatgccaca ggcctctcac ccaaggcttc actcctccac caggactcgg
      541 agtccagacg actgccccgt tctaattcac tgggagccgg gggaaaaatc ctttcccaac
      601 gccctccctg gtctctcatc cacagggttc tgcctgatca cccctggggt accctgaatc
      661 ccagtgtgtc ctggggaggt ggaggccctg ggactggttg gggaacgagg cccatgccac
      721 accctgaggg aatctggggt atcaataatc aacccccagg taccagctgg ggaaatatta
      781 atcggtatcc aggaggcagc tggggaaata ttaatcggta tccaggaggc agctggggga
      841 atattaatcg gtatccagga ggcagctggg ggaatattca tctataccca ggtatcaata
      901 acccatttcc tcctggagtc ctccgccctc ctggctcttc ttggaacatc ccagctggct
      961 tccctaatcc tccaagccct aggttgcagt ggggctagag cacgatagag ggaaacccaa
     1021 cattgggagt tagagtcctg ctcccgcccc ttgctgtgtg ggctcaatcc aggccctgtc
     1081 agcatgtttc cagcactatc cccacttttc agtgcctccc ctgctcatct ccaataaaat
     1141 aaaagcactt atggaa
//
