LOCUS       NM_001145652            1428 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens chromosome 6 open reading frame 141 (C6orf141),
            transcript variant 1, mRNA.
ACCESSION   NM_001145652 XR_040195 XR_040196 XR_040197 XR_040198 XR_040199
            XR_040200
VERSION     NM_001145652.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1428)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1428)
  AUTHORS   Yang,C.M., Chang,H.S., Chen,H.C., You,J.J., Liou,H.H., Ting,S.C.,
            Ger,L.P., Li,S.C. and Tsai,K.W.
  TITLE     Low C6orf141 Expression is Significantly Associated with a Poor
            Prognosis in Patients with Oral Cancer
  JOURNAL   Sci Rep 9 (1), 4520 (2019)
   PUBMED   30872783
  REMARK    GeneRIF: Low C6orf141 Expression is Significantly Associated with a
            Poor Prognosis in Patients with Oral Cancer.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590244.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001145652.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK289889.1, SRR1660805.234789.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000529246.4/ ENSP00000434602.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1428              AL590244.5         73029-74456
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..1428
                     /gene="C6orf141"
                     /note="chromosome 6 open reading frame 141"
                     /db_xref="GeneID:135398"
                     /db_xref="HGNC:HGNC:21351"
     exon            1..1428
                     /gene="C6orf141"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..860
                     /gene="C6orf141"
                     /codon_start=1
                     /product="uncharacterized protein C6orf141"
                     /protein_id="NP_001139124.2"
                     /db_xref="CCDS:CCDS55018.1"
                     /db_xref="GeneID:135398"
                     /db_xref="HGNC:HGNC:21351"
                     /translation="MNDPFARMETRGPQGAANPMDSSRSLGDLGPFPREVGRGAPLAP
                     GARNPATAGASRSQGGGHEDRTADRALGPRAGEELDRESWVREKVLFLLHPERWLGTR
                     GDPAREEVAGAEDLPHAGGEDHGEEPNYPSVFQRQKRISGRRVAPPRDAADPPKYVLV
                     RVEDYQVTQEVLQTSWAKGRMTTRTEEHFVTALTFRSSREGQPGERWGPAESRALQAR
                     TGASRVHAAGRRVSPSPGTWLEEIKL"
     regulatory      1314..1319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf141"
                     /note="hexamer: AAGAAA"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf141"
                     /note="hexamer: AGTAAA"
     polyA_site      1332
                     /gene="C6orf141"
                     /note="major polyA site"
     polyA_site      1348
                     /gene="C6orf141"
                     /note="major polyA site"
ORIGIN      
        1 agtcttcagc tttcaccggc tgggagtccg gagctgcagc agaggccaca cccagggctt
       61 ggtggtcccg cgctttccgg agctcagcag gcgcttgctg cttgaaccgg tcaaagaagg
      121 aacgaatgaa tgaccctttt gccaggatgg agacccgggg gcctcaggga gctgcgaatc
      181 ccatggactc ctcccgcagc ctgggggacc tcgggccttt tccgcgggag gtagggcgcg
      241 gggctccgct agctccgggc gcccggaatc ccgcgacggc aggggcgagc cgaagccagg
      301 gcggcggcca cgaggacaga acggcagatc gggccctcgg acctcgggcc ggggaggaat
      361 tggaccgtga gtcctgggtc agagagaaag tgctctttct cctgcaccca gagaggtggt
      421 tagggactcg aggggaccct gcacgggaag aggtggccgg tgcagaggac cttcctcatg
      481 cgggtggaga ggaccacggc gaggagccca actacccttc tgtctttcaa cgacaaaagc
      541 gaatttctgg caggcgtgta gccccgccgc gggacgcagc agacccaccc aaatacgtgc
      601 ttgtgcgggt ggaggattat caggtaacac aagaagtgtt gcagacctcc tgggccaagg
      661 gtcgcatgac cacgaggact gaggagcact tcgtgaccgc gctcactttt cgcagcagta
      721 gagagggaca gcctggggaa cgctggggcc ctgctgaatc ccgggctctc caggcacgaa
      781 caggggcatc ccgcgtccac gccgcgggga ggagggtttc accgtctcca gggacttggc
      841 tcgaggaaat taaactctaa tgagtagctc gagaaatgtt ccgggatggt ggatgagcga
      901 tcatccttaa aagaaaatgc tattctggga gctccaacct gcaattaacc tacagaagga
      961 accttttgag aggctggtgc agcgcttcgg ggaggcagat taagaactgt aagcagcata
     1021 atacctcctt tgtggcttga attccttcgc tgtctgggga cctaagtcat tcagaagagg
     1081 tggagaaaag atattttcag attggcagaa tgtgggagtt ttgaaatgag aaaacctgtt
     1141 gttaatttgc attttggaat aactctcaat tgatctcttt tctgttcccc gcccccctct
     1201 tgtttctctt taggacctag aaacagaagt gaagtttgaa gtctgctctc tgcaaagagg
     1261 gtgggagtgg gtggagaaga ggcttgtttt aaaagccaaa aacagaaagt aaaaagaaat
     1321 gggaaagtaa aaccaaagca gcaagtgact ctcttctgat gtgcactttt catttttctc
     1381 ccccacattt cagtgttaga aagaaaacga gaggagctag ggaaagaa
//
