LOCUS       NM_001161376            1882 bp    mRNA    linear   PRI 19-FEB-2025
DEFINITION  Homo sapiens chromosome 6 open reading frame 136 (C6orf136),
            transcript variant 3, mRNA.
ACCESSION   NM_001161376
VERSION     NM_001161376.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1882)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Paterno,R.,
            Sherry,D.M., Johnson,A.C. and Dunn,I.F.
  TITLE     Spontaneous mutation in 2310061I04Rik results in reduced expression
            of mitochondrial genes and impaired brain myelination
  JOURNAL   PLoS One 19 (12), e0290487 (2024)
   PUBMED   39631040
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1882)
  AUTHORS   Liu,Q., Li,R., Wu,H. and Liang,Z.
  TITLE     A novel cuproptosis-related gene model predicts outcomes and
            treatment responses in pancreatic adenocarcinoma
  JOURNAL   BMC Cancer 23 (1), 226 (2023)
   PUBMED   36894917
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1882)
  AUTHORS   Teh,M.T., Gemenetzidis,E., Patel,D., Tariq,R., Nadir,A.,
            Bahta,A.W., Waseem,A. and Hutchison,I.L.
  TITLE     FOXM1 induces a global methylation signature that mimics the cancer
            epigenome in head and neck squamous cell carcinoma
  JOURNAL   PLoS One 7 (3), e34329 (2012)
   PUBMED   22461910
  REMARK    GeneRIF: C6orf136 was found to be differentially methylated and
            differentially expressed in human squamous cell carcinomas
REFERENCE   4  (bases 1 to 1882)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA200997.1, BC064397.1 and AI536982.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001161376.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (3) that is longer than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.260522.1, BC064397.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651131.1/ ENSP00000499201.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               DA200997.1         120-407
            289-1784            BC064397.1         1-1496
            1785-1882           AI536982.1         9-106               c
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1882
                     /gene="C6orf136"
                     /note="chromosome 6 open reading frame 136"
                     /db_xref="GeneID:221545"
                     /db_xref="HGNC:HGNC:21301"
     exon            1..714
                     /gene="C6orf136"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1590
                     /gene="C6orf136"
                     /note="isoform 3 is encoded by transcript variant 3;
                     uncharacterized protein C6orf136"
                     /codon_start=1
                     /product="uncharacterized protein C6orf136 isoform 3"
                     /protein_id="NP_001154848.1"
                     /db_xref="CCDS:CCDS54979.1"
                     /db_xref="GeneID:221545"
                     /db_xref="HGNC:HGNC:21301"
                     /translation="MYQPSRGAARRLGPCLRAYQARPQVSGGEEGGRRGGGERPSSKP
                     VRGAERALGSAQAQRHPPPLPTCALQRVDRLGVAGAGGRRCRACRARTSVLPGLRAVR
                     RGQGQAAGRVCVAPDSPRLPVPRGDLKGRGREIRSPAAAPSRSSPAQTRPAGRPQQPA
                     RLALGERSWQEGRPVCTRFGPLRPGWQDGHAPSRDGASRTPSGTEDQLYPGTLPFPPL
                     WPHSTTTTSPSSPLFWSPLPPRLPTQRLPQVPPLPLPQIQALSSAWVVLPPGKGEEGP
                     GPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPGTAHPSPATPSGDPSMEEHLSVMYE
                     RLRQELPKLFLQSHDYSLYSLDVEFINEILNIRTKGRTWYILSLTLCRFLAWNYFAHL
                     RLEVLQLTRHPENWTLQARWRLVGLPVHLLFLRFYKRDKDEHYRTYDAYSTFYLNSSG
                     LICRHRLDKLMPSHSPPTPVKKLLVGALVALGLSEPEPDLNLCSKP"
     exon            715..1116
                     /gene="C6orf136"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1205
                     /gene="C6orf136"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1406
                     /gene="C6orf136"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1476
                     /gene="C6orf136"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1882
                     /gene="C6orf136"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1754..1759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf136"
                     /note="hexamer: AATAAA"
     polyA_site      1777
                     /gene="C6orf136"
                     /note="major polyA site"
     regulatory      1863..1868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf136"
                     /note="hexamer: AATAAT"
     polyA_site      1882
                     /gene="C6orf136"
ORIGIN      
        1 ctcctttccc cttcacgaag ccggctctgg ggcgcgctca cccctgtgag gaggccggag
       61 gtcggactca ggaggctcct tctccactcc cggaagatca tgtaccagcc cagccggggt
      121 gcggcccggc gtctcggccc ttgcctgcgc gcctaccagg ctcgacccca ggtgagcgga
      181 ggagaagagg gagggaggag agggggcggg gagagaccct cctcaaagcc ggtgcgtggg
      241 gcggagcgcg cgctgggttc cgcgcaggcg cagagacacc cgccgcccct tcccacctgt
      301 gccctgcagc gcgtggacag gctaggggtc gcgggagcgg gagggaggcg ctgccgggcc
      361 tgtcgcgcaa ggacgtcggt cctcccaggt ttgagggcgg tcaggcgggg tcaaggccag
      421 gcagcggggc gcgtctgcgt tgcgcccgac tctccgcggt tacctgtgcc tagaggtgat
      481 ttgaagggca ggggccgaga gattcgtagc cctgctgcgg cgccgtcccg gagttccccg
      541 gcccagacca gacccgcggg gcgccctcag cagcccgccc gtcttgcact cggagagcgg
      601 tcctggcagg aaggccggcc agtgtgcacc cggttcgggc ccctgcgccc gggctggcaa
      661 gatggccacg cccccagcag agacggcgcc tctaggacac catcggggac cgaggaccag
      721 ctttatccag ggactctacc attcccaccc ctttggcccc actccacgac aaccacttcc
      781 ccatcttctc ctctattctg gtctcccctg cccccacgcc ttcccaccca gcgtcttccc
      841 caggttcccc cactacctct ccctcagatc caggccctca gctcagcatg ggtggttctc
      901 cctccaggaa agggggagga gggaccagga cctgagttgc atagcggctg cctggatggg
      961 cttagaagcc tttttgaggg acctccctgc ccctatcctg gggcttggat acctttccaa
     1021 gtccctggaa ctgcccaccc ttcccctgcc accccgtcag gagatcctag tatggaggaa
     1081 catctgtctg tcatgtatga gagactgaga caagagcttc ccaagctctt ccttcagtcc
     1141 cacgactaca gtctgtattc cttggatgtg gaattcatca atgagatcct caacatacgt
     1201 accaagggcc ggacatggta cattctttca ctgaccctct gccgtttcct ggcctggaat
     1261 tattttgcac accttcgttt ggaggtttta cagctgaccc gccaccctga gaactggacc
     1321 ctgcaagccc ggtggcggct tgtggggctg cccgtccact tgctcttttt gcggttctac
     1381 aagcgtgaca aagacgagca ttaccggacc tatgatgcct actccacttt ctacctgaat
     1441 tccagtggcc tcatttgtcg ccatcgtcta gataaactga tgccttcaca ctcacctcca
     1501 acgcctgtga agaagctgct agtgggagcc ctggtggccc tggggctgtc agagccagaa
     1561 cctgacttaa acctgtgttc caagccctga tccttgacct tggagtggag gcagcactga
     1621 agactgctac gcccaagaga aggaggtgga ggcagccaag aatctcagga gccagcttcc
     1681 tctcctcgtt tctctccttc cttcctttcc atctcatgct gtgtaaagct gctgtgtaat
     1741 ttaacttgta aataataaag tttaactgac tatatgagat agaatttcac atatcacttt
     1801 ctctagatcc caaatgttcc cacaagcttt attccaaaaa taattttatt taataggtat
     1861 taaataatgt atagaaggaa aa
//
