LOCUS       NM_001029863            4235 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens chromosome 6 open reading frame 120 (C6orf120),
            transcript variant 1, mRNA.
ACCESSION   NM_001029863
VERSION     NM_001029863.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4235)
  AUTHORS   Wang,X., Liu,H., Wang,Y., Wang,P., Yi,Y., Lin,Y. and Li,X.
  TITLE     Novel protein C6ORF120 promotes liver fibrosis by activating
            hepatic stellate cells through the PI3K/Akt/mTOR pathway
  JOURNAL   J Gastroenterol Hepatol 39 (7), 1422-1430 (2024)
   PUBMED   38523410
  REMARK    GeneRIF: Novel protein C6ORF120 promotes liver fibrosis by
            activating hepatic stellate cells through the PI3K/Akt/mTOR
            pathway.
REFERENCE   2  (bases 1 to 4235)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4235)
  AUTHORS   Zhang,M.K., Ma,H.M., Zhang,J., Song,X.C., Ye,X.H., Li,Y.F.,
            Zhang,Y.F., He,L.L., Wei,H.S. and Li,X.
  TITLE     Deletion of the C6orf120 gene with unknown function ameliorates
            autoimmune hepatitis induced by concanavalin A
  JOURNAL   Cell Immunol 331, 9-15 (2018)
   PUBMED   29748000
REFERENCE   4  (bases 1 to 4235)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4235)
  AUTHORS   Li,X., Qiao,Y., Chang,L.S., Xiao,F., Lu,L.H., Hao,X.H., Zhang,R.W.,
            Wu,H. and Wei,H.S.
  TITLE     Role of C6ORF120, an N-glycosylated protein, is implicated in
            apoptosis of CD4 T lymphocytes
  JOURNAL   Chin Med J (Engl) 124 (21), 3560-3567 (2011)
   PUBMED   22340178
  REMARK    GeneRIF: Results suggested that C6ORF120 could induce apoptosis of
            CD4(+) T cells, at least in part, mediated with endoplasmic
            reticulum stress.
REFERENCE   6  (bases 1 to 4235)
  AUTHORS   Bradfield,J.P., Qu,H.Q., Wang,K., Zhang,H., Sleiman,P.M., Kim,C.E.,
            Mentch,F.D., Qiu,H., Glessner,J.T., Thomas,K.A., Frackelton,E.C.,
            Chiavacci,R.M., Imielinski,M., Monos,D.S., Pandey,R., Bakay,M.,
            Grant,S.F., Polychronakos,C. and Hakonarson,H.
  TITLE     A genome-wide meta-analysis of six type 1 diabetes cohorts
            identifies multiple associated loci
  JOURNAL   PLoS Genet 7 (9), e1002293 (2011)
   PUBMED   21980299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513547.16.
            
            On May 21, 2021 this sequence version replaced NM_001029863.2.
            
            Summary: This gene encodes a conserved, N-glycosylated protein that
            likely functions in the cellular response to endoplasmic reticulum
            stress. This protein is able to induce apoptosis in vitro in CD4+
            T-cells. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC051700.1, AK295061.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332290.4/ ENSP00000346931.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4235              AL513547.16        69142-73376
FEATURES             Location/Qualifiers
     source          1..4235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..4235
                     /gene="C6orf120"
                     /note="chromosome 6 open reading frame 120"
                     /db_xref="GeneID:387263"
                     /db_xref="HGNC:HGNC:21247"
                     /db_xref="MIM:616987"
     exon            1..4235
                     /gene="C6orf120"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..910
                     /gene="C6orf120"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; UPF0669 protein C6orf120"
                     /codon_start=1
                     /product="UPF0669 protein C6orf120 isoform 1 precursor"
                     /protein_id="NP_001025034.1"
                     /db_xref="CCDS:CCDS34575.1"
                     /db_xref="GeneID:387263"
                     /db_xref="HGNC:HGNC:21247"
                     /db_xref="MIM:616987"
                     /translation="MAAPRGRAAPWTTALLLLLASQVLSPGSCADEEEVPEEWVLLHV
                     VQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHPSFDDYELQSATCGPD
                     AVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKH
                     AGAPEDASQEEESVLWTILISILKLVLEILF"
     regulatory      2719..2724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf120"
                     /note="hexamer: AATAAA"
     polyA_site      2742
                     /gene="C6orf120"
                     /note="major polyA site"
     regulatory      4159..4164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf120"
                     /note="hexamer: CATAAA"
     polyA_site      4181
                     /gene="C6orf120"
                     /note="major polyA site"
     regulatory      4210..4215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf120"
                     /note="hexamer: AATAAA"
     polyA_site      4235
                     /gene="C6orf120"
ORIGIN      
        1 acttccgcct ccggcgaggc tccggcctcg ggtccggatg tataaagcgc ggccccctgc
       61 ggggagtggt ggtgagtccg agggtgccac agcggccctg cccctgcccc tgcccctgcc
      121 ctgagtgggc gccgcgctac gggggagggg ttaacccacc cctcctcccc ggggcctcac
      181 gcgggtggga agggacagtc ccagcgacag accaggcgcc tggacgcgcc gtggacccgc
      241 gtgcggacgg cggggacagg ctccggtgct gagcgcctcc ggtgtcccca gcagcactga
      301 cccacttgca ggccccggag ctgagccgcc agccatggcc gctccccgcg ggagggccgc
      361 gccctggacg acggccctgc tgctgctcct agcctcgcag gtcctgtctc cgggaagctg
      421 cgcggacgag gaggaggtcc ccgaggagtg ggtgctcctg cacgtcgtcc agggccagat
      481 aggcgccggg aactacagct acctgcggct gaaccacgag ggcaagatag tcctcaggat
      541 gcgcagcctc aagggagatg cggatctgta cgtctccgcc agcagcctgc accccagctt
      601 cgacgactac gagctgcaat cggccacctg cggcccggac gccgtgtcca tccccgcgca
      661 cttccggcgc ccagtgggca tcggcgtcta tggacacccc tcccacctgg agagcgagtt
      721 cgagatgaag gtgtactacg acggcacggt cgagcagcac ccgttcggcg aggccgccta
      781 ccccgccgac ggcgcagatg ccggccagaa gcacgctggt gccccggaag acgcctcgca
      841 agaggaggaa tctgttctct ggacgatatt aattagcatt ttgaaactgg tacttgaaat
      901 tctcttttga gtcgttgacc acactctggg atataaaacc ctccatctgt gaagctgatt
      961 gcagtttgct gtgaaccttg ctacttgtac ttggttgaag ttctaggtac ctttagtcaa
     1021 gggatggaaa aataaagcca tacgcagttt tgttacctca gttaccccaa aaataggaaa
     1081 agcagcaagc acagtatttt aaagatcata attcctataa aaggactgtg cacaaagtgt
     1141 ttagactcca ttttcattag gcaggttgac taaaaatgat tgcagtaaca ggtttatata
     1201 aaatagagca acctttcatg ctgtgacaca aatcaaaagg ttgataactt tgtaatttta
     1261 ctctggagat tctaaccgaa gttggtgtaa gttttcaaga gttactaaaa tcaagttgga
     1321 aatgatttac gtacacttcc ctgagcctgg actaaagcct catgcctgta ccccaagtag
     1381 gtgatggtac ttttctatac aaaaaggatt tcctggcagg caggtattta caaagtttgt
     1441 tcctgtacca gtccaataat gacaactcta aatccagctg caccaaatct tagtgggcca
     1501 tttgtcatac ctatgaaaat tcttcagtta ttaaataact ttgtcagtgc tacctatggt
     1561 aggccggaaa caatgtagat taggaagttt catgaaaatt aacttttggg gctatggaga
     1621 aacagttaag tatcttaagt tactaaacat ttccactgaa tttttggagt gagccaaggt
     1681 tactataaaa tactttggaa gatgaattct ctacctggag ttagtttcga gagtaagcgt
     1741 agcttttaac agaaataact gcagatttta agctcataat ttgcaaaaaa aatcttttat
     1801 tggcatgaaa ataatgttgt aaatggcacc aaatattcca cttaaatgca tatacagtat
     1861 tagagtcaaa aactatttta tccctctttg ctgtttttcc cccttctgcc cactttcctg
     1921 ggtgttgggg gggcccgctg acaacagtca caaatccagc gacctaggaa aaaaattgtt
     1981 aatatagaat gaaaaattat ctttacagga ctgaatttta agcccatcta aactcttctg
     2041 ccttagctat cactaatgat attcctctct ggattttgtg gtgagaaggg cactatgagt
     2101 tccttaattt aaggaaaaaa tgtaaactta atcaatgtaa tcaatgccat gcaaaattca
     2161 ttgcaagtca agggggatgg gagagatgca atgccatacg gtgatacgga cctttaagaa
     2221 agtacaatct ttcctgaaat tcaaacacta tcatacttca aaaggtcaaa acccattccg
     2281 gaatttggct tttttaagac tttttctctc ctgctcactg gcagctgtgt gtcttaacag
     2341 cattctttca agtcctggtg tactctgctg acagcacttt aaaactttaa cagcacaatg
     2401 ataacttgta ctacatactt gatctgaatt actacagaaa aataattatg ttgcttgctt
     2461 aatgattccc aggaaacttc gttgtaggca tatattttat aagagtatta tacagtgtta
     2521 actatgcaag taagttctaa aattacacaa ttatctgtgt aatgttttag tccaattact
     2581 gtgatttatt caactctgtt ctaaagttat ctggaattgt catgctgcct caatttacag
     2641 aaatctataa tagatttcta tagaaatgta taaagacgta gcagtcattt tgttgtttct
     2701 aaatagataa catataaaaa taaaggcttt gttactttag tatttcagta gaaaaacacc
     2761 agctcattct atagaactat acttccaaaa cttagcaggg gcattctggc ctttcactta
     2821 tcctttagtt ggaattgtct agggatgaaa agctggtgga catgacctgt ataatcacag
     2881 ctttggtcat atttgcacat aagagtccac aagctcttca tgtcatgata gcgtttatgc
     2941 agccttttgg agtgctggga gagtctcatc acccaaagat aatgtttgct ctttttttaa
     3001 tctttacctg atggaatagc accaaggccc acacaaaaag tatgataacc tctgtcacac
     3061 atatcacaga acatcatttc ttcttcatgg tggggttgtc cacatataat gcatgtttta
     3121 cattccatac actgccatgg gtaggtctta atcatagaaa caagctccat tgtcatatcc
     3181 aggcaagaag gatggcctaa atcaaaacca gtattagtgg tatctcacat aagaaatttt
     3241 aacttaatat ggcacataaa atactagttt gctttaggac ttccagagaa tggctataat
     3301 gtcaaatcgc caaagagaaa tgaatataca atgtagagga aaacacatgg gctgtgtcta
     3361 tgcctcacaa gctaccctgt gtatttaatt tggtgactct ttggttgaaa tctgcctgaa
     3421 actataaatt ctagtttttg aaccaataaa tacggtggtt aaaattttaa aaagacattt
     3481 caatacttac cactattctc acattgggag cagtgtataa gtgattcagc ctttcctttc
     3541 ttgttggact ccttaccctt cagacaaatt ccacatatag catttggaat gacctttggc
     3601 tggaagggta gaagagggct ataaattcat gccagaagag cttactatgg gtttaaaagg
     3661 aattctgtta ctttattgcc ctatttttac ttttggtaac ttgctaatga ggaccatttt
     3721 gaaagacaaa acttgacagg agtctgccta caatgtaaga ctgcctactg aagaaagcat
     3781 taatttcatc ataaaatttg gtaaacagca tgatctcgta agattaaatg tagcattcta
     3841 tactccctac atgcacagta agatttgttt aatgaatgga aggaaagact aaatacaatg
     3901 tcaaatgtca ctattaattg gacaagaaaa tccaagtagc aaatgaccat tatgtgtaag
     3961 acttactcta aaaagaccat tttaaatagc tcatatatta attttgttta aaacctgcta
     4021 ttttccaaaa ctgcaaaact agagctataa aatctaagtt aaaaaatcag cttatcctca
     4081 ttggtatagt ggtatttaaa aaaaaatcag tttaaacatt tttaattgaa agatgtctca
     4141 tgcatacatt ggcgtgtaca taaacgtttg tggaaaactt agttgtgtga ttattctctt
     4201 tgcatgtcta ataaaagaat ctatacttag aaaga
//
