LOCUS       NM_144980               1822 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens chromosome 6 open reading frame 118 (C6orf118), mRNA.
ACCESSION   NM_144980
VERSION     NM_144980.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1822)
  AUTHORS   Kaneda,Y., Miyata,H., Shimada,K., Oura,S. and Ikawa,M.
  TITLE     Testis-specific proteins, TSNAXIP1 and 1700010I14RIK, are important
            for sperm motility and male fertility in mice
  JOURNAL   Andrology 11 (5), 799-807 (2023)
   PUBMED   36598146
REFERENCE   2  (bases 1 to 1822)
  AUTHORS   Duek,P., Mary,C., Zahn-Zabal,M., Bairoch,A. and Lane,L.
  TITLE     Functionathon: a manual data mining workflow to generate functional
            hypotheses for uncharacterized human proteins and its application
            by undergraduate students
  JOURNAL   Database (Oxford) 2021 (2021)
   PUBMED   34318869
REFERENCE   3  (bases 1 to 1822)
  AUTHORS   Hong,E.P., Go,M.J., Kim,H.L. and Park,J.W.
  TITLE     Risk prediction of pulmonary tuberculosis using genetic and
            conventional risk factors in adult Korean population
  JOURNAL   PLoS One 12 (3), e0174642 (2017)
   PUBMED   28355295
  REMARK    GeneRIF: Data indicate that an intergenic single nucleotide
            polymorphisms (SNPs), rs9365798, located downstream of the C6orf118
            gene showed the most significant association.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1822)
  AUTHORS   Myers,R.A., Scott,N.M., Gauderman,W.J., Qiu,W., Mathias,R.A.,
            Romieu,I., Levin,A.M., Pino-Yanes,M., Graves,P.E., Villarreal,A.B.,
            Beaty,T.H., Carey,V.J., Croteau-Chonka,D.C., del Rio Navarro,B.,
            Edlund,C., Hernandez-Cadena,L., Navarro-Olivos,E.,
            Padhukasahasram,B., Salam,M.T., Torgerson,D.G., Van den Berg,D.J.,
            Vora,H., Bleecker,E.R., Meyers,D.A., Williams,L.K., Martinez,F.D.,
            Burchard,E.G., Barnes,K.C., Gilliland,F.D., Weiss,S.T.,
            London,S.J., Raby,B.A., Ober,C. and Nicolae,D.L.
  CONSRTM   GRAAD
  TITLE     Genome-wide interaction studies reveal sex-specific asthma risk
            alleles
  JOURNAL   Hum Mol Genet 23 (19), 5251-5259 (2014)
   PUBMED   24824216
REFERENCE   5  (bases 1 to 1822)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   6  (bases 1 to 1822)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB454755.1, BC026278.1, AI333765.1 and BM968092.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144980.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230301.9/ ENSP00000230301.8
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               DB454755.1         18-387
            371-786             BC026278.1         375-790
            787-1245            AI333765.1         31-489
            1246-1810           BC026278.1         1250-1814
            1811-1822           BM968092.1         14-25               c
FEATURES             Location/Qualifiers
     source          1..1822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..1822
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /note="chromosome 6 open reading frame 118"
                     /db_xref="GeneID:168090"
                     /db_xref="HGNC:HGNC:21233"
     exon            1..44
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1429
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /codon_start=1
                     /product="uncharacterized protein C6orf118"
                     /protein_id="NP_659417.2"
                     /db_xref="CCDS:CCDS5288.1"
                     /db_xref="GeneID:168090"
                     /db_xref="HGNC:HGNC:21233"
                     /translation="MAEEREPELYLKWKHCETPGVKTLCNLKHCETPGVKTLCNLKKL
                     LNRLQKDHREDVYLYISGHLNPNKLYQPPETILQHWPNAHRPKGERASEVGEPPAGKV
                     ARMKEALAHFTIHTALVPSEAQDTPLFRYLNPQASLSHTSEEDFLPVEAVREGKEEKK
                     GGPPGRGPPGWRRREELRLPDLKVLCYQEAGSRGTRDRHHYVSSYLAGATSADRYRMF
                     LRFQKEVLAKQDLLKNDFTGSKAAAGHERKLQQELQKICTCSPQQFNRLHVFGKVFED
                     ICNSSLIFGDLLKKVKDEYELYMATLLESQPAAQYEALLAQLKALGQRPVKTADMDLA
                     REELRMLVTATKAALEQNDRLRSELEMEVALLQSAKERSESSEKHIIDENRLTLTEKV
                     EKKRCEILSKWDEIQALEKEIKTTLVHTGISDITENRIKSIEHEAIQLETENMILKKK
                     IKGPLEIYQGICKIRGNRR"
     exon            45..772
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..895
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..955
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1080
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1139
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1321
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1375
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1822
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1513..1518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /note="hexamer: CATAAA"
     polyA_site      1544
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /note="hexamer: AATAAA"
     polyA_site      1822
                     /gene="C6orf118"
                     /gene_synonym="bA85G2.1; dJ416F21.2"
                     /note="major polyA site"
ORIGIN      
        1 agctggaggg aaggaagcga tggcggagga gcgggagcct gaattgtacc tgaagtggaa
       61 gcactgcgag acgccaggcg tgaagaccct gtgtaatctg aagcactgcg agacgccagg
      121 agtgaagacc ctgtgtaatc tgaagaaact tctgaatcgg cttcagaaag accaccggga
      181 ggacgtctac ctctacatct ctggacacct gaaccccaac aagctctacc agcctccgga
      241 gacgatctta cagcactggc ccaatgccca ccggcccaag ggggagcgcg cctctgaggt
      301 gggagagccg cccgcaggga aggtggcgag gatgaaggag gccctggccc acttcaccat
      361 ccacacggcc ctggtcccca gtgaggccca ggacaccccg ctgttcaggt acctgaaccc
      421 ccaggcctct ctttcccaca cttcagagga ggatttcctt ccagtggagg ctgtcagaga
      481 ggggaaggaa gaaaagaaag gaggccctcc tggacggggc cctcctggat ggcgcaggag
      541 ggaagaactc cggctgcccg acttgaaggt gctgtgctac caggaggccg ggtccagagg
      601 caccagggac cggcaccact atgtcagctc ctacctggcc ggagccacca gcgcagacag
      661 gtacaggatg ttcctgcgtt tccagaagga agtgctcgcc aagcaagatc tcctgaagaa
      721 tgacttcact gggagcaagg cggccgcggg ccacgagaga aagctgcagc aggagctcca
      781 gaaaatttgc acgtgcagcc cccagcagtt caacagactg cacgtctttg gaaaagtctt
      841 tgaagatatt tgtaacagtt ctttgatatt tggtgatctc ttgaaaaaag ttaaggatga
      901 atatgaactc tacatggcaa cgctcctgga gtcccagcct gcagcacagt acgaggctct
      961 tctggctcaa ctcaaggcgc tggggcagag gccggtgaag acggcggaca tggatctcgc
     1021 cagggaagag ctgaggatgc tcgtgacagc cacaaaagca gccctggagc agaatgatag
     1081 actcagaagt gaactggaga tggaggtggc attgctgcag tctgcaaagg aacgatcaga
     1141 atcatctgag aaacatataa ttgatgaaaa ccgacttact cttactgaga aggttgaaaa
     1201 gaagaggtgt gaaatactca gtaagtggga tgagatacaa gctctggaaa aagaaattaa
     1261 aacaactttg gttcatactg gaatttcaga tatcactgag aataggatta aaagcataga
     1321 gcatgaagct atacaattgg aaacagaaaa tatgatttta aagaagaaaa taaaagggcc
     1381 tttggaaatt tatcaaggaa tttgtaaaat cagaggaaac agaagataac gctcaagtgg
     1441 ctgaacaaat ggccagtgga aattcttaac ttccatgtat gtagcatgga tatttgcaga
     1501 tgcatataca ttcataaaga tacatttcat ttcatcagct ttaatctcta gtaaaattaa
     1561 tgtggtatat gtatcctact caggatactg aaatacacac atgcgtacac atgattagtt
     1621 tctgttgcat acatatttac aacaatacta gttcttaacg tatgttttac tttcatttaa
     1681 taatgttcaa ctttggaaaa tacttttgat tatttgctaa gaataaggaa ttcagcgctg
     1741 cttgaataca gctcaaattt gtttatttgc caacacaagt ttacatatat gcatttaata
     1801 aaattttata gtgatttaat aa
//
