LOCUS       NM_001102609             471 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens chromosome 5 open reading frame 58 (C5orf58),
            transcript variant 1, mRNA.
ACCESSION   NM_001102609 XM_059672 XM_945807
VERSION     NM_001102609.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008660.5 and AC034199.6.
            
            On Mar 29, 2019 this sequence version replaced NM_001102609.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX100176.1, HY016595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000593851.5/
                                                ENSP00000490013.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC008660.5         129240-129262
            24-107              AC008660.5         130370-130453
            108-201             AC008660.5         131232-131325
            202-471             AC034199.6         14936-15205
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..471
                     /gene="C5orf58"
                     /note="chromosome 5 open reading frame 58"
                     /db_xref="GeneID:133874"
                     /db_xref="HGNC:HGNC:37272"
     exon            1..23
                     /gene="C5orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            24..107
                     /gene="C5orf58"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..353
                     /gene="C5orf58"
                     /codon_start=1
                     /product="putative uncharacterized protein C5orf58"
                     /protein_id="NP_001096079.2"
                     /db_xref="CCDS:CCDS47338.1"
                     /db_xref="GeneID:133874"
                     /db_xref="HGNC:HGNC:37272"
                     /translation="MGKKRVTDHKLNVDKVIKNINTISSELKKIKELSQLLLCDLILH
                     FNHPIKTENLAEAERNNPLFEESKISDVSLVSNSFSI"
     exon            108..201
                     /gene="C5orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            202..471
                     /gene="C5orf58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      449..454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C5orf58"
                     /note="hexamer: AATAAA"
     polyA_site      471
                     /gene="C5orf58"
                     /note="major polyA site"
ORIGIN      
        1 gaacctcggt gacggttggc cagttttttt acagtggctc tgaaatgaga gaaattgcag
       61 aaattctccc tgctcaggaa aaggtagagg caaggattga cttaaagatg ggtaagaagc
      121 gtgttactga tcataagcta aatgtggaca aagtaattaa aaatattaac acaatttctt
      181 cggagttgaa gaagataaaa gagctctccc agttattgct ttgtgacctt atcctacatt
      241 ttaatcatcc catcaagact gagaacttag cagaagcaga aagaaacaac cccctctttg
      301 aagagtctaa aatatcagat gtatcccttg tttctaacag tttttctatc tgatttctta
      361 tttgttatga gtttctgttt tattgttgaa ctaacaaata tttgggagag ttgagtttac
      421 taatttgtat atatataatt taaaacaaaa taaaaataat gtaaacaagc a
//
