LOCUS       NM_001164478             976 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chromosome 5 open reading frame 63 (C5orf63),
            transcript variant 2, mRNA.
ACCESSION   NM_001164478 XM_002342552 XM_002345828 XM_002346727
VERSION     NM_001164478.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 976)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005915.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001164478.1.
            
            Transcript Variant: This variant (2) uses an alternate 3' exon with
            a distinct 3' coding region and 3' UTR, compared to variant 1. The
            resulting isoform (2) has a distinct and shorter C-terminus,
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1522721.1,
                                           SRR5189652.180555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296662.10/ ENSP00000453964.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC005915.1         26911-26962         c
            53-154              AC005915.1         25044-25145         c
            155-275             AC005915.1         12342-12462         c
            276-332             AC005915.1         6073-6129           c
            333-976             AC005915.1         4764-5407           c
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..976
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /note="chromosome 5 open reading frame 63"
                     /db_xref="GeneID:401207"
                     /db_xref="HGNC:HGNC:40051"
     exon            1..52
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /inference="alignment:Splign:2.1.0"
     exon            53..154
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /inference="alignment:Splign:2.1.0"
     exon            155..275
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..509
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /note="isoform 2 is encoded by transcript variant 2;
                     glutaredoxin-like protein C5orf63; glutaredoxin-like
                     protein YDR286C homolog"
                     /codon_start=1
                     /product="glutaredoxin-like protein C5orf63 isoform 2"
                     /protein_id="NP_001157950.1"
                     /db_xref="CCDS:CCDS54896.1"
                     /db_xref="GeneID:401207"
                     /db_xref="HGNC:HGNC:40051"
                     /translation="MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLC
                     DEAKEVLKPYENRFILQEVNITLPENSVWYERYKFDIPVFHLNGQFLMMHRVNTSKLE
                     KQLLKLEQQSTGG"
     exon            276..332
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /inference="alignment:Splign:2.1.0"
     exon            333..976
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      953..958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /note="hexamer: AATAAA"
     polyA_site      976
                     /gene="C5orf63"
                     /gene_synonym="YDR286C"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgccc ggcgcagggc ggaagcagag gcgttggcgg cgtgaggctc aggactgtac
       61 atcagaggaa gccaaaagcc agctggaata cttcctgaat acagttttaa tcttgtttgc
      121 aattatttcg aaggggagaa atcatctgga tcagaattaa gatgctctgg tttcaaggaa
      181 atagcatgca acttgccaga tcctcctttg gactcttctt gagaaattgc tctgcctcta
      241 agacaactct gcctgtgttg accttattca caaaggaccc atgccccctt tgtgatgaag
      301 ccaaggaagt actcaagcct tatgaaaaca ggttcatttt acaggaggtg aacatcacac
      361 ttccagaaaa ctctgtctgg tatgaaaggt ataaatttga tattcctgtc tttcacttga
      421 atggccagtt tctgatgatg catcgagtaa acacctcaaa acttgaaaaa cagctcctga
      481 aacttgagca gcaaagtact ggaggctgac tgatgccctc atgattttcc accctctctt
      541 cccataaagc atcttcctaa ggaaatgacc atggcctgat actcattttg tcacttgtac
      601 agagccctaa ggatgttctg aattcagtgg tgccaaataa atgttgacat tccccttttg
      661 gttgatggaa gtatcagtgt gggaactgtt tgcttaatgg cattttataa aataagaaga
      721 gcatattagc agggagggag atgatggagg gagggagaag tccatttgtc ttatttatcc
      781 tttttgtatt aatagagaag cacttcacag tcactgggca atgccattta taggaagaag
      841 gttctgcatt cctgctgctg ccccggaggg cttaactttt taatgaaaga ataaatgctc
      901 ttccactcag tagataaagt gaaatgtgaa ttgttaataa ctgtgcacgg tcaataaagc
      961 gatgttttaa ggaata
//
